{"id":"https://openalex.org/W98930995","doi":"https://doi.org/10.1002/cpt1976202184","title":"Blood levels and electroencephalographic effects of diazepam and bromazepam","display_name":"Blood levels and electroencephalographic effects of diazepam and bromazepam","publication_year":1976,"publication_date":"1976-08-01","ids":{"openalex":"https://openalex.org/W98930995","doi":"https://doi.org/10.1002/cpt1976202184","mag":"98930995","pmid":"https://pubmed.ncbi.nlm.nih.gov/7375"},"language":"en","primary_location":{"id":"doi:10.1002/cpt1976202184","doi":"https://doi.org/10.1002/cpt1976202184","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt1976202184","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103038026","display_name":"Max Fink","orcid":"https://orcid.org/0000-0002-7582-2637","observed_orcids":["https://orcid.org/0000-0002-7582-2637"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max Fink","raw_affiliation_strings":["Department of Psychiatry, Health Sciences Center, SUNY at Stony Brook, Stony Brook, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Health Sciences Center, SUNY at Stony Brook, Stony Brook, N. Y","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Irwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Irwin","raw_affiliation_strings":["Department of Psychiatry, Health Sciences Center, SUNY at Stony Brook, Stony Brook, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Health Sciences Center, SUNY at Stony Brook, Stony Brook, N. Y","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027784171","display_name":"Robert E. Weinfeld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert E. Weinfeld","raw_affiliation_strings":["Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Stony Brook, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Stony Brook, N. Y","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112195286","display_name":"Morton A. Schwartz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morton A. Schwartz","raw_affiliation_strings":["Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Stony Brook, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Stony Brook, N. Y","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007717642","display_name":"Allan H. Canney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allan H. Canney","raw_affiliation_strings":["Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Stony Brook, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Stony Brook, N. Y","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":4.4293,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.92775665,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"20","issue":"2","first_page":"184","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.31859999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.31859999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.16459999978542328,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.11819999665021896,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bromazepam","display_name":"bromazepam","score":1.0},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9539999961853027},{"id":"https://openalex.org/keywords/blood-levels","display_name":"blood concentration","score":0.6290000081062317},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.703000009059906},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"EEG","score":0.8519999980926514},{"id":"https://openalex.org/keywords/quantitative-eeg","display_name":"quantitative EEG","score":0.6949999928474426},{"id":"https://openalex.org/keywords/beta-band-activity","display_name":"beta activity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/alpha-activity","display_name":"alpha activity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-effects-on-brain-activity","display_name":"drug effects on brain activity","score":0.5580000281333923},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6000000238418579},{"id":"https://openalex.org/keywords/single-oral-dose","display_name":"single oral dose","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2778519950","wikidata":"https://www.wikidata.org/wiki/Q422435","display_name":"Bromazepam","level":4,"score":0.9935942888259888},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.828810453414917},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.7469027042388916},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4547703266143799},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.4461386203765869},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.4230617880821228},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4125072956085205},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3815631568431854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3667345643043518},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36670777201652527},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3317292034626007},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26477980613708496},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.25133875012397766},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.2252105474472046},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.12922576069831848},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.06430473923683167},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001611","descriptor_name":"Beta Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001960","descriptor_name":"Bromazepam","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001960","descriptor_name":"Bromazepam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/cpt1976202184","doi":"https://doi.org/10.1002/cpt1976202184","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt1976202184","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:7375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1996394825","https://openalex.org/W2004145008","https://openalex.org/W1991365002","https://openalex.org/W2379290489","https://openalex.org/W1973071360","https://openalex.org/W2468289672","https://openalex.org/W1983523654","https://openalex.org/W2413324007","https://openalex.org/W2147103043","https://openalex.org/W4238199039"],"abstract_inverted_index":{"Blood":[0,53],"levels":[1,54,89,104,118],"and":[2,22,40,105,119,143],"electroencephalographic":[3],"(EEG)":[4],"data":[5],"were":[6,65],"collected":[7],"for":[8],"2":[9],"hr":[10],"after":[11,79],"single":[12],"oral":[13],"doses":[14],"of":[15,55,58,63,81,87,90,107,122,146],"bromazepam":[16,64,84,116],"(9":[17,46],"mg),":[18,21],"diazepam":[19,59,82,102],"(10":[20],"placebo":[23],"in":[24,34,43,50,70,76,137],"13":[25,38],"male":[26],"adult":[27],"volunteers.":[28],"Both":[29],"drugs":[30],"caused":[31],"an":[32],"increase":[33],"beta":[35,72,110],"activity":[36,45],"(above":[37],"Hz)":[39,49],"a":[41,94,131],"decrease":[42],"alpha":[44],"to":[47],"11":[48],"the":[51,77,112,120],"EEG.":[52],"100":[56],"ng/ml":[57,62],"or":[60,83],"50":[61],"associated":[66],"with":[67],"significant":[68,96],"changes":[69,75,124],"EEG":[71,78,109,123,129],"activity.":[73],"Temporal":[74],"administration":[80],"paralleled":[85],"development":[86],"plasma":[88],"these":[91],"drugs.":[92],"Although":[93],"weakly":[95],"correlation":[97],"was":[98,125],"found":[99],"between":[100,114],"measurable":[101,115],"blood":[103,117],"amount":[106],"increased":[108],"activity,":[111,140],"relationship":[113],"degree":[121],"not":[126],"significant.":[127],"Quantitative":[128],"is":[130],"sensitive":[132],"continuous":[133],"response":[134,141],"measure,":[135],"useful":[136],"defining":[138],"cerebral":[139],"latency,":[142],"relative":[144],"potency":[145],"psychoactive":[147],"benzodiazepines.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
