{"id":"https://openalex.org/W99776329","doi":null,"title":"Chitosan derivatives for tissue engineering","display_name":"Chitosan derivatives for tissue engineering","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W99776329","mag":"99776329"},"language":"en","primary_location":{"id":"pmh:oai:tigerprints.clemson.edu:all_dissertations-1267","doi":null,"is_oa":true,"landing_page_url":"https://tigerprints.clemson.edu/all_dissertations/267","pdf_url":"https://tigerprints.clemson.edu/all_dissertations/267","source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://tigerprints.clemson.edu/all_dissertations/267","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066552119","display_name":"Yongzhi Qiu","orcid":"https://orcid.org/0000-0002-3837-824X","observed_orcids":["https://orcid.org/0000-0002-3837-824X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yongzhi Qiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5066552119"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10488","display_name":"Nanocomposite Films for Food Packaging","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitosan-derivatives","display_name":"chitosan derivatives","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.8209999799728394},{"id":"https://openalex.org/keywords/antithrombogenicity","display_name":"antithrombogenicity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/vascular-engineering","display_name":"vascular engineering","score":0.6449999809265137},{"id":"https://openalex.org/keywords/small-diameter-blood-vessels","display_name":"small-diameter blood vessels","score":0.8119999766349792},{"id":"https://openalex.org/keywords/wet-phase-inversion","display_name":"wet phase inversion","score":0.652999997138977},{"id":"https://openalex.org/keywords/porous-scaffolds","display_name":"porous scaffolds","score":0.7300000190734863},{"id":"https://openalex.org/keywords/osteoconductivity","display_name":"osteoconductivity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/heparin-immobilization","display_name":"heparin immobilization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8970000147819519},{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cartilage-tissue-engineering","display_name":"cartilage tissue engineering","score":0.8679999709129333},{"id":"https://openalex.org/keywords/extracellular-matrix-mimicry","display_name":"extracellular matrix mimicry","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.593011200428009},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.579609751701355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3246819078922272},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32106491923332214},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3040112257003784},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2815641760826111},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.25985074043273926},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.19682154059410095}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:tigerprints.clemson.edu:all_dissertations-1267","doi":null,"is_oa":true,"landing_page_url":"https://tigerprints.clemson.edu/all_dissertations/267","pdf_url":"https://tigerprints.clemson.edu/all_dissertations/267","source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},{"id":"pmh:oai:open.clemson.edu:all_dissertations-1267","doi":null,"is_oa":false,"landing_page_url":"https://open.clemson.edu/all_dissertations/267","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},{"id":"mag:99776329","doi":null,"is_oa":false,"landing_page_url":"https://tigerprints.clemson.edu/cgi/viewcontent.cgi?article=1267&context=all_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:tigerprints.clemson.edu:all_dissertations-1267","doi":null,"is_oa":true,"landing_page_url":"https://tigerprints.clemson.edu/all_dissertations/267","pdf_url":"https://tigerprints.clemson.edu/all_dissertations/267","source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W99776329.pdf","grobid_xml":"https://content.openalex.org/works/W99776329.grobid-xml"},"referenced_works_count":223,"referenced_works":["https://openalex.org/W68704341","https://openalex.org/W177952160","https://openalex.org/W1518703574","https://openalex.org/W1530120375","https://openalex.org/W1548923710","https://openalex.org/W1559528293","https://openalex.org/W1908897958","https://openalex.org/W1966645403","https://openalex.org/W1966983766","https://openalex.org/W1967754359","https://openalex.org/W1968421500","https://openalex.org/W1969668076","https://openalex.org/W1969902985","https://openalex.org/W1970198213","https://openalex.org/W1971339046","https://openalex.org/W1972133951","https://openalex.org/W1973462560","https://openalex.org/W1973700834","https://openalex.org/W1973762194","https://openalex.org/W1975732126","https://openalex.org/W1978018138","https://openalex.org/W1978103010","https://openalex.org/W1979507778","https://openalex.org/W1979577729","https://openalex.org/W1979782989","https://openalex.org/W1981220452","https://openalex.org/W1981799157","https://openalex.org/W1982655217","https://openalex.org/W1982769493","https://openalex.org/W1983398893","https://openalex.org/W1984061441","https://openalex.org/W1985395264","https://openalex.org/W1988998955","https://openalex.org/W1989145720","https://openalex.org/W1989251966","https://openalex.org/W1989729853","https://openalex.org/W1991378342","https://openalex.org/W1993652436","https://openalex.org/W1993790504","https://openalex.org/W1994031144","https://openalex.org/W1994156875","https://openalex.org/W1994192502","https://openalex.org/W1994354984","https://openalex.org/W1994572076","https://openalex.org/W1995166151","https://openalex.org/W1996219864","https://openalex.org/W1996616740","https://openalex.org/W1997246078","https://openalex.org/W1998873979","https://openalex.org/W1999301099","https://openalex.org/W1999935822","https://openalex.org/W2000347459","https://openalex.org/W2001308282","https://openalex.org/W2001633027","https://openalex.org/W2001909877","https://openalex.org/W2001918706","https://openalex.org/W2002439257","https://openalex.org/W2003330618","https://openalex.org/W2004089994","https://openalex.org/W2005352626","https://openalex.org/W2005361414","https://openalex.org/W2007163597","https://openalex.org/W2008540968","https://openalex.org/W2010893508","https://openalex.org/W2011562448","https://openalex.org/W2014483104","https://openalex.org/W2014891480","https://openalex.org/W2015141925","https://openalex.org/W2015574865","https://openalex.org/W2020192493","https://openalex.org/W2020284696","https://openalex.org/W2020591453","https://openalex.org/W2021247136","https://openalex.org/W2021395515","https://openalex.org/W2021531882","https://openalex.org/W2022689478","https://openalex.org/W2022768480","https://openalex.org/W2024105738","https://openalex.org/W2024364032","https://openalex.org/W2024649205","https://openalex.org/W2025223433","https://openalex.org/W2025552558","https://openalex.org/W2026327624","https://openalex.org/W2027646275","https://openalex.org/W2028174136","https://openalex.org/W2028705917","https://openalex.org/W2029145815","https://openalex.org/W2029203624","https://openalex.org/W2029218412","https://openalex.org/W2029665289","https://openalex.org/W2030360808","https://openalex.org/W2030494692","https://openalex.org/W2031336983","https://openalex.org/W2031379133","https://openalex.org/W2033518295","https://openalex.org/W2034158607","https://openalex.org/W2034264323","https://openalex.org/W2034479167","https://openalex.org/W2035851415","https://openalex.org/W2036493022","https://openalex.org/W2037821234","https://openalex.org/W2041406939","https://openalex.org/W2041599153","https://openalex.org/W2043226014","https://openalex.org/W2043963000","https://openalex.org/W2044090471","https://openalex.org/W2045284257","https://openalex.org/W2046303644","https://openalex.org/W2046919490","https://openalex.org/W2048079578","https://openalex.org/W2048101528","https://openalex.org/W2049294046","https://openalex.org/W2051069490","https://openalex.org/W2051920559","https://openalex.org/W2053443529","https://openalex.org/W2054657065","https://openalex.org/W2055476008","https://openalex.org/W2056296645","https://openalex.org/W2056963672","https://openalex.org/W2057189525","https://openalex.org/W2057410741","https://openalex.org/W2058624239","https://openalex.org/W2058633963","https://openalex.org/W2059785458","https://openalex.org/W2060877214","https://openalex.org/W2061142495","https://openalex.org/W2061311087","https://openalex.org/W2062224667","https://openalex.org/W2064106627","https://openalex.org/W2064271764","https://openalex.org/W2065166540","https://openalex.org/W2065386894","https://openalex.org/W2066465530","https://openalex.org/W2066511695","https://openalex.org/W2066533176","https://openalex.org/W2066966685","https://openalex.org/W2067215489","https://openalex.org/W2067251168","https://openalex.org/W2067580462","https://openalex.org/W2068422401","https://openalex.org/W2069934178","https://openalex.org/W2070854162","https://openalex.org/W2071898176","https://openalex.org/W2073126451","https://openalex.org/W2073248736","https://openalex.org/W2073849368","https://openalex.org/W2075145397","https://openalex.org/W2075353072","https://openalex.org/W2075959897","https://openalex.org/W2076077968","https://openalex.org/W2076276686","https://openalex.org/W2076314352","https://openalex.org/W2076352514","https://openalex.org/W2076486958","https://openalex.org/W2077644034","https://openalex.org/W2077645754","https://openalex.org/W2077648724","https://openalex.org/W2078126231","https://openalex.org/W2078267560","https://openalex.org/W2079309828","https://openalex.org/W2079745748","https://openalex.org/W2081595045","https://openalex.org/W2081789842","https://openalex.org/W2081926521","https://openalex.org/W2082849468","https://openalex.org/W2084939931","https://openalex.org/W2086514756","https://openalex.org/W2086530747","https://openalex.org/W2088071059","https://openalex.org/W2088699248","https://openalex.org/W2089153310","https://openalex.org/W2089858094","https://openalex.org/W2089925824","https://openalex.org/W2090180975","https://openalex.org/W2090247174","https://openalex.org/W2091053173","https://openalex.org/W2091084882","https://openalex.org/W2091094988","https://openalex.org/W2091425988","https://openalex.org/W2091463810","https://openalex.org/W2092389312","https://openalex.org/W2092567809","https://openalex.org/W2094034579","https://openalex.org/W2096136468","https://openalex.org/W2098298726","https://openalex.org/W2100976156","https://openalex.org/W2101889508","https://openalex.org/W2102374658","https://openalex.org/W2103562180","https://openalex.org/W2105643583","https://openalex.org/W2105960546","https://openalex.org/W2108015341","https://openalex.org/W2109855721","https://openalex.org/W2112020248","https://openalex.org/W2112062256","https://openalex.org/W2113042424","https://openalex.org/W2117376536","https://openalex.org/W2117763376","https://openalex.org/W2121356794","https://openalex.org/W2122531454","https://openalex.org/W2124926420","https://openalex.org/W2126002708","https://openalex.org/W2131382465","https://openalex.org/W2134669388","https://openalex.org/W2136505065","https://openalex.org/W2139457077","https://openalex.org/W2139586508","https://openalex.org/W2145142129","https://openalex.org/W2148009863","https://openalex.org/W2153282993","https://openalex.org/W2157592498","https://openalex.org/W2157986418","https://openalex.org/W2162622650","https://openalex.org/W2165715446","https://openalex.org/W2168902269","https://openalex.org/W2170515999","https://openalex.org/W2171236530","https://openalex.org/W2226673738","https://openalex.org/W2341171988","https://openalex.org/W2357030456","https://openalex.org/W2403103180","https://openalex.org/W2403438573","https://openalex.org/W2501058771"],"related_works":["https://openalex.org/W2065386894","https://openalex.org/W2765432771","https://openalex.org/W2366952689","https://openalex.org/W2738946644","https://openalex.org/W2376601554","https://openalex.org/W4391730815","https://openalex.org/W3200351407","https://openalex.org/W2203217923","https://openalex.org/W4365396244","https://openalex.org/W2493934139"],"abstract_inverted_index":{"Chitosan,":[0],"a":[1,26,95,116],"naturally":[2],"occurring":[3],"polysaccharide,":[4],"and":[5,19,57,86,105,126,154,165,234,256,271,273],"its":[6,113,129],"derivatives":[7,30,36,130],"have":[8,218,339],"been":[9],"widely":[10],"explored":[11],"for":[12,67,118,135],"biomedical":[13],"applications":[14],"due":[15],"to":[16,151,243,264],"their":[17],"biocompatibility":[18],"biodegradability.":[20],"In":[21,77,138,241],"our":[22,78,139],"studies,":[23,79,140],"we":[24,141],"developed":[25,186,215],"series":[27],"of":[28,101,124,128,209,247,281,294,331],"chitosan":[29,35,80,89,125,153,173,183,217,255,270],"through":[31,190],"chemical":[32],"modifications.":[33],"These":[34,170],"not":[37],"only":[38],"possess":[39,147],"better":[40],"processibility":[41,149],"in":[42,50,72,178,221,226,317,342,346],"scaffolds":[43,159,174,184,189,252,303,338],"fabrication,":[44],"but":[45],"also":[46,287],"show":[47],"excellent":[48,62,122],"potentials":[49,341],"tissue":[51,59,343,348],"engineering":[52,69,73],"applications,":[53,70],"including":[54],"blood":[55,75],"vessel":[56],"bone":[58,201,227,232,236,315],"engineering.":[60,120,349],"The":[61,121],"antithrombogenic":[63,92],"property":[64],"is":[65,203,261],"crucial":[66],"vascular":[68,119],"especially":[71,345],"small-diameter":[74],"vessels.":[76],"was":[81],"chemically":[82],"modified":[83],"by":[84,197,312],"phthalization":[85],"the":[87,181,194,213,245,250,267,274,279,282,292,300,313,328],"phthalized":[88,110],"exhibited":[90],"great":[91,148,176,219,340],"property.":[93],"Through":[94],"wet-":[96],"phase-inversion":[97],"process,":[98],"tubular":[99],"constructs":[100],"varying":[102],"sizes,":[103],"morphology,":[104],"permeability":[106],"were":[107,185,258],"fabricated":[108,157],"from":[109],"chitosan,":[111],"suggesting":[112],"potential":[114,220,329],"as":[115,230,307,310],"scaffold":[117,322],"osteoconductivity":[123,177],"some":[127,223],"make":[131],"them":[132],"good":[133],"candicates":[134],"orthorpaedic":[136],"applications.":[137],"synthesized":[142],"novel":[143],"photocurable":[144,216,254],"chitosans":[145],"which":[146],"compared":[150],"raw":[152],"can":[155,277,286,304],"be":[156,288,305],"into":[158,187],"with":[160,238,298,327],"desired":[161],"shape,":[162],"pore":[163],"size":[164],"topography":[166],"upon":[167],"light":[168],"exposure.":[169],"photocured":[171,182],"porous":[172],"showed":[175],"vivo.":[179,318],"Moreover,":[180,319],"osteoinductive":[188,308],"immobilizing":[191],"heparin":[192],"on":[193,291],"surface":[195,293],"followed":[196],"loading":[198],"BMP-2.":[199],"Ectopic":[200],"growth":[202,316,334],"observed":[204],"when":[205],"subcutaneously":[206],"implanted.":[207],"All":[208],"these":[210],"indicated":[211,311],"that":[212,266],"newly":[214],"solving":[222],"thorny":[224],"problems":[225],"repair,":[228],"such":[229],"non-union":[231],"defects":[233,237],"long":[235],"irregular":[239],"shapes.":[240],"order":[242],"mimic":[244],"structure":[246],"extracellular":[248],"matrix,":[249],"hybrid":[251],"containing":[253],"gelatin":[257],"developed.":[259],"It":[260],"very":[262],"interesting":[263],"note":[265],"interaction":[268],"between":[269],"gelatin,":[272],"photocuring":[275],"process":[276],"control":[278],"morphology":[280],"complex":[283,295,302,321,337],"scaffolds.":[284,296],"Heparin":[285],"effectively":[289],"immobilized":[290],"Loaded":[297],"BMP-2,":[299],"heparinized":[301],"used":[306],"scaffolds,":[309],"ectopic":[314],"this":[320,336],"shows":[323],"intriguing":[324],"elasticity.":[325],"Combined":[326],"ability":[330],"delivering":[332],"various":[333],"factors,":[335],"engineering,":[344],"cartilage":[347]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}