{"id":"https://openalex.org/W993602271","doi":null,"title":"Relationship between glutathione S-transferase P1 polymorphism and clinical outcomes of advanced gastric cancer patients treated with DDP-based chemotherapy","display_name":"Relationship between glutathione S-transferase P1 polymorphism and clinical outcomes of advanced gastric cancer patients treated with DDP-based chemotherapy","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W993602271","mag":"993602271"},"language":"en","primary_location":{"id":"mag:2357317952","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZLYD201102008.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764366365","display_name":"Zhonghua linchuang yishi zazhi","issn_l":"1674-0785","issn":["1674-0785"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua linchuang yishi zazhi","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072246330","display_name":"\u5b63\u679a","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5b63\u679a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034265373","display_name":"\u5434\u660c\u5e73","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5434\u660c\u5e73","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009572297","display_name":"\u848b\u656c\u5ead","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u848b\u656c\u5ead","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066541978","display_name":"\u5f90\u658c","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5f90\u658c","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080805885","display_name":"\u5434\u9a8f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5434\u9a8f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076462419","display_name":"\u8d75\u4f1f\u5e86","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u8d75\u4f1f\u5e86","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033334978","display_name":"\u5f20\u7ea2\u5b87","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5f20\u7ea2\u5b87","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012247951","display_name":"\u5468\u6587\u6770","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5468\u6587\u6770","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04983924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"2","first_page":"25","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.15760000050067902,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.08030000329017639,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gstp1","display_name":"GSTP1","score":0.7379999756813049},{"id":"https://openalex.org/keywords/glutathione-s-transferase-pi","display_name":"glutathione S-transferase pi","score":0.9779999852180481},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cisplatin-based-chemotherapy","display_name":"cisplatin-based chemotherapy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.753000020980835},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chemotherapy-response-prediction","display_name":"chemotherapy response prediction","score":0.7059999704360962},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7310000061988831},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33116328716278076}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2357317952","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZLYD201102008.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764366365","display_name":"Zhonghua linchuang yishi zazhi","issn_l":"1674-0785","issn":["1674-0785"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua linchuang yishi zazhi","raw_type":null},{"id":"mag:993602271","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/88648X/201102/36684459.html","pdf_url":null,"source":{"id":"https://openalex.org/S2764366365","display_name":"Zhonghua linchuang yishi zazhi","issn_l":"1674-0785","issn":["1674-0785"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u4e34\u5e8a\u533b\u5e08\u6742\u5fd7\uff08\u7535\u5b50\u7248\uff09","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2997190965","https://openalex.org/W934100581","https://openalex.org/W3029260857","https://openalex.org/W2223578591","https://openalex.org/W2357317952","https://openalex.org/W2949658822","https://openalex.org/W3030152628","https://openalex.org/W1515044623","https://openalex.org/W966736230","https://openalex.org/W2338438345"],"abstract_inverted_index":{"\u76ee\u7684\u57fa\u56e0\u591a\u6001\u6027\u901a\u8fc7\u5f71\u54cd\u836f\u7269\u7684\u4ee3\u8c22\u3001\u8f6c\u8fd0\u548c\u4f5c\u7528\u9776\u70b9\u4ece\u800c\u5bfc\u81f4\u836f\u7269\u7597\u6548\u548c\u6bd2\u6027\u7684\u4e2a\u4f53\u5dee\u5f02,\u5bfb\u627e\u660e\u786e\u7684\u751f\u7269\u5b66\u6807\u8bb0\u6765\u8bc6\u522b\u83b7\u76ca\u4eba\u7fa4\u5df2\u6210\u4e3a\u6700\u5927\u7684\u6311\u6218\u3002\u672c\u7814\u7a76\u65e8\u5728\u89c2\u5bdf\u8c37\u80f1\u7518\u80bd-S-\u8f6c\u79fb\u9176P1\uff08GSTP1\uff09\u57fa\u56e0\u591a\u6001\u6027\u4e0e\u4ee5\u987a\u94c2\uff08DDP\uff09\u4e3a\u57fa\u7840\u7684\u5316\u7597\u65b9\u6848\u6cbb\u7597\u665a\u671f\u80c3\u764c\u7597\u6548\u95f4\u7684\u5173\u7cfb\u3002\u65b9\u6cd5\u6536\u96c6\u7ecf\u75c5\u7406\u5b66\u786e\u8bca\u7684\u665a\u671f\u80c3\u764c\u60a3\u800559\u4f8b\u3002\u6240\u6709\u75c5\u4f8b\u5316\u7597\u524d\u62bd\u53d6\u5916\u5468\u9759\u8109\u8840,\u63d0\u53d6\u8131\u6c27\u6838\u7cd6\u6838\u9178\uff08DNA\uff09,\u7528\u8fde\u63a5\u9176\u68c0\u6d4b\u53cd\u5e94\u6280\u672f\uff08PCR-LDR\uff09\u68c0\u6d4b\u7814\u7a76\u5bf9\u8c61\u7684GSTP1\u57fa\u56e0\u578b\u3002\u6240\u6709\u60a3\u8005\u7ecf\u591a\u897f\u4ed6\u8d5b\uff08DOCETAXEL\uff09/DDP/5-\u6c1f\u5c3f\u5627\u5576\uff085-FU\uff09\u8054\u5408\u65b9\u6848\u5316\u7597,\u5316\u7597\u7ed3\u675f\u540e\u89c2\u5bdf\u7597\u6548\u53ca\u5176\u4e0eGSTP1\u57fa\u56e0\u591a\u6001\u6027\u7684\u5173\u7cfb\u3002\u7ed3\u679c":[0],"59\u4f8b\u665a\u671f\u80c3\u764c\u60a3\u8005\u4e2d,15\u4f8b\uff0825.4%\uff09\u4e3aGSTP1G/G\u57fa\u56e0\u578b,21\u4f8b\uff0835.6%\uff09\u4e3aGSTP1G/A\u57fa\u56e0\u578b,23\u4f8b\uff0839.0%\uff09\u4e3aGSTP1A/A\u57fa\u56e0\u578b\u3002\u5176\u4e2d4\u4f8b\u5b8c\u5168\u7f13\u89e3,14\u4f8b\u90e8\u5206\u7f13\u89e3,19\u4f8b\u7a33\u5b9a,22\u4f8b\u8fdb\u5c55,\u603b\u6709\u6548\u7387\u4e3a30.5%\uff0818/59\uff09\u3002GSTP1G/G\u57fa\u56e0\u578b\u60a3\u8005\u7684\u5316\u7597\u6709\u6548\u7387\uff0873.3%\uff09\u660e\u663e\u9ad8\u4e8eG/A\u57fa\u56e0\u578b\u60a3\u8005\uff0819.0%\uff09\uff08\u03c72=10.616,P=0.005\uff09,\u540c\u6837\u660e\u663e\u9ad8\u4e8eA/A\u57fa\u56e0\u578b\u60a3\u8005\uff0813.0%\uff09\uff08\u03c72=14.202,P=0.001\uff09\u3002G/A\u57fa\u56e0\u578b\u60a3\u8005\u7684\u5316\u7597\u6709\u6548\u7387\u4e0eA/A\u57fa\u56e0\u578b\u60a3\u8005\u4e4b\u95f4\u5dee\u5f02\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\uff08\u03c72=0.31,P=0.856\uff09\u3002\u7a81\u53d8\u57fa\u56e0\u578b\uff08G/G\uff0bG/A\uff09\u5bf9\u5316\u7597\u8f83\u654f\u611f,\u5176\u5316\u7597\u6709\u6548\u7387\u662f\u91ce\u751f\u57fa\u56e0\u578b\uff08A/A\uff09\u76843.2\u500d\uff0895%CI1.442\uff5e7.302,P=0.004\uff09\u3002\u7ed3\u8bba":[1],"GSTP1\u57fa\u56e0\u578b\u5bf9\u9884\u6d4b\u4ee5DDP\u4e3a\u57fa\u7840\u5316\u7597\u65b9\u6848\u6cbb\u7597\u665a\u671f\u80c3\u764c\u7684\u7597\u6548\u5177\u6709\u8f83\u597d\u7684\u4e34\u5e8a\u610f\u4e49\u3002":[2]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}