{"id":"https://openalex.org/W9948372","doi":null,"title":"B cells lacking complement receptors 1 and 2 are equally efficient producers of IgG in vivo as wildtype B cells","display_name":"B cells lacking complement receptors 1 and 2 are equally efficient producers of IgG in vivo as wildtype B cells","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W9948372","mag":"9948372"},"language":"en","primary_location":{"id":"mag:9948372","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:451774","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001742935","display_name":"Christian Rutemark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Rutemark","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111547942","display_name":"Anna A. Bergman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Bergman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033378036","display_name":"Andrew Getahun","orcid":"https://orcid.org/0000-0002-5663-6812","observed_orcids":["https://orcid.org/0000-0002-5663-6812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Getahun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5663-6812","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Fredrik Carlsson","orcid":"https://orcid.org/0000-0001-9791-3356","observed_orcids":["https://orcid.org/0000-0001-9791-3356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fredrik Carlsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9791-3356","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004646639","display_name":"Frida Henningsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frida Henningson-Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036667319","display_name":"Jenny Hallgren","orcid":"https://orcid.org/0000-0002-3685-5364","observed_orcids":["https://orcid.org/0000-0002-3685-5364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jenny Hallgren Martinsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053828310","display_name":"Birgitta Heyman","orcid":"https://orcid.org/0000-0003-0869-0483","observed_orcids":["https://orcid.org/0000-0003-0869-0483"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Birgitta Heyman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0869-0483","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00053449,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-receptor-1","display_name":"complement receptor 1","score":0.7620000243186951},{"id":"https://openalex.org/keywords/complement-receptor-2","display_name":"CR2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/classical-complement-pathway","display_name":"classical complement pathway","score":0.7739999890327454},{"id":"https://openalex.org/keywords/natural-igm-antibodies","display_name":"natural IgM","score":0.8299999833106995},{"id":"https://openalex.org/keywords/igg-production","display_name":"IgG production","score":0.6420000195503235},{"id":"https://openalex.org/keywords/follicular-dendritic-cells","display_name":"follicular dendritic cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/marginal-zone-b-cells","display_name":"marginal zone B cells","score":0.7269999980926514},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.6190000176429749},{"id":"https://openalex.org/keywords/chimeric-mice","display_name":"chimeric mice","score":0.7229999899864197},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.5329999923706055},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.3580000102519989},{"id":"https://openalex.org/keywords/immunoglobulin-mu-chain","display_name":"immunoglobulin mu chain","score":0.36899998784065247},{"id":"https://openalex.org/keywords/sheep-red-blood-cells","display_name":"sheep red blood cells","score":0.3959999978542328},{"id":"https://openalex.org/keywords/keyhole-limpet-hemocyanin","display_name":"keyhole limpet hemocyanin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/antibody-isotypes","display_name":"antibody isotypes","score":0.32600000500679016},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.6949999928474426},{"id":"https://openalex.org/keywords/antigen-retention","display_name":"antigen retention","score":0.3959999978542328},{"id":"https://openalex.org/keywords/marginal-zone","display_name":"marginal zone","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C171279029","wikidata":"https://www.wikidata.org/wiki/Q5128320","display_name":"Classical complement pathway","level":4,"score":0.8443004488945007},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7238649129867554},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6816425323486328},{"id":"https://openalex.org/C175773311","wikidata":"https://www.wikidata.org/wiki/Q5156412","display_name":"Complement receptor","level":4,"score":0.6719998121261597},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.6656448841094971},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5600968599319458},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47430992126464844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46826818585395813},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45928215980529785},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.43462979793548584},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42687657475471497},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33547329902648926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10744476318359375}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:9948372","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:451774","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W95512195","https://openalex.org/W1764394422","https://openalex.org/W1845422805","https://openalex.org/W4390665424","https://openalex.org/W2070387391","https://openalex.org/W2590237498","https://openalex.org/W2114198497","https://openalex.org/W2098704706","https://openalex.org/W2130960171","https://openalex.org/W7097961315"],"abstract_inverted_index":{"An":[0],"intact":[1],"complement":[2,6,40],"system":[3],"including":[4],"the":[5,15,29,79,103,113,125,138,154,170,186,223,242,276,283,289,406,417,422],"receptors":[7],"1":[8],"and":[9,24,130,144,163,205,309,348,412,439],"2":[10],"(CR1/2)":[11],"is":[12,32,55,65,150,212,220,414,430],"crucial":[13,73,415],"for":[14,74,195,222,291,416],"generation":[16,187,224],"of":[17,28,81,140,156,169,188,218,225,281,312,332,373,387],"a":[18,226],"normal":[19,179,227],"antibody":[20,50,76,126,148,180,228,321,366,392,407],"response":[21,127,367,408,423],"in":[22,39,87,132,147,304,323,426],"animals":[23],"humans.":[25],"Moreover,":[26],"activation":[27,70,143,183],"classical":[30,53,68,104,141,171],"pathway":[31,54,69,105,142],"thought":[33],"to":[34,48,61,121,158,185,306,314,330,336,409,424],"be":[35,72],"important":[36],"since":[37,78],"deficiency":[38],"components":[41],"C1q,":[42],"C2,":[43],"C4":[44],"or":[45,271,356,361],"C3":[46,189],"lead":[47],"impaired":[49],"responses.":[51,181],"The":[52,365],"mainly":[56],"initiated":[57],"by":[58,237],"antibodies":[59,83],"bound":[60],"their":[62],"antigen.":[63],"It":[64,90],"unclear":[66,213],"how":[67],"can":[71,101,404],"primary":[75],"responses":[77,149,322],"levels":[80],"specific":[82],"are":[84,165,193,200,260,302,327],"very":[85],"low":[86],"naive":[88],"animals.":[89],"has":[91],"been":[92,295],"hypothesized":[93],"that":[94,233,319,410,421],"natural":[95,145],"IgM,":[96],"with":[97,286,341,401,428],"high":[98],"enough":[99],"affinity,":[100],"initiate":[102],"after":[106],"immunization.":[107],"To":[108],"test":[109],"this,":[110],"we":[111],"generated":[112],"knock-in":[114],"mouse":[115],"strain":[116],"C\u03bc13,":[117],"producing":[118],"IgM":[119,146,157,399,425],"unable":[120],"activate":[122,159],"complement.":[123,160],"Surprisingly,":[124],"against":[128,368],"SRBC":[129,369,429],"KLH":[131],"C\u00b513":[133],"mice":[134,174,324,340],"was":[135,370,381],"normal.":[136],"Thus,":[137],"importance":[139],"not":[151,328],"dependent":[152,372,431],"on":[153,202,214,257,299,344,350,357,375,432,435],"ability":[155],"SIGN-R1,":[161],"SAP":[162],"CRP":[164],"other":[166],"known":[167],"activators":[168],"pathway,":[172],"but":[173,210],"lacking":[175,325],"these":[176],"also":[177],"had":[178],"Complement":[182],"leads":[184],"split":[190],"products":[191],"which":[192,215],"ligands":[194],"CR1/2.":[196],"In":[197,251],"mice,":[198],"CR1/2":[199,219,256,274,298,326,342,388,433],"expressed":[201],"B":[203,258,265,300,346,352,359,383,396,437],"cells":[204,208,259,266,301,347,353,360,384,438],"follicular":[206],"dendritic":[207],"(FDC),":[209],"it":[211],"cell-type":[216],"expression":[217,343,386,434],"needed":[221],"response.":[229],"Some":[230],"reports":[231],"argue":[232],"increased":[234],"antigen":[235,244,270,313,334,403,411],"retention":[236],"CR1/2+":[238],"FDC":[239],"would":[240],"increase":[241],"effective":[243,248],"concentration,":[245],"giving":[246],"more":[247],"B-cell":[249,284,292],"stimulation.":[250],"contrast,":[252],"several":[253],"mechanisms":[254],"involving":[255],"suggested.":[261],"First,":[262],"marginal":[263],"zone":[264],"could":[267],"transport":[268],"complement-coated":[269],"IC":[272],"via":[273],"into":[275],"follicle.":[277],"Second,":[278],"different":[279],"ways":[280],"co-crosslinking":[282],"receptor":[285],"CR1/2,":[287],"lowering":[288],"threshold":[290],"activation,":[293],"have":[294],"proposed.":[296],"Finally,":[297],"shown":[303],"vitro":[305],"facilitate":[307],"endocytosis":[308],"thereby":[310],"presentation":[311,335],"T":[315,337],"cells.":[316,338,397],"We":[317,419],"show":[318,420],"abrogated":[320],"due":[329],"lack":[331],"CR1/2-mediated":[333],"Chimeric":[339],"both":[345,436],"FDC,":[349,355,362],"neither":[351],"nor":[354],"either":[358],"were":[363,389],"generated.":[364],"completely":[371],"CR1/2-expression":[374,413],"FDC.":[376,440],"However,":[377],"when":[378],"this":[379],"requirement":[380],"fulfilled,":[382],"without":[385],"equally":[390],"efficient":[391],"producers":[393],"as":[394],"wildtype":[395],"Antigen-specific":[398],"together":[400],"its":[402],"enhance":[405],"enhancement.":[418],"complex":[427]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}