{"id":"https://openalex.org/W996557688","doi":null,"title":"Changes of CD4~+CD25~+ T cells and expression of foxp3 mRNA in peripheral blood mononuclear cell from patients with lung cancer and breast cancer","display_name":"Changes of CD4~+CD25~+ T cells and expression of foxp3 mRNA in peripheral blood mononuclear cell from patients with lung cancer and breast cancer","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W996557688","mag":"996557688"},"language":"en","primary_location":{"id":"mag:2372654008","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-BQEB200605038.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764935964","display_name":"Journal of Jilin University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322696411","host_organization_name":"Jilin University","host_organization_lineage":["https://openalex.org/P4322696411"],"host_organization_lineage_names":["Jilin University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Jilin University","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016490456","display_name":"\u5d14\u6c38\u751f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5d14\u6c38\u751f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029516239","display_name":"Xin Li","orcid":"https://orcid.org/0000-0001-6334-0369","observed_orcids":["https://orcid.org/0000-0001-6334-0369"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6334-0369","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037479671","display_name":"\u4e8e\u6625\u96f7","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u4e8e\u6625\u96f7","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048493724","display_name":"\u8f9b\u7cbe\u536b","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u8f9b\u7cbe\u536b","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088382575","display_name":"\u674e\u4e00","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u674e\u4e00","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022186592","display_name":"\u4ed8\u5f64","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u4ed8\u5f64","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06189122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"5","first_page":"843","last_page":"846"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cd4-cd25-regulatory-t-cells","display_name":"CD4+CD25+ T cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/foxp3-mrna-expression","display_name":"Foxp3 mRNA expression","score":0.8759999871253967},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.303566038608551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.272141695022583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20790332555770874},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13134852051734924}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2372654008","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-BQEB200605038.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764935964","display_name":"Journal of Jilin University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322696411","host_organization_name":"Jilin University","host_organization_lineage":["https://openalex.org/P4322696411"],"host_organization_lineage_names":["Jilin University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Jilin University","raw_type":null},{"id":"mag:996557688","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/92319A/200605/22906276.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306545403","display_name":"\u5409\u6797\u5927\u5b66\u5b66\u62a5\uff1a\u533b\u5b66\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u5409\u6797\u5927\u5b66\u5b66\u62a5\uff1a\u533b\u5b66\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W790019545","https://openalex.org/W2372654008","https://openalex.org/W2258094855","https://openalex.org/W388836436","https://openalex.org/W283241383","https://openalex.org/W2210029693","https://openalex.org/W208560388","https://openalex.org/W1408541166","https://openalex.org/W1200257191","https://openalex.org/W945174909"],"abstract_inverted_index":{"\u76ee\u7684\uff1a\u63a2\u8ba8\u80ba\u764c\u3001\u4e73\u817a\u764c\u60a3\u8005\u5916\u5468\u8840\u4e2dCD4^\uff0bCD25^\uff0b\u8c03\u8282\u6027T\u7ec6\u80de\u6c34\u5e73\u7684\u53d8\u5316\u53ca\u4e34\u5e8a\u610f\u4e49\u3002\u65b9\u6cd5\uff1a\u5e94\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u68c0\u6d4b9\u4f8b\u80ba\u764c\u30019\u4f8b\u4e73\u817a\u764c\u60a3\u8005\u53ca10\u4f8b\u975e\u80bf\u7624\u60a3\u8005\u5916\u5468\u8840\u5355\u4e2a\u6838\u7ec6\u80de\uff08PBMC\uff09\u4e2dCD4^\uff0bCD25^\uff0bT\u7ec6\u80de\u5360CD4^\uff0bT\u7ec6\u80de\u7684\u6bd4\u4f8b\uff0c\u5e94\u7528RT\u2014PCR\u6280\u672f\u68c0\u6d4b\u4eba\u5916\u5468\u8840PBMCfoxp3\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u7ed3\u679c\uff1a\u6d41\u5f0f\u7ec6\u80de\u672f\u68c0\u6d4b\u663e\u793a\uff0c\u80ba\u764c\u53ca\u4e73\u817a\u764c\u60a3\u8005\u5916\u5468\u8840PBMC\u4e2dCD4^\uff0bCD25^\uff0bT\u7ec6\u80de\u5360CD4^\uff0bT\u7ec6\u80de\u7684\u6bd4\u4f8b[\uff0821\uff0e30\u00b111\uff0e26\uff09\uff05]\u9ad8\u4e8e\u975e\u80bf\u7624\u60a3\u8005[\uff0814\uff0e19\u00b18\uff0e56\uff09\uff05]\uff08P\u30080\uff0e05\uff09\uff0c\u80ba\u764c\u53ca\u4e73\u817a\u764c\u60a3\u8005\u5916\u5468\u8840PBMC\u4e2dfoxp3":[0],"mRNA\u7684\u8868\u8fbe\u6c34\u5e73\u9ad8\u4e8e\u975e\u80bf\u7624\u60a3\u8005\u8868\u8fbe\u6c34\u5e73\uff08P\u30080\uff0e05\uff09\uff0c\u80ba\u764c\u548c\u4e73\u817a\u764c\u60a3\u8005\u5916\u5468\u8840CD4^\uff0bCD25^\uff0b\u8c03\u8282\u6027T\u7ec6\u80de\u6bd4\u4f8b\u589e\u52a0\u3002\u7ed3\u8bba\uff1aCD4^\uff0bCD25^\uff0b\u8c03\u8282\u6027T\u7ec6\u80de\u5728\u7ef4\u6301\u81ea\u8eab\u514d\u75ab\u7a33\u5b9a\u7684\u540c\u65f6\u5bf9\u80bf\u7624\u514d\u75ab\u5177\u6709\u6291\u5236\u4f5c\u7528\uff0c\u8be5\u7ec6\u80de\u7fa4\u6bd4\u4f8b\u7684\u589e\u52a0\u53ef\u80fd\u53c2\u4e0e\u80bf\u7624\u7684\u53d1\u751f\u3002":[1]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}