{"id":"https://openalex.org/W99757637","doi":null,"title":"Brain insulin signalling in the regulation of energy balance and peripheral metabolism.","display_name":"Brain insulin signalling in the regulation of energy balance and peripheral metabolism.","publication_year":2007,"publication_date":"2007-03-30","ids":{"openalex":"https://openalex.org/W99757637","mag":"99757637","pmid":"https://pubmed.ncbi.nlm.nih.gov/17451048"},"language":"en","primary_location":{"id":"pmid:17451048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ideggyogyaszati szemle","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109335776","display_name":"Micha\u00ebla Diamant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Michaela Diamant","raw_affiliation_strings":["Department of Endocrinology, VU University Medical Center, PO BOX 7057, 1007 MB Amsterdam, The Netherlands. m.diamant@vumc.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, VU University Medical Center, PO BOX 7057, 1007 MB Amsterdam, The Netherlands. m.diamant@vumc.nl","institution_ids":["https://openalex.org/I911458345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109335776"],"corresponding_institution_ids":["https://openalex.org/I911458345"],"apc_list":null,"apc_paid":null,"fwci":0.387,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.53136364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"60","issue":"3-4","first_page":"97","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.8299999833106995},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.800000011920929},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.953000009059906},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/diabesity","display_name":"diabesity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/hypothalamic-neuropeptides","display_name":"hypothalamic neuropeptides","score":0.925000011920929},{"id":"https://openalex.org/keywords/peripheral-glucose-metabolism","display_name":"peripheral glucose metabolism","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7775422930717468},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7693369388580322},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5963947772979736},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.5675656795501709},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5446800589561462},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.5113077163696289},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.4546331763267517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4286680221557617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4217260181903839},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.23890045285224915}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D004196","descriptor_name":"Disease Outbreaks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005082","descriptor_name":"Physical Exertion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008019","descriptor_name":"Life Style","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17451048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ideggyogyaszati szemle","raw_type":"Journal Article"},{"id":"mag:99757637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2740815791","https://openalex.org/W3167467420","https://openalex.org/W2075668179","https://openalex.org/W2069911669","https://openalex.org/W18711741","https://openalex.org/W3135366741","https://openalex.org/W2079503496","https://openalex.org/W2124915420","https://openalex.org/W2142437855","https://openalex.org/W3027292275"],"abstract_inverted_index":{"The":[0,107,129],"unparalleled":[1],"global":[2],"rates":[3],"of":[4,34,61,64,77,100,109,131,141,155,187,195,208,217,225,234,243],"obesity":[5,48,255],"and":[6,16,37,49,79,87,104,122,151,190,236,239,256],"type":[7,257],"2":[8,258],"diabetes,":[9],"together":[10],"with":[11,126],"the":[12,22,31,43,59,62,69,75,120,135,139,144,152,164,184,206,215,221,226,231,241,254],"associated":[13,125],"cardiovascular":[14],"morbidity":[15],"mortality,":[17],"are":[18,40],"referred":[19],"to":[20,68,118,175],"as":[21,42,54,91,166,179,223,249],"\"diabesity":[23],"pandemic\".":[24],"Changes":[25],"in":[26,74,97,113,134,143,205,220,230,253],"lifestyle":[27],"occurring":[28],"worldwide,":[29],"including":[30],"increased":[32,70],"consumption":[33],"high-caloric":[35],"foods":[36],"reduced":[38],"exercise,":[39],"regarded":[41,90],"main":[44],"causal":[45],"factors.":[46],"Central":[47],"insulin":[50,93,111,127,132,142,149,158,171,200,218,247],"resistance":[51],"have":[52,162],"emerged":[53],"important":[55,168],"linking":[56],"components.":[57],"Understanding":[58],"aetiology":[60],"cluster":[63],"pathologies":[65],"that":[66,192],"leads":[67],"risk":[71],"is":[72,202],"instrumental":[73],"development":[76],"preventive":[78],"therapeutic":[80],"strategies.":[81],"Historically,":[82],"skeletal":[83],"muscle,":[84],"adipose":[85],"tissue":[86],"liver":[88],"were":[89,116],"key":[92],"target":[94,169],"organs":[95,115],"involved":[96,229],"insulin-mediated":[98],"regulation":[99,207,233],"peripheral":[101,148,181,209],"carbohydrate,":[102],"lipid":[103],"protein":[105],"metabolism.":[106,211],"consequences":[108],"impaired":[110,244],"action":[112,219],"these":[114],"deemed":[117],"explain":[119],"functional":[121],"structural":[123],"abnormalities":[124],"resistance.":[128],"discovery":[130],"receptors":[133],"central":[136,198,232,245],"nervous":[137,199,246],"system,":[138],"detection":[140],"cerebrospinal":[145],"fluid":[146],"after":[147],"administration":[150],"well-documented":[153],"effects":[154],"intracerebroventricularly":[156],"injected":[157],"on":[159],"energy":[160,196,235],"homeostasis,":[161,238],"identified":[163],"brain":[165,222],"an":[167],"for":[170],"action.":[172],"In":[173],"addition":[174],"its":[176],"critical":[177],"role":[178,242],"a":[180,250],"signal":[182],"integrating":[183],"complex":[185],"network":[186],"hypothalamic":[188],"neuropeptides":[189],"neurotransmitters":[191],"influence":[193],"parameters":[194],"balance,":[197],"signalling":[201,248],"also":[203],"implicated":[204],"glucose":[210,237],"This":[212],"review":[213],"summarizes":[214],"evidence":[216],"part":[224],"multifaceted":[227],"circuit":[228],"discuss":[240],"pathogenic":[251],"factor":[252],"diabetes":[259],"epidemic.":[260]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
