{"id":"https://openalex.org/W99061854","doi":"https://doi.org/10.1177/548.6505","title":"Triple-Negative Breast Cancer: Current State of the Art","display_name":"Triple-Negative Breast Cancer: Current State of the Art","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W99061854","doi":"https://doi.org/10.1177/548.6505","mag":"99061854","pmid":"https://pubmed.ncbi.nlm.nih.gov/21388048"},"language":"en","primary_location":{"id":"doi:10.1177/548.6505","doi":"https://doi.org/10.1177/548.6505","is_oa":false,"landing_page_url":"https://doi.org/10.1177/548.6505","pdf_url":null,"source":{"id":"https://openalex.org/S4210189328","display_name":"Tumori Journal","issn_l":"0300-8916","issn":["0300-8916","2038-2529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071422886","display_name":"Francesca Rastelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Rastelli","raw_affiliation_strings":["Oncology Unit Zona Territoriale 11, Ospedale \u201cMurri\u201d, Azienda Sanitaria Unica Regionale Marche, Fermo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit Zona Territoriale 11, Ospedale \u201cMurri\u201d, Azienda Sanitaria Unica Regionale Marche, Fermo;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059575427","display_name":"Sandra Biancanelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sandra Biancanelli","raw_affiliation_strings":["Oncology Department AUSL 7, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department AUSL 7, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000768511","display_name":"Amalia Falzetta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Amalia Falzetta","raw_affiliation_strings":["Oncology Department AUSL 7, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department AUSL 7, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000699628","display_name":"Angelo Martignetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo Martignetti","raw_affiliation_strings":["Oncology Department AUSL 7, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department AUSL 7, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007013948","display_name":"Camilla Casi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Camilla Casi","raw_affiliation_strings":["Oncology Department AUSL 7, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department AUSL 7, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086269583","display_name":"Romeo Bascioni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romeo Bascioni","raw_affiliation_strings":["Oncology Unit Zona Territoriale 11, Ospedale \u201cMurri\u201d, Azienda Sanitaria Unica Regionale Marche, Fermo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit Zona Territoriale 11, Ospedale \u201cMurri\u201d, Azienda Sanitaria Unica Regionale Marche, Fermo;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058581227","display_name":"Lucio Giustini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucio Giustini","raw_affiliation_strings":["Oncology Unit Zona Territoriale 11, Ospedale \u201cMurri\u201d, Azienda Sanitaria Unica Regionale Marche, Fermo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit Zona Territoriale 11, Ospedale \u201cMurri\u201d, Azienda Sanitaria Unica Regionale Marche, Fermo;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019583292","display_name":"Sergio Crispino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sergio Crispino","raw_affiliation_strings":["Oncology Department AUSL 7, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department AUSL 7, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":2.2435,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.88289351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"96","issue":"6","first_page":"875","last_page":"888"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.4269999861717224},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.8119999766349792},{"id":"https://openalex.org/keywords/basal-cytokeratins","display_name":"basal cytokeratins","score":0.9409999847412109},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8920000195503235},{"id":"https://openalex.org/keywords/brca1-mutation","display_name":"BRCA1 mutation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/brcaness","display_name":"BRCAness","score":0.8709999918937683},{"id":"https://openalex.org/keywords/dna-repair-deficiency","display_name":"DNA repair deficiency","score":0.7670000195503235},{"id":"https://openalex.org/keywords/anthracyclines","display_name":"anthracyclines","score":0.8870000243186951},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.7639999985694885},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/epothilones","display_name":"epothilones","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8039224743843079},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.800493597984314},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5869744420051575},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5498356223106384},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.532333254814148},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4418155252933502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4301567077636719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.396220326423645},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3335545063018799},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3282036781311035},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016391","descriptor_name":"Genes, src","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019398","descriptor_name":"Genes, BRCA1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/548.6505","doi":"https://doi.org/10.1177/548.6505","is_oa":false,"landing_page_url":"https://doi.org/10.1177/548.6505","pdf_url":null,"source":{"id":"https://openalex.org/S4210189328","display_name":"Tumori Journal","issn_l":"0300-8916","issn":["0300-8916","2038-2529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori Journal","raw_type":"journal-article"},{"id":"pmid:21388048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21388048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1523531555","https://openalex.org/W1973807269","https://openalex.org/W1979223612","https://openalex.org/W1988698939","https://openalex.org/W1989663680","https://openalex.org/W1995224853","https://openalex.org/W1996457137","https://openalex.org/W2003278673","https://openalex.org/W2017631747","https://openalex.org/W2017937144","https://openalex.org/W2044858733","https://openalex.org/W2052161680","https://openalex.org/W2052387052","https://openalex.org/W2097255042","https://openalex.org/W2099335989","https://openalex.org/W2101745705","https://openalex.org/W2112595184","https://openalex.org/W2114710110","https://openalex.org/W2116918515","https://openalex.org/W2117972559","https://openalex.org/W2118034665","https://openalex.org/W2118083160","https://openalex.org/W2118605519","https://openalex.org/W2126275851","https://openalex.org/W2126575569","https://openalex.org/W2127340468","https://openalex.org/W2127518232","https://openalex.org/W2131994307","https://openalex.org/W2135736714","https://openalex.org/W2136983579","https://openalex.org/W2138095640","https://openalex.org/W2138929540","https://openalex.org/W2142460765","https://openalex.org/W2142486051","https://openalex.org/W2142588358","https://openalex.org/W2143383125","https://openalex.org/W2145444267","https://openalex.org/W2145539398","https://openalex.org/W2147094816","https://openalex.org/W2149719146","https://openalex.org/W2152296362","https://openalex.org/W2154142993","https://openalex.org/W2156078357","https://openalex.org/W2157285286","https://openalex.org/W2162760540","https://openalex.org/W2167926320","https://openalex.org/W2168379483","https://openalex.org/W2170602872","https://openalex.org/W2170856503","https://openalex.org/W2207221522","https://openalex.org/W2225739806","https://openalex.org/W2280778178","https://openalex.org/W2340978282","https://openalex.org/W4234394290","https://openalex.org/W4234869569","https://openalex.org/W4235689777","https://openalex.org/W4242011915"],"related_works":["https://openalex.org/W2014715698","https://openalex.org/W2096027508","https://openalex.org/W2139015981","https://openalex.org/W2052422202","https://openalex.org/W2082318061","https://openalex.org/W2144247813","https://openalex.org/W2030457654","https://openalex.org/W2007377401","https://openalex.org/W2164792086","https://openalex.org/W2036647671"],"abstract_inverted_index":{"AIMS":[0],"AND":[1],"BACKGROUND:":[2],"Triple-negative":[3],"breast":[4,25,49,146,199,218,260],"cancer,":[5],"defined":[6,116],"by":[7,224,364],"a":[8,31,71,187,192,225,255,266,339],"lack":[9],"of":[10,12,21,24,41,64,70,75,151,177,207,228,241,352,372,391,397],"expression":[11,121,176],"estrogen,":[13],"progesterone":[14],"and":[15,51,61,78,83,96,99,108,171,173,182,190,210,231,252,281,321,325,369,394],"HER-2":[16],"receptors,":[17],"accounts":[18],"for":[19,39,86,129,258,360,405],"15%":[20],"all":[22,42,117],"types":[23,220],"cancer.":[26,200],"The":[27,175,239],"subtype":[28,37],"mainly":[29],"includes":[30],"molecularly":[32],"distinct":[33,194],"subgroup,":[34],"the":[35,58,103,112,132,197,313,353,366,370,380,392],"basal-like":[36,55],"(accounting":[38],"75%":[40],"cases).":[43],"We":[44,90],"attempt":[45],"to":[46,136,142,186,269,283,297,402],"define":[47],"triple-negative":[48,65,198,208],"cancer":[50,147,261],"compare":[52],"it":[53],"with":[54,272,287],"disease,":[56,66],"review":[57],"molecular,":[59],"pathologic":[60,273,393],"clinical":[62,76,97,137],"features":[63,98],"provide":[67],"an":[68],"overview":[69],"retrospective":[72,293],"subset":[73],"analysis":[74,133],"trials,":[77],"outline":[79],"ongoing":[80,315],"therapeutic":[81,376],"trials":[82,316],"possible":[84],"paths":[85],"future":[87],"research.":[88],"METHODS:":[89],"collected":[91],"data":[92,264,341],"regarding":[93],"classification,":[94],"molecular":[95,395],"treatment,":[100],"drawn":[101],"from":[102,277],"existing":[104,354],"literature,":[105],"including":[106],"abstracts":[107],"verbal":[109],"accounts.":[110],"By":[111],"term":[113],"\"basal-like\",":[114],"we":[115,140],"cases":[118],"where":[119],"gene":[120],"array":[122],"or":[123],"more":[124,212,284],"sophisticated":[125],"immunophenotypes":[126],"are":[127,203,221,342],"used":[128],"identification.":[130],"When":[131],"is":[134,184,214,307],"restricted":[135],"assay":[138],"(immunohistochemistry),":[139],"refer":[141],"\"triple-negative\".":[143],"RESULTS:":[144],"Basal-like":[145],"expresses":[148],"genes":[149],"characteristic":[150],"basal":[152,159,178],"epithelial":[153],"cells,":[154],"which":[155,345],"include":[156,317],"high-molecular":[157],"weight":[158],"cytokeratins":[160,181],"(CK5/6,":[161],"CK14,":[162],"CK17),":[163],"vimentin,":[164],"p-cadherin,":[165],"alpha":[166],"B":[167],"crystalline,":[168],"caveolins":[169],"1":[170],"2":[172],"EGFR.":[174],"markers":[179],"(basal":[180],"EGFR)":[183],"related":[185],"worse":[188],"prognosis":[189],"identifies":[191],"clinically":[193],"subgroup":[195,363,384],"within":[196],"BRCA1":[201],"mutations":[202],"present":[204],"in":[205,312,382],"11%":[206],"tumors":[209],"even":[211],"rare":[213],"BRCA2":[215],"deficiency.":[216],"BR-CA1-associated":[217],"cancers":[219],"typically":[222],"characterized":[223],"high":[226],"rate":[227],"DNA":[229,233],"aberrations":[230],"defective":[232],"repair":[234],"pathways":[235],"(the":[236],"so-called":[237],"\"BRCAness\").":[238],"use":[240],"regimens":[242],"based":[243,291],"on":[244,292,344],"DNA-damaging":[245],"agents,":[246,319],"such":[247],"as":[248,375,385],"anthracyclines,":[249],"platinum":[250],"derivatives":[251],"cyclophosphamide":[253],"seems":[254],"sensible":[256],"option":[257],"this":[259,361,383,398],"subtypes.":[262],"Clinical":[263],"support":[265],"strong":[267],"sensitivity":[268],"primary":[270],"chemotherapy":[271,298],"response":[274,296],"rates":[275],"ranging":[276],"27-45%":[278],"(with":[279],"anthracyclines":[280],"taxanes)":[282],"than":[285],"60%":[286],"platinum-based":[288],"triplets.":[289],"However,":[290],"data,":[294],"major":[295],"does":[299],"not":[300],"carry":[301],"better":[302],"survival":[303],"(\"triple-negative":[304],"paradox\").":[305],"There":[306],"no":[308],"specific":[309,330],"targeted":[310],"therapy":[311],"armamentarium:":[314],"anti-angiogenic":[318],"anti-EGFR":[320],"EGFR-TK":[322],"inhibitors,":[323],"epothilones":[324],"PARP":[326],"inhibitors.":[327],"CONCLUSIONS:":[328],"A":[329,388],"systemic":[331],"regimen":[332],"cannot":[333],"yet":[334],"be":[335,349,358],"recommended.":[336],"Moreover,":[337],"only":[338],"few":[340],"available":[343],"treatment":[346,404],"selection":[347],"can":[348,357],"based.":[350],"Use":[351],"cytotoxic":[355],"agents":[356],"optimized":[359],"patient":[362],"investigating":[365],"proliferative":[367],"signals":[368,374],"suitability":[371],"these":[373,406],"targets,":[377],"besides":[378],"assessing":[379],"BRCA1-pathway":[381],"regards":[386],"treatment.":[387],"greater":[389],"understanding":[390],"characteristics":[396],"phenotype":[399],"may":[400],"lead":[401],"customized":[403],"patients.":[407]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
