{"id":"https://openalex.org/W99697349","doi":null,"title":"The role of TP53 network in the pathogenesis of chronic lymphocytic leukemia.","display_name":"The role of TP53 network in the pathogenesis of chronic lymphocytic leukemia.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W99697349","mag":"99697349","pmid":"https://pubmed.ncbi.nlm.nih.gov/23826404","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3693188"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2696444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3693188","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3693188","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100619877","display_name":"Cheng Wang","orcid":"https://orcid.org/0000-0002-4693-6424","observed_orcids":["https://orcid.org/0000-0002-4693-6424","https://orcid.org/0009-0000-3402-0286"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Wang","raw_affiliation_strings":["Department of Hematology, Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan, Shandong 250021, P R China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan, Shandong 250021, P R China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100327835","display_name":"Xin Wang","orcid":"https://orcid.org/0000-0001-8051-1481","observed_orcids":["https://orcid.org/0000-0001-8051-1481","https://orcid.org/0000-0001-5457-5799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4259,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64831949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"6","issue":"7","first_page":"1223","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.9769999980926514},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cytogenetics","display_name":"cytogenetics","score":0.7160000205039978},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9350000023841858},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.9414499998092651},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.9088178277015686},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5547918081283569},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5405757427215576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4787047207355499},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44870132207870483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.367495059967041},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1884533166885376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18230336904525757}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2696444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3693188","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23826404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23826404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3693188","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3693188/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:99697349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23826404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2696444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3693188","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1182810993","https://openalex.org/W1527161131","https://openalex.org/W1559356541","https://openalex.org/W1564039428","https://openalex.org/W1969357584","https://openalex.org/W1970431885","https://openalex.org/W1972466227","https://openalex.org/W1978177909","https://openalex.org/W1980260104","https://openalex.org/W1984682374","https://openalex.org/W1985099044","https://openalex.org/W1986250681","https://openalex.org/W1987282310","https://openalex.org/W1990689171","https://openalex.org/W1994079658","https://openalex.org/W1994979282","https://openalex.org/W1996453162","https://openalex.org/W1998185169","https://openalex.org/W2001944431","https://openalex.org/W2009288597","https://openalex.org/W2013721931","https://openalex.org/W2020924517","https://openalex.org/W2022054497","https://openalex.org/W2032320747","https://openalex.org/W2035918677","https://openalex.org/W2037771959","https://openalex.org/W2038167014","https://openalex.org/W2043085961","https://openalex.org/W2043478931","https://openalex.org/W2051663161","https://openalex.org/W2053548004","https://openalex.org/W2063627118","https://openalex.org/W2066717966","https://openalex.org/W2072688209","https://openalex.org/W2077317574","https://openalex.org/W2077408537","https://openalex.org/W2080077828","https://openalex.org/W2083158631","https://openalex.org/W2085625452","https://openalex.org/W2091109436","https://openalex.org/W2111893233","https://openalex.org/W2113895281","https://openalex.org/W2119337308","https://openalex.org/W2132813248","https://openalex.org/W2135314242","https://openalex.org/W2139193302","https://openalex.org/W2140325124","https://openalex.org/W2142980479","https://openalex.org/W2144154026","https://openalex.org/W2147632335","https://openalex.org/W2151445680","https://openalex.org/W2152256447","https://openalex.org/W2162667797","https://openalex.org/W2163923077","https://openalex.org/W2164736957","https://openalex.org/W2170004810","https://openalex.org/W2170892717","https://openalex.org/W2993123216"],"related_works":["https://openalex.org/W2002200949","https://openalex.org/W2064965338","https://openalex.org/W2335449177","https://openalex.org/W2152256447","https://openalex.org/W4205803483","https://openalex.org/W2008225116","https://openalex.org/W4391184954","https://openalex.org/W7161551975","https://openalex.org/W7209442703","https://openalex.org/W2982269129"],"abstract_inverted_index":{"TP53":[0,18],"is":[1],"one":[2],"of":[3,15,43,72],"the":[4,63,70],"most":[5],"important":[6,38],"prognostic":[7],"factors":[8],"in":[9,19,40,52,69],"chronic":[10],"lymphocytic":[11],"leukemia":[12],"(CLL).":[13],"Modulation":[14],"microRNAs":[16],"by":[17],"CLL":[20,53],"pathogenesis":[21,54,71],"has":[22,28],"been":[23],"a":[24],"hotspot.":[25],"Besides,":[26],"it":[27],"an":[29,37,48],"intimate":[30],"association":[31],"with":[32],"other":[33],"cytogenetics":[34],"and":[35,55,66],"plays":[36],"part":[39],"drug":[41],"resistance":[42],"CLL.":[44,73],"All":[45],"above":[46],"indicate":[47],"embedded":[49],"TP53-centered":[50,64],"network":[51,65],"prognosis.":[56],"In":[57],"this":[58],"review,":[59],"we":[60],"focus":[61],"on":[62],"its":[67],"roles":[68]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}