{"id":"https://openalex.org/W99806461","doi":null,"title":"Management of the metabolic syndrome.","display_name":"Management of the metabolic syndrome.","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W99806461","mag":"99806461","pmid":"https://pubmed.ncbi.nlm.nih.gov/15257254"},"language":"en","primary_location":{"id":"pmid:15257254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15257254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva endocrinologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orbi.uliege.be/handle/2268/11710","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039563874","display_name":"Andr\u00e9 Jacques Scheen","orcid":"https://orcid.org/0000-0001-9743-4371","observed_orcids":["https://orcid.org/0000-0001-9743-4371"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"A J Scheen","raw_affiliation_strings":["Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Sart Tilman, Li\u00e8ge, Belgium. andre.scheen@chu.ulg.ac.be"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Sart Tilman, Li\u00e8ge, Belgium. andre.scheen@chu.ulg.ac.be","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039563874"],"corresponding_institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"],"apc_list":null,"apc_paid":null,"fwci":5.0011,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.95570715,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"29","issue":"2","first_page":"31","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":1.0},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/type-2-diabetes-prevention","display_name":"type 2 diabetes prevention","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8840000033378601},{"id":"https://openalex.org/keywords/lifestyle-modification","display_name":"lifestyle modification","score":0.8740000128746033},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9380000233650208},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9380000233650208},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.5329999923706055},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.9710000157356262},{"id":"https://openalex.org/keywords/insulin-sensitizers","display_name":"insulin sensitizers","score":0.9110000133514404},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":1.0},{"id":"https://openalex.org/keywords/polypill","display_name":"polypill","score":0.9539999961853027},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/acarbose","display_name":"acarbose","score":0.9319999814033508},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.968999981880188},{"id":"https://openalex.org/keywords/renin-angiotensin-system-inhibitors","display_name":"renin-angiotensin system inhibitors","score":0.9179999828338623},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/multitargeted-therapy","display_name":"multitargeted therapy","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.936058521270752},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.8139604926109314},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6644001603126526},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.606802225112915},{"id":"https://openalex.org/C2777758740","wikidata":"https://www.wikidata.org/wiki/Q2103071","display_name":"Polypill","level":3,"score":0.566804051399231},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5337904691696167},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5125691890716553},{"id":"https://openalex.org/C2776923340","wikidata":"https://www.wikidata.org/wiki/Q1393556","display_name":"Thiazolidinedione","level":4,"score":0.4658642113208771},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.45564350485801697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45255246758461},{"id":"https://openalex.org/C2776217022","wikidata":"https://www.wikidata.org/wiki/Q1100933","display_name":"Diabetes management","level":4,"score":0.4124162197113037},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40783631801605225},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.38776957988739014},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37591540813446045}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008019","descriptor_name":"Life Style","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:15257254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15257254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva endocrinologica","raw_type":"Journal Article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/11710","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/11710","pdf_url":"https://orbi.uliege.be/handle/2268/11710","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Minerva Endocrinologica, 29 (2), 31-45 (2004)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"mag:99806461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15257254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:orbi.ulg.ac.be:2268/11710","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/11710","pdf_url":"https://orbi.uliege.be/handle/2268/11710","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Minerva Endocrinologica, 29 (2), 31-45 (2004)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W99806461.pdf","grobid_xml":"https://content.openalex.org/works/W99806461.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W7211792","https://openalex.org/W8744681","https://openalex.org/W15717562","https://openalex.org/W172874805","https://openalex.org/W1502524639","https://openalex.org/W1504527804","https://openalex.org/W1543297732","https://openalex.org/W1969623610","https://openalex.org/W1971175832","https://openalex.org/W1978249847","https://openalex.org/W1982657942","https://openalex.org/W1986349550","https://openalex.org/W1986858103","https://openalex.org/W1992386743","https://openalex.org/W1992777999","https://openalex.org/W2014877159","https://openalex.org/W2014977165","https://openalex.org/W2021976026","https://openalex.org/W2030968730","https://openalex.org/W2032048326","https://openalex.org/W2032119684","https://openalex.org/W2032549598","https://openalex.org/W2044428655","https://openalex.org/W2046503553","https://openalex.org/W2051181865","https://openalex.org/W2056971497","https://openalex.org/W2060449981","https://openalex.org/W2067207917","https://openalex.org/W2069680000","https://openalex.org/W2073069227","https://openalex.org/W2096531477","https://openalex.org/W2096773810","https://openalex.org/W2115728877","https://openalex.org/W2116623091","https://openalex.org/W2123289485","https://openalex.org/W2127187614","https://openalex.org/W2134293572","https://openalex.org/W2136798233","https://openalex.org/W2139634859","https://openalex.org/W2140603676","https://openalex.org/W2140855573","https://openalex.org/W2141917949","https://openalex.org/W2147612813","https://openalex.org/W2149040949","https://openalex.org/W2152598925","https://openalex.org/W2156121263","https://openalex.org/W2158822657","https://openalex.org/W2163207768","https://openalex.org/W2163895795","https://openalex.org/W2164597948","https://openalex.org/W2165924268","https://openalex.org/W2171569022","https://openalex.org/W2279761563","https://openalex.org/W2332951586","https://openalex.org/W2334392786","https://openalex.org/W2335336537","https://openalex.org/W2416937488","https://openalex.org/W4252666375"],"related_works":["https://openalex.org/W2109473323","https://openalex.org/W2405178752","https://openalex.org/W2396855598","https://openalex.org/W1522999720","https://openalex.org/W2410242527","https://openalex.org/W2004465027","https://openalex.org/W4300034997","https://openalex.org/W1549410588","https://openalex.org/W2090468346","https://openalex.org/W2007712503"],"abstract_inverted_index":{"The":[0,100,221],"metabolic":[1],"syndrome":[2],"(MetS)":[3],"is":[4,124],"strongly":[5],"associated":[6],"with":[7,52,108,235,242],"insulin":[8,90,95],"resistance":[9,91],"and":[10,24,40,69,84,87,116,145,224,238],"consists":[11],"of":[12,15,31,36,45,57,75,163,178,181,202,216,227],"a":[13,153,173,185,196,208,210,212],"constellation":[14],"factors":[16,78],"that":[17,156,192],"raise":[18],"the":[19,28,125,160,164,179,200,217,230],"risk":[20,59,77],"for":[21,50,199],"cardiovascular":[22,41],"diseases":[23],"diabetes":[25,39],"mellitus.":[26],"Therefore,":[27],"primary":[29],"goals":[30,139],"treating":[32],"MetS":[33,53,109,203,228],"are":[34],"prevention":[35],"type":[37],"2":[38],"events.":[42],"Three":[43],"levels":[44],"intervention":[46,104],"may":[47,130],"be":[48,131,170],"considered":[49],"individuals":[51,234],":":[54],"1)":[55],"management":[56,74,201],"underlying":[58,161],"conditions":[60],"by":[61,92],"controlling":[62],"weight":[63,114],"excess,":[64],"enhancing":[65],"regular":[66,117],"physical":[67,119],"exercise":[68],"promoting":[70],"healthy":[71],"diet;":[72],"2)":[73],"individual":[76],"such":[79,97,184,204],"as":[80,98,205],"dyslipidaemia,":[81],"hypertension,":[82],"hyperglycaemia":[83],"prothrombotic":[85],"state;":[86],"3)":[88],"targeting":[89,176],"using":[93],"specific":[94],"sensitizers":[96],"thiazolidinediones.":[99],"most":[101],"important":[102],"therapeutic":[103],"effective":[105],"in":[106,133],"subjects":[107],"should":[110,187],"focus":[111],"on":[112],"modest":[113],"reduction":[115],"leisure-time":[118],"activities.":[120],"Although":[121],"lifestyle":[122],"modification":[123],"first-line":[126],"therapy,":[127],"drug":[128],"therapy":[129],"necessary":[132],"many":[134],"patients":[135],"to":[136,151,171,232,239],"achieve":[137],"recommended":[138],"regarding":[140],"lipid":[141],"profile,":[142],"blood":[143,146],"pressure":[144],"glucose":[147],"control.":[148],"Rather":[149],"than":[150],"use":[152,172],"magic":[154],"bullet":[155],"might":[157],"fully":[158],"reverse":[159],"cause":[162],"syndrome,":[165],"one":[166],"appealing":[167],"alternative":[168],"would":[169],"so-called":[174],"\"polypill\"":[175],"each":[177],"components":[180],"MetS.":[182],"However,":[183],"polypill":[186],"ideally":[188],"contain":[189],"numerous":[190],"molecules":[191],"all":[193],"have":[194],"shown":[195],"potential":[197],"interest":[198],"metformin,":[206],"acarbose,":[207],"thiazolidinedione,":[209],"statin,":[211],"fibrate,":[213],"an":[214,243],"inhibitor":[215],"renin-angiotensin":[218],"system,":[219],"aspirin.":[220],"growing":[222],"prevalence":[223],"high-risk":[225],"nature":[226],"highlights":[229],"need":[231],"identify":[233],"this":[236],"condition":[237],"treat":[240],"them":[241],"aggressive":[244],"multitargeted":[245],"approach.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
