{"id":"https://openalex.org/W993232853","doi":null,"title":"Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production.","display_name":"Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production.","publication_year":2014,"publication_date":"2014-09-01","ids":{"openalex":"https://openalex.org/W993232853","mag":"993232853","pmid":"https://pubmed.ncbi.nlm.nih.gov/25151985"},"language":"en","primary_location":{"id":"pmid:25151985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25151985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042709274","display_name":"Baihui Li","orcid":"https://orcid.org/0009-0004-7660-0480","observed_orcids":["https://orcid.org/0009-0004-7660-0480"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baihui Li","raw_affiliation_strings":["Jiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Science, Soochow University, Suzhou, China. rainpeerless@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Science, Soochow University, Suzhou, China. rainpeerless@126.com","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Yue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Yue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102026067","display_name":"Chunsheng Dong","orcid":"https://orcid.org/0000-0003-4184-6398","observed_orcids":["https://orcid.org/0000-0003-4184-6398"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunsheng Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107916263","display_name":"Yongbing Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongbing Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101445508","display_name":"Sidong Xiong","orcid":"https://orcid.org/0000-0002-0321-5635","observed_orcids":["https://orcid.org/0000-0002-0321-5635"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sidong Xiong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4762,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.91574233,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"32","issue":"5","first_page":"705","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9049999713897705},{"id":"https://openalex.org/keywords/macrophage-autophagy","display_name":"macrophage autophagy","score":0.972000002861023},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.7850000262260437},{"id":"https://openalex.org/keywords/murine-lupus","display_name":"murine lupus","score":0.7749999761581421},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9129999876022339},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/anti-dsdna-antibodies","display_name":"anti-dsDNA antibodies","score":0.8309999704360962},{"id":"https://openalex.org/keywords/glomerulonephritis","display_name":"glomerulonephritis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/immune-complex-deposition","display_name":"immune complex deposition","score":0.8069999814033508},{"id":"https://openalex.org/keywords/autophagy-related-genes","display_name":"autophagy-related genes","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.883234977722168},{"id":"https://openalex.org/C2781000418","wikidata":"https://www.wikidata.org/wiki/Q18034312","display_name":"ATG5","level":4,"score":0.6971393823623657},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6733718514442444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.658401370048523},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.6114211678504944},{"id":"https://openalex.org/C2780329694","wikidata":"https://www.wikidata.org/wiki/Q18033863","display_name":"ATG12","level":5,"score":0.6110243201255798},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5335426926612854},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.5239877104759216},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.4847816824913025},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48013803362846375},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.47686585783958435},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4386628568172455},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.27732425928115845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19195672869682312},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.16866254806518555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10491544008255005},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.07225301861763},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071186","descriptor_name":"Beclin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25151985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25151985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:993232853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25151985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1508090369","https://openalex.org/W1832653552","https://openalex.org/W1977238482","https://openalex.org/W1981932438","https://openalex.org/W1992463330","https://openalex.org/W1993677761","https://openalex.org/W1997113795","https://openalex.org/W1998399313","https://openalex.org/W2005194145","https://openalex.org/W2018071293","https://openalex.org/W2019652948","https://openalex.org/W2028677517","https://openalex.org/W2036169992","https://openalex.org/W2041943889","https://openalex.org/W2043259568","https://openalex.org/W2054893509","https://openalex.org/W2063879734","https://openalex.org/W2068709938","https://openalex.org/W2069952533","https://openalex.org/W2072127157","https://openalex.org/W2076062022","https://openalex.org/W2076735703","https://openalex.org/W2096753387","https://openalex.org/W2102559531","https://openalex.org/W2112523199","https://openalex.org/W2119370317","https://openalex.org/W2126923269","https://openalex.org/W2127638965","https://openalex.org/W2132551929","https://openalex.org/W2138809149","https://openalex.org/W2144002025","https://openalex.org/W2146981539","https://openalex.org/W2148281700","https://openalex.org/W2152993559","https://openalex.org/W2162966650","https://openalex.org/W2165066268","https://openalex.org/W2169643027","https://openalex.org/W2171873710","https://openalex.org/W2405464979"],"related_works":["https://openalex.org/W3110155548","https://openalex.org/W2018071293","https://openalex.org/W2911381983","https://openalex.org/W2891517372","https://openalex.org/W4282939013","https://openalex.org/W4313356008","https://openalex.org/W4232427643","https://openalex.org/W4221020542","https://openalex.org/W2162966650","https://openalex.org/W2550091286"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Systemic":[1],"lupus":[2,79,150,222],"erythematosus":[3],"(SLE)":[4],"is":[5],"a":[6,25,240,251],"typical":[7],"inflammatory":[8,47,111],"autoimmune":[9],"disease":[10,114],"for":[11,244,255],"its":[12,30],"unknown":[13],"pathogenesis":[14,34,219],"and":[15,65,113,121,146,152,172,181,204,232,234,250],"potential":[16,103],"fatality.":[17],"It":[18],"has":[19,24],"been":[20],"reported":[21],"that":[22,136,210],"autophagy":[23,45,107,137,213,237],"crosstalk":[26],"with":[27,195],"autoimmunity,":[28],"but":[29],"impact":[31],"on":[32,108],"the":[33,42,58,69,84,102,109,144,154,169,185,196,218,226],"of":[35,44,49,60,94,105,149,156,161,187,200,220,228,236,247],"SLE":[36,52,87,157],"remains":[37],"unclear.":[38],"Here,":[39],"we":[40,56,99],"investigated":[41,101],"role":[43],"in":[46,68,83,143,153,214],"response":[48,112],"macrophages":[50,70,148,165,215,249],"under":[51],"conditions.":[53],"METHODS:":[54],"First,":[55],"detected":[57],"expression":[59],"autophagy-related":[61],"genes":[62,139],"(Atg5,":[63],"Atg12":[64],"Beclin":[66,95,162],"1)":[67],"derived":[71],"from":[72,86],"activated":[73,212],"lymphocytes-derived":[74],"DNA":[75],"(ALD-DNA)":[76],"induced":[77],"murine":[78,188,221],"as":[80,82,127,129],"well":[81,128],"PBMC":[85,155],"patients.":[88,158],"And":[89],"then":[90],"through":[91],"adoptive":[92],"transfer":[93,160],"1":[96,163],"knockdown":[97,164],"macrophages,":[98],"further":[100],"effect":[104,192],"macrophage":[106],"SLE-associated":[110],"severity":[115],"by":[116],"evaluating":[117],"serum":[118],"anti-dsDNA":[119,170],"antibodies":[120,171],"proteinuria":[122,173],"levels,":[123,174],"immune":[124,178],"complex":[125,179],"deposition":[126,180],"renal":[130,147,177],"pathological":[131],"changes.":[132],"RESULTS:":[133],"We":[134],"found":[135],"related":[138],"were":[140],"significantly":[141,167],"upregulated":[142],"splenic":[145],"mice":[151],"Adoptive":[159],"could":[166],"decrease":[168],"robustly":[175],"reduce":[176],"remit":[182],"glomerulonephritis,":[183],"indicating":[184],"amelioration":[186],"lupus.":[189],"This":[190],"protective":[191],"was":[193],"associated":[194],"obviously":[197],"decreased":[198],"production":[199,227],"proinflammatory":[201,229,248],"cytokines":[202,230],"IL-6":[203],"TNF-\u03b1.":[205],"CONCLUSIONS:":[206],"Our":[207],"results":[208],"suggested":[209],"aberrant":[211],"contributed":[216],"to":[217],"possibly":[223],"via":[224],"promoting":[225],"TNF-\u03b1":[231],"IL-6,":[233],"inhibition":[235],"might":[238],"represent":[239],"novel":[241],"regulation":[242],"strategy":[243],"excessive":[245],"activation":[246],"new":[252],"therapeutic":[253],"regime":[254],"SLE.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}