{"id":"https://openalex.org/W989088954","doi":"https://doi.org/10.1016/s0091-679x(08)60769-4","title":"Chapter 15 Serial Cultivation of Normal Human Epidermal Keratinocytes","display_name":"Chapter 15 Serial Cultivation of Normal Human Epidermal Keratinocytes","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W989088954","doi":"https://doi.org/10.1016/s0091-679x(08)60769-4","mag":"989088954","pmid":"https://pubmed.ncbi.nlm.nih.gov/6157968"},"language":"en","primary_location":{"id":"doi:10.1016/s0091-679x(08)60769-4","doi":"https://doi.org/10.1016/s0091-679x(08)60769-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0091-679x(08)60769-4","pdf_url":null,"source":{"id":"https://openalex.org/S177811526","display_name":"Methods in cell biology","issn_l":"0091-679X","issn":["0091-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Cell Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4241958508","display_name":null},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108202793","display_name":"James G. Rheinwald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James G. Rheinwald","raw_affiliation_strings":["Laboratory of Tumor Biology, Sidney Farber Cancer Institute, and Department of Physiology, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor Biology, Sidney Farber Cancer Institute, and Department of Physiology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108202793"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":9.8116,"has_fulltext":false,"cited_by_count":263,"citation_normalized_percentile":{"value":0.97769517,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21A","issue":null,"first_page":"229","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-epidermal-keratinocytes","display_name":"human epidermal keratinocytes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/serial-passage","display_name":"serial passage","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.972000002861023},{"id":"https://openalex.org/keywords/epithelioid-morphology","display_name":"epithelioid morphology","score":0.8199999928474426},{"id":"https://openalex.org/keywords/plating-efficiency","display_name":"plating efficiency","score":0.8080000281333923},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2781140480","wikidata":"https://www.wikidata.org/wiki/Q673203","display_name":"Foreskin","level":3,"score":0.9445335865020752},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.7782642841339111},{"id":"https://openalex.org/C132351222","wikidata":"https://www.wikidata.org/wiki/Q7454699","display_name":"Serial passage","level":3,"score":0.6306331157684326},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.5729820132255554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5334202647209167},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5264374017715454},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.5240490436553955},{"id":"https://openalex.org/C2910180214","wikidata":"https://www.wikidata.org/wiki/Q96072446","display_name":"Colony morphology","level":3,"score":0.5108065605163574},{"id":"https://openalex.org/C2776127477","wikidata":"https://www.wikidata.org/wiki/Q17093220","display_name":"Plating efficiency","level":3,"score":0.48087266087532043},{"id":"https://openalex.org/C2776746612","wikidata":"https://www.wikidata.org/wiki/Q68153243","display_name":"3T3 cells","level":4,"score":0.4607132375240326},{"id":"https://openalex.org/C90703135","wikidata":"https://www.wikidata.org/wiki/Q3287622","display_name":"Tissue culture","level":3,"score":0.4545542001724243},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4521132707595825},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3679952621459961},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09601181745529175},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08920720219612122},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.07304456830024719},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0091-679x(08)60769-4","doi":"https://doi.org/10.1016/s0091-679x(08)60769-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0091-679x(08)60769-4","pdf_url":null,"source":{"id":"https://openalex.org/S177811526","display_name":"Methods in cell biology","issn_l":"0091-679X","issn":["0091-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Cell Biology","raw_type":"book-chapter"},{"id":"pmid:6157968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6157968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W265175382","https://openalex.org/W1480464953","https://openalex.org/W1489798343","https://openalex.org/W1498071142","https://openalex.org/W1579523891","https://openalex.org/W1975032189","https://openalex.org/W1979580749","https://openalex.org/W1988351869","https://openalex.org/W1995352333","https://openalex.org/W2001571525","https://openalex.org/W2012046594","https://openalex.org/W2012587946","https://openalex.org/W2012933891","https://openalex.org/W2014651656","https://openalex.org/W2020931110","https://openalex.org/W2022608661","https://openalex.org/W2030685916","https://openalex.org/W2032320245","https://openalex.org/W2044625627","https://openalex.org/W2045934824","https://openalex.org/W2048274205","https://openalex.org/W2049043712","https://openalex.org/W2051908231","https://openalex.org/W2056971358","https://openalex.org/W2063034532","https://openalex.org/W2070989663","https://openalex.org/W2078497185","https://openalex.org/W2134398178","https://openalex.org/W2142279254","https://openalex.org/W2143296539","https://openalex.org/W2149239195","https://openalex.org/W2161229567","https://openalex.org/W2169413646","https://openalex.org/W2204543574","https://openalex.org/W2405664399"],"related_works":["https://openalex.org/W2049043712","https://openalex.org/W1980494221","https://openalex.org/W4233116709","https://openalex.org/W2073053122","https://openalex.org/W33493984","https://openalex.org/W2398404409","https://openalex.org/W130818297","https://openalex.org/W2075198678","https://openalex.org/W2049879342","https://openalex.org/W2097754571"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
