{"id":"https://openalex.org/W9910132","doi":"https://doi.org/10.1096/fasebj.21.5.a172-c","title":"Dietary Flaxseed Prevents Fibrosis And Oxidative Lung Damage And Improves Mouse Survival In Experimental Thoracic Radiation Injury","display_name":"Dietary Flaxseed Prevents Fibrosis And Oxidative Lung Damage And Improves Mouse Survival In Experimental Thoracic Radiation Injury","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W9910132","doi":"https://doi.org/10.1096/fasebj.21.5.a172-c","mag":"9910132"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a172-c","doi":"https://doi.org/10.1096/fasebj.21.5.a172-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a172-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"James C Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C Lee","raw_affiliation_strings":["Department of Medicine University of Pennsylvania, Abramson Research Center Philadelphia PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine University of Pennsylvania, Abramson Research Center Philadelphia PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070392597","display_name":"Keith A. Cengel","orcid":"https://orcid.org/0000-0001-6960-5882","observed_orcids":["https://orcid.org/0000-0001-6960-5882"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Cengel","raw_affiliation_strings":["Department of Radiation Oncology University of Pennsylvania JMB Philadelphia PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology University of Pennsylvania JMB Philadelphia PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029248993","display_name":"Stathis Kanterakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stathis Kanterakis","raw_affiliation_strings":["Department of Medicine University of Pennsylvania, Abramson Research Center Philadelphia PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine University of Pennsylvania, Abramson Research Center Philadelphia PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035185785","display_name":"Ryan Krochak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Krochak","raw_affiliation_strings":["Department of Medicine University of Pennsylvania, Abramson Research Center Philadelphia PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine University of Pennsylvania, Abramson Research Center Philadelphia PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065576440","display_name":"Evguenia Arguiri","orcid":"https://orcid.org/0000-0002-5363-3376","observed_orcids":["https://orcid.org/0000-0002-5363-3376"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evguenia Arguiri","raw_affiliation_strings":["Department of Medicine University of Pennsylvania, Abramson Research Center Philadelphia PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine University of Pennsylvania, Abramson Research Center Philadelphia PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080849169","display_name":"Charalambos Solomides","orcid":"https://orcid.org/0000-0002-4769-8122","observed_orcids":["https://orcid.org/0000-0002-4769-8122"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. C. Solomides","raw_affiliation_strings":["Department of Pathology Temple University 3401 N. Broad Street Philadelphia PA 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Temple University 3401 N. Broad Street Philadelphia PA 19140","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017021744","display_name":"Melpo Christofidou\u2010Solomidou","orcid":"https://orcid.org/0000-0002-5945-6569","observed_orcids":["https://orcid.org/0000-0002-5945-6569"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melpo Christofidou Solomidou","raw_affiliation_strings":["Department of Medicine University of Pennsylvania, Abramson Research Center Philadelphia PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine University of Pennsylvania, Abramson Research Center Philadelphia PA 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00123045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flaxseed","display_name":"flaxseed","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/radiation-induced-pulmonary-fibrosis","display_name":"radiation-induced pulmonary fibrosis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/radiation-pneumonitis","display_name":"radiation pneumonitis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hydroxyproline","display_name":"hydroxyproline","score":0.8799999952316284},{"id":"https://openalex.org/keywords/antioxidant-nutrition","display_name":"antioxidant nutrition","score":0.5410000085830688},{"id":"https://openalex.org/keywords/mouse-survival","display_name":"mouse survival","score":0.6570000052452087},{"id":"https://openalex.org/keywords/lung-tumor-growth","display_name":"lung tumor growth","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.7107080817222595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6677263975143433},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6672556400299072},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5829777717590332},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.5702313184738159},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5496503114700317},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5202013850212097},{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.5127890706062317},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4727914035320282},{"id":"https://openalex.org/C2779524853","wikidata":"https://www.wikidata.org/wiki/Q1284347","display_name":"Pneumonitis","level":3,"score":0.4528277516365051},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4283062815666199},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39336568117141724}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a172-c","doi":"https://doi.org/10.1096/fasebj.21.5.a172-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a172-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306231","display_name":"American Institute for Cancer Research","ror":"https://ror.org/03b3akj74"},{"id":"https://openalex.org/F4320309229","display_name":"National Institute on Handicapped Research","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2018165119","https://openalex.org/W2011573190","https://openalex.org/W7099147799","https://openalex.org/W596647164","https://openalex.org/W3173802662","https://openalex.org/W2167298849","https://openalex.org/W2314795694","https://openalex.org/W2155918577","https://openalex.org/W193942800","https://openalex.org/W2031523928"],"abstract_inverted_index":{"Flaxseed":[0],"(FS)":[1],"is":[2,186],"a":[3,120,198],"nutritional":[4],"supplement":[5],"with":[6,93],"antioxidant":[7],"properties.":[8],"Its":[9],"usefulness":[10],"in":[11,84,112,117,150,203],"thoracic":[12,37],"X\u2010ray":[13],"radiation":[14,182],"(XRT)\u2010induced":[15],"pneumonopathy":[16],"has":[17],"not":[18,64,168,174],"been":[19],"investigated.":[20],"We":[21],"evaluated":[22,43,101],"mice":[23,129],"fed":[24],"either":[25],"10%":[26,85,113,162],"FS":[27,62,86,114,145,163,172,185],"or":[28],"0%":[29],"control":[30,128],"diets":[31],"for":[32,49,56,161],"3":[33,45],"weeks":[34,46],"prior":[35],"to":[36,181],"XRT.":[38],"Irradiated":[39],"mouse":[40,147],"lungs":[41],"were":[42],"at":[44,53],"post":[47],"XRT":[48],"early":[50,66],"pneumonitis":[51],"and":[52,157,191,195,211],"4":[54],"months":[55],"late,":[57],"radiation\u2010induced":[58],"fibrosis.":[59],"Although":[60],"dietary":[61],"did":[63,173],"improve":[65],"lung":[67,70,83,98,104,111,176,193,204],"inflammation,":[68],"oxidative":[69,192],"damage":[71,194],"shown":[72],"by":[73,103,140],"malondialdehyde":[74],"levels":[75],"was":[76,91,137],"significantly":[77,169],"decreased":[78],"(0.111\u00b10.007":[79],"vs.":[80,87,115,122,155,159,164],"0.163\u00b10.0.015":[81],"\u03bcM/g":[82],"0%FS,":[88,118],"respectively).":[89],"This":[90,135],"associated":[92],"an":[94],"abrogation":[95],"of":[96],"late":[97],"fibrosis":[99,190],"as":[100],"quantitatively":[102],"hydroxyl\u2010proline":[105],"content":[106],"(1.47\u00b10.01":[107],"\u03bcg/ml":[108],"OH":[109],"per":[110],"1.70\u00b10.03":[116],"representing":[119],"10.5%":[121],"39%":[123],"increase":[124],"from":[125,179],"non\u2010irradiated,":[126],"age\u2010matched":[127],"placed":[130],"on":[131],"the":[132],"respective":[133],"diets).":[134],"finding":[136],"confirmed":[138],"histologically":[139],"Trichrome\u2010blue":[141],"staining.":[142],"In":[143],"addition,":[144],"improved":[146],"survival":[148],"rates":[149],"two":[151],"separate":[152],"experiments":[153],"(65%":[154],"40%":[156],"93%":[158],"66%":[160],"0%FS":[165],"respectively),":[166],"although":[167],"(p=0.06).":[170],"Importantly,":[171],"protect":[175],"tumor":[177],"growth":[178],"responding":[180],"treatment.":[183,206],"Dietary":[184],"protective":[187],"against":[188],"pulmonary":[189],"may":[196],"be":[197],"useful,":[199],"safe":[200],"adjuvant":[201],"therapy":[202],"cancer":[205],"Funded":[207],"by:":[208],"NIHR21,":[209],"AICR":[210],"U.":[212],"Penn":[213],"Research":[214],"Foundation":[215],"(MCS).":[216]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}