{"id":"https://openalex.org/W999834301","doi":null,"title":"Traumatized muscle-derived multipotent progenitor cells: Pro-angiogenic activity, promotion of nerve growth, and osteogenic differentiation","display_name":"Traumatized muscle-derived multipotent progenitor cells: Pro-angiogenic activity, promotion of nerve growth, and osteogenic differentiation","publication_year":2015,"publication_date":"2015-06-09","ids":{"openalex":"https://openalex.org/W999834301","mag":"999834301"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:24282","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/24282/1/HOFERHR_ETD2015.pdf","pdf_url":"http://d-scholarship.pitt.edu/24282/1/HOFERHR_ETD2015.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/24282/1/HOFERHR_ETD2015.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060333082","display_name":"Heidi R. Hofer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Heidi R. Hofer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060333082"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01287359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blast-injury","display_name":"blast injury","score":0.765999972820282},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/peripheral-nerve-repair","display_name":"peripheral nerve repair","score":0.7009999752044678},{"id":"https://openalex.org/keywords/nerve-guidance-conduits","display_name":"nerve conduits","score":0.7279999852180481},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/secretome","display_name":"secretome","score":0.7129999995231628},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8629999756813049},{"id":"https://openalex.org/keywords/injectable-hydrogel","display_name":"injectable hydrogel","score":0.6039999723434448},{"id":"https://openalex.org/keywords/nanofibrous-scaffolds","display_name":"nanofibrous scaffolds","score":0.7889999747276306},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.7820000052452087},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7319999933242798},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8299999833106995},{"id":"https://openalex.org/keywords/heterotopic-ossification","display_name":"heterotopic ossification","score":0.875},{"id":"https://openalex.org/keywords/limb-regeneration","display_name":"limb regeneration","score":0.6050000190734863},{"id":"https://openalex.org/keywords/extremity-injuries","display_name":"extremity injuries","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.697822093963623},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6298195123672485},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5565462112426758},{"id":"https://openalex.org/C136940099","wikidata":"https://www.wikidata.org/wiki/Q6996839","display_name":"Nerve guidance conduit","level":3,"score":0.5090591311454773},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.4980952739715576},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4928853511810303},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4045931398868561},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3985939025878906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3806220293045044},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3446362018585205},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.337081640958786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30330443382263184},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.19261318445205688},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:24282","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/24282/1/HOFERHR_ETD2015.pdf","pdf_url":"http://d-scholarship.pitt.edu/24282/1/HOFERHR_ETD2015.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:999834301","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/24282/1/HOFERHR_ETD2015.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:24282","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/24282/1/HOFERHR_ETD2015.pdf","pdf_url":"http://d-scholarship.pitt.edu/24282/1/HOFERHR_ETD2015.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W999834301.pdf","grobid_xml":"https://content.openalex.org/works/W999834301.grobid-xml"},"referenced_works_count":234,"referenced_works":["https://openalex.org/W31979510","https://openalex.org/W95114340","https://openalex.org/W227158685","https://openalex.org/W640783451","https://openalex.org/W1148638342","https://openalex.org/W1475713056","https://openalex.org/W1483526410","https://openalex.org/W1508072561","https://openalex.org/W1525492868","https://openalex.org/W1530170256","https://openalex.org/W1538428879","https://openalex.org/W1569171918","https://openalex.org/W1618653001","https://openalex.org/W1882688223","https://openalex.org/W1883289549","https://openalex.org/W1887760770","https://openalex.org/W1963128268","https://openalex.org/W1963488997","https://openalex.org/W1964417650","https://openalex.org/W1964793085","https://openalex.org/W1964913381","https://openalex.org/W1965462287","https://openalex.org/W1966208727","https://openalex.org/W1967679504","https://openalex.org/W1968566156","https://openalex.org/W1968814074","https://openalex.org/W1969118281","https://openalex.org/W1970270213","https://openalex.org/W1972674412","https://openalex.org/W1974061076","https://openalex.org/W1975158306","https://openalex.org/W1975216289","https://openalex.org/W1976740525","https://openalex.org/W1977268622","https://openalex.org/W1977679952","https://openalex.org/W1977802309","https://openalex.org/W1978366029","https://openalex.org/W1978370369","https://openalex.org/W1978702852","https://openalex.org/W1978993910","https://openalex.org/W1980285125","https://openalex.org/W1981225176","https://openalex.org/W1984023554","https://openalex.org/W1984417662","https://openalex.org/W1986049860","https://openalex.org/W1988680604","https://openalex.org/W1989021197","https://openalex.org/W1989494547","https://openalex.org/W1989904854","https://openalex.org/W1990487327","https://openalex.org/W1990630756","https://openalex.org/W1991062038","https://openalex.org/W1991554693","https://openalex.org/W1991973189","https://openalex.org/W1992112921","https://openalex.org/W1992542606","https://openalex.org/W1992881271","https://openalex.org/W1993895799","https://openalex.org/W1993980410","https://openalex.org/W1994812362","https://openalex.org/W1995031048","https://openalex.org/W1996910230","https://openalex.org/W1997061938","https://openalex.org/W1998057512","https://openalex.org/W2000389046","https://openalex.org/W2000489529","https://openalex.org/W2001740738","https://openalex.org/W2001890367","https://openalex.org/W2007553857","https://openalex.org/W2011546750","https://openalex.org/W2012060637","https://openalex.org/W2014368942","https://openalex.org/W2014386715","https://openalex.org/W2014640240","https://openalex.org/W2016305198","https://openalex.org/W2016685143","https://openalex.org/W2017208938","https://openalex.org/W2017215856","https://openalex.org/W2018266638","https://openalex.org/W2019214943","https://openalex.org/W2019602403","https://openalex.org/W2020545615","https://openalex.org/W2022106358","https://openalex.org/W2022558733","https://openalex.org/W2022728491","https://openalex.org/W2023287513","https://openalex.org/W2024744072","https://openalex.org/W2025371271","https://openalex.org/W2025476044","https://openalex.org/W2025566941","https://openalex.org/W2027099431","https://openalex.org/W2027745827","https://openalex.org/W2027831359","https://openalex.org/W2027970223","https://openalex.org/W2028616581","https://openalex.org/W2030508471","https://openalex.org/W2031613531","https://openalex.org/W2031857489","https://openalex.org/W2031966932","https://openalex.org/W2033360488","https://openalex.org/W2033559662","https://openalex.org/W2034825883","https://openalex.org/W2035379099","https://openalex.org/W2035750176","https://openalex.org/W2036659255","https://openalex.org/W2038399651","https://openalex.org/W2041340918","https://openalex.org/W2041591721","https://openalex.org/W2042142213","https://openalex.org/W2042432265","https://openalex.org/W2043011130","https://openalex.org/W2044490216","https://openalex.org/W2045705524","https://openalex.org/W2046440184","https://openalex.org/W2046905210","https://openalex.org/W2047740136","https://openalex.org/W2047792712","https://openalex.org/W2048037688","https://openalex.org/W2049567191","https://openalex.org/W2049655446","https://openalex.org/W2049890943","https://openalex.org/W2050802468","https://openalex.org/W2052230588","https://openalex.org/W2052520062","https://openalex.org/W2054095354","https://openalex.org/W2054417819","https://openalex.org/W2056663971","https://openalex.org/W2057130072","https://openalex.org/W2057410741","https://openalex.org/W2057425253","https://openalex.org/W2058239698","https://openalex.org/W2064116577","https://openalex.org/W2064900331","https://openalex.org/W2065123875","https://openalex.org/W2065617830","https://openalex.org/W2065699924","https://openalex.org/W2065955533","https://openalex.org/W2067131837","https://openalex.org/W2068720223","https://openalex.org/W2072607005","https://openalex.org/W2073024911","https://openalex.org/W2074196937","https://openalex.org/W2077324135","https://openalex.org/W2077501711","https://openalex.org/W2077709457","https://openalex.org/W2078691010","https://openalex.org/W2081843874","https://openalex.org/W2082604867","https://openalex.org/W2083219632","https://openalex.org/W2086859574","https://openalex.org/W2087127958","https://openalex.org/W2087131768","https://openalex.org/W2089249601","https://openalex.org/W2089813431","https://openalex.org/W2092539489","https://openalex.org/W2092950961","https://openalex.org/W2093760230","https://openalex.org/W2094482631","https://openalex.org/W2095666785","https://openalex.org/W2095685494","https://openalex.org/W2098734814","https://openalex.org/W2100223622","https://openalex.org/W2100432653","https://openalex.org/W2100704394","https://openalex.org/W2101682146","https://openalex.org/W2102105402","https://openalex.org/W2103227975","https://openalex.org/W2104016130","https://openalex.org/W2105016447","https://openalex.org/W2106647511","https://openalex.org/W2109041605","https://openalex.org/W2109962985","https://openalex.org/W2111830995","https://openalex.org/W2113167876","https://openalex.org/W2113358240","https://openalex.org/W2114222046","https://openalex.org/W2115368694","https://openalex.org/W2115480192","https://openalex.org/W2116333903","https://openalex.org/W2117228071","https://openalex.org/W2117247924","https://openalex.org/W2117518170","https://openalex.org/W2117923390","https://openalex.org/W2118355184","https://openalex.org/W2119402264","https://openalex.org/W2120002445","https://openalex.org/W2120064042","https://openalex.org/W2120396169","https://openalex.org/W2121050534","https://openalex.org/W2122479265","https://openalex.org/W2123771262","https://openalex.org/W2126974532","https://openalex.org/W2129574021","https://openalex.org/W2130038062","https://openalex.org/W2131717731","https://openalex.org/W2131916287","https://openalex.org/W2132419184","https://openalex.org/W2134082960","https://openalex.org/W2134614924","https://openalex.org/W2139908236","https://openalex.org/W2140202284","https://openalex.org/W2140892442","https://openalex.org/W2141046053","https://openalex.org/W2142254746","https://openalex.org/W2142746463","https://openalex.org/W2144201350","https://openalex.org/W2144966500","https://openalex.org/W2145901145","https://openalex.org/W2146180782","https://openalex.org/W2147673404","https://openalex.org/W2149783092","https://openalex.org/W2150554886","https://openalex.org/W2153484787","https://openalex.org/W2153949260","https://openalex.org/W2158016927","https://openalex.org/W2161042757","https://openalex.org/W2164032186","https://openalex.org/W2165078118","https://openalex.org/W2166365091","https://openalex.org/W2166572577","https://openalex.org/W2169872175","https://openalex.org/W2170001740","https://openalex.org/W2171253121","https://openalex.org/W2179425800","https://openalex.org/W2274900184","https://openalex.org/W2280905139","https://openalex.org/W2318133431","https://openalex.org/W2331218368","https://openalex.org/W2489356553","https://openalex.org/W2903658413","https://openalex.org/W3090292617","https://openalex.org/W4230909310","https://openalex.org/W4298052720","https://openalex.org/W4323254784"],"related_works":["https://openalex.org/W2575173359","https://openalex.org/W2760846415","https://openalex.org/W1882688223","https://openalex.org/W7097090465","https://openalex.org/W2048037688","https://openalex.org/W2140892442","https://openalex.org/W3145475788","https://openalex.org/W3120504531","https://openalex.org/W4387701823","https://openalex.org/W2772429441"],"abstract_inverted_index":{"Following":[0],"trauma":[1],"from":[2,15,42],"high-energy":[3],"blasts,":[4],"a":[5,88,250],"population":[6],"of":[7,24,60,68,81,94,148,159,171,192,211,216,227],"multipotent":[8],"progenitor":[9],"cells":[10,40,132],"(MPCs)":[11],"can":[12],"be":[13,163,242,247],"derived":[14,41],"the":[16,21,34,56,66,209,214,224,254,260],"debrided":[17],"muscle":[18],"tissue.":[19],"Given":[20],"non-intrusive":[22],"nature":[23],"MPC":[25,92,179],"isolation,":[26],"MPCs":[27,61,82,107,161,193,228,245],"represent":[28],"an":[29],"attractive":[30],"clinical":[31,118],"alternative":[32],"to":[33,65,165,259],"more":[35],"widely":[36],"used":[37],"mesenchymal":[38],"stem":[39],"bone":[43,77,195,205],"marrow":[44],"and":[45,58,76,146,177,183],"other":[46],"tissue":[47,255],"sources.":[48],"This":[49],"dissertation":[50],"presents":[51],"work":[52,222],"which":[53],"further":[54],"defines":[55],"utility":[57,226],"limitations":[59],"in":[62,84,87,114,128,194,201],"applications":[63,197],"relevant":[64],"repair":[67,170],"extremity":[69],"injuries,":[70],"including":[71],"angiogenesis,":[72,86],"peripheral":[73,172],"nerve":[74,167,238],"repair,":[75],"formation.":[78],"The":[79,190],"secretome":[80,141],"enhanced":[83,121,235],"vitro":[85],"manner":[89],"dependent":[90],"on":[91,135,208],"production":[93],"vascular":[95],"endothelial":[96,131],"growth":[97],"factor-A":[98],"(VEGF).":[99],"Encapsulated":[100],"within":[101],"mechanically":[102],"tunable":[103],"injectable":[104],"hydrogel":[105],"constructs,":[106],"retained":[108],"strong":[109],"pro-angiogenic":[110],"activity":[111],"when":[112,120],"implanted":[113],"vivo,":[115],"supporting":[116],"potential":[117,225],"use":[119,191],"vessel":[122,236],"recruitment":[123],"is":[124],"desired.":[125],"Neurotrophically-induced":[126],"MPCs,":[127],"combination":[129],"with":[130,187],"(ECs)":[133],"co-cultured":[134],"aligned,":[136],"nanofibrous":[137],"scaffolds":[138],"or":[139,237],"via":[140],"interactions,":[142],"supported":[143],"neurite":[144],"outgrowth":[145],"extension":[147],"chick":[149],"embryonic":[150],"dorsal":[151],"root":[152],"ganglia.":[153],"These":[154],"findings":[155],"suggest":[156],"that":[157],"products":[158],"induced":[160],"may":[162,198,246],"useful":[164],"enhance":[166],"guide":[168],"conduit-based":[169],"nerves.":[173],"ECs":[174],"influenced":[175,248],"earlier":[176],"stronger":[178],"osteogenic":[180],"gene":[181],"expression,":[182],"IL-1\u03b2":[184],"was":[185],"associated":[186],"increased":[188],"mineralization.":[189],"replacement":[196],"thus":[199],"result":[200],"mineralization":[202],"without":[203],"functional":[204],"formation,":[206],"depending":[207],"level":[210],"inflammation":[212],"at":[213],"site":[215],"construct":[217],"implantation.":[218],"Taken":[219],"together,":[220],"this":[221],"extends":[223],"for":[229,234],"limb":[230],"regenerative":[231],"applications,":[232],"especially":[233],"recruitment.":[239],"Caution":[240],"must":[241],"exercised":[243],"as":[244],"towards":[249],"mineralizing":[251],"phenotype":[252],"by":[253],"environment,":[256],"likely":[257],"contributing":[258],"heterotopic":[261],"ossification":[262],"pathology":[263],"commonly":[264],"seen":[265],"following":[266],"blast":[267],"trauma.":[268]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
