{"id":"https://openalex.org/W996978425","doi":null,"title":"The Tissue Response to Infectious Burden and Implantable Devices in Healthy and Diabetic Animal Models","display_name":"The Tissue Response to Infectious Burden and Implantable Devices in Healthy and Diabetic Animal Models","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W996978425","mag":"996978425"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/9809","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/9809","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027383640","display_name":"Nga L. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nga Le Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5027383640"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.07639999687671661,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.06260000169277191,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-response","display_name":"tissue reaction","score":0.7239999771118164},{"id":"https://openalex.org/keywords/infectious-burden","display_name":"infectious burden","score":0.8500000238418579},{"id":"https://openalex.org/keywords/biomedical-implants","display_name":"biomedical implants","score":0.9599999785423279},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8370000123977661},{"id":"https://openalex.org/keywords/animal-models-of-diabetes","display_name":"animal models of diabetes","score":0.6759999990463257},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5001523494720459},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3906206786632538}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/9809","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/9809","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:996978425","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/handle/10161/9809","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9987000226974487}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2336915737","https://openalex.org/W2771644116","https://openalex.org/W2027847067","https://openalex.org/W6902981639","https://openalex.org/W2793748350","https://openalex.org/W2088810004","https://openalex.org/W3199916473","https://openalex.org/W3213342137","https://openalex.org/W2487012081","https://openalex.org/W2260315153"],"abstract_inverted_index":{"Performance":[0],"of":[1,32,43,53,76,85,193,223,231,252,266,277,304,319,334,351,387,405,423,478,480,500,508,556,566,591,611,625,649,698,709,768,788,810,816,835,908,937,951,960,1029,1072,1084,1144,1250,1291,1348,1436],"biomedical":[2],"implants":[3,778],"has":[4,730],"been":[5,116],"hindered":[6],"by":[7,47,68,748,841,1020,1090],"fibrosis,":[8],"infection,":[9,77],"and":[10,35,72,127,144,160,202,296,344,358,372,420,432,467,588,676,752,761,861,882,912,995,1002,1026,1066,1098,1129,1156,1169,1183,1219,1236,1397],"deficient":[11],"tissue":[12,103,149,774,1055,1132,1200,1276],"integration":[13],"due":[14],"in":[15,36,60,93,175,312,340,348,356,459,547,608,618,646,653,664,695,706,764,781,796,832,855,901,1048,1064,1079,1107,1192,1198,1266,1295,1382],"part":[16],"to":[17,97,105,118,121,137,151,156,170,272,326,384,434,513,537,599,623,643,719,740,771,776,988,1050,1057,1076,1117,1135,1211,1227,1245,1258,1303,1321,1362,1393],"the":[18,37,41,44,95,102,123,129,147,219,263,274,278,302,305,317,320,349,363,385,409,417,439,465,471,481,487,492,528,553,557,571,596,600,609,635,641,647,665,669,674,696,707,721,736,773,824,859,867,879,888,917,920,1023,1108,1118,1136,1246,1251,1259,1346,1376,1407,1417],"body's":[19,737],"foreign":[20,124,722],"body":[21,125,723],"response.":[22,1053],"In":[23,362,491,784,887,1205],"addition,":[24],"diabetes":[25,48,64,174,638,702,1078],"mellitus":[26],"is":[27,65,154],"affecting":[28],"a":[29,50,73,176,313,376,403,421,475,496,504,576,660,682,797,807,846,883,973,1213,1298,1352],"greater":[30,74,1299,1319],"number":[31],"people":[33],"worldwide":[34],"United":[38],"States.":[39],"As":[40,1223],"percentage":[42],"population":[45],"affected":[46,1019],"increases,":[49],"larger":[51],"fraction":[52],"these":[54,152,1033,1308],"implanted":[55,107,352,613,726,790,899,1059,1106,1363],"devices":[56,120,153,353],"will":[57],"be":[58,282,717,1045],"placed":[59],"diabetic":[61,138,148,221,279,309,359,493,619,675,744,1067],"patients.":[62],"Unfortunately,":[63],"often":[66],"complicated":[67],"poor":[69],"wound":[70,130,759],"healing":[71,131,760],"risk":[75],"issues":[78],"that":[79,624,637,693,733,805,1042,1345,1356],"could":[80],"adversely":[81,639],"affect":[82],"proper":[83],"acceptance":[84,763],"an":[86,106,228,450,612,650,654,699,710,948],"implant.":[87,711],"Diabetic":[88],"animal":[89,360,365,494,558,655],"models":[90],"are":[91,140,746],"useful":[92],"studying":[94],"response":[96,104,126,132,150,347,724,739,775,1016,1056,1149,1301,1355],"infection":[98,645,704],"as":[99,101,111,337,575,1150,1430],"well":[100],"device.":[108],"Therapies":[109],"such":[110,336],"nitric":[112,749,769],"oxide":[113,713,750,770],"release":[114,715,809,896,962,982,999],"have":[115],"applied":[117],"indwelling":[119,651,777],"mediate":[122,720],"improve":[128],"around":[133,725],"implants.":[134],"Particularly":[135],"relevant":[136],"patients":[139],"implantable":[141,1086],"glucose":[142,210,215,288,507,786,843,856,1060,1087,1122],"sensors,":[143,1088,1197,1306,1323],"so":[145],"determining":[146],"crucial":[155],"improving":[157],"their":[158],"lifetime":[159],"performance.":[161],"A":[162,427,812,1069,1389],"novel":[163,497],"outcome-based":[164],"streptozotocin":[165,196,501,1073],"dosing":[166,498],"regimen":[167,499,1071],"was":[168,211,216,235,289,354,430,511,519,559,584,593,615,658,779,794,821,929,944,1017,1062,1074,1138,1177,1241,1255,1317,1327],"developed":[169,308],"induce":[171,514,1077],"Type":[172],"1":[173,1127],"rodent":[177],"model.":[178,656],"Male":[179],"CD":[180],"(Sprague-Dawley":[181],"type)":[182],"rats":[183,226,242,247],"weighing":[184],"150-200":[185],"g":[186],"were":[187,248,270,382,393,412,425,442,447,462,535,839,864,898,963,970,1035,1092,1104,1115,1161,1271,1310,1384],"given":[188,249],"three":[189],"consecutive":[190],"daily":[191],"doses":[192,251],"40":[194],"mg/kg":[195],"(STZ)":[197],"on":[198,259,503,552],"Days":[199],"1,":[200],"2,":[201],"3.":[203],"On":[204],"Day":[205],"5,":[206],"tail":[207],"vein":[208],"blood":[209,214,260,506],"checked.":[212],"If":[213],"not":[217,443,659,1036,1311,1329,1358,1373],"within":[218],"target":[220,244,505,529],"range":[222],"350-600":[224,509],"mg/dl,":[225],"received":[227],"additional":[229],"dose":[230,1028],"STZ.":[232],"This":[233,942],"procedure":[234],"repeated":[236],"every":[237,291],"48":[238],"hours":[239,829],"until":[240],"all":[241,1288,1341],"achieved":[243],"hyperglycemia.":[245],"Control":[246],"similar":[250],"vehicle":[253,922],"(saline/citrate),":[254],"which":[255],"had":[256,1406],"no":[257,589,1379],"effect":[258],"glucose.":[261],"After":[262,414,578],"last":[264],"injection":[265],"streptozotocin,":[267],"two":[268,782],"weeks":[269,525],"allowed":[271],"ensure":[273],"full":[275],"effects":[276,834],"state":[280],"would":[281],"present":[283],"at":[284,484,586,850,878,935,993,1010,1038,1411,1423,1443],"device":[285,614,652],"implantation.":[286],"Blood":[287],"measured":[290,1151],"2":[292,327],"days":[293,298],"for":[294,299,301,316,402,521,668,827,1140,1179,1287,1340,1395,1449],"diabetics":[295],"4":[297,1130],"controls":[300],"duration":[303,318,1025],"experiment.":[306],"The":[307,549,766,831,1013,1054,1102,1401],"model":[310,800],"resulted":[311],"stable":[314,1337,1367],"hyperglycemia":[315,518],"experiment":[321],"(in":[322],"some":[323],"cases,":[324],"up":[325],"months).":[328],"Animals":[329],"also":[330,729,1328,1391,1415],"exhibited":[331],"typical":[332],"symptoms":[333],"diabetes,":[335],"minimal":[338],"changes":[339],"weight,":[341],"excessive":[342],"thirst,":[343],"polyuria.":[345],"Infection":[346,603],"presence":[350,610,648,708,1347],"investigated":[355,1063],"healthy":[357,364,798,1065],"models.":[361],"model,":[366,495],"control":[367,466,626,860],"stainless":[368,531,541],"steel":[369,532,542],"compression":[370],"plates":[371,373,534],"coated":[374],"with":[375,395,486,540,561,893,905,947,979,1022],"nitric-oxide":[377],"releasing":[378],"xerogel":[379],"(20%":[380],"AHAP)":[381],"attached":[383,1116],"femurs":[386,392],"12":[388],"adult":[389],"rabbits.":[390],"Both":[391],"inoculated":[394,560,597],"3x106":[396],"CFU":[397,565],"MSSA":[398],"(methicillin-sensitive":[399],"Staph":[400],"aureus)":[401],"period":[404],"20":[406],"minutes":[407],"before":[408],"surgical":[410],"sites":[411],"sutured.":[413],"7":[415,851],"days,":[416,580,852,1126],"wound,":[418],"device,":[419],"portion":[422,1249],"bone":[424],"cultured.":[426],"muscle":[428,483],"biopsy":[429],"removed":[431],"homogenized":[433],"quantify":[435],"bacterial":[436,460,489,582],"infection.":[437,742],"Since":[438],"microbiologic":[440],"data":[441,969,1176],"normally":[444],"distributed,":[445],"they":[446],"compared":[448,622,680],"using":[449,681,801,965,972],"unpaired":[451],"Wilcoxon":[452,683,975],"Rank":[453],"Sum":[454],"Test.":[455],"No":[456],"significant":[457,661,853,1190,1264,1380,1440],"differences":[458,854,1191,1265,1381],"burden":[461,667],"observed":[463,1272],"between":[464,673,858,1215],"NO-eluting":[468],"devices,":[469],"however":[470,689,1004,1324],"study":[472],"did":[473],"find":[474],"high":[476],"correlation":[477],"temperature":[479],"adjacent":[482,1134,1226,1244,1257,1302,1320,1361],"implantation":[485],"ensuing":[488],"content.":[490],"based":[502],"mg/dl":[510],"used":[512,718,1075],"type-1":[515],"diabetes.":[516],"Stable":[517],"maintained":[520],"21":[522],"days.":[523,914],"Two":[524],"after":[526,604],"achieving":[527],"hyperglycemia,":[530],"fracture":[533],"secured":[536],"each":[538],"femur":[539],"screws":[543],"approximately":[544],"3":[545,562,994,1125],"mm":[546],"length.":[548],"implant":[550,762],"site":[551],"right":[554],"side":[555,573,598],"x":[563],"107":[564],"methicillin-sensitive":[567],"S.":[568],"aureus":[569,606],"while":[570,1414],"left":[572],"served":[574],"control.":[577],"seven":[579],"quantitative":[581],"count":[583],"performed":[585],"explantation":[587],"cross-over":[590],"bacteria":[592],"detected":[594,663],"from":[595],"non-inoculated":[601,670],"side.":[602],"S":[605],"inoculation":[607],"significantly":[616,1005,1018],"higher":[617],"animals":[620,627],"when":[621,679],"(p":[628,686],"=":[629,687],"0.0003,":[630],"Wilcoxin":[631],"Rank-Sum":[632,684],"Test)":[633],"supporting":[634],"hypothesis":[636],"affects":[640],"ability":[642],"fight":[644],"There":[657],"difference":[662],"infectious":[666],"limb":[671],"(left)":[672],"non-diabetic":[677,1322,1402],"groups":[678],"Test":[685],"0.0682),":[688],"this":[690,1325],"near-significance":[691],"suggests":[692],"even":[694],"absence":[697],"introduced":[700],"inoculum,":[701],"increases":[703],"susceptibility":[705],"Nitric":[712],"(NO)":[714],"can":[716],"devices.":[727],"NO":[728,754,803,814,838,895,961,981,1030,1043],"antibacterial":[731],"properties":[732,897],"may":[734,756],"enhance":[735],"immune":[738],"implant-associated":[741],"Additionally,":[743,1172,1313],"wounds":[745],"characterized":[747],"deficiency,":[751],"thus":[753],"supplementation":[755],"promote":[757],"better":[758],"diabetics.":[765],"use":[767],"modulate":[772],"explored":[780],"studies.":[783],"vivo":[785,833],"recovery":[787,844,857],"subcutaneously":[789,900],"NO-releasing":[791,862,918,921],"microdialysis":[792],"probes":[793,863],"evaluated":[795,840,1139,1162,1178],"rat":[799,1109],"saturated":[802],"solutions":[804],"provided":[806],"steady":[808],"NO.":[811],"constant":[813,1284],"flux":[815],"162":[817],"pmol":[818],"cm-2":[819],"s-1":[820],"perfused":[822],"through":[823],"probe":[825,880],"membrane":[826],"8":[828],"daily.":[830],"increased":[836,1225,1334,1432],"localized":[837],"monitoring":[842],"over":[845,1203,1229,1279,1285,1338,1368],"14-day":[847,868],"period.":[848],"Beginning":[849],"observed.":[865],"At":[866,1124,1375],"time":[869,906,1286,1339],"point,":[870],"histological":[871,966],"analysis":[872,1435],"revealed":[873,1188,1297],"decreased":[874,1234,1428,1447],"inflammatory":[875,1015,1052,1148,1153,1220,1292,1300,1314,1354,1398,1419],"cell":[876,1154,1221,1293,1315,1332,1399,1420],"density":[877,1143,1268,1294,1316,1333,1410,1427],"surface":[881],"thinner":[884],"collagen":[885,990,1007,1141,1146,1193,1216,1231,1267],"capsule.":[886],"second":[889],"study,":[890],"polyurethane-coated":[891],"wires":[892],"varying":[894],"17":[902],"Yorkshire":[903],"piglets":[904],"points":[907],"3,":[909],"7,":[910],"21,":[911],"42":[913],"To":[915],"create":[916],"coating,":[919],"(i.e.,":[923,984],"PROLI/NO,":[924],"AEAP3":[925],"or":[926,939,1202,1278,1335],"MPTMS":[927],"nanoparticles)":[928],"dispersed":[930],"into":[931],"EtOH":[932],"(2.5":[933],"mL)":[934],"concentrations":[936],"36":[938],"72":[940],"mg/mL.":[941],"solution":[943],"then":[945],"mixed":[946],"equal":[949],"volume":[950],"50:50":[952],"wt%":[953],"HPU/TPU":[954],"(160":[955],"mg/mL":[956],"total":[957],"PU).":[958],"Effects":[959],"analyzed":[964,971],"data.":[967],"These":[968,1159],"non-parametric":[974],"rank-sum":[976],"test.":[977],"Coatings":[978],"short":[980],"durations":[983,1000],"24":[985],"h)":[986],"failed":[987],"reduce":[989],"capsule":[991,1008,1217,1232,1239],"thickness":[992,1009,1194,1233],"6":[996],"weeks.":[997],"Longer":[998],"(3":[1001],"14d)":[1003],"reduced":[1006],"longer":[1011,1444],"timepoints.":[1012,1445],"acute":[1014],"coatings":[1021],"longest":[1024],"greatest":[1027,1256,1408,1418],"release.":[1031],"However":[1032],"benefits":[1034],"realized":[1037],"later":[1039,1424],"timepoints,":[1040,1413,1425],"suggesting":[1041,1344],"must":[1044],"actively":[1046],"released":[1047],"order":[1049],"influence":[1051],"percutaneously":[1058,1105],"sensors":[1061,1103,1137,1228,1350,1364],"rats.":[1068,1081],"multi-dose":[1070],"experimental":[1080],"Three":[1082],"types":[1083],"functional,":[1085],"supplied":[1089],"Medtronic\u00ae":[1091],"used:":[1093],"SofTM":[1094],"sensor,":[1095,1097],"EnliteTM":[1096],"Enlite":[1099,1305,1404],"2TM":[1100],"sensor.":[1101],"dorsum":[1110],"subcutaneous":[1111],"space.":[1112],"MiniLinkTM":[1113],"transmitters":[1114],"rats,":[1119],"permitting":[1120],"continuous":[1121,1173],"monitoring.":[1123],"week,":[1128],"weeks,":[1131],"directly":[1133],"encapsulation,":[1142,1147],"any":[1145],"via":[1152,1164],"density,":[1155],"microvessel":[1157,1396,1409,1426],"density.":[1158,1222,1421],"endpoints":[1160],"histologically":[1163],"Masson's":[1165,1207],"trichrome,":[1166],"Hoechst,":[1167],"H&E,":[1168],"CD31":[1170],"staining.":[1171],"functional":[1174],"sensor":[1175,1180,1252,1274,1342,1387,1405,1437,1441],"accuracy,":[1181],"attenuation,":[1182],"lag":[1184],"time.":[1185,1204,1280],"Histological":[1186],"analyses":[1187],"few":[1189,1263],"among":[1195,1273,1386],"different":[1196,1199],"types,":[1201,1275,1277,1343],"general,":[1206],"trichrome-stained":[1208],"images":[1209],"seem":[1210],"suggest":[1212],"balance":[1214,1390],"formation":[1218,1240],"inflammation":[1224,1254,1431],"time,":[1230,1369],"somewhat":[1235,1429,1448],"stabilized.":[1237],"Collagen":[1238],"most":[1242],"evident":[1243],"plastic":[1247],"tubing":[1248],"whereas":[1253],"sensing":[1260],"electrode.":[1261],"Likewise,":[1262],"index":[1269],"(CDI)":[1270],"CDI":[1281],"remained":[1282,1336,1365],"relatively":[1283],"sensors.":[1289],"Analysis":[1290],"general":[1296],"percutaneous":[1304,1403],"though":[1307],"results":[1309],"significant.":[1312,1330],"generally":[1318,1366],"result":[1326],"Inflammatory":[1331],"percutaneously-implanted":[1349],"produces":[1351],"chronic":[1353],"does":[1357],"resolve.":[1359],"Vascularity":[1360],"sometimes":[1370],"decreasing":[1371],"but":[1372],"significantly.":[1374],"1-month":[1377],"timepoint,":[1378],"vasculature":[1383],"seen":[1385],"types.":[1388],"appears":[1392],"exist":[1394],"densities.":[1400],"earlier":[1412],"having":[1416],"However,":[1422],"somewhat.":[1433],"Finally,":[1434],"performance":[1438],"showed":[1439],"failure":[1442],"Sensitivity":[1446],"al":[1450]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}