{"id":"https://openalex.org/W99549095","doi":null,"title":"Vasculopathy and amyloid beta reactivity in brains of patients with acquired immune deficiency (AIDS).","display_name":"Vasculopathy and amyloid beta reactivity in brains of patients with acquired immune deficiency (AIDS).","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W99549095","mag":"99549095","pmid":"https://pubmed.ncbi.nlm.nih.gov/11693722"},"language":"en","primary_location":{"id":"pmid:11693722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11693722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia neuropathologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080154093","display_name":"Ewa I\u017cycka\u2010\u015awieszewska","orcid":"https://orcid.org/0000-0001-7550-1326","observed_orcids":["https://orcid.org/0000-0001-7550-1326"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"E Izycka-Swieszewska","raw_affiliation_strings":["Department of Pathology, Department of Immunopathology, Medical University, Gda\u0144sk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Department of Immunopathology, Medical University, Gda\u0144sk","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084320713","display_name":"Agata \u017b\u00f3\u0142towska","orcid":"https://orcid.org/0000-0003-2667-6693","observed_orcids":["https://orcid.org/0000-0003-2667-6693"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Z\u00f3\u0142towska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008897387","display_name":"Robert Rzepko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Rzepko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Gross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Gross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041234244","display_name":"Jolanta Borowska-Lehman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Borowska-Lehman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.00518135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"38","issue":"4","first_page":"175","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.6449999809265137},{"id":"https://openalex.org/keywords/hiv-associated-neurocognitive-disorders","display_name":"HIV-associated neurocognitive disorders","score":0.6190000176429749},{"id":"https://openalex.org/keywords/cerebral-vasculopathy","display_name":"cerebral vasculopathy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.753000020980835},{"id":"https://openalex.org/keywords/axonal-injury","display_name":"axonal injury","score":0.8700000047683716},{"id":"https://openalex.org/keywords/perivascular-lymphocytic-infiltration","display_name":"perivascular lymphocytic infiltrate","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hiv-neuropathology","display_name":"HIV neuropathology","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.8623223304748535},{"id":"https://openalex.org/C2777799939","wikidata":"https://www.wikidata.org/wiki/Q1711381","display_name":"Perivascular space","level":2,"score":0.7783108949661255},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.6222614049911499},{"id":"https://openalex.org/C59469219","wikidata":"https://www.wikidata.org/wiki/Q7841079","display_name":"Trichrome","level":4,"score":0.6062211990356445},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.523811936378479},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.46231609582901},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.4154108166694641},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38363116979599},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3683180809020996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3383200466632843},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.0893963873386383},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002536","descriptor_name":"Cerebral Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002550","descriptor_name":"Cerebral Veins","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003224","descriptor_name":"Congo Red","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007968","descriptor_name":"Leukoencephalopathy, Progressive Multifocal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014657","descriptor_name":"Vasculitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014657","descriptor_name":"Vasculitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015526","descriptor_name":"AIDS Dementia Complex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016483","descriptor_name":"Lymphoma, AIDS-Related","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016781","descriptor_name":"Toxoplasmosis, Cerebral","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016919","descriptor_name":"Meningitis, Cryptococcal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11693722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11693722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia neuropathologica","raw_type":"Journal Article"},{"id":"mag:99549095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11693722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992320273","https://openalex.org/W2077968305","https://openalex.org/W2409764011","https://openalex.org/W2056473993","https://openalex.org/W1974439007","https://openalex.org/W2412356470","https://openalex.org/W1497190535","https://openalex.org/W7036405311","https://openalex.org/W1974638282","https://openalex.org/W1971819297"],"abstract_inverted_index":{"The":[0,25,93,104,124,222],"authors":[1,223],"examined":[2],"multiple":[3],"brain":[4,232,263],"sections":[5,53,60,75],"from":[6,76],"15":[7],"autopsy":[8],"cases":[9,48,174],"of":[10,17,22,84,96,118,145,157,159,166,206,227,240,245,254],"AIDS":[11,238],"for":[12,81],"the":[13,82,119,137,146,160,167,188,211,231,241,252,255,262],"vascular":[14,97,161,242],"changes,":[15],"presence":[16,83],"amyloid":[18,246],"plaques":[19,247],"and":[20,46,70,91,113,121,140,164,179,215,233,248,258],"signs":[21,165],"axonal":[23,249],"damage.":[24],"mean":[26],"patients":[27],"age":[28],"was":[29,132,194],"33.8":[30],"years":[31],"(range":[32],"24-48":[33],"years).":[34],"Neuropathological":[35],"findings":[36],"included:":[37],"HIV-specific":[38],"changes":[39,98,106,229],"(5),":[40],"opportunistic":[41],"infections":[42],"(7),":[43],"lymphoma":[44],"(1)":[45],"two":[47],"with":[49,56,63],"nonspecific":[50],"changes.":[51],"All":[52],"were":[54,61,79,99,185,219],"stained":[55,62],"hematoxylin-eosin":[57],"(H-E),":[58],"selected":[59],"Masson":[64],"trichrome,":[65],"Gomori":[66],"reticulin,":[67],"Congo":[68,177],"red":[69,178],"thioflavine":[71,180],"S":[72],"method.":[73],"Two":[74],"each":[77],"case":[78],"immunostained":[80],"beta-amyloid":[85,183],"(4G8).":[86],"ubiquitin,":[87],"alpha-smooth":[88],"muscle":[89],"actin":[90],"CD31.":[92],"different":[94],"forms":[95],"found":[100],"in":[101,136,187,210,237,261,269],"all":[102],"cases.":[103],"common":[105],"were:":[107],"lymphocytic":[108],"perivascular":[109,125],"or":[110,116,203],"transmural":[111],"infiltrations":[112],"hyalinization,":[114],"thickening":[115],"fibrosis":[117],"arterial":[120],"arteriolar":[122],"wall.":[123],"space":[126],"widening":[127],"up":[128],"to":[129],"status":[130],"lacunaris":[131],"a":[133],"frequent":[134],"phenomenon":[135],"basal":[138],"ganglia":[139],"deep":[141],"white":[142,212],"matter.":[143],"Some":[144],"cortical":[147],"arterioles":[148],"formed":[149],"little":[150],"multiluminal":[151],"structures.":[152],"Immunohistochemical":[153],"examination":[154],"revealed":[155],"features":[156],"hypertrophy":[158],"muscular":[162],"layer":[163],"slight":[168],"endothelial":[169],"cells":[170],"proliferation.":[171],"In":[172],"three":[173],"4G8":[175],"immunopositive.":[176],"S-negative,":[181],"diffuse":[182],"deposits":[184],"present":[186],"gray":[189],"matter,":[190,213],"focally":[191],"their":[192],"localization":[193],"perivascular.":[195],"Ubiquitin":[196],"immunoreactivity":[197],"presented":[198],"as":[199],"numerous":[200],"dot-like":[201],"structures":[202],"focal":[204],"bundles":[205],"positive":[207,217],"widened":[208],"axons":[209],"spheroids":[214],"scattered":[216],"neurons":[218],"also":[220],"found.":[221],"suggest":[224],"that":[225],"some":[226],"morphological":[228],"within":[230],"consecutive":[234],"neuropsychological":[235],"symptoms":[236],"are":[239,251],"origin.":[243],"Presence":[244],"damage":[250],"elements":[253],"complex":[256],"degenerative":[257],"inflammatory":[259,267],"process":[260],"caused":[264],"by":[265],"chronic":[266],"stimulation":[268],"HIV":[270],"infection.":[271]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
