{"id":"https://openalex.org/W998367305","doi":"https://doi.org/10.1016/j.bej.2015.07.015","title":"Evaluation of a monitored multiplate bioreactor for large-scale expansion of human periosteum derived stem cells for bone tissue engineering applications","display_name":"Evaluation of a monitored multiplate bioreactor for large-scale expansion of human periosteum derived stem cells for bone tissue engineering applications","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W998367305","doi":"https://doi.org/10.1016/j.bej.2015.07.015","mag":"998367305"},"language":"en","primary_location":{"id":"doi:10.1016/j.bej.2015.07.015","doi":"https://doi.org/10.1016/j.bej.2015.07.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bej.2015.07.015","pdf_url":null,"source":{"id":"https://openalex.org/S168210271","display_name":"Biochemical Engineering Journal","issn_l":"1369-703X","issn":["1369-703X","1873-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Engineering Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lirias.kuleuven.be/retrieve/55ae4fd6-32c1-4205-80b5-1e56bcc1885f","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082650427","display_name":"Toon Lambrechts","orcid":"https://orcid.org/0000-0002-1021-6011","observed_orcids":["https://orcid.org/0000-0002-1021-6011"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"T. Lambrechts","raw_affiliation_strings":["M3-BIORES, KU Leuven, Kasteelpark Arenberg 30, 3001 Heverlee, Belgium","Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M3-BIORES, KU Leuven, Kasteelpark Arenberg 30, 3001 Heverlee, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102983116","display_name":"Ioannis Papantoniou","orcid":"https://orcid.org/0000-0002-4754-5492","observed_orcids":["https://orcid.org/0000-0002-4754-5492","https://orcid.org/0000-0002-1498-7905"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"I. Papantoniou","raw_affiliation_strings":["Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium","Skeletal Biology and Engineering Research Center, KU Leuven, Herestraat 49, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Skeletal Biology and Engineering Research Center, KU Leuven, Herestraat 49, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081524916","display_name":"Stefano Viazzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"S. Viazzi","raw_affiliation_strings":["M3-BIORES, KU Leuven, Kasteelpark Arenberg 30, 3001 Heverlee, Belgium","Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M3-BIORES, KU Leuven, Kasteelpark Arenberg 30, 3001 Heverlee, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065297531","display_name":"Thierry Bovy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Bovy","raw_affiliation_strings":["Pall Life Sciences, Rue de Ransbeek 310, 1120 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pall Life Sciences, Rue de Ransbeek 310, 1120 Brussels, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111686915","display_name":"Jan Schrooten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J. Schrooten","raw_affiliation_strings":["Department of Materials Engineering, KU Leuven, Kasteelpark Arenberg 44 PB2450, 3001 Heverlee, Belgium","Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Engineering, KU Leuven, Kasteelpark Arenberg 44 PB2450, 3001 Heverlee, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059823367","display_name":"Frank P. Luyten","orcid":"https://orcid.org/0000-0003-3186-0276","observed_orcids":["https://orcid.org/0000-0003-3186-0276"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"F.P. Luyten","raw_affiliation_strings":["Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium","Skeletal Biology and Engineering Research Center, KU Leuven, Herestraat 49, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Skeletal Biology and Engineering Research Center, KU Leuven, Herestraat 49, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":null,"display_name":"J.-M. Aerts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"J.-M. Aerts","raw_affiliation_strings":["M3-BIORES, KU Leuven, Kasteelpark Arenberg 30, 3001 Heverlee, Belgium","Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M3-BIORES, KU Leuven, Kasteelpark Arenberg 30, 3001 Heverlee, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":3820,"currency":"USD","value_usd":3820},"apc_paid":null,"fwci":1.5925,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.80483454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"108","issue":null,"first_page":"58","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.4514000117778778,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-expansion","display_name":"cell expansion","score":0.6460000276565552},{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.9620000123977661},{"id":"https://openalex.org/keywords/holographic-imaging","display_name":"holographic imaging","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.546999990940094},{"id":"https://openalex.org/keywords/cell-recovery","display_name":"cell recovery","score":0.367000013589859},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.7770000100135803},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/heterotopic-bone-formation","display_name":"ectopic bone formation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/large-bone-defects","display_name":"large bone defects","score":0.7929999828338623},{"id":"https://openalex.org/keywords/bioprocessing","display_name":"bioprocessing","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.7738206386566162},{"id":"https://openalex.org/C2777674748","wikidata":"https://www.wikidata.org/wiki/Q367423","display_name":"Periosteum","level":2,"score":0.7019332051277161},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6991039514541626},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6609646081924438},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.6225292682647705},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5797029733657837},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5185073614120483},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4718632400035858},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41094210743904114},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40285980701446533},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3958742916584015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3121981620788574},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21326369047164917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1869710087776184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1462859809398651},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bej.2015.07.015","doi":"https://doi.org/10.1016/j.bej.2015.07.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bej.2015.07.015","pdf_url":null,"source":{"id":"https://openalex.org/S168210271","display_name":"Biochemical Engineering Journal","issn_l":"1369-703X","issn":["1369-703X","1873-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Engineering Journal","raw_type":"journal-article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/505827","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/505827","pdf_url":"https://lirias.kuleuven.be/retrieve/55ae4fd6-32c1-4205-80b5-1e56bcc1885f","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemical Engineering Journal, vol. 108, Art.No. C, (58-68)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/505827","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/505827","pdf_url":"https://lirias.kuleuven.be/retrieve/55ae4fd6-32c1-4205-80b5-1e56bcc1885f","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemical Engineering Journal, vol. 108, Art.No. C, (58-68)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2925406512","display_name":null,"funder_award_id":"GOA/13/016","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"}],"funders":[{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320327651","display_name":"Herculesstichting","ror":"https://ror.org/04at1ex44"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W998367305.pdf","grobid_xml":"https://content.openalex.org/works/W998367305.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1514803062","https://openalex.org/W1530824105","https://openalex.org/W1550985860","https://openalex.org/W1834170136","https://openalex.org/W1894559552","https://openalex.org/W1936552712","https://openalex.org/W1961471458","https://openalex.org/W1965738390","https://openalex.org/W1966071529","https://openalex.org/W1969166539","https://openalex.org/W1969305640","https://openalex.org/W1974610140","https://openalex.org/W1975371675","https://openalex.org/W1976906682","https://openalex.org/W1979185843","https://openalex.org/W1984252017","https://openalex.org/W1984652179","https://openalex.org/W1985424146","https://openalex.org/W1985481249","https://openalex.org/W1998650056","https://openalex.org/W2001733628","https://openalex.org/W2020078448","https://openalex.org/W2023999940","https://openalex.org/W2025371271","https://openalex.org/W2034450471","https://openalex.org/W2037690890","https://openalex.org/W2042221627","https://openalex.org/W2045149934","https://openalex.org/W2045366610","https://openalex.org/W2054746101","https://openalex.org/W2054790157","https://openalex.org/W2061617750","https://openalex.org/W2066568391","https://openalex.org/W2078119592","https://openalex.org/W2078266417","https://openalex.org/W2107029990","https://openalex.org/W2114464951","https://openalex.org/W2122449012","https://openalex.org/W2126989579","https://openalex.org/W2137541327","https://openalex.org/W2137610591","https://openalex.org/W2138965870","https://openalex.org/W2146216718","https://openalex.org/W2155825917","https://openalex.org/W2156509094","https://openalex.org/W2260927297","https://openalex.org/W2289870196","https://openalex.org/W2319797071","https://openalex.org/W4233346909"],"related_works":["https://openalex.org/W2028417873","https://openalex.org/W2534662310","https://openalex.org/W2463206263","https://openalex.org/W2112468634","https://openalex.org/W3026293070","https://openalex.org/W2118108729","https://openalex.org/W2017394391","https://openalex.org/W1562801294","https://openalex.org/W2193039371","https://openalex.org/W2945852193"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}