{"id":"https://openalex.org/W99982198","doi":null,"title":"Role of beta-1 integrins in organ specific adhesion of melanoma cells in vitro.","display_name":"Role of beta-1 integrins in organ specific adhesion of melanoma cells in vitro.","publication_year":1993,"publication_date":"1993-02-01","ids":{"openalex":"https://openalex.org/W99982198","mag":"99982198","pmid":"https://pubmed.ncbi.nlm.nih.gov/7680081"},"language":"en","primary_location":{"id":"pmid:7680081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7680081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109182019","display_name":"Jacqueline Vink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Vink","raw_affiliation_strings":["Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081297649","display_name":"Luc Thomas","orcid":"https://orcid.org/0000-0003-1995-2434","observed_orcids":["https://orcid.org/0000-0003-1995-2434","https://orcid.org/0000-0002-4315-5374","https://orcid.org/0000-0002-8329-7262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Thomas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Etoh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Etoh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111548396","display_name":"Jan A. Bruijn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Bruijn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025710827","display_name":"Mart\u00edn C. Mihm","orcid":"https://orcid.org/0000-0002-7275-6945","observed_orcids":["https://orcid.org/0000-0002-7275-6945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Mihm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053814059","display_name":"Sebastiano Gattoni\u2010Celli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Gattoni-Celli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112101717","display_name":"Hugh Randolph Byers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H R Byers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2809,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.77192982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"68","issue":"2","first_page":"192","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9240000247955322},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7450000047683716},{"id":"https://openalex.org/keywords/organ-specific-metastasis","display_name":"organ-specific metastasis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/integrin-alpha2beta1","display_name":"alpha2beta1 integrin","score":0.7749999761581421},{"id":"https://openalex.org/keywords/integrin-alpha6beta1","display_name":"alpha6beta1 integrin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/integrin-expression","display_name":"integrin expression","score":0.48500001430511475},{"id":"https://openalex.org/keywords/melanoma-cell-adhesion","display_name":"melanoma cell adhesion","score":0.7929999828338623},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7559999823570251},{"id":"https://openalex.org/keywords/experimental-metastasis","display_name":"experimental metastasis","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2777141677","wikidata":"https://www.wikidata.org/wiki/Q50254584","display_name":"Alpha-v beta-3","level":5,"score":0.7722941637039185},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6812583208084106},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5519119501113892},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5264393091201782},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47851765155792236},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.45663338899612427},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45558270812034607},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.451673686504364},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4465913474559784},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4116531014442444},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36918649077415466},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3317469358444214},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.30636611580848694},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2680872678756714},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24906855821609497},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.24349799752235413},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24124440550804138},{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.23449361324310303},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2304898500442505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1878126859664917},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019012","descriptor_name":"Integrin beta1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7680081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7680081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:99982198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7680081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2115146277","https://openalex.org/W1968907600","https://openalex.org/W1516353866","https://openalex.org/W2081841536","https://openalex.org/W1982768448","https://openalex.org/W2039496775","https://openalex.org/W1988717603","https://openalex.org/W2072995607","https://openalex.org/W2018060238","https://openalex.org/W2354972079"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recent":[1],"data":[2,280],"suggest":[3,281],"that":[4,282,304],"the":[5,127,214,260,271],"extracellular":[6],"matrix":[7],"of":[8,14,39,60,100,121,216,273,309],"organs":[9],"and":[10,42,66,94,106,129,136,146,151,155,162,179,205,218,232,287,303],"heterogeneous":[11,58],"integrin":[12,31,307],"expression":[13,59,99,308],"tumor":[15],"cells":[16,220,312],"may":[17,313],"influence":[18],"metastasis":[19],"distribution.":[20],"EXPERIMENTAL":[21],"DESIGN:":[22],"Three":[23],"human":[24],"melanoma":[25,71,294,311],"cell":[26,55,72,250,295],"lines":[27,56,117],"were":[28],"characterized":[29],"for":[30],"expression,":[32],"in":[33,48,301,306,316,320],"vitro":[34,302],"binding":[35,62,183,197,272],"to":[36,44,63,79,87,174,184,203,221,275,297],"cryostat":[37,64],"sections":[38,300],"different":[40],"organs,":[41],"ability":[43],"generate":[45],"experimental":[46,80],"metastases":[47],"triple":[49],"immunodeficient":[50],"mice.":[51],"RESULTS:":[52],"The":[53],"three":[54],"exhibited":[57,118,171],"integrins,":[61],"sections,":[65,93,191],"organ":[67,91,122,298,318],"colonization.":[68],"A":[69],"primary":[70],"line":[73],"(PM-WK)":[74],"did":[75,240],"not":[76,256],"give":[77],"rise":[78],"metastases,":[81],"showed":[82,95],"scant":[83],"or":[84,97,188],"mild":[85],"attachment":[86,173,202,215,296],"only":[88,126],"a":[89,195],"few":[90],"tissue":[92,190,299],"absent":[96],"minimal":[98],"alpha-integrin":[101],"subunits":[102],"tested":[103],"(VLA":[104],"1-6)":[105],"alpha":[107,132,137,158,163,265,283,288],"v":[108,138],"beta":[109,134,139,160,165,267,285,290],"3.":[110],"In":[111,168],"contrast,":[112],"two":[113],"lymph":[114],"node":[115],"derived":[116],"distinct":[119],"patterns":[120],"colonization:":[123],"MM-RU":[124,170,217,249],"colonized":[125,144],"lungs":[128],"expressed":[130,156],"predominantly":[131,157],"2":[133,159,245,284],"1":[135,161,166,210,268,286,291],"3":[140],"integrin,":[141],"whereas":[142,192,227],"MM-AN":[143,193,219,257,274],"lung":[145],"extrapulmonary":[147],"sites":[148],"including":[149],"pancreas":[150],"subcutaneous":[152],"brown":[153,176],"fat":[154],"6":[164,266,289],"integrin.":[167],"vitro,":[169],"marked":[172],"lung,":[175],"fat,":[177],"kidney,":[178],"adrenal":[180],"with":[181,200],"no":[182],"liver,":[185],"pancreas,":[186],"brain,":[187],"muscle":[189],"had":[194],"similar":[196],"profile":[198],"but":[199,255],"additional":[201],"liver":[204],"pancreas.":[206],"Function":[207,242],"blocking":[208,229,243,262],"anti-beta":[209],"monoclonal":[211,235,246,263],"antibody":[212,236,247,264],"inhibited":[213,248,270],"these":[222,276,310],"tissues":[223],"(p":[224,252],"<":[225,253],"0.001),":[226],"function":[228,261],"anti-alpha":[230,244],"5":[231],"an":[233],"unrelated":[234],"(HLA":[237],"class":[238],"I)":[239],"not.":[241],"adhesion":[251],"0.001)":[254],"adhesion.":[258],"However,":[259],"significantly":[269],"tissues.":[277],"CONCLUSIONS:":[278],"These":[279],"mediate":[292],"differential":[293,317],"differences":[305],"be":[314],"involved":[315],"colonization":[319],"vivo.":[321]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}