{"id":"https://openalex.org/W99203335","doi":null,"title":"Regulation of the pituitary somatotroph cell by GHRH and its receptor.","display_name":"Regulation of the pituitary somatotroph cell by GHRH and its receptor.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W99203335","mag":"99203335","pmid":"https://pubmed.ncbi.nlm.nih.gov/11036940"},"language":"en","primary_location":{"id":"pmid:11036940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11036940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent progress in hormone research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055696858","display_name":"Kelly E. Mayo","orcid":"https://orcid.org/0000-0002-0587-0094","observed_orcids":["https://orcid.org/0000-0002-0587-0094"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K E Mayo","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology & Cell Biology, Northwestern University, Evanston, Illinois 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology & Cell Biology, Northwestern University, Evanston, Illinois 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073561330","display_name":"Venita I. DeAlmeida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V DeAlmeida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025594566","display_name":"Paul A. Godfrey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Godfrey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075356724","display_name":"Jing Zheng","orcid":"https://orcid.org/0000-0003-2790-1143","observed_orcids":["https://orcid.org/0000-0003-2790-1143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Zheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"S R Cunha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S R Cunha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1558,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.91450003,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"55","issue":null,"first_page":"237","last_page":"66; discussion 266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-releasing-hormone","display_name":"growth hormone-releasing hormone","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ghrh-receptor","display_name":"GHRH receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pit-1","display_name":"Pit-1","score":0.7089999914169312},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.7960000038146973},{"id":"https://openalex.org/keywords/sexual-dimorphism","display_name":"sexual dimorphism","score":0.9319999814033508},{"id":"https://openalex.org/keywords/glucocorticoid-regulation","display_name":"glucocorticoid regulation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.871999979019165},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8450000286102295},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.7400000095367432},{"id":"https://openalex.org/keywords/receptor-mutants","display_name":"receptor mutants","score":0.5580000281333923},{"id":"https://openalex.org/keywords/growth-disorders","display_name":"growth disorders","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C94984642","wikidata":"https://www.wikidata.org/wiki/Q3015605","display_name":"Somatotropic cell","level":4,"score":0.8470199108123779},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7169457077980042},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6950963735580444},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6725114583969116},{"id":"https://openalex.org/C54143909","wikidata":"https://www.wikidata.org/wiki/Q15318729","display_name":"Growth-hormone-releasing hormone receptor","level":5,"score":0.636391282081604},{"id":"https://openalex.org/C2781042741","wikidata":"https://www.wikidata.org/wiki/Q409489","display_name":"Growth hormone\u2013releasing hormone","level":4,"score":0.5741257071495056},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.5347676873207092},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.5315919518470764},{"id":"https://openalex.org/C133603901","wikidata":"https://www.wikidata.org/wiki/Q14905267","display_name":"Thyrotropin-releasing hormone receptor","level":5,"score":0.5042344331741333},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.4243863821029663},{"id":"https://openalex.org/C79381400","wikidata":"https://www.wikidata.org/wiki/Q5173293","display_name":"Corticotropic cell","level":4,"score":0.4114498496055603},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41074544191360474},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.289151132106781},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08973154425621033},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.05239146947860718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0519871711730957},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018013","descriptor_name":"Receptors, Neuropeptide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018013","descriptor_name":"Receptors, Neuropeptide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018013","descriptor_name":"Receptors, Neuropeptide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018017","descriptor_name":"Receptors, Pituitary Hormone-Regulating Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018017","descriptor_name":"Receptors, Pituitary Hormone-Regulating Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018017","descriptor_name":"Receptors, Pituitary Hormone-Regulating Hormone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11036940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11036940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent progress in hormone research","raw_type":"Journal Article"},{"id":"mag:99203335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11036940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3419453210","display_name":"MOLECULAR ANALYSIS OF THE PITUITARY GHRH RECEPTOR","funder_award_id":"R01DK048071","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060400391","https://openalex.org/W7095726753","https://openalex.org/W85380111","https://openalex.org/W2058387484","https://openalex.org/W4252604925","https://openalex.org/W1582872354","https://openalex.org/W2130724168","https://openalex.org/W2490485407","https://openalex.org/W1580683769","https://openalex.org/W2215844862"],"abstract_inverted_index":{"Hormones":[0],"from":[1],"the":[2,7,14,21,72,85,99,121,136,167,173,181,190,194,199,216,230,241,247,277,284,325,328],"hypothalamus":[3],"mediate":[4],"interactions":[5],"between":[6],"nervous":[8],"and":[9,43,50,88,96,105,117,169,202,243,251,318,338],"endocrine":[10],"systems":[11],"by":[12,59,120,141],"controlling":[13],"activity":[15,171],"of":[16,71,151,172,193,246,276,302,316,327,335],"specific":[17],"target":[18],"cells":[19,36,116],"in":[20,84,89,114,131,135,165,180,189,206,212,234,332],"anterior":[22],"pituitary":[23,34,86,115,235],"gland.":[24],"The":[25,77,107,264],"hypothalamic":[26],"peptide,":[27],"growth":[28,52],"hormone-releasing":[29],"hormone":[30,53],"(GHRH),":[31],"acts":[32],"on":[33,324],"somatotroph":[35,90,174,208,221,236],"to":[37,44,48,68,159,257,297],"stimulate":[38],"their":[39,46],"proliferation":[40,168],"during":[41],"development":[42],"regulate":[45],"ability":[47],"produce":[49],"secrete":[51],"(GH).":[54],"These":[55],"actions":[56],"are":[57,147],"mediated":[58],"a":[60,128,187,273,306],"recently":[61],"identified":[62],"receptor":[63,75,80,100,108,133,153,196,266,279,303,320],"for":[64,163,261],"GHRH":[65,79,132,152,164,195,218,227,248,262,265,278,294,317,329],"that":[66,197],"belongs":[67],"family":[69],"B-III":[70],"G":[73],"protein-coupled":[74],"superfamily.":[76],"rat":[78,137],"is":[81,111,118,127,177],"expressed":[82,113],"predominantly":[83,268],"gland":[87],"cells.":[91,237],"To":[92,238],"investigate":[93],"this":[94],"tissue-":[95],"cell-specific":[97],"expression,":[98],"gene":[101,109,154],"has":[102],"been":[103,255],"cloned":[104],"characterized.":[106],"promoter":[110],"selectively":[112],"regulated":[119],"pituitary-specific":[122],"transcription":[123],"factor":[124],"Pit-1.":[125],"There":[126],"sexual":[129],"dimorphism":[130],"expression":[134],"pituitary,":[138],"suggesting":[139,299],"regulation":[140],"gonadal":[142],"steroids.":[143],"In":[144],"addition,":[145],"glucocorticoids":[146],"potent":[148],"positive":[149],"regulators":[150],"expression.":[155],"Substantial":[156],"evidence":[157],"points":[158],"an":[160,281],"important":[161,260],"role":[162],"regulating":[166],"functional":[170],"cell.":[175],"This":[176,309],"best":[178],"observed":[179],"dwarf":[182],"little":[183],"mouse,":[184],"which":[185],"harbors":[186],"mutation":[188],"extracellular":[191],"domain":[192],"abolishes":[198],"receptor's":[200],"hormone-binding":[201,242],"signaling":[203,244,330],"properties,":[204],"resulting":[205],"severe":[207],"hypoplasia.":[209],"Complementary":[210],"studies":[211],"transgenic":[213],"mice":[214],"overexpressing":[215],"ligand":[217],"reveal":[219],"corresponding":[220],"hyperplasia.":[222],"Consistent":[223],"with":[224,280,321],"these":[225,313],"observations,":[226],"potently":[228],"activates":[229],"MAP":[231],"kinase":[232],"pathway":[233],"better":[239],"understand":[240],"properties":[245],"receptor,":[249],"mutant":[250],"chimeric":[252],"receptors":[253],"have":[254],"analyzed":[256],"define":[258],"domains":[259],"interaction.":[263],"signals":[267],"through":[269,289],"cAMP-dependent":[270],"pathways;":[271],"however,":[272],"variant":[274],"form":[275],"insertion":[282],"into":[283],"third":[285],"intracellular":[286],"domain,":[287],"generated":[288],"alternative":[290],"RNA":[291],"processing,":[292],"binds":[293],"but":[295],"fails":[296],"signal,":[298],"potential":[300],"modulation":[301],"function":[304],"at":[305],"post-transcriptional":[307],"level.":[308],"chapter":[310],"will":[311],"integrate":[312],"basic":[314],"investigations":[315],"its":[319],"current":[322],"information":[323],"involvement":[326],"system":[331],"human":[333],"diseases":[334],"GH":[336],"secretion":[337],"growth.":[339]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
