{"id":"https://openalex.org/W994618445","doi":null,"title":"Inhibition of cathepsin B activity in human breast cancer tissue by cysteine peptidase inhibitor isolated from human placenta: immunohistochemical and biochemical studies.","display_name":"Inhibition of cathepsin B activity in human breast cancer tissue by cysteine peptidase inhibitor isolated from human placenta: immunohistochemical and biochemical studies.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W994618445","mag":"994618445","pmid":"https://pubmed.ncbi.nlm.nih.gov/13678335"},"language":"en","primary_location":{"id":"pmid:13678335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13678335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia histochemica et cytobiologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111848515","display_name":"Yousif Saleh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Yousif Saleh","raw_affiliation_strings":["1st Department of Obstetrics and Gynaecology, Medical University, Wroc\u0142aw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Obstetrics and Gynaecology, Medical University, Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013097667","display_name":"Maciej Siewi\u0144ski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maciej Siewi\u0144ski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039894135","display_name":"Tadeusz Sebzda","orcid":"https://orcid.org/0000-0003-3985-5834","observed_orcids":["https://orcid.org/0000-0003-3985-5834"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tadeusz Sebzda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086043859","display_name":"Micha\u0142 Jele\u0144","orcid":"https://orcid.org/0000-0002-4570-5237","observed_orcids":["https://orcid.org/0000-0002-4570-5237"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Micha\u0142 Jele\u0144","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046676947","display_name":"Piotr P. Ziolkowski","orcid":"https://orcid.org/0000-0003-3036-2611","observed_orcids":["https://orcid.org/0000-0003-3036-2611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Piotr Zi\u00f3\u0142kowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013176677","display_name":"Jan Gutowicz","orcid":"https://orcid.org/0000-0001-9071-6632","observed_orcids":["https://orcid.org/0000-0001-9071-6632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Gutowicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102795049","display_name":"Marian Grybo\u015b","orcid":"https://orcid.org/0000-0003-0216-8088","observed_orcids":["https://orcid.org/0000-0003-0216-8088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marian Grybo\u015b","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061782956","display_name":"Ma\u0142gorzata Pawelec","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ma\u0142gorzata Pawelec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4793,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.58644168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"41","issue":"3","first_page":"161","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cysteine-protease-inhibitors","display_name":"cysteine protease inhibitors","score":0.9629999995231628},{"id":"https://openalex.org/keywords/human-placenta","display_name":"human placenta","score":0.8320000171661377},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9300000071525574},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"invasive ductal carcinoma","score":0.8859999775886536},{"id":"https://openalex.org/keywords/lobular-carcinoma","display_name":"lobular carcinoma","score":0.8569999933242798},{"id":"https://openalex.org/keywords/benign-breast-disease","display_name":"benign breast disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cysteine-peptidases","display_name":"cysteine peptidases","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.7383441925048828},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.663837730884552},{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.6060948371887207},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.535244345664978},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.510365903377533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.449973464012146},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4303474724292755},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4282819628715515},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3358350396156311},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21558579802513123},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18739727139472961},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15772899985313416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002401","descriptor_name":"Cathepsin B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002401","descriptor_name":"Cathepsin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:13678335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13678335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia histochemica et cytobiologica","raw_type":"Journal Article"},{"id":"mag:994618445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13678335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2410154757","https://openalex.org/W2260004679","https://openalex.org/W2331921896","https://openalex.org/W2100786878","https://openalex.org/W2007431327","https://openalex.org/W2423382329","https://openalex.org/W1973371617","https://openalex.org/W2025626085","https://openalex.org/W2187355786","https://openalex.org/W2408571163"],"abstract_inverted_index":{"Cysteine":[0],"peptidases":[1],"and":[2,16,56,63,73,77,111,120,150,200,214],"their":[3,19,121],"endogenous":[4,122],"inhibitors":[5,123],"(CPI)":[6],"have":[7],"been":[8,22],"shown":[9],"to":[10,24,116],"be":[11,25,117],"involved":[12],"in":[13,27,59,125,176,198,210],"tumor":[14,28,156,163],"progression":[15],"metastasis.":[17],"Since":[18],"activity":[20,58,149],"has":[21],"found":[23,115],"changed":[26],"tissue":[29,66,93,164,179],"and/or":[30,195],"body":[31],"fluids":[32],"of":[33,38,47,51,61,68,90,127,154,161,192],"cancer":[34],"patients,":[35],"the":[36,39,91,151,155,162,177,181,190],"determination":[37],"peptidase/inhibitor":[40],"levels":[41],"is":[42],"considered":[43],"as":[44,143,145,205],"a":[45,206],"procedure":[46],"diagnostic":[48],"value.":[49],"Determination":[50],"cathepsin":[52,112,140,193],"B,":[53],"its":[54,196],"precursor":[55,197],"inhibitor":[57,104,148],"homogenates":[60,126],"tumors":[62,128,202],"control":[64,178],"breast":[65,75,80,92,132],"samples":[67,94,160,180],"patients":[69,130],"with":[70,78,131,168],"invasive":[71,215],"ductal":[72],"lobular":[74],"carcinoma":[76],"benign":[79,201,213],"disease":[81],"(BBD)":[82],"was":[83,95,157,183],"performed":[84],"using":[85,98],"fluorometric":[86],"assay.":[87],"Immunohistochemical":[88],"staining":[89],"carried":[96],"out":[97],"polyclonal":[99],"antibody":[100,169],"against":[101,171],"cysteine":[102,146,172],"peptidase":[103,147,173],"isolated":[105],"from":[106,129],"human":[107],"placenta.":[108],"Procathepsin":[109],"B":[110,113,138,141,194],"were":[114],"significantly":[118],"increased":[119],"decreased":[124],"cancer.":[133],"A":[134],"correlation":[135],"between":[136,189,212],"procathepsin":[137],"or":[139],"activities":[142,191],"well":[144],"histopathological":[152],"grading":[153],"observed.":[158],"All":[159],"showed":[165],"positive":[166],"immunostaining":[167,182],"raised":[170],"inhibitor,":[174],"while":[175],"much":[184],"weaker.":[185],"Significant":[186],"difference":[187],"observed":[188],"malignant":[199],"might":[203],"serve":[204],"useful":[207],"clinical":[208],"indicator":[209],"discrimination":[211],"tumors.":[216]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
