{"id":"https://openalex.org/W992478709","doi":null,"title":"PROTEKTIVE WIRKUNG AUSGEW\u00c4HLTER PFLANZLICHER POLYPHENOLE GEGEN OXIDATIVEN STRESS: UNTERSUCHUNGEN AN C6 RATTENGLIOMZELLEN IN VITRO","display_name":"PROTEKTIVE WIRKUNG AUSGEW\u00c4HLTER PFLANZLICHER POLYPHENOLE GEGEN OXIDATIVEN STRESS: UNTERSUCHUNGEN AN C6 RATTENGLIOMZELLEN IN VITRO","publication_year":2010,"publication_date":"2010-05-17","ids":{"openalex":"https://openalex.org/W992478709","mag":"992478709"},"language":"de","primary_location":{"id":"pmh:oai:macau.uni-kiel.de:dissertation_diss_00004894","doi":null,"is_oa":true,"landing_page_url":"https://macau.uni-kiel.de/receive/dissertation_diss_00004894","pdf_url":"https://macau.uni-kiel.de/receive/dissertation_diss_00004894","source":{"id":"https://openalex.org/S4306400664","display_name":"Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universit\u00e4t zu Kiel (Christian-Albrechts-Universit\u00e4t zu Kiel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151221077","host_organization_name":"Chung Yuan Christian University","host_organization_lineage":["https://openalex.org/I151221077"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://macau.uni-kiel.de/receive/dissertation_diss_00004894","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086449964","display_name":"Maria Kuziw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Kuziw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086449964"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plant-polyphenols","display_name":"plant polyphenols","score":0.9300000071525574},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9729999899864197},{"id":"https://openalex.org/keywords/c6-glioma-cells","display_name":"C6 glioma cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.859000027179718},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/galangin","display_name":"galangin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/taxifolin","display_name":"taxifolin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/catechins","display_name":"catechins","score":0.9100000262260437},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":1.0},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8479999899864197},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cell-membrane-damage","display_name":"cell membrane damage","score":0.4020000100135803},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5910000205039978},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5559555888175964},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4222419559955597},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4218323230743408},{"id":"https://openalex.org/C2777302768","wikidata":"https://www.wikidata.org/wiki/Q2456591","display_name":"Galangin","level":5,"score":0.41572651267051697},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.16159138083457947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13401073217391968},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.09894445538520813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.056170105934143066},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.050681233406066895},{"id":"https://openalex.org/C2777810353","wikidata":"https://www.wikidata.org/wiki/Q393336","display_name":"Kaempferol","level":4,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:macau.uni-kiel.de:dissertation_diss_00004894","doi":null,"is_oa":true,"landing_page_url":"https://macau.uni-kiel.de/receive/dissertation_diss_00004894","pdf_url":"https://macau.uni-kiel.de/receive/dissertation_diss_00004894","source":{"id":"https://openalex.org/S4306400664","display_name":"Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universit\u00e4t zu Kiel (Christian-Albrechts-Universit\u00e4t zu Kiel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151221077","host_organization_name":"Chung Yuan Christian University","host_organization_lineage":["https://openalex.org/I151221077"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},{"id":"pmh:oai:macau.uni-kiel.de:diss_mods_00004894","doi":null,"is_oa":false,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:gbv:8-diss-48942","pdf_url":null,"source":{"id":"https://openalex.org/S4306400664","display_name":"Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universit\u00e4t zu Kiel (Christian-Albrechts-Universit\u00e4t zu Kiel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151221077","host_organization_name":"Chung Yuan Christian University","host_organization_lineage":["https://openalex.org/I151221077"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation"},{"id":"mag:992478709","doi":null,"is_oa":false,"landing_page_url":"https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/dissertation_derivate_00003144/MKuziwDiss2009.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:macau.uni-kiel.de:dissertation_diss_00004894","doi":null,"is_oa":true,"landing_page_url":"https://macau.uni-kiel.de/receive/dissertation_diss_00004894","pdf_url":"https://macau.uni-kiel.de/receive/dissertation_diss_00004894","source":{"id":"https://openalex.org/S4306400664","display_name":"Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universit\u00e4t zu Kiel (Christian-Albrechts-Universit\u00e4t zu Kiel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151221077","host_organization_name":"Chung Yuan Christian University","host_organization_lineage":["https://openalex.org/I151221077"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W992478709.pdf","grobid_xml":"https://content.openalex.org/works/W992478709.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W50981894","https://openalex.org/W1528535835","https://openalex.org/W1533335439","https://openalex.org/W1972060131","https://openalex.org/W1972144891","https://openalex.org/W1976754594","https://openalex.org/W1979182110","https://openalex.org/W1980790707","https://openalex.org/W1980834707","https://openalex.org/W1984470183","https://openalex.org/W1996585908","https://openalex.org/W2002907671","https://openalex.org/W2011222740","https://openalex.org/W2012402919","https://openalex.org/W2017083562","https://openalex.org/W2020263041","https://openalex.org/W2028272823","https://openalex.org/W2031244557","https://openalex.org/W2036333470","https://openalex.org/W2036690811","https://openalex.org/W2062523063","https://openalex.org/W2071369173","https://openalex.org/W2076961963","https://openalex.org/W2086381409","https://openalex.org/W2093885819","https://openalex.org/W2102689108","https://openalex.org/W2133971230","https://openalex.org/W2137924654","https://openalex.org/W2151089147","https://openalex.org/W2154587590","https://openalex.org/W2180470224","https://openalex.org/W2190311698","https://openalex.org/W2415055161"],"related_works":["https://openalex.org/W2111489123","https://openalex.org/W859858898","https://openalex.org/W2093885819","https://openalex.org/W7098677495","https://openalex.org/W2072448420","https://openalex.org/W25097053","https://openalex.org/W7064349500","https://openalex.org/W2126285155","https://openalex.org/W2265077360","https://openalex.org/W3177400707"],"abstract_inverted_index":{"Der":[0,344],"in":[1,33,120,177,201,266,282,320,338,361,542,579,600,602],"epidemiologischen":[2],"Studien":[3],"beobachtete":[4],"Zusammenhang":[5,480],"zwischen":[6,481],"einem":[7,127,434,462],"hohen":[8],"Konsum":[9],"von":[10,19,100,109,188,318,329,381,436,449,464,597],"obst-":[11],"und":[12,15,22,59,85,148,161,172,232,370,399,411,453,472,483,492,515,535,555],"gem\u00fcsereicher":[13],"Ern\u00e4hrung":[14],"einer":[16],"erniedrigten":[17],"Inzidenz":[18],"Krebs,":[20],"kardiovaskul\u00e4ren":[21],"altersassoziierten":[23],"Erkrankungen":[24],"hat":[25],"zur":[26,170,263],"Suche":[27],"nach":[28,193],"m\u00f6glichen":[29],"protektiven":[30,562],"Pflanzeninhaltsstoffen":[31],"gef\u00fchrt,":[32],"der":[34,121,136,174,186,191,198,203,209,216,249,290,321,389,443,470,473,475,507,580],"Hoffnung":[35],"diese":[36],"therapeutisch":[37],"nutzen":[38],"zu":[39,93,245,260,296],"k\u00f6nnen.":[40],"Das":[41],"wissenschaftliche":[42],"Interesse":[43],"gilt":[44],"unter":[45],"anderem":[46],"Polyphenolen,":[47],"die":[48,149,183,238,253,265,274,286,356,365,375,385,495,561,587,599],"sich":[49,310,373,431],"durch":[50,55,217,239,252,355,364,393,405,496,550,584],"ihre":[51,56],"antioxidativen":[52],"aber":[53],"auch":[54,301,396],"antiviralen,":[57],"antiinflammatorischen":[58],"antimutagenen":[60],"F\u00e4higkeiten":[61],"auszeichnen.":[62],"Da":[63],"ein":[64,570],"Therapeutikum":[65],"\u00fcber":[66],"eine":[67,304,327,504,545],"m\u00f6glichst":[68],"gro\u00dfe":[69],"therapeutische":[70],"Breite":[71],"verf\u00fcgen":[72],"sollte,":[73],"war":[74,503],"es":[75],"Ziel":[76],"dieser":[77,543,603],"Arbeit,":[78],"ausgew\u00e4hlte":[79],"Polyphenole":[80,175,199,367,424,476,489,552,585],"einerseits":[81],"hinsichtlich":[82,87,234],"ihrer":[83,88,235],"Zytotoxizit\u00e4t":[84,171,287],"andererseits":[86],"Zytoprotektivit\u00e4t":[89,173],"gegen\u00fcber":[90],"oxidativem":[91,548],"Stress":[92,105,549],"untersuchen.":[94],"Die":[95,157,168,196,206,247,354,467,487],"Versuche":[96,169],"wurden":[97,176,229],"an":[98,117,135],"Kulturen":[99],"C6":[101,386],"Rattengliomzellen":[102],"durchgef\u00fchrt.":[103,179],"Oxidativer":[104],"wurde":[106,185,200,211,271,360],"mit":[107,159,190,276,433,442,461],"Hilfe":[108,277],"Wasserstoffperoxid":[110],"(H2O2),":[111],"das":[112,145,312,440],"auf":[113,316,478,595],"Grund":[114,317,596],"seiner":[115],"Hydrophilie":[116],"vielen":[118],"Orten":[119],"Zelle":[122],"wirkt,":[123],"sowie":[124,155],"Cumolhydroperoxid":[125],"(CHP),":[126],"lipophilen":[128],"organischen":[129],"Peroxid,":[130],"welches":[131],"seine":[132],"Wirkung":[133,208,416,524],"haupts\u00e4chlich":[134],"Zellmembran":[137],"entfaltet,":[138],"ausgel\u00f6st.":[139],"Zu":[140],"den":[141,261,336,339,404,457],"untersuchten":[142,366],"Polyphenolen":[143],"z\u00e4hlten":[144],"Hydroxystilben":[146],"Resveratrol":[147,400,452],"Flavonoide":[150,292,377],"Quercetin,":[151,230,450,490],"Galangin,":[152,451],"Taxifolin,":[153],"(+)-Catechin":[154,410,455],"Genistein.":[156],"Exposition":[158],"Peroxiden":[160],"/":[162],"oder":[163,221],"Antioxidantien":[164,210],"betrug":[165,348],"24":[166],"Stunden.":[167],"96-Well-Mikrotiterplatten":[178,340],"Als":[180],"Ma\u00df":[181],"f\u00fcr":[182,346,531],"Zellsch\u00e4digung":[184,226,359],"Verlust":[187],"Zellprotein":[189],"Methode":[192],"Lowry":[194],"bestimmt.":[195],"Zytotoxizt\u00e4t":[197],"Abwesenheit":[202],"Peroxide":[204,357],"erfasst.":[205],"zytoprotektive":[207,523],"als":[212,300,311,374,395,439],"Hemmung":[213],"bzw.":[214,288],"Verminderung":[215],"500":[218,240,497],"\u00b5M":[219,223,241,333,383,438,498,537],"H2O2":[220,302,347],"100":[222],"CHP":[224,242,299,308,334,394,406,499],"ausgel\u00f6sten":[225],"aufgefasst.":[227],"Zus\u00e4tzlich":[228],"Galangin":[231,371,491,556],"Taxifolin":[233,398,493,516],"F\u00e4higkeit":[236],"untersucht,":[237],"induzierte":[243,500],"Lipidperoxidation":[244,250],"hemmen.":[246],"Messung":[248],"erfolgte":[251],"Bestimmung":[254],"Thiobarbiturat":[255],"reaktiver":[256],"Substanzen":[257],"(TBARS).":[258],"Parallel":[259],"Versuchen":[262],"Lipidperoxidation,":[264],"24-Well-Platten":[267,283],"durchgef\u00fchrt":[268],"worden":[269],"sind,":[270],"zus\u00e4tzlich":[272],"noch":[273],"Zellvitalit\u00e4t":[275],"des":[278],"MTT":[279],"Assays":[280],"ebenfalls":[281],"bestimmt,":[284],"um":[285,341],"\u2013protektivit\u00e4t":[289],"drei":[291,488],"bei":[293,510,533],"h\u00f6heren":[294],"Zellproteinkonzentrationen":[295],"erfassen.":[297],"Sowohl":[298],"zeigten":[303],"konzentrationsabh\u00e4ngige":[305],"zytotoxische":[306],"Wirkung.":[307],"erwies":[309],"potentere":[313],"Peroxid":[314],"m\u00f6glicherweise":[315,594],"Unterschieden":[319],"intrazellul\u00e4ren":[322],"Elimination":[323],"beider":[324],"Substanzen.":[325],"Bereits":[326,379],"Konzentration":[328],"37,6":[330],"\u00b1":[331,351],"12,5":[332],"reduzierte":[335],"Proteingehalt":[337],"50":[342],"%.":[343],"EC50-Wert":[345],"hingegen":[349,402],"146,8":[350],"54,9":[352],"\u00b5M.":[353,466],"verursachte":[358],"unterschiedlichem":[362],"Ausma\u00df":[363],"beeinflusst.":[368],"Quercetin":[369,511,532,554],"haben":[372],"wirksamsten":[376],"erwiesen.":[378],"Konzentrationen":[380,563],"10":[382,534],"sch\u00fctzten":[384],"Zellen":[387],"vor":[388,547],"toxischen":[390],"Sch\u00e4digung":[391],"sowohl":[392],"H2O2.":[397],"reduzierten":[401],"nur":[403,509,530],"induzierten":[407],"Zellschaden,":[408],"w\u00e4hrend":[409],"Genistein":[412,432],"gar":[413],"keine":[414],"protektive":[415,582],"entfalteten.":[417],"Gleichzeitig":[418],"konnte":[419,529,541],"beobachtet":[420],"werden,":[421,558],"dass":[422,569],"alle":[423],"konzentrationsabh\u00e4ngig":[425],"zum":[426],"Zellverlust":[427],"f\u00fchrten.":[428],"Dabei":[429],"stellte":[430],"EC20-Wert":[435,463],"8":[437],"Flavonoid":[441],"h\u00f6chsten":[444],"zytotoxischen":[445,459,566],"Potenz":[446],"dar,":[447],"gefolgt":[448],"Taxifolin.":[454],"hatte":[456],"geringsten":[458],"Effekt":[460],"358":[465],"positive":[468],"Korrelation":[469],"EC20-Werte":[471],"Octanol-Wasser-Verteilungskoeffizienten":[474],"l\u00e4sst":[477],"einen":[479],"Lipophilie":[482],"zytotoxischer":[484],"Aktivit\u00e4t":[485],"schlie\u00dfen.":[486],"verminderten":[494],"Lipidperoxidation.":[501],"Jedoch":[502],"signifikante":[505,522],"Reduktion":[506],"TBARS-Produktion":[508],"(ab":[512,517],"5":[513],"\u00b5M)":[514,519],"20":[518,536],"nachweisbar.":[520],"Eine":[521],"im":[525,590],"parallel":[526],"durchgef\u00fchrten":[527],"MTT-Test":[528],"belegt":[538],"werden.":[539],"Zwar":[540],"Arbeit":[544,604],"Zytoprotektion":[546],"bestimmte":[551],"wie":[553],"nachgewiesen":[557],"jedoch":[559],"lagen":[560],"nah":[564],"am":[565],"Bereich,":[567],"so":[568],"therapeutischer":[571],"Nutzen":[572],"kritisch":[573],"hinterfragt":[574],"werden":[575,609],"muss.":[576],"Andererseits":[577],"sind":[578],"Literatur":[581],"Effekte":[583],"beschrieben,":[586],"teilweise":[588],"bereits":[589],"nanomolaren":[591],"Konzentrationsbereich":[592],"auftraten,":[593],"Wirkmechanismen,":[598],"dem":[601],"verwendeten":[605],"Testsystem":[606],"nicht":[607],"erfasst":[608],"konnten.":[610]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}