{"id":"https://openalex.org/W99098322","doi":null,"title":"Identification of FcgammaRIIA STAT6 Interaction and the Subsequent Effects","display_name":"Identification of FcgammaRIIA STAT6 Interaction and the Subsequent Effects","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W99098322","mag":"99098322"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:mco1332933291","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1332933291","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=mco1332933291&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1332933291","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=mco1332933291&disposition=inline","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067588751","display_name":"Elizabeth P. Beil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth P. Beil","raw_affiliation_strings":["University of Toledo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067588751"],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00912507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.050700001418590546,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fcgammariia","display_name":"Fc\u03b3RIIa","score":0.9909999966621399},{"id":"https://openalex.org/keywords/stat6","display_name":"STAT6","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fc-gamma-receptor-signaling","display_name":"Fc\u03b3 receptor signaling","score":0.6510000228881836},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.7260000109672546},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.949999988079071},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8149999976158142},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.6679999828338623},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/respiratory-burst","display_name":"respiratory burst","score":0.8930000066757202},{"id":"https://openalex.org/keywords/heat-aggregated-igg","display_name":"heat-aggregated IgG","score":0.7089999914169312},{"id":"https://openalex.org/keywords/receptor-ligation","display_name":"receptor ligation","score":0.37299999594688416},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.7549999952316284},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5849027037620544},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.41376766562461853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2121918797492981},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.20235958695411682}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:mco1332933291","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1332933291","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=mco1332933291&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1332933291","raw_type":"text"},{"id":"mag:99098322","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1332933291","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:mco1332933291","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1332933291","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=mco1332933291&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1332933291","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W99098322.pdf","grobid_xml":"https://content.openalex.org/works/W99098322.grobid-xml"},"referenced_works_count":215,"referenced_works":["https://openalex.org/W4585564","https://openalex.org/W6044372","https://openalex.org/W44416003","https://openalex.org/W54107245","https://openalex.org/W106950157","https://openalex.org/W127053136","https://openalex.org/W156684494","https://openalex.org/W236733732","https://openalex.org/W261402719","https://openalex.org/W326936453","https://openalex.org/W1480646216","https://openalex.org/W1481966022","https://openalex.org/W1482082625","https://openalex.org/W1491270159","https://openalex.org/W1494678290","https://openalex.org/W1509361070","https://openalex.org/W1510351486","https://openalex.org/W1510771719","https://openalex.org/W1514153753","https://openalex.org/W1520646806","https://openalex.org/W1526905466","https://openalex.org/W1528523002","https://openalex.org/W1530340727","https://openalex.org/W1531340672","https://openalex.org/W1535428241","https://openalex.org/W1539756723","https://openalex.org/W1554188305","https://openalex.org/W1559239706","https://openalex.org/W1564132479","https://openalex.org/W1564846750","https://openalex.org/W1565411191","https://openalex.org/W1570678799","https://openalex.org/W1576402354","https://openalex.org/W1576448444","https://openalex.org/W1582170718","https://openalex.org/W1595075646","https://openalex.org/W1605822460","https://openalex.org/W1618519163","https://openalex.org/W1651802458","https://openalex.org/W1789341793","https://openalex.org/W1818471554","https://openalex.org/W1821858011","https://openalex.org/W1882823390","https://openalex.org/W1884773148","https://openalex.org/W1897226866","https://openalex.org/W1914303074","https://openalex.org/W1921314723","https://openalex.org/W1921414939","https://openalex.org/W1923737223","https://openalex.org/W1935632736","https://openalex.org/W1942668068","https://openalex.org/W1958440406","https://openalex.org/W1964815717","https://openalex.org/W1965340455","https://openalex.org/W1966644054","https://openalex.org/W1970474351","https://openalex.org/W1971349333","https://openalex.org/W1972108403","https://openalex.org/W1974472077","https://openalex.org/W1978295098","https://openalex.org/W1978432820","https://openalex.org/W1979676829","https://openalex.org/W1980307210","https://openalex.org/W1982557722","https://openalex.org/W1983632974","https://openalex.org/W1986184758","https://openalex.org/W1987968095","https://openalex.org/W1988945757","https://openalex.org/W1989105619","https://openalex.org/W1989950888","https://openalex.org/W1990463170","https://openalex.org/W1990679714","https://openalex.org/W1991656907","https://openalex.org/W1991761360","https://openalex.org/W1994570769","https://openalex.org/W1994584656","https://openalex.org/W1994805857","https://openalex.org/W2000061036","https://openalex.org/W2001692359","https://openalex.org/W2001713238","https://openalex.org/W2002186586","https://openalex.org/W2002726220","https://openalex.org/W2003959866","https://openalex.org/W2004345134","https://openalex.org/W2005873851","https://openalex.org/W2007163229","https://openalex.org/W2007163754","https://openalex.org/W2009481807","https://openalex.org/W2013629240","https://openalex.org/W2016708646","https://openalex.org/W2016738490","https://openalex.org/W2016868307","https://openalex.org/W2018317768","https://openalex.org/W2018699957","https://openalex.org/W2019182330","https://openalex.org/W2021820438","https://openalex.org/W2023084000","https://openalex.org/W2023122744","https://openalex.org/W2023448876","https://openalex.org/W2023497277","https://openalex.org/W2025970341","https://openalex.org/W2026975595","https://openalex.org/W2027519552","https://openalex.org/W2029262008","https://openalex.org/W2029860358","https://openalex.org/W2029863258","https://openalex.org/W2030655955","https://openalex.org/W2033222990","https://openalex.org/W2034408745","https://openalex.org/W2035439001","https://openalex.org/W2036648301","https://openalex.org/W2037061225","https://openalex.org/W2040272267","https://openalex.org/W2040355733","https://openalex.org/W2040507646","https://openalex.org/W2041647537","https://openalex.org/W2044719429","https://openalex.org/W2045628444","https://openalex.org/W2046273714","https://openalex.org/W2047081723","https://openalex.org/W2049266087","https://openalex.org/W2049583989","https://openalex.org/W2049750787","https://openalex.org/W2051699993","https://openalex.org/W2052172628","https://openalex.org/W2052605623","https://openalex.org/W2052779439","https://openalex.org/W2053574863","https://openalex.org/W2058660177","https://openalex.org/W2059660229","https://openalex.org/W2060958975","https://openalex.org/W2061441324","https://openalex.org/W2061895065","https://openalex.org/W2062244945","https://openalex.org/W2065635612","https://openalex.org/W2066439239","https://openalex.org/W2068544809","https://openalex.org/W2068626888","https://openalex.org/W2069545269","https://openalex.org/W2069957298","https://openalex.org/W2070551264","https://openalex.org/W2072970918","https://openalex.org/W2075714453","https://openalex.org/W2076586496","https://openalex.org/W2077352509","https://openalex.org/W2078668858","https://openalex.org/W2081659051","https://openalex.org/W2081717004","https://openalex.org/W2082077002","https://openalex.org/W2082293350","https://openalex.org/W2085308188","https://openalex.org/W2088618181","https://openalex.org/W2088767734","https://openalex.org/W2088948208","https://openalex.org/W2089865395","https://openalex.org/W2091018161","https://openalex.org/W2091943511","https://openalex.org/W2092881768","https://openalex.org/W2093151008","https://openalex.org/W2093294507","https://openalex.org/W2095537212","https://openalex.org/W2099019634","https://openalex.org/W2100930825","https://openalex.org/W2101647368","https://openalex.org/W2102184268","https://openalex.org/W2102402967","https://openalex.org/W2103214176","https://openalex.org/W2104603012","https://openalex.org/W2106994186","https://openalex.org/W2107469094","https://openalex.org/W2111063314","https://openalex.org/W2115569719","https://openalex.org/W2115848892","https://openalex.org/W2115928735","https://openalex.org/W2120464397","https://openalex.org/W2122541507","https://openalex.org/W2122699286","https://openalex.org/W2123640179","https://openalex.org/W2123735453","https://openalex.org/W2124723318","https://openalex.org/W2125986772","https://openalex.org/W2127310510","https://openalex.org/W2127434853","https://openalex.org/W2127618101","https://openalex.org/W2128627731","https://openalex.org/W2145218870","https://openalex.org/W2145355599","https://openalex.org/W2146671478","https://openalex.org/W2151444009","https://openalex.org/W2151900684","https://openalex.org/W2155185836","https://openalex.org/W2155341876","https://openalex.org/W2155449991","https://openalex.org/W2158602749","https://openalex.org/W2159584083","https://openalex.org/W2160097418","https://openalex.org/W2160345282","https://openalex.org/W2165448884","https://openalex.org/W2166504548","https://openalex.org/W2166982025","https://openalex.org/W2167381279","https://openalex.org/W2168203604","https://openalex.org/W2170240282","https://openalex.org/W2291704802","https://openalex.org/W2331141333","https://openalex.org/W2331800545","https://openalex.org/W2413658434","https://openalex.org/W2416376983","https://openalex.org/W2425249855","https://openalex.org/W2437051860","https://openalex.org/W2439117707","https://openalex.org/W2791218690","https://openalex.org/W4313333678","https://openalex.org/W4313376218","https://openalex.org/W4313377050"],"related_works":["https://openalex.org/W7019760580","https://openalex.org/W7135895153","https://openalex.org/W2155185836","https://openalex.org/W1965702849","https://openalex.org/W7098782809","https://openalex.org/W2011047122","https://openalex.org/W2302829497","https://openalex.org/W4249078245","https://openalex.org/W7101043736","https://openalex.org/W7097796484"],"abstract_inverted_index":{"Fc\u03b3RIIA,":[0],"a":[1,32,212,261],"transmembrane":[2],"receptor":[3],"for":[4,413,417,421,425,429],"immunoglobulin":[5],"G":[6,458],"(IgG),":[7],"triggers":[8],"phagocytosis,":[9],"endocytosis":[10,298,368],"and":[11,50,71,87,90,127,176,271,309,345],"oxidative":[12],"burst":[13],"in":[14,57,73,83,141,156,337],"leukocytes.Signal":[15],"transduction":[16],"via":[17],"Fc\u03b3RIIA":[18,41,115,126,135,168,175,308,397,441],"leading":[19],"to":[20,66,80,85,91,93,101,108,124,129,151,197,226,232,246,255,291],"these":[21],"outcomes":[22],"has":[23,104],"been":[24,78,106],"relatively":[25],"well":[26],"studied.To":[27],"identify":[28],"additional":[29],"signaling":[30],"partners,":[31],"yeast":[33],"twohybrid":[34],"analysis":[35,357,373],"employing":[36],"the":[37,44,111,147,157,177,187,277,312,339],"cytoplasmic":[38],"domain":[39,46,314],"of":[40,47,52,69,96,114,134,143,146,174,190,203,222,279,288,315,320,325,335,341,343,352,358,367,374,383],"was":[42,184,236],"performed.Interestingly,":[43],"SH2":[45,313],"signal":[48,331],"transducer":[49],"activator":[51],"transcription":[53],"6":[54],"(STAT6)":[55],"appeared":[56],"our":[58,153],"analysis.STAT6":[59],"traditionally":[60],"interacts":[61],"with":[62,116,193,206,269,362,378,395,403],"interleukin-4":[63],"(IL-4)":[64],"receptors":[65],"induce":[67],"expression":[68,145],"IL-4":[70,82,97,210,235,248,257,280,292,326],"IL-13":[72,99],"T":[74,263],"cells.Macrophages":[75],"have":[76],"also":[77],"observed":[79,186,216,284],"produce":[81],"response":[84],"pharmaceutical":[86],"pathogenic":[88],"stimuli":[89],"respond":[92],"IL-4.However,":[94],"production":[95],"or":[98,299],"subsequent":[100,154],"Fc\u03b3R":[102,208,242],"ligation":[103,133],"not":[105],"observed.Therefore,":[107],"better":[109],"define":[110],"specific":[112,132],"interaction":[113,189,305],"STAT6,":[117],"we":[118,215],"engineered":[119],"Chinese":[120],"hamster":[121],"ovary":[122],"cells":[123,228,401],"express":[125],"RFP-STAT6":[128,148],"determine":[130,233],"if":[131,234],"induces":[136,219],"STAT6":[137,192,199,223,310,316,322,344,346],"nuclear":[138,318],"translocation.This":[139],"resulted":[140],"lack":[142],"consistent":[144],"causing":[149],"us":[150],"perform":[152],"experiments":[155],"human":[158,262,396],"macrophage-like":[159],"cell":[160,179,264],"line,":[161,265],"THP-1.To":[162],"iii":[163],"further":[164],"elucidate":[165],"this":[166],"interaction,":[167],"immunoprecipitation":[169],"followed":[170],"by":[171],"western":[172],"blotting":[173],"whole":[178],"lysates":[180],"from":[181,238,249,258],"THP-1":[182,204,239,250,289,359,375],"macrophages,":[183,251],"performed.We":[185],"constitutive":[188],"non-phosphorylated":[191,321],"Fc\u03b3RIIA.We":[194],"subsequently":[195],"sought":[196,231],"examine":[198],"activation":[200],"after":[201,241],"stimulation":[202],"macrophages":[205,240,290,360,376],"various":[207],"ligands.Using":[209],"as":[211],"positive":[213],"control,":[214],"heat-aggregated":[217],"IgG":[218,426,444],"significant":[220,295],"amounts":[221],"translocation":[224,319],"compared":[225],"untreated":[227],"(p<0.05).We":[229],"then":[230,275],"produced":[237],"ligation.We":[243],"were":[244,253,267],"unable":[245],"detect":[247,256],"but":[252],"able":[254],"Jurkat":[259],"cells,":[260],"that":[266,285],"stimulated":[268,361,377],"ionomycin":[270],"phorbol":[272],"myristal":[273],"acetate.We":[274],"examined":[276],"effects":[278],"on":[281,297],"Fc\u03b3R-mediated":[282],"activities.We":[283],"transient":[286],"exposure":[287],"had":[293],"no":[294],"effect":[296],"phagocytosis.Our":[300],"current":[301],"observations":[302],"indicate":[303],"an":[304,332],"exists":[306],"between":[307],"through":[311,370],"producing":[317],"without":[323],"induction":[324],"gene":[327,348],"expression.This":[328],"observance":[329],"may":[330],"important":[333],"avenue":[334],"research":[336],"understanding":[338],"mechanisms":[340],"phosphorylation":[342],"induced":[347],"expression.ix":[349],"4-5":[350],"Quantification":[351],"phagocytosis":[353],"using":[354],"epifluorescence":[355],"microscopy":[356],"50ng/mL":[363,379],"IL-4\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u202641":[364],"4-6":[365],"Trend":[366],"analyzed":[369],"flow":[371],"cytometric":[372],"IL-4\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u202642":[380],"x":[381],"List":[382],"Abbreviations":[384],"Ab\u2026\u2026\u2026\u2026\u2026\u2026\u2026Antibody":[385],"CHO\u2026\u2026\u2026\u2026\u2026\u2026Chinese":[386],"Hamster":[387,391,399],"Ovary":[388,392,400],"Cells":[389,393],"CHO-IIA\u2026\u2026\u2026\u2026.Chinese":[390],"transfected":[394,402],"CHO-IIAGFP\u2026\u2026..Chinese":[398],"Fc\u03b3RIIA-GFP":[404],"CXCL8\u2026\u2026\u2026\u2026\u2026Chemokine":[405],"Interleukin-8":[406],"EA\u2026\u2026\u2026\u2026\u2026\u2026\u2026IgG-opsonized":[407],"erythrocytes":[408],"FcR\u2026\u2026\u2026\u2026\u2026\u2026...Fc":[409],"Receptor":[410,412,416,420,424,428,451],"Fc\u03b1R\u2026\u2026\u2026\u2026\u2026\u2026.Fc":[411],"IgA":[414],"Fc\u03b4R\u2026\u2026\u2026\u2026\u2026\u2026.Fc":[415],"IgD":[418],"Fc\u03b5R\u2026\u2026\u2026\u2026\u2026\u2026.Fc":[419],"IgE":[422],"Fc\u03b3R\u2026\u2026\u2026\u2026\u2026\u2026.Fc":[423],"Fc\u00b5R\u2026\u2026\u2026\u2026\u2026\u2026Fc":[427],"IgM":[430],"FITC\u2026\u2026\u2026\u2026\u2026\u2026.Fluorescein":[431],"Isothiocyanate":[432],"FITC-haIgG\u2026\u2026\u2026.FITC-conjugated":[433],"haIgG":[434],"\u03b3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026.Common":[435],"Gamma":[436],"Chain":[437],"H":[438],"131":[439],"\u2026\u2026\u2026\u2026\u2026\u2026.High-responder":[440],"isoform":[442],"HaIgG\u2026\u2026\u2026\u2026\u2026..Heat-Aggregated":[443],"Complexes":[445],"IC\u2026\u2026\u2026\u2026\u2026\u2026\u2026..Immune":[446],"Complex":[447],"IFN\u2026\u2026\u2026\u2026\u2026\u2026...Interferon":[448],"IL\u2026\u2026\u2026\u2026\u2026\u2026\u2026..Interleukin":[449],"IL-4R\u2026\u2026\u2026\u2026\u2026\u2026Interleukin-4":[450],"Ig\u2026\u2026\u2026\u2026\u2026\u2026\u2026...Immunoglobulin":[452],"IgA\u2026\u2026\u2026\u2026\u2026\u2026\u2026Immunoglobulin":[453],"A":[454],"IgE\u2026\u2026\u2026\u2026\u2026\u2026\u2026.Immunoglobulin":[455],"E":[456],"IgG\u2026\u2026\u2026\u2026\u2026\u2026\u2026.Immunoglobulin":[457],"IP":[459],"3":[460],"\u2026\u2026\u2026\u2026\u2026\u2026\u2026.Inositol":[461],"triphosphate":[462],"ITAM\u2026\u2026\u2026\u2026\u2026\u2026.Immunoreceptor":[463],"Tyrosine-based":[464,468],"Activation":[465],"Motif":[466,470],"ITIM\u2026\u2026\u2026\u2026\u2026\u2026..Immunoreceptor":[467],"Inhibitory":[469],"kDa\u2026\u2026\u2026\u2026\u2026\u2026\u2026Kilodalton":[471],"M1\u2026\u2026\u2026\u2026\u2026\u2026\u2026.Classically":[472],"Activated":[473],"Macrophages":[474],"M2\u2026\u2026\u2026\u2026\u2026\u2026\u2026":[475]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
