{"id":"https://openalex.org/W99795278","doi":null,"title":"AAV-mediated gene transfer to synovium: enhancing effects of inflammatory cytokines and proteasome inhibitors","display_name":"AAV-mediated gene transfer to synovium: enhancing effects of inflammatory cytokines and proteasome inhibitors","publication_year":2006,"publication_date":"2006-08-30","ids":{"openalex":"https://openalex.org/W99795278","mag":"99795278"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9290","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9290/1/TraisterRussellETD82906.pdf","pdf_url":"http://d-scholarship.pitt.edu/9290/1/TraisterRussellETD82906.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/9290/1/TraisterRussellETD82906.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018215916","display_name":"Russell S. Traister","orcid":"https://orcid.org/0000-0002-4909-0073","observed_orcids":["https://orcid.org/0000-0002-4909-0073"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Russell S. Traister","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4909-0073","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018215916"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00896736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":0.8130000233650208},{"id":"https://openalex.org/keywords/gene-transfer","display_name":"gene transfer","score":0.5199999809265137},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/synovium","display_name":"synovium","score":0.7400000095367432},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.777999997138977},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9070000052452087},{"id":"https://openalex.org/keywords/aav-serotypes","display_name":"AAV serotypes","score":0.8320000171661377},{"id":"https://openalex.org/keywords/transduction-efficiency","display_name":"transduction efficiency","score":0.6439999938011169},{"id":"https://openalex.org/keywords/viral-uncoating","display_name":"viral uncoating","score":0.8550000190734863},{"id":"https://openalex.org/keywords/transgene-expression","display_name":"transgene expression","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2777746085","wikidata":"https://www.wikidata.org/wiki/Q1506304","display_name":"Pannus","level":3,"score":0.7227288484573364},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6976318359375},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.5983699560165405},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5611795783042908},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.555779218673706},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.4873974919319153},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.44556912779808044},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4399017095565796},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.420704185962677},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38846442103385925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37823009490966797},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.36728668212890625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33271872997283936},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.3046942949295044},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30022478103637695},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1294359564781189},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.10449522733688354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:9290","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9290/1/TraisterRussellETD82906.pdf","pdf_url":"http://d-scholarship.pitt.edu/9290/1/TraisterRussellETD82906.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:99795278","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/9290/1/TraisterRussellETD82906.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9290","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9290/1/TraisterRussellETD82906.pdf","pdf_url":"http://d-scholarship.pitt.edu/9290/1/TraisterRussellETD82906.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W99795278.pdf","grobid_xml":"https://content.openalex.org/works/W99795278.grobid-xml"},"referenced_works_count":307,"referenced_works":["https://openalex.org/W51250104","https://openalex.org/W56671020","https://openalex.org/W90963048","https://openalex.org/W126651838","https://openalex.org/W153249915","https://openalex.org/W195130957","https://openalex.org/W1482964233","https://openalex.org/W1503366574","https://openalex.org/W1504723104","https://openalex.org/W1516914607","https://openalex.org/W1517879691","https://openalex.org/W1522136107","https://openalex.org/W1522287604","https://openalex.org/W1524529935","https://openalex.org/W1525995077","https://openalex.org/W1526425334","https://openalex.org/W1542198680","https://openalex.org/W1547652970","https://openalex.org/W1554330891","https://openalex.org/W1561259918","https://openalex.org/W1564486248","https://openalex.org/W1598111769","https://openalex.org/W1598188453","https://openalex.org/W1608776257","https://openalex.org/W1655974196","https://openalex.org/W1662367630","https://openalex.org/W1698502276","https://openalex.org/W1723589129","https://openalex.org/W1748809707","https://openalex.org/W1754391675","https://openalex.org/W1756236371","https://openalex.org/W1792226828","https://openalex.org/W1813893175","https://openalex.org/W1861255861","https://openalex.org/W1886972027","https://openalex.org/W1887346136","https://openalex.org/W1897678469","https://openalex.org/W1943760307","https://openalex.org/W1943985333","https://openalex.org/W1963623233","https://openalex.org/W1964241088","https://openalex.org/W1964544263","https://openalex.org/W1964861983","https://openalex.org/W1965105897","https://openalex.org/W1965372133","https://openalex.org/W1967704552","https://openalex.org/W1967843179","https://openalex.org/W1968912221","https://openalex.org/W1969475775","https://openalex.org/W1969906109","https://openalex.org/W1970037245","https://openalex.org/W1970138286","https://openalex.org/W1971765006","https://openalex.org/W1971921768","https://openalex.org/W1972011429","https://openalex.org/W1973469936","https://openalex.org/W1973598383","https://openalex.org/W1973963032","https://openalex.org/W1974514897","https://openalex.org/W1974944377","https://openalex.org/W1976239063","https://openalex.org/W1976538463","https://openalex.org/W1976960856","https://openalex.org/W1977115071","https://openalex.org/W1980613658","https://openalex.org/W1980956022","https://openalex.org/W1982346550","https://openalex.org/W1983480010","https://openalex.org/W1984496091","https://openalex.org/W1984907444","https://openalex.org/W1984915505","https://openalex.org/W1987453834","https://openalex.org/W1988197108","https://openalex.org/W1990065831","https://openalex.org/W1990373812","https://openalex.org/W1990642211","https://openalex.org/W1991855740","https://openalex.org/W1993884243","https://openalex.org/W1994396884","https://openalex.org/W1994595940","https://openalex.org/W1997883896","https://openalex.org/W1998993397","https://openalex.org/W2000217017","https://openalex.org/W2000627935","https://openalex.org/W2002134849","https://openalex.org/W2002688702","https://openalex.org/W2002812447","https://openalex.org/W2003264964","https://openalex.org/W2003456064","https://openalex.org/W2003694933","https://openalex.org/W2004590552","https://openalex.org/W2004854210","https://openalex.org/W2004983645","https://openalex.org/W2005975820","https://openalex.org/W2006394078","https://openalex.org/W2006534560","https://openalex.org/W2006922136","https://openalex.org/W2008744347","https://openalex.org/W2009170690","https://openalex.org/W2009681413","https://openalex.org/W2009792531","https://openalex.org/W2011391073","https://openalex.org/W2011415255","https://openalex.org/W2011626700","https://openalex.org/W2012620430","https://openalex.org/W2015433718","https://openalex.org/W2017888326","https://openalex.org/W2019814860","https://openalex.org/W2022968301","https://openalex.org/W2024522405","https://openalex.org/W2029658169","https://openalex.org/W2029750163","https://openalex.org/W2031092466","https://openalex.org/W2032591467","https://openalex.org/W2033005054","https://openalex.org/W2033602138","https://openalex.org/W2034672236","https://openalex.org/W2035180752","https://openalex.org/W2037529688","https://openalex.org/W2037871518","https://openalex.org/W2038063798","https://openalex.org/W2038691967","https://openalex.org/W2042259141","https://openalex.org/W2042928063","https://openalex.org/W2043512479","https://openalex.org/W2043763521","https://openalex.org/W2043945412","https://openalex.org/W2044002373","https://openalex.org/W2044005085","https://openalex.org/W2044296969","https://openalex.org/W2045219935","https://openalex.org/W2046488302","https://openalex.org/W2046566574","https://openalex.org/W2046621489","https://openalex.org/W2046683434","https://openalex.org/W2047127326","https://openalex.org/W2047230995","https://openalex.org/W2049134806","https://openalex.org/W2049958940","https://openalex.org/W2050314347","https://openalex.org/W2050770858","https://openalex.org/W2051379594","https://openalex.org/W2052186992","https://openalex.org/W2052855868","https://openalex.org/W2053222398","https://openalex.org/W2053706844","https://openalex.org/W2053849856","https://openalex.org/W2054677438","https://openalex.org/W2054862304","https://openalex.org/W2055552847","https://openalex.org/W2056105585","https://openalex.org/W2056602419","https://openalex.org/W2056743234","https://openalex.org/W2057842018","https://openalex.org/W2059088288","https://openalex.org/W2059202997","https://openalex.org/W2059473494","https://openalex.org/W2059864468","https://openalex.org/W2060801600","https://openalex.org/W2060917621","https://openalex.org/W2061707913","https://openalex.org/W2062787494","https://openalex.org/W2062840171","https://openalex.org/W2063303944","https://openalex.org/W2063640156","https://openalex.org/W2063917170","https://openalex.org/W2066015597","https://openalex.org/W2066284211","https://openalex.org/W2066314640","https://openalex.org/W2066875565","https://openalex.org/W2067434585","https://openalex.org/W2068823402","https://openalex.org/W2069138015","https://openalex.org/W2070415473","https://openalex.org/W2070754430","https://openalex.org/W2070853191","https://openalex.org/W2072156444","https://openalex.org/W2072635353","https://openalex.org/W2074438676","https://openalex.org/W2075273726","https://openalex.org/W2077723733","https://openalex.org/W2078526614","https://openalex.org/W2078624814","https://openalex.org/W2079017842","https://openalex.org/W2079837731","https://openalex.org/W2080917061","https://openalex.org/W2081064825","https://openalex.org/W2082583103","https://openalex.org/W2083161096","https://openalex.org/W2084017165","https://openalex.org/W2084693487","https://openalex.org/W2084927515","https://openalex.org/W2086047915","https://openalex.org/W2087596041","https://openalex.org/W2087953526","https://openalex.org/W2088135539","https://openalex.org/W2089846634","https://openalex.org/W2090256568","https://openalex.org/W2091887840","https://openalex.org/W2092088084","https://openalex.org/W2092340983","https://openalex.org/W2092718923","https://openalex.org/W2097939208","https://openalex.org/W2098898935","https://openalex.org/W2099790854","https://openalex.org/W2099893191","https://openalex.org/W2102618449","https://openalex.org/W2103185055","https://openalex.org/W2103497996","https://openalex.org/W2103904163","https://openalex.org/W2105106090","https://openalex.org/W2105176806","https://openalex.org/W2105914045","https://openalex.org/W2106378095","https://openalex.org/W2108136672","https://openalex.org/W2109152260","https://openalex.org/W2111247770","https://openalex.org/W2111357564","https://openalex.org/W2113017107","https://openalex.org/W2113444875","https://openalex.org/W2113606609","https://openalex.org/W2113637218","https://openalex.org/W2113876758","https://openalex.org/W2114458218","https://openalex.org/W2115109015","https://openalex.org/W2115332379","https://openalex.org/W2116856042","https://openalex.org/W2117382612","https://openalex.org/W2119164964","https://openalex.org/W2120066089","https://openalex.org/W2120683337","https://openalex.org/W2122762677","https://openalex.org/W2123257768","https://openalex.org/W2124007067","https://openalex.org/W2126012630","https://openalex.org/W2126993634","https://openalex.org/W2134124671","https://openalex.org/W2134766536","https://openalex.org/W2134994441","https://openalex.org/W2136735139","https://openalex.org/W2137005738","https://openalex.org/W2137440275","https://openalex.org/W2138104392","https://openalex.org/W2140523898","https://openalex.org/W2141399945","https://openalex.org/W2141482826","https://openalex.org/W2141797403","https://openalex.org/W2141829156","https://openalex.org/W2143529139","https://openalex.org/W2147368157","https://openalex.org/W2148223197","https://openalex.org/W2148601484","https://openalex.org/W2149026148","https://openalex.org/W2149275181","https://openalex.org/W2149568416","https://openalex.org/W2149661493","https://openalex.org/W2151183790","https://openalex.org/W2151374310","https://openalex.org/W2152187442","https://openalex.org/W2152833992","https://openalex.org/W2154329712","https://openalex.org/W2155456837","https://openalex.org/W2155898643","https://openalex.org/W2157309969","https://openalex.org/W2157466002","https://openalex.org/W2158480664","https://openalex.org/W2158749858","https://openalex.org/W2158859763","https://openalex.org/W2160121070","https://openalex.org/W2161074777","https://openalex.org/W2161655523","https://openalex.org/W2162886054","https://openalex.org/W2163720085","https://openalex.org/W2165815741","https://openalex.org/W2165935023","https://openalex.org/W2165975808","https://openalex.org/W2166458134","https://openalex.org/W2166618642","https://openalex.org/W2170392860","https://openalex.org/W2170475021","https://openalex.org/W2170614901","https://openalex.org/W2171329403","https://openalex.org/W2175576464","https://openalex.org/W2176509176","https://openalex.org/W2183423932","https://openalex.org/W2188252132","https://openalex.org/W2289723514","https://openalex.org/W2313069436","https://openalex.org/W2313914167","https://openalex.org/W2314192167","https://openalex.org/W2314307545","https://openalex.org/W2316735326","https://openalex.org/W2317269439","https://openalex.org/W2320848983","https://openalex.org/W2323474162","https://openalex.org/W2326606386","https://openalex.org/W2333763885","https://openalex.org/W2334267628","https://openalex.org/W2335173351","https://openalex.org/W2335277478","https://openalex.org/W2335967535","https://openalex.org/W2397692860","https://openalex.org/W2411719742","https://openalex.org/W2441533782","https://openalex.org/W4229724440","https://openalex.org/W4235169145","https://openalex.org/W7128481943"],"related_works":["https://openalex.org/W2084693487","https://openalex.org/W1564486248","https://openalex.org/W2012584214","https://openalex.org/W1902651051","https://openalex.org/W2152468597","https://openalex.org/W1832772344","https://openalex.org/W1889605196","https://openalex.org/W1565051761","https://openalex.org/W1833127814","https://openalex.org/W1515379335"],"abstract_inverted_index":{"Rheumatoid":[0],"arthritis":[1,50],"(RA)":[2],"is":[3,76,85,111,162],"an":[4],"autoimmune":[5],"disease":[6],"affecting":[7],"nearly":[8],"1%":[9],"of":[10,15,23,49,54,64,67,105,120,123,144,160,180,234,247,254,264,314,320],"the":[11,59,65,109,112,121,158,203,235,244,248,255,287,311,318],"population.":[12],"The":[13,102,177,224],"joints":[14],"RA":[16],"patients":[17],"become":[18],"inflamed":[19],"and":[20,28,40,92,96,128,139,182,202,250,268,283,293,303],"a":[21,79],"pannus":[22,122],"synovial":[24],"tissue":[25,94,124],"invades":[26],"cartilage":[27,127],"destroys":[29],"bone.":[30],"Current":[31],"treatments,":[32],"though":[33],"moderately":[34],"successful,":[35,155],"are":[36,41,133,217],"often":[37],"administered":[38],"systemically":[39],"associated":[42],"with":[43,150],"significant":[44],"side":[45],"effects.":[46],"Local":[47],"treatment":[48,69,149,319],"by":[51,137,231,241,251],"intra-articular":[52],"injection":[53],"gene":[55,80,106],"transfer":[56,81,107],"vectors":[57,152,316],"has":[58,89,191],"potential":[60],"to":[61,153,169,220,227,273],"overcome":[62],"some":[63],"obstacles":[66],"other":[68,174],"regimens.":[70],"In":[71,258],"particular,":[72],"adeno-associated":[73],"virus":[74,249],"(AAV)":[75],"attractive":[77],"as":[78],"vector":[82],"because":[83],"it":[84],"non-pathogenic":[86],"in":[87,108,157,173,189,211,229,291,310,317],"humans,":[88],"low":[90,142],"immunogenicity":[91],"broad":[93],"tropism,":[95],"provides":[97],"for":[98,126,270,301],"long-term":[99],"transgene":[100,145,187,209,222,289],"expression.":[101,146,223],"primary":[103],"target":[104],"joint":[110],"fibroblast-like":[113],"synoviocytes":[114],"(FLS),":[115],"which":[116],"make":[117],"up":[118],"part":[119,230],"responsible":[125],"bone":[129],"destruction.":[130],"However,":[131],"FLS":[132,161,190,212,275],"only":[134,141],"minimally":[135],"transduced":[136],"AAV":[138,151,171,265,315],"provide":[140],"levels":[143],"For":[147],"local":[148],"be":[154],"improvement":[156],"transduction":[159,172],"necessary.":[163],"Several":[164],"agents":[165,216],"have":[166,308],"been":[167,193],"shown":[168],"increase":[170,208],"cell":[175],"types.":[176],"specific":[178],"effect":[179],"inflammation":[181],"proteasome":[183,204,238],"inhibition":[184,239],"on":[185],"AAV-mediated":[186],"expression":[188,210,290],"not":[192],"examined.":[194],"Here":[195],"we":[196,260],"show":[197],"that":[198],"both":[199,215,242],"inflammatory":[200],"cytokines":[201,225],"inhibitor":[205],"zLLL":[206],"can":[207],"dramatically.":[213],"Remarkably,":[214],"also":[218],"able":[219],"regulate":[221],"appear":[226],"act":[228],"promoting":[232],"uncoating":[233],"virus,":[236],"while":[237,296],"works":[240],"increasing":[243,252],"nuclear":[245],"trafficking":[246],"transcription":[253],"viral":[256],"DNA.":[257],"addtion,":[259],"screened":[261],"3":[262],"serotypes":[263],"(2,":[266],"2.5,":[267],"5)":[269],"their":[271],"ability":[272],"transduce":[274],"from":[276],"4":[277],"different":[278],"species:":[279],"human,":[280],"mouse,":[281],"horse,":[282],"rabbit.":[284],"AAV2":[285],"provided":[286],"highest":[288],"human":[292],"horse":[294],"FLS,":[295],"AAV2.5":[297],"was":[298],"better":[299],"suited":[300],"mouse":[302],"rabbit":[304],"FLS.":[305],"These":[306],"results":[307],"implications":[309],"future":[312],"use":[313],"RA.":[321]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}