{"id":"https://openalex.org/W99402501","doi":null,"title":"Spectrin and ubiquitination: a review.","display_name":"Spectrin and ubiquitination: a review.","publication_year":2005,"publication_date":"2005-10-24","ids":{"openalex":"https://openalex.org/W99402501","mag":"99402501","pmid":"https://pubmed.ncbi.nlm.nih.gov/16405856"},"language":"en","primary_location":{"id":"pmid:16405856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16405856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075238239","display_name":"Y-J Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y-J Hsu","raw_affiliation_strings":["Institute of Biomedical Sciences and Technology, Sickle Cell Disease Research Center, Dept. of Molecular and Cell Biology, University of Texas at Dallas, Richardson, TX 75083, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences and Technology, Sickle Cell Disease Research Center, Dept. of Molecular and Cell Biology, University of Texas at Dallas, Richardson, TX 75083, USA","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076232055","display_name":"Steven R. Goodman","orcid":"https://orcid.org/0000-0002-7607-6525","observed_orcids":["https://orcid.org/0000-0002-7607-6525"]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S R Goodman","raw_affiliation_strings":["University of Texas at Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Dallas","institution_ids":["https://openalex.org/I162577319"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I162577319"],"apc_list":null,"apc_paid":null,"fwci":0.6996,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.62664234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"Suppl 51","issue":null,"first_page":"OL801","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spectrin","display_name":"spectrin","score":0.7929999828338623},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9200000166893005},{"id":"https://openalex.org/keywords/alpha-spectrin","display_name":"alpha-spectrin","score":0.8709999918937683},{"id":"https://openalex.org/keywords/erythrocyte-membrane-skeleton","display_name":"erythrocyte membrane skeleton","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ubiquitin-conjugating-enzyme","display_name":"E2 ubiquitin-conjugating enzyme","score":0.8769999742507935},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/erythrocyte-deformability","display_name":"erythrocyte deformability","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cysteine-residues","display_name":"cysteine residues","score":0.7350000143051147},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C50244902","wikidata":"https://www.wikidata.org/wiki/Q420870","display_name":"Spectrin","level":4,"score":0.976212739944458},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7881122827529907},{"id":"https://openalex.org/C182561583","wikidata":"https://www.wikidata.org/wiki/Q7876535","display_name":"Ubiquitin-conjugating enzyme","level":5,"score":0.6601715087890625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5725558996200562},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5627468228340149},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.5179402232170105},{"id":"https://openalex.org/C74966100","wikidata":"https://www.wikidata.org/wiki/Q14908148","display_name":"EPB41","level":5,"score":0.5080487728118896},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.47988760471343994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43365585803985596},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.42031538486480713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38524049520492554},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3705834746360779},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33487552404403687},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.19772887229919434},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.11819210648536682},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1037023663520813}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013049","descriptor_name":"Spectrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044763","descriptor_name":"Ubiquitin-Conjugating Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044763","descriptor_name":"Ubiquitin-Conjugating Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16405856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16405856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},{"id":"mag:99402501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16405856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G979955607","display_name":"Southwestern Comprehensive Sickle Cell Center","funder_award_id":"U54HL070588","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1495786714","https://openalex.org/W1497941038","https://openalex.org/W1524908216","https://openalex.org/W1542522931","https://openalex.org/W1550726815","https://openalex.org/W1561589021","https://openalex.org/W1963905518","https://openalex.org/W1972131508","https://openalex.org/W1976925736","https://openalex.org/W1981906600","https://openalex.org/W1982601925","https://openalex.org/W1986048086","https://openalex.org/W2008044453","https://openalex.org/W2014582084","https://openalex.org/W2015634801","https://openalex.org/W2020357108","https://openalex.org/W2020684160","https://openalex.org/W2022046189","https://openalex.org/W2036727875","https://openalex.org/W2036871159","https://openalex.org/W2037454778","https://openalex.org/W2039839254","https://openalex.org/W2041022871","https://openalex.org/W2053718310","https://openalex.org/W2059193889","https://openalex.org/W2062205148","https://openalex.org/W2064850779","https://openalex.org/W2066752502","https://openalex.org/W2073936529","https://openalex.org/W2075519243","https://openalex.org/W2077829361","https://openalex.org/W2080553628","https://openalex.org/W2098143583","https://openalex.org/W2101667070","https://openalex.org/W2103210188","https://openalex.org/W2121781216","https://openalex.org/W2125637066","https://openalex.org/W2131255875","https://openalex.org/W2131575598","https://openalex.org/W2139469867","https://openalex.org/W2141652419","https://openalex.org/W2158708535","https://openalex.org/W2166987747","https://openalex.org/W2167019394","https://openalex.org/W2170939558","https://openalex.org/W2206785872","https://openalex.org/W2221257039","https://openalex.org/W2282760807","https://openalex.org/W2410200334","https://openalex.org/W2410772834","https://openalex.org/W2427907494","https://openalex.org/W2465839801"],"related_works":["https://openalex.org/W2410772834","https://openalex.org/W647540523","https://openalex.org/W2041022871","https://openalex.org/W2265652283","https://openalex.org/W2071812384","https://openalex.org/W7097839975","https://openalex.org/W2023512583","https://openalex.org/W1495786714","https://openalex.org/W1736697457","https://openalex.org/W2020357108"],"abstract_inverted_index":{"This":[0,177,230],"review":[1],"covers":[2],"the":[3,7,20,26,32,35,39,57,121,195,200,209],"observations":[4],"leading":[5],"to":[6,48,87,98,172],"conclusion":[8],"that":[9,83,144],"erythrocyte":[10,64,201],"spectrin":[11,55,193],"is":[12,29,194],"a":[13,100,131,179],"chimeric":[14,187],"E2/E3":[15,123,154,188],"ubiquitin":[16,104,109,167,189],"conjugating/ligating":[17,190],"enzyme":[18,106,171],"and":[19,34,46,72,92,95,108,120,147,161,204,227],"impact":[21],"of":[22,38,53,69,165,181,199,208,240],"this":[23,238],"activity":[24,155,217],"on":[25],"cell.":[27],"Spectrin":[28],"important":[30,221],"for":[31,102,152,183,236],"shape":[33],"physical":[36],"properties":[37],"red":[40],"blood":[41],"cell,":[42],"such":[43],"as":[44,156],"deformability":[45],"resistance":[47],"mechanical":[49],"stress.":[50],"The":[51,115,141],"involvement":[52],"RBC":[54,185,211],"in":[56,74,135,137,223],"ubiquitination":[58,215],"process":[59],"has":[60,117],"been":[61,118],"demonstrated.":[62],"Human":[63],"alpha-spectrin":[65,103],"can":[66],"facilitate":[67],"formation":[68],"ubiquitin-spectrin":[70],"adducts":[71],"conjugates":[73],"cell":[75],"free":[76],"systems":[77],"(28).":[78],"Computer":[79],"analysis":[80],"revealed":[81,178],"domains":[82],"contained":[84],"significant":[85],"homologies":[86],"known":[88],"consensus":[89],"catalytic":[90],"E2":[91],"E3":[93],"sequences,":[94],"allowed":[96],"us":[97],"develop":[99],"model":[101,116],"conjugating":[105],"(E2)":[107],"protein":[110],"ligase":[111],"(E3)":[112],"enzymatic":[113,216],"activities.":[114],"tested":[119],"precise":[122],"site(s)":[124],"identified":[125],"by":[126],"site-specific":[127],"mutational":[128],"analyses":[129],"using":[130],"GST-fusion":[132],"alpha-spectrin(2005-2415)":[133,153],"recombinant":[134],"an":[136,169,220],"vitroubiquitination":[138],"assay":[139],"(26).":[140],"results":[142],"indicated":[143],"cysteine":[145,148],"2071":[146],"2100":[149],"are":[150,163],"critical":[151],"expected.":[157],"However,":[158],"both":[159,224],"Cys2071":[160],"Cys2100":[162],"capable":[164],"transferring":[166],"from":[168],"E1":[170],"target":[173],"sites":[174],"within":[175],"alpha-spectrin(2005-2415).":[176],"redundancy":[180,239],"function":[182],"human":[184],"spectrin's":[186],"activity.":[191],"Since":[192],"major":[196],"structural":[197],"component":[198],"membrane":[202,212],"skeleton,":[203],"it":[205],"constitutes":[206],"20%":[207],"total":[210],"protein,":[213],"its":[214],"could":[218,231],"play":[219],"role":[222],"erythropoietic":[225],"cells":[226],"mature":[228],"RBCs.":[229],"also":[232],"be":[233],"one":[234],"reason":[235],"evolving":[237],"function.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
