{"id":"https://openalex.org/W99985103","doi":null,"title":"DNA methylation profiling of fish tumours","display_name":"DNA methylation profiling of fish tumours","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W99985103","mag":"99985103"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:3633","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/3633/8/Leda_Mirbahai_Appendix.zip","pdf_url":null,"source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/51010","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016967754","display_name":"Leda Mirbahai","orcid":"https://orcid.org/0009-0007-5132-0417","observed_orcids":["https://orcid.org/0009-0007-5132-0417"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Leda Mirbahai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-5132-0417","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016967754"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/limanda-limanda","display_name":"Limanda limanda","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dab","display_name":"digital audio broadcasting","score":0.7630000114440918},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hepatocellular-adenoma","display_name":"hepatocellular adenoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/liver-tumors","display_name":"liver tumors","score":0.6970000267028809},{"id":"https://openalex.org/keywords/global-dna-hypomethylation","display_name":"global DNA hypomethylation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.875},{"id":"https://openalex.org/keywords/tumourigenesis","display_name":"tumourigenesis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/marine-pollutants","display_name":"marine contaminants","score":0.699999988079071},{"id":"https://openalex.org/keywords/marine-environment","display_name":"marine environment","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C2780384893","wikidata":"https://www.wikidata.org/wiki/Q901804","display_name":"Danio","level":4,"score":0.8008462190628052},{"id":"https://openalex.org/C2776195089","wikidata":"https://www.wikidata.org/wiki/Q2081138","display_name":"Limanda","level":4,"score":0.7991890907287598},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7731402516365051},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7696846723556519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.76662278175354},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6860480308532715},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.6848087310791016},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5660625696182251},{"id":"https://openalex.org/C2779950014","wikidata":"https://www.wikidata.org/wiki/Q59577","display_name":"Flatfish","level":3,"score":0.5518857836723328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39854544401168823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3635363280773163},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3223022222518921},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.2451111078262329},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.19356712698936462},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12774208188056946}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:3633","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/3633/8/Leda_Mirbahai_Appendix.zip","pdf_url":null,"source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:uilis.unsyiah.ac.id:51010","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/3633/8/Leda_Mirbahai_Appendix.zip","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/51010","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:99985103","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/3633/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:51010","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/3633/8/Leda_Mirbahai_Appendix.zip","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/51010","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W99985103.pdf","grobid_xml":"https://content.openalex.org/works/W99985103.grobid-xml"},"referenced_works_count":276,"referenced_works":["https://openalex.org/W17045203","https://openalex.org/W38556188","https://openalex.org/W1481549430","https://openalex.org/W1496670813","https://openalex.org/W1499500424","https://openalex.org/W1525107890","https://openalex.org/W1526580148","https://openalex.org/W1540744482","https://openalex.org/W1543891416","https://openalex.org/W1544893850","https://openalex.org/W1551034491","https://openalex.org/W1576834187","https://openalex.org/W1577875429","https://openalex.org/W1589379007","https://openalex.org/W1643500256","https://openalex.org/W1658127082","https://openalex.org/W1673514954","https://openalex.org/W1715660697","https://openalex.org/W1808852910","https://openalex.org/W1893545268","https://openalex.org/W1910910895","https://openalex.org/W1912673154","https://openalex.org/W1918492045","https://openalex.org/W1935061717","https://openalex.org/W1963498389","https://openalex.org/W1965262464","https://openalex.org/W1966963107","https://openalex.org/W1967064280","https://openalex.org/W1969052874","https://openalex.org/W1970419068","https://openalex.org/W1971708895","https://openalex.org/W1971723950","https://openalex.org/W1972169216","https://openalex.org/W1972944037","https://openalex.org/W1973318715","https://openalex.org/W1974116356","https://openalex.org/W1975995583","https://openalex.org/W1976457281","https://openalex.org/W1978324852","https://openalex.org/W1978661875","https://openalex.org/W1978983799","https://openalex.org/W1979674827","https://openalex.org/W1979954557","https://openalex.org/W1979995768","https://openalex.org/W1980681096","https://openalex.org/W1983521494","https://openalex.org/W1984491334","https://openalex.org/W1985339713","https://openalex.org/W1985421298","https://openalex.org/W1986193321","https://openalex.org/W1987189614","https://openalex.org/W1989578834","https://openalex.org/W1990109007","https://openalex.org/W1994048261","https://openalex.org/W1995397347","https://openalex.org/W1995643652","https://openalex.org/W1998715453","https://openalex.org/W1998941814","https://openalex.org/W2003203989","https://openalex.org/W2003500892","https://openalex.org/W2003919516","https://openalex.org/W2003946492","https://openalex.org/W2004114662","https://openalex.org/W2004167290","https://openalex.org/W2004172747","https://openalex.org/W2004968463","https://openalex.org/W2007810446","https://openalex.org/W2007977711","https://openalex.org/W2008269062","https://openalex.org/W2010291571","https://openalex.org/W2010768718","https://openalex.org/W2011912935","https://openalex.org/W2013687234","https://openalex.org/W2014541052","https://openalex.org/W2014623973","https://openalex.org/W2016770221","https://openalex.org/W2016776053","https://openalex.org/W2017102177","https://openalex.org/W2019688984","https://openalex.org/W2019937806","https://openalex.org/W2020428655","https://openalex.org/W2020956187","https://openalex.org/W2021149137","https://openalex.org/W2021821558","https://openalex.org/W2022797399","https://openalex.org/W2023326581","https://openalex.org/W2023528901","https://openalex.org/W2026569438","https://openalex.org/W2027988966","https://openalex.org/W2028382049","https://openalex.org/W2029038413","https://openalex.org/W2029197798","https://openalex.org/W2029815513","https://openalex.org/W2030864780","https://openalex.org/W2033364737","https://openalex.org/W2034105248","https://openalex.org/W2034199074","https://openalex.org/W2034269086","https://openalex.org/W2034545013","https://openalex.org/W2035063750","https://openalex.org/W2035736338","https://openalex.org/W2036300762","https://openalex.org/W2036367015","https://openalex.org/W2036986058","https://openalex.org/W2037024562","https://openalex.org/W2037341016","https://openalex.org/W2037786647","https://openalex.org/W2039453229","https://openalex.org/W2040149948","https://openalex.org/W2041951073","https://openalex.org/W2043178719","https://openalex.org/W2044721366","https://openalex.org/W2044887289","https://openalex.org/W2046387526","https://openalex.org/W2046980861","https://openalex.org/W2047945525","https://openalex.org/W2048408822","https://openalex.org/W2048465346","https://openalex.org/W2048844921","https://openalex.org/W2052716733","https://openalex.org/W2054776840","https://openalex.org/W2056182559","https://openalex.org/W2056467018","https://openalex.org/W2056643340","https://openalex.org/W2057299232","https://openalex.org/W2057955426","https://openalex.org/W2059520437","https://openalex.org/W2062289724","https://openalex.org/W2062421371","https://openalex.org/W2063148024","https://openalex.org/W2063305894","https://openalex.org/W2063885993","https://openalex.org/W2064813976","https://openalex.org/W2065285343","https://openalex.org/W2065525499","https://openalex.org/W2065544392","https://openalex.org/W2066899566","https://openalex.org/W2067022150","https://openalex.org/W2067323501","https://openalex.org/W2068649963","https://openalex.org/W2070484728","https://openalex.org/W2071213636","https://openalex.org/W2071267746","https://openalex.org/W2072139119","https://openalex.org/W2072610667","https://openalex.org/W2072827995","https://openalex.org/W2073157961","https://openalex.org/W2074092968","https://openalex.org/W2074687765","https://openalex.org/W2077217951","https://openalex.org/W2077249217","https://openalex.org/W2077359776","https://openalex.org/W2077775555","https://openalex.org/W2078028724","https://openalex.org/W2078654003","https://openalex.org/W2079705969","https://openalex.org/W2080230060","https://openalex.org/W2082091586","https://openalex.org/W2083168128","https://openalex.org/W2084202366","https://openalex.org/W2084363318","https://openalex.org/W2084412363","https://openalex.org/W2084748297","https://openalex.org/W2085714273","https://openalex.org/W2086120628","https://openalex.org/W2088086606","https://openalex.org/W2089552551","https://openalex.org/W2090796152","https://openalex.org/W2091789935","https://openalex.org/W2092067928","https://openalex.org/W2092951908","https://openalex.org/W2093188241","https://openalex.org/W2093284719","https://openalex.org/W2094395530","https://openalex.org/W2098271615","https://openalex.org/W2098866520","https://openalex.org/W2099008463","https://openalex.org/W2099521632","https://openalex.org/W2099668082","https://openalex.org/W2099907183","https://openalex.org/W2099930946","https://openalex.org/W2101037833","https://openalex.org/W2103059623","https://openalex.org/W2103166769","https://openalex.org/W2103554498","https://openalex.org/W2104693960","https://openalex.org/W2105224706","https://openalex.org/W2106159137","https://openalex.org/W2106195345","https://openalex.org/W2106787323","https://openalex.org/W2107277218","https://openalex.org/W2107337799","https://openalex.org/W2107410714","https://openalex.org/W2107419302","https://openalex.org/W2108664872","https://openalex.org/W2108931268","https://openalex.org/W2109219174","https://openalex.org/W2109661077","https://openalex.org/W2110065044","https://openalex.org/W2110237282","https://openalex.org/W2110913360","https://openalex.org/W2113002917","https://openalex.org/W2113120945","https://openalex.org/W2114970231","https://openalex.org/W2116897441","https://openalex.org/W2117692326","https://openalex.org/W2118750047","https://openalex.org/W2119263245","https://openalex.org/W2120432300","https://openalex.org/W2120629724","https://openalex.org/W2120929142","https://openalex.org/W2121090755","https://openalex.org/W2121278687","https://openalex.org/W2121417064","https://openalex.org/W2122624442","https://openalex.org/W2123174009","https://openalex.org/W2123424849","https://openalex.org/W2123892768","https://openalex.org/W2124040125","https://openalex.org/W2124049725","https://openalex.org/W2124468353","https://openalex.org/W2125310307","https://openalex.org/W2125625276","https://openalex.org/W2127203480","https://openalex.org/W2131892345","https://openalex.org/W2132649218","https://openalex.org/W2134087142","https://openalex.org/W2134555277","https://openalex.org/W2135449253","https://openalex.org/W2135908778","https://openalex.org/W2136113495","https://openalex.org/W2137477400","https://openalex.org/W2137915568","https://openalex.org/W2138192222","https://openalex.org/W2138253156","https://openalex.org/W2139077902","https://openalex.org/W2139122477","https://openalex.org/W2139779831","https://openalex.org/W2140061289","https://openalex.org/W2140291328","https://openalex.org/W2140418591","https://openalex.org/W2142979837","https://openalex.org/W2143138913","https://openalex.org/W2143958725","https://openalex.org/W2145273814","https://openalex.org/W2145975061","https://openalex.org/W2146064872","https://openalex.org/W2149206894","https://openalex.org/W2149406533","https://openalex.org/W2149548143","https://openalex.org/W2150173639","https://openalex.org/W2150663160","https://openalex.org/W2150914815","https://openalex.org/W2151595202","https://openalex.org/W2156098590","https://openalex.org/W2158143138","https://openalex.org/W2158227917","https://openalex.org/W2158581865","https://openalex.org/W2159922182","https://openalex.org/W2160704282","https://openalex.org/W2161098391","https://openalex.org/W2162085688","https://openalex.org/W2163821350","https://openalex.org/W2164065953","https://openalex.org/W2164154943","https://openalex.org/W2164326183","https://openalex.org/W2165316077","https://openalex.org/W2170546016","https://openalex.org/W2170973713","https://openalex.org/W2172283024","https://openalex.org/W2214306521","https://openalex.org/W2327263867","https://openalex.org/W2413728151","https://openalex.org/W3169573270","https://openalex.org/W4235185594","https://openalex.org/W4249052994"],"related_works":["https://openalex.org/W1993216686","https://openalex.org/W2143958725","https://openalex.org/W2331763913","https://openalex.org/W2156688038","https://openalex.org/W2314569474","https://openalex.org/W2066431595","https://openalex.org/W2031652365","https://openalex.org/W4378781882","https://openalex.org/W2735742223","https://openalex.org/W1994707478"],"abstract_inverted_index":{"Assessment":[0],"of":[1,11,15,28,41,53,65,79,104,115,121,136,155,172,190],"disease":[2],"status":[3],"in":[4,17,31,58,63,72,77,108,117,124,127,142,162,192,205,208],"fish":[5,81,206],"is":[6,61],"used":[7],"as":[8],"an":[9],"indicator":[10],"the":[12,18,26,38,45,73,83,90,112,188,200,209],"biological":[13],"effects":[14],"contaminants":[16],"marine":[19,92],"environment.":[20],"At":[21],"some":[22],"UK":[23],"offshore":[24],"sites":[25],"prevalence":[27],"liver":[29,110,149,154],"tumours":[30,64,78,191,207],"Limanda":[32],"limanda":[33],"(dab)":[34],"exceeds":[35],"20%.":[36],"However,":[37],"molecular":[39],"mechanisms":[40],"tumour":[42],"formation":[43],"and":[44,89,111,146,183,203],"causative":[46],"agents":[47],"are":[48],"not":[49],"known.":[50],"The":[51,97,159],"contribution":[52],"epigenetic":[54,182],"mechanisms,":[55],"although":[56],"well-established":[57],"human":[59],"tumourigenesis,":[60],"under-studied":[62],"aquatic":[66,129],"species.":[67,130],"In":[68],"this":[69,163],"thesis,":[70],"alteration":[71],"DNA":[74,105,118,138,177],"methylation":[75,106,119,139],"patterns":[76],"two":[80],"species,":[82],"model":[84],"species":[85],"zebrafish":[86,109],"(Danio":[87],"rerio)":[88],"un-sequenced":[91],"flatfish":[93],"dab,":[94],"were":[95],"investigated.":[96],"data":[98],"presented":[99,161],"provided":[100],"a":[101,170,197],"comprehensive":[102],"characterisation":[103],"pattern":[107],"first":[113],"evidence":[114,160],"alterations":[116],"profiles":[120],"key":[122],"genes":[123],"tumourigenesis":[125],"pathways":[126],"any":[128],"A":[131],"statistically":[132],"significant":[133],"lower":[134],"level":[135],"global":[137,176],"was":[140],"demonstrated":[141],"hepatocellular":[143],"adenoma":[144],"(HCA)":[145],"non-cancerous":[147],"surrounding":[148],"tissue":[150],"(ST)":[151],"compared":[152],"to":[153,169,175,187],"non-cancer":[156],"bearing":[157],"dab.":[158,193],"thesis":[164],"suggests":[165],"that":[166],"chronic":[167],"exposure":[168],"mixture":[171],"pollutants":[173],"contribute":[174],"hypomethylation":[178],"followed":[179],"by":[180],"further":[181],"genomic":[184],"changes,":[185],"leading":[186],"development":[189],"These":[194],"findings":[195],"suggest":[196],"link":[198],"between":[199],"environment,":[201],"epigenome":[202],"cancer":[204],"wild.":[210]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
