{"id":"https://openalex.org/W99184495","doi":null,"title":"Altered vascular homeostasis in chronic kidney disease.","display_name":"Altered vascular homeostasis in chronic kidney disease.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W99184495","mag":"99184495","pmid":"https://pubmed.ncbi.nlm.nih.gov/18239262"},"language":"en","primary_location":{"id":"pmid:18239262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18239262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062652247","display_name":"Narisa Futrakul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Narisa Futrakul","raw_affiliation_strings":["Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. fmednft@md.chula.ac.th"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. fmednft@md.chula.ac.th","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035644050","display_name":"Punnee Butthep","orcid":"https://orcid.org/0000-0002-7233-1920","observed_orcids":["https://orcid.org/0000-0002-7233-1920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Punnee Butthep","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057498843","display_name":"Prasit Futrakul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prasit Futrakul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3818,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.88930596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"38","issue":"3","first_page":"201","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":1.0},{"id":"https://openalex.org/keywords/vascular-homeostasis","display_name":"vascular homeostasis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/circulating-endothelial-cells","display_name":"circulating endothelial cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/vascular-repair","display_name":"vascular repair","score":0.7459999918937683},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8510000109672546},{"id":"https://openalex.org/keywords/angiopoietin-1","display_name":"angiopoietin-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vegf-receptor-2","display_name":"VEGF receptor 2","score":0.7770000100135803},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.7249174118041992},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7160155773162842},{"id":"https://openalex.org/C2779094623","wikidata":"https://www.wikidata.org/wiki/Q539710","display_name":"Angiopoietin","level":4,"score":0.6979095935821533},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6390999555587769},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.623765230178833},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5340282917022705},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5302034616470337},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.5226994752883911},{"id":"https://openalex.org/C85219853","wikidata":"https://www.wikidata.org/wiki/Q4763284","display_name":"Angiopoietin receptor","level":3,"score":0.5118672251701355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4874536991119385},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4491446614265442},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.4230811297893524},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.42237409949302673},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36981236934661865},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.34387820959091187},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.2046791911125183}],"mesh":[{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18239262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18239262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},{"id":"mag:99184495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18239262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W297145862","https://openalex.org/W991855153","https://openalex.org/W1604542334","https://openalex.org/W1970283763","https://openalex.org/W1973746219","https://openalex.org/W1981722890","https://openalex.org/W1991912375","https://openalex.org/W1994205207","https://openalex.org/W2022040158","https://openalex.org/W2026275202","https://openalex.org/W2028938930","https://openalex.org/W2031687741","https://openalex.org/W2033113613","https://openalex.org/W2052823646","https://openalex.org/W2075895818","https://openalex.org/W2104158979","https://openalex.org/W2129859917","https://openalex.org/W2136531729","https://openalex.org/W2138670606","https://openalex.org/W2142577667","https://openalex.org/W2154732343","https://openalex.org/W2397025944"],"related_works":["https://openalex.org/W2159534713","https://openalex.org/W2144770608","https://openalex.org/W2007230638","https://openalex.org/W47776119","https://openalex.org/W3162035977","https://openalex.org/W2970561412","https://openalex.org/W2976109378","https://openalex.org/W2292473833","https://openalex.org/W2914142343","https://openalex.org/W2365114157"],"abstract_inverted_index":{"Current":[0],"treatments":[1],"of":[2,29,33,39,48,74,103,148,151,182],"chronic":[3],"kidney":[4],"disease":[5],"(CKD)":[6],"patients":[7,53],"frequently":[8],"result":[9,91],"in":[10,13,51,118,154,169],"progressive":[11,31],"decline":[12],"renal":[14,20,23,34,57,159],"perfusion,":[15],"leading":[16],"to":[17,44,63],"the":[18,30,40,46,127,139,146,165],"end-stage":[19],"disease.":[21,36],"Such":[22],"failures":[24],"may":[25,163],"be":[26,185],"a":[27,109],"reflection":[28],"nature":[32],"microvascular":[35,49],"The":[37,89],"aim":[38],"present":[41,90,166],"study":[42],"is":[43],"elucidate":[45],"mechanism":[47],"homeostasis":[50],"CKD":[52,155,172,183],"with":[54,156],"moderately":[55,157],"impaired":[56,158],"function.":[58,160],"We":[59],"determined":[60],"biomarkers":[61,73],"relevant":[62],"vascular":[64,75,79,95,111,142,152],"homeostasis,":[65],"such":[66,77,121,130],"as":[67,78,122,131],"circulating":[68,104],"endothelial":[69,80,105],"cell":[70],"(CEC),":[71],"and":[72,87,124,133,174],"repair,":[76],"growth":[81],"factor":[82],"(VEGF),":[83],"angiopoietin-1,":[84,125],"tie-2,":[85],"angiopoietin-2":[86,132],"VEGF-R2.":[88],"revealed":[92],"an":[93,179],"enhanced":[94],"injury":[96],"which":[97],"was":[98,113],"reflected":[99,115],"by":[100,116],"increased":[101,144],"number":[102],"cells.":[106],"In":[107,137],"addition,":[108],"defective":[110,149],"repair":[112,153],"also":[114],"deficiencies":[117],"angiogenic":[119],"factors":[120,129],"VEGF,":[123],"whereas":[126],"anti-angiogenic":[128],"VEGF-R2":[134],"were":[135],"elevated.":[136],"conclusion,":[138],"activity":[140],"against":[141],"injuries":[143],"under":[145],"presence":[147],"ability":[150],"This":[161],"finding":[162],"explain":[164],"therapeutic":[167],"failure":[168],"treating":[170],"these":[171],"patients,":[173],"imply":[175],"that":[176],"treatment":[177],"at":[178],"earlier":[180],"stage":[181],"should":[184],"implemented.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}