{"id":"https://openalex.org/W9966168","doi":null,"title":"Synaptic Degeneration in Alzheimer's Disease","display_name":"Synaptic Degeneration in Alzheimer's Disease","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W9966168","mag":"9966168"},"language":"en","primary_location":{"id":"mag:9966168","doi":null,"is_oa":false,"landing_page_url":"https://espace.library.uq.edu.au/view/UQ:255405","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071624932","display_name":"Raymond Chuen\u2010Chung Chang","orcid":"https://orcid.org/0000-0001-8538-7993","observed_orcids":["https://orcid.org/0000-0001-8538-7993"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond Chuen\u2010Chung Chang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8538-7993","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013922319","display_name":"Naomi Etheridge","orcid":"https://orcid.org/0000-0001-8131-5300","observed_orcids":["https://orcid.org/0000-0001-8131-5300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naomi Etheridge","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8131-5300","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071276262","display_name":"Amanda S. Nouwens","orcid":"https://orcid.org/0000-0003-4069-8266","observed_orcids":["https://orcid.org/0000-0003-4069-8266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Nouwens","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4069-8266","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059609950","display_name":"Peter Ronald Dodd","orcid":"https://orcid.org/0000-0001-5970-0181","observed_orcids":["https://orcid.org/0000-0001-5970-0181"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. R. Dodd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00044738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/synaptic-degeneration","display_name":"synaptic degeneration","score":0.9509999752044678},{"id":"https://openalex.org/keywords/synaptic-proteins","display_name":"synaptic proteins","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6930000185966492},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.7250000238418579},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.7200000286102295},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.7960000038146973},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.9139999747276306},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antioxidant-function","display_name":"antioxidant function","score":0.8840000033378601},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.6647129058837891},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6571543216705322},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6475633978843689},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.551576554775238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5191473364830017},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.47579750418663025},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.4699034094810486},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.46270066499710083},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.445004940032959},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.41440558433532715},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33375808596611023},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20364734530448914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19992050528526306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15067586302757263},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12002086639404297},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.07016584277153015},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:9966168","doi":null,"is_oa":false,"landing_page_url":"https://espace.library.uq.edu.au/view/UQ:255405","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1990659183","https://openalex.org/W116855244","https://openalex.org/W2102366629","https://openalex.org/W1563170829","https://openalex.org/W2009210467","https://openalex.org/W4390199415","https://openalex.org/W21428969","https://openalex.org/W2989340731","https://openalex.org/W1977744354","https://openalex.org/W7116881942"],"abstract_inverted_index":{"Purpose:":[0],"Synaptic":[1],"dysfunction":[2,23],"occurs":[3],"early":[4],"in":[5,62,111,125,152,183,218,227,234,242,249],"Alzheimer\u2019s":[6],"disease":[7],"(AD)":[8],"and":[9,34,71,102,128,145,208],"is":[10,116],"recognized":[11],"as":[12],"a":[13,237,247],"primary":[14],"pathologic":[15],"target":[16],"for":[17],"AD":[18,63,83,98,114,186,220,263],"treatment.":[19],"Synapse":[20],"degeneration":[21,51],"or":[22,165],"contributes":[24],"to":[25,67,74,179,190,262],"clinical":[26],"signs":[27],"of":[28,37,77,97,185],"dementia":[29],"through":[30],"altered":[31],"neuronal":[32],"communication":[33],"the":[35,75,87,231],"degree":[36],"synaptic":[38,50,60,175,216,258],"loss":[39],"strongly":[40],"correlates":[41],"with":[42,139,260],"cognitive":[43],"impairment.":[44],"The":[45,253],"exact":[46],"molecular":[47],"mechanisms":[48,70],"underlying":[49],"are":[52,194,222],"still":[53],"relatively":[54,141],"unclear;":[55],"therefore,":[56],"identifying":[57],"abnormally":[58],"expressed":[59],"proteins":[61,176,193,217,232,259],"brain":[64,95,187,221,251],"will":[65,264],"help":[66],"elucidate":[68],"those":[69,226],"can":[72,121],"lead":[73],"identification":[76],"therapeutic":[78],"targets":[79],"that":[80,215],"might":[81],"slow":[82],"progression.":[84],"Methods:":[85],"In":[86],"present":[88],"study,":[89,236],"synaptosomal":[90],"fractions":[91],"from":[92,225],"post-mortem":[93],"human":[94,119,219,250],"tissue":[96],"(n":[99,104],"=":[100,105],"6)":[101,106],"control":[103,228],"were":[107,155,177],"compared":[108,138,189],"using":[109,162],"2D-differential":[110],"gel":[112],"electrophoresis.":[113],"pathology":[115],"region":[117],"specific;":[118],"subjects":[120],"be":[122,180,265],"highly":[123],"variable":[124],"age,":[126],"medication":[127],"other":[129],"factors.":[130],"Consequently,":[131],"within":[132],"each":[133],"diseased":[134],"state,":[135],"hippocampus":[136,184],"was":[137],"two":[140],"spared":[142],"areas":[143],"(motor":[144],"occipital":[146],"cortices).":[147],"Proteins":[148],"exhibiting":[149],"significant":[150],"changes":[151],"their":[153],"expression":[154],"identified":[156,233],"(\u226520%":[157],"change,":[158],"Newman-Keuls":[159],"P-value":[160],"<0.05)":[161],"either":[163],"MALDI-TOF":[164],"ESI-QTOF":[166],"mass":[167],"spectrometry.":[168],"Results:":[169],"Using":[170],"this":[171,235],"proteomics":[172],"approach,":[173],"70":[174],"found":[178],"differentially":[181],"regulated":[182,255],"when":[188],"controls.":[191],"These":[192],"involved":[195],"regulating":[196],"different":[197,224],"cellular":[198],"functions":[199,254],"including":[200],"energy":[201],"metabolism,":[202],"signal":[203],"transduction,":[204],"vesicle":[205],"transport,":[206],"structural":[207],"antioxidant":[209],"function.":[210],"Conclusion:":[211],"This":[212],"study":[213],"showed":[214],"significantly":[223],"brain.":[229],"Of":[230],"number":[238],"have":[239],"been":[240],"studied":[241],"animal":[243],"models,":[244],"but":[245],"only":[246],"few":[248],"tissues.":[252],"by":[256],"these":[257],"respect":[261],"discussed.":[266]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}