{"id":"https://openalex.org/W996992909","doi":null,"title":"UNDERSTANDING THE ROLE OF SUMOYLATION IN REGULATING LKB1 FUNCTION","display_name":"UNDERSTANDING THE ROLE OF SUMOYLATION IN REGULATING LKB1 FUNCTION","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W996992909","mag":"996992909"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1611","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/570","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/570","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/570","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003278356","display_name":"Joan Ritho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joan Ritho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003278356"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.47749999165534973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.47749999165534973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.42579999566078186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/liver-kinase-b1","display_name":"LKB1","score":0.984000027179718},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.6119999885559082},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/sumo1","display_name":"SUMO1","score":0.7900000214576721},{"id":"https://openalex.org/keywords/sumo2-3","display_name":"SUMO2/3","score":0.9010000228881836},{"id":"https://openalex.org/keywords/metabolic-stress","display_name":"metabolic stress","score":0.5370000004768372},{"id":"https://openalex.org/keywords/peutz-jeghers-syndrome","display_name":"Peutz-Jeghers syndrome","score":0.722000002861023},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7540000081062317},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8140000104904175},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.44600000977516174},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.5580000281333923},{"id":"https://openalex.org/keywords/sumo-interacting-motif","display_name":"SUMO-interacting motif","score":0.6620000004768372},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.6083346009254456},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5446519255638123},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3628874123096466},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29087603092193604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27059561014175415},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20492646098136902},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.14630445837974548},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11290854215621948}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1611","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/570","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/570","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:996992909","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1611&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1611","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/570","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/570","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322320","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W996992909.pdf","grobid_xml":"https://content.openalex.org/works/W996992909.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W168671060","https://openalex.org/W200286807","https://openalex.org/W1536070820","https://openalex.org/W1619212443","https://openalex.org/W1619256199","https://openalex.org/W1760694280","https://openalex.org/W1959908262","https://openalex.org/W1967707683","https://openalex.org/W1969165489","https://openalex.org/W1973480232","https://openalex.org/W1976760923","https://openalex.org/W1979275431","https://openalex.org/W1981243923","https://openalex.org/W1982985819","https://openalex.org/W1983602021","https://openalex.org/W1984405912","https://openalex.org/W1987211450","https://openalex.org/W1989710643","https://openalex.org/W1990278643","https://openalex.org/W1991308933","https://openalex.org/W1991452864","https://openalex.org/W1994218254","https://openalex.org/W1995069275","https://openalex.org/W1997003352","https://openalex.org/W1997224005","https://openalex.org/W2001041080","https://openalex.org/W2001341780","https://openalex.org/W2004214053","https://openalex.org/W2009616259","https://openalex.org/W2011169071","https://openalex.org/W2013108773","https://openalex.org/W2015022497","https://openalex.org/W2016752484","https://openalex.org/W2018649316","https://openalex.org/W2018686658","https://openalex.org/W2018846363","https://openalex.org/W2020627337","https://openalex.org/W2023540360","https://openalex.org/W2023947368","https://openalex.org/W2024935012","https://openalex.org/W2026421562","https://openalex.org/W2037845650","https://openalex.org/W2039212784","https://openalex.org/W2040624923","https://openalex.org/W2042862271","https://openalex.org/W2044874695","https://openalex.org/W2045815767","https://openalex.org/W2046037983","https://openalex.org/W2050013545","https://openalex.org/W2050895547","https://openalex.org/W2052498320","https://openalex.org/W2052929547","https://openalex.org/W2053627244","https://openalex.org/W2065260669","https://openalex.org/W2070182263","https://openalex.org/W2070910260","https://openalex.org/W2071228044","https://openalex.org/W2072451938","https://openalex.org/W2078192821","https://openalex.org/W2079551052","https://openalex.org/W2080107084","https://openalex.org/W2080253509","https://openalex.org/W2080481362","https://openalex.org/W2083265600","https://openalex.org/W2085458306","https://openalex.org/W2086810510","https://openalex.org/W2087102845","https://openalex.org/W2091069088","https://openalex.org/W2091077559","https://openalex.org/W2091175626","https://openalex.org/W2091602394","https://openalex.org/W2094638529","https://openalex.org/W2095454212","https://openalex.org/W2097259163","https://openalex.org/W2102891343","https://openalex.org/W2103659405","https://openalex.org/W2114591766","https://openalex.org/W2122341467","https://openalex.org/W2123669269","https://openalex.org/W2126147061","https://openalex.org/W2127192155","https://openalex.org/W2138319716","https://openalex.org/W2141261455","https://openalex.org/W2144401190","https://openalex.org/W2148694780","https://openalex.org/W2148792455","https://openalex.org/W2150419930","https://openalex.org/W2152712845","https://openalex.org/W2155250843","https://openalex.org/W2157388608","https://openalex.org/W2167536088","https://openalex.org/W2168249970","https://openalex.org/W2169265947","https://openalex.org/W2169520827","https://openalex.org/W2172298521"],"related_works":["https://openalex.org/W1961425337","https://openalex.org/W2800848489","https://openalex.org/W2102891343","https://openalex.org/W2050079419","https://openalex.org/W1583510684","https://openalex.org/W2053134659","https://openalex.org/W2283117243","https://openalex.org/W4322761908","https://openalex.org/W2038758196","https://openalex.org/W7154706328"],"abstract_inverted_index":{"Energy":[0],"homeostasis":[1],"in":[2,34,41,85,98,154,171,180,212,281,316,327,357,380,422,430],"a":[3,30,64,193,200,248,259,324,378,428],"cell":[4],"is":[5,147,184,187,337,355],"critical":[6],"for":[7,392],"its":[8,238,273,443],"survival":[9],"during":[10,288],"metabolic":[11,334,458],"stress.":[12],"Liver":[13],"kinase":[14,67,74,153,302],"B1":[15],"(LKB1),":[16],"one":[17],"of":[18,22,68,82,106,116,123,161,167,178,192,247,268,304,319,364,372,384,387,437,460],"the":[19,69,80,104,124,165,176,188,204,225,232,235,252,256,266,269,276,282,293,301,317,362,365,369,381,388,408,435,449,457,461],"key":[20],"regulators":[21],"cellular":[23,156],"energy":[24,70,83,88,157,289,311,432],"balance,":[25],"was":[26],"initially":[27],"discovered":[28],"as":[29,110,120,150,216],"tumor":[31],"suppressor":[32],"mutated":[33],"patients":[35,44],"with":[36,79,407,445],"Peutz-Jeghers":[37],"syndrome.":[38],"Germline":[39],"mutations":[40],"LKB1":[42,90,146,173,182,320,336,396,409,438],"predispose":[43],"to":[45,103,199,456],"develop":[46],"several":[47,59],"benign":[48],"and":[49,54,114,141,220,237,296,330,399,417],"malignant":[50],"tumors":[51],"including":[52],"gastrointestinal":[53],"lung":[55],"cancers.":[56],"In":[57],"2003,":[58],"groups":[60],"demonstrated":[61],"that":[62,297,310,405],"LKB1is":[63],"major":[65],"upstream":[66],"sensor":[71],"AMP-activated":[72],"protein":[73,198,218,221],"(AMPK),":[75],"directly":[76],"associating":[77],"it":[78],"regulation":[81],"balance":[84],"cells.":[86,424],"During":[87,333],"stress,":[89,290,335],"phosphorylates":[91],"AMPK":[92,99,415,453],"at":[93,342,451],"threonine":[94],"172":[95],"(T172)":[96],"resulting":[97],"activation.":[100],"This":[101,207,353,447],"leads":[102],"inhibition":[105],"anabolic":[107],"pathways":[108,118],"such":[109,119,215],"fatty":[111],"acid":[112,130,134],"synthesis":[113],"activation":[115],"energy-producing":[117],"glycolysis.":[121],"Some":[122],"proteins":[125],"targeted":[126],"include:":[127],"ACC1":[128],"(fatty":[129,133],"synthesis),":[131,138],"ACC2":[132],"oxidation),":[135],"mTORC1":[136],"(protein":[137],"ULK1":[139],"(mitophagy)":[140],"GLUT1":[142],"(glucose":[143],"uptake).":[144],"Therefore,":[145],"strategically":[148],"positioned":[149],"an":[151,314],"essential":[152,356],"maintaining":[155],"balance.":[158],"A":[159],"number":[160],"studies":[162],"have":[163],"described":[164],"influence":[166],"covalent":[168,190],"post-translational":[169],"modifications":[170],"governing":[172],"activity.":[174],"However,":[175],"role":[177],"SUMOylation":[179,186,228,279,291],"regulating":[181],"function":[183],"unknown.":[185],"reversible":[189],"modification":[191,318,354,436],"SUMO":[194,411],"(small":[195],"ubiquitin-related":[196],"modifier)":[197],"specific":[201],"lysine":[202,343],"on":[203],"target":[205,236,253],"protein.":[206],"process":[208],"has":[209],"been":[210],"implicated":[211],"important":[213],"processes":[214],"transcription,":[217],"stability,":[219],"subcellular":[222],"localization.":[223],"At":[224],"molecular":[226],"level,":[227],"can":[229,454],"(1)":[230],"inhibit":[231],"interaction":[233,244,295,394,444],"between":[234],"interacting":[239],"partner,":[240],"(2)":[241],"enhance":[242],"this":[243,298],"through":[245],"creation":[246],"binding":[249],"surface":[250],"where":[251],"would":[254],"recognize":[255],"partner":[257],"via":[258],"SUMO-interacting":[260],"motif":[261],"(SIM),":[262],"or":[263,351],"(3)":[264],"change":[265],"conformation":[267],"target,":[270],"thereby":[271,441],"altering":[272],"function.":[274],"Given":[275],"diverse":[277],"roles":[278],"plays":[280],"eukaryotic":[283],"cell,":[284],"we":[285,376,403,426],"hypothesized":[286],"that,":[287],"regulates":[292],"LKB1-AMPK":[294,359],"accordingly":[299],"affects":[300],"activity":[303],"AMPK.":[305,385,401,446],"Our":[306],"findings":[307],"here":[308],"demonstrate":[309],"deficit":[312],"triggers":[313],"increase":[315],"by":[321,340,348,374,439],"SUMO1":[322,329,341,373,393],"despite":[323],"global":[325],"reduction":[326],"both":[328],"SUMO2/3":[331],"conjugates.":[332],"specifically":[338],"modified":[339],"178":[344],"(K178)":[345],"but":[346],"not":[347],"SUMO2/3,":[349],"acetylation,":[350],"ubiquitination.":[352],"promoting":[358],"interaction.":[360],"On":[361],"basis":[363],"crystal":[366],"structure":[367],"depicting":[368],"non-covalent":[370],"recognition":[371],"RanBP2,":[375],"identified":[377],"SIM":[379],"N-terminal":[382],"region":[383],"Mutation":[386],"hydrophobic":[389],"residues":[390],"necessary":[391],"prevented":[395],"from":[397],"recognizing":[398],"activating":[400],"Finally,":[402],"observed":[404],"cells":[406],"K178R":[410],"mutant":[412],"had":[413],"defective":[414],"signaling":[416],"mitochondrial":[418],"function,":[419],"inducing":[420],"apoptosis":[421],"energy-deprived":[423],"Thus,":[425],"propose":[427],"model":[429],"which":[431,452],"stress":[433],"upregulates":[434],"SUMO1,":[440],"facilitating":[442],"enhances":[448],"rate":[450],"respond":[455],"needs":[459],"cell.":[462]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}
