{"id":"https://openalex.org/W991855153","doi":null,"title":"Early detection of endothelial injury and dysfunction in conjunction with correction of hemodynamic maladjustment can effectively restore renal function in type 2 diabetic nephropathy.","display_name":"Early detection of endothelial injury and dysfunction in conjunction with correction of hemodynamic maladjustment can effectively restore renal function in type 2 diabetic nephropathy.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W991855153","mag":"991855153","pmid":"https://pubmed.ncbi.nlm.nih.gov/16614461"},"language":"en","primary_location":{"id":"pmid:16614461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16614461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062652247","display_name":"Narisa Futrakul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802209374","display_name":"King Chulalongkorn Memorial Hospital","ror":"https://ror.org/05jd2pj53","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I2802209374"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Narisa Futrakul","raw_affiliation_strings":["Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. fmednft@md.chula.ac.th"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. fmednft@md.chula.ac.th","institution_ids":["https://openalex.org/I2802209374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035644050","display_name":"Punnee Butthep","orcid":"https://orcid.org/0000-0002-7233-1920","observed_orcids":["https://orcid.org/0000-0002-7233-1920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Punnee Butthep","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089930425","display_name":"Varaphon Vongthavaravat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Varaphon Vongthavarawat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057498843","display_name":"Prasit Futrakul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prasit Futrakul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042264557","display_name":"Sasitorn Sirisalipoch","orcid":"https://orcid.org/0000-0002-5313-5393","observed_orcids":["https://orcid.org/0000-0002-5313-5393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sasitorn Sirisalipoch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015608151","display_name":"Tawatchai Chaivatanarat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tawatchai Chaivatanarat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091242093","display_name":"Sompongse Suwanwalaikorn","orcid":"https://orcid.org/0000-0003-4321-5063","observed_orcids":["https://orcid.org/0000-0003-4321-5063"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sompongse Suwanwalaikorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8431,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.8509645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"34","issue":"3","first_page":"373","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetic-nephropathy","display_name":"type 2 diabetic nephropathy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.9089999794960022},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9679999947547913},{"id":"https://openalex.org/keywords/circulating-endothelial-cells","display_name":"circulating endothelial cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9380000233650208},{"id":"https://openalex.org/keywords/soluble-vascular-cell-adhesion-molecule","display_name":"soluble vascular cell adhesion molecule","score":0.9909999966621399},{"id":"https://openalex.org/keywords/intrarenal-hemodynamics","display_name":"intrarenal hemodynamics","score":0.9850000143051147},{"id":"https://openalex.org/keywords/intraglomerular-hypertension","display_name":"intraglomerular hypertension","score":0.9940000176429749},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.8029999732971191},{"id":"https://openalex.org/keywords/early-biomarkers","display_name":"early biomarkers","score":0.5619999766349792},{"id":"https://openalex.org/keywords/vasodilator-therapy","display_name":"vasodilator therapy","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.8196132183074951},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5976890325546265},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5751564502716064},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.5718382596969604},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.538287878036499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5346829891204834},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4706011712551117},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4565839171409607},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4121629595756531},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36179229617118835},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.26621174812316895}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:16614461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16614461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W264266275","https://openalex.org/W297145862","https://openalex.org/W1655047282","https://openalex.org/W1965533367","https://openalex.org/W1966348997","https://openalex.org/W1970283763","https://openalex.org/W1972738102","https://openalex.org/W1991061419","https://openalex.org/W1991403690","https://openalex.org/W1991912375","https://openalex.org/W2009938201","https://openalex.org/W2032667836","https://openalex.org/W2034034315","https://openalex.org/W2036972369","https://openalex.org/W2040766066","https://openalex.org/W2041990217","https://openalex.org/W2057107933","https://openalex.org/W2068793587","https://openalex.org/W2075895818","https://openalex.org/W2087511197","https://openalex.org/W2091754751","https://openalex.org/W2097887036","https://openalex.org/W2173426014"],"related_works":["https://openalex.org/W2121359148","https://openalex.org/W2023466972","https://openalex.org/W2061302316","https://openalex.org/W2955148535","https://openalex.org/W2123386794","https://openalex.org/W264266275","https://openalex.org/W2070436355","https://openalex.org/W2391740642","https://openalex.org/W7119425132","https://openalex.org/W2544529150"],"abstract_inverted_index":{"This":[0],"paper":[1],"was":[2,47,60,130],"aimed":[3],"to":[4,30],"investigate":[5],"(1)":[6],"the":[7,18,26,58,118,149],"early":[8,133],"marker":[9,134],"of":[10,51,64,71,93,101,117,135,143,159,165],"endothelial":[11,54,136,151,160],"injury":[12,137,161],"in":[13,125,176],"type":[14,41,177],"2":[15,42,178],"diabetes,":[16],"(2)":[17],"intrarenal":[19],"hemodynamics":[20,80],"and":[21,24,38,57,73,81,98,123,162],"renal":[22,32,82,174],"function,":[23],"(3)":[25],"therapeutic":[27],"strategy":[28],"aiming":[29],"restore":[31,173],"function.":[33],"Fifty":[34],"patients":[35],"(35":[36],"normoalbuminuric":[37],"15":[39],"albuminuric":[40],"diabetes)":[43],"were":[44,84,103],"examined.":[45],"Blood":[46],"collected":[48],"for":[49,62],"determination":[50,63],"circulating":[52,94],"vascular":[53,75],"cells":[55],"(CEC)":[56],"serum":[59],"prepared":[61],"transforming":[65],"growth":[66],"factor":[67],"beta":[68],"(TGFbeta),":[69],"ratio":[70,100],"CEC/TGFbeta,":[72],"soluble":[74],"cell":[76],"adhesion":[77],"molecule.":[78],"Intrarenal":[79,106],"function":[83,175],"also":[85],"assessed.":[86],"The":[87],"results":[88],"showed":[89],"that":[90,132],"increased":[91],"number":[92,142],"EC,":[95],"elevated":[96],"TGFbeta":[97],"depleted":[99],"CEC/TGFbeta":[102],"significantly":[104],"observed.":[105],"hemodynamic":[107,111,155,166],"study":[108],"revealed":[109],"a":[110],"maladjustment":[112,167],"characterized":[113],"by":[114,140,168],"preferential":[115],"constriction":[116],"efferent":[119],"arteriole,":[120],"intraglomerular":[121],"hypertension":[122],"reduction":[124],"peritubular":[126],"capillary":[127],"flow.":[128],"It":[129],"concluded":[131],"is":[138],"reflected":[139],"increasing":[141],"CEC.":[144],"Such":[145],"markers":[146],"correlate":[147],"with":[148,154],"glomerular":[150],"dysfunction":[152],"associated":[153],"maladjustment.":[156],"Early":[157],"detection":[158],"appropriate":[163],"correction":[164],"multidrug":[169],"vasodilators":[170],"can":[171],"effectively":[172],"diabetic":[179],"nephropathy.":[180]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
