{"id":"https://openalex.org/W989016276","doi":null,"title":"Role of the brain-gut axis in alcohol-related gastrointestinal diseases--what can we learn from new animal models?","display_name":"Role of the brain-gut axis in alcohol-related gastrointestinal diseases--what can we learn from new animal models?","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W989016276","mag":"989016276","pmid":"https://pubmed.ncbi.nlm.nih.gov/15075460"},"language":"en","primary_location":{"id":"pmid:15075460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15075460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016339618","display_name":"S\u00f6ren Siegmund","orcid":"https://orcid.org/0000-0002-6864-7316","observed_orcids":["https://orcid.org/0000-0002-6864-7316"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Siegmund","raw_affiliation_strings":["Department of Medicine II (Gastroenterology, Hepatology and Infectious Diseases), University Hospital of Heidelberg at Mannheim, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II (Gastroenterology, Hepatology and Infectious Diseases), University Hospital of Heidelberg at Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I4210156450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016315764","display_name":"Rainer Spanagel","orcid":"https://orcid.org/0000-0003-2151-4521","observed_orcids":["https://orcid.org/0000-0003-2151-4521"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Spanagel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112219226","display_name":"Manfred Vincenz Singer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M V Singer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3916,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.80531365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"54 Suppl 4","issue":null,"first_page":"191","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.6514000296592712,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.6514000296592712,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.3416000008583069,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.996999979019165},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.7549999952316284},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.46399998664855957},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5550000071525574},{"id":"https://openalex.org/keywords/gastrointestinal-tract","display_name":"gastrointestinal tract","score":0.38999998569488525},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.7404968738555908},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.661585807800293},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.5822486281394958},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5716906785964966},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.4768570363521576},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.46484607458114624},{"id":"https://openalex.org/C3019635848","wikidata":"https://www.wikidata.org/wiki/Q154","display_name":"Alcohol consumption","level":3,"score":0.4366248548030853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40048304200172424},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38502436876296997},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.378826379776001},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34971553087234497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33469265699386597},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1544111967086792}],"mesh":[{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15075460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15075460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:989016276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15075460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W56354511","https://openalex.org/W308313725","https://openalex.org/W1483577471","https://openalex.org/W1520851017","https://openalex.org/W1531194275","https://openalex.org/W1549277110","https://openalex.org/W1568862341","https://openalex.org/W1571328655","https://openalex.org/W1746875878","https://openalex.org/W1882587848","https://openalex.org/W1895496048","https://openalex.org/W1912712793","https://openalex.org/W1964022477","https://openalex.org/W1967644451","https://openalex.org/W1970177916","https://openalex.org/W1971264634","https://openalex.org/W1971453658","https://openalex.org/W1972011401","https://openalex.org/W1973807311","https://openalex.org/W1975101709","https://openalex.org/W1977646879","https://openalex.org/W1981991060","https://openalex.org/W1983756178","https://openalex.org/W1984451937","https://openalex.org/W1990259332","https://openalex.org/W1990716431","https://openalex.org/W1993229630","https://openalex.org/W1995541582","https://openalex.org/W1997807930","https://openalex.org/W1998126165","https://openalex.org/W1999909480","https://openalex.org/W2016601048","https://openalex.org/W2018284650","https://openalex.org/W2019785605","https://openalex.org/W2028537662","https://openalex.org/W2038215286","https://openalex.org/W2050516272","https://openalex.org/W2052411813","https://openalex.org/W2058445485","https://openalex.org/W2059579259","https://openalex.org/W2060124672","https://openalex.org/W2067034672","https://openalex.org/W2068936134","https://openalex.org/W2069957666","https://openalex.org/W2076899974","https://openalex.org/W2077890443","https://openalex.org/W2079419480","https://openalex.org/W2080862729","https://openalex.org/W2089933763","https://openalex.org/W2091474137","https://openalex.org/W2091556962","https://openalex.org/W2091882501","https://openalex.org/W2092018837","https://openalex.org/W2109229257","https://openalex.org/W2116322652","https://openalex.org/W2120727644","https://openalex.org/W2121734550","https://openalex.org/W2129003075","https://openalex.org/W2129350012","https://openalex.org/W2144658154","https://openalex.org/W2158115297","https://openalex.org/W2159077908","https://openalex.org/W2170870992","https://openalex.org/W2171987385","https://openalex.org/W2395883610","https://openalex.org/W2401472268","https://openalex.org/W2404843966","https://openalex.org/W2410370109","https://openalex.org/W2411646242","https://openalex.org/W2413670161","https://openalex.org/W2416268145"],"related_works":["https://openalex.org/W2317699938","https://openalex.org/W3068313476","https://openalex.org/W7217167007","https://openalex.org/W1973807311","https://openalex.org/W3169627004","https://openalex.org/W2159084443","https://openalex.org/W4398165479","https://openalex.org/W2951452761","https://openalex.org/W4405247087","https://openalex.org/W4388840630"],"abstract_inverted_index":{"Ethanol":[0],"exerts":[1],"multiple":[2],"actions":[3],"on":[4,12,30,94],"nearly":[5],"all":[6],"organs":[7],"of":[8,45,133,143,172,192,208,243,256],"the":[9,13,18,26,31,34,37,42,46,74,95,120,124,130,144,176,204,248,254],"body,":[10],"especially":[11],"central":[14,38],"nervous":[15],"system":[16,40],"and":[17,41,77,136,196,199,271,273],"gastrointestinal":[19,47,84,179],"tract.":[20,48],"However,":[21,110],"little":[22],"is":[23,50,66],"known":[24],"about":[25],"effects":[27,93],"ethanol":[28,53,92,134],"has":[29],"brain-gut":[32,75,96,145,249],"axis,":[33],"linkage":[35],"between":[36],"neural":[39],"autonomous":[43],"innervation":[44],"It":[49],"indisputable":[51],"that":[52],"consumption":[54,71,135],"does":[55],"affect":[56,247],"e.g.":[57,119,154],"exocrine":[58],"pancreatic":[59],"secretion":[60],"or":[61,123,251],"intestinal":[62],"motility,":[63],"but":[64],"it":[65],"poorly":[67],"understood,":[68],"how":[69,78],"alcohol":[70,117,151,180,193,209],"may":[72,80],"disturb":[73],"axis":[76,97,250],"this":[79,108,164,183,224],"cause":[81],"damage":[82],"to":[83,87,106,163,190,223,236],"organs.":[85],"Due":[86,162],"difficulties":[88],"in":[89,98,116,178,213,229,280],"directly":[90],"assessing":[91],"humans,":[99],"animal":[100,112,170,282],"models":[101,113,148],"represent":[102],"a":[103],"versatile":[104],"tool":[105],"study":[107],"topic.":[109],"conventional":[111],"widely":[114],"utilized":[115],"research,":[118,156],"Tsukamoto-French":[121],"model":[122,171,225],"Lieber-DeCarli":[125],"model,":[126,184,260],"do":[127],"not":[128,139],"mimic":[129],"human":[131],"conditions":[132],"are":[137,157,186,226],"therefore":[138],"suitable":[140],"for":[141,175,232],"studies":[142],"axis.":[146],"Established":[147],"from":[149,220],"other":[150],"research":[152],"disciplines,":[153],"addiction":[155],"by":[158],"far":[159],"more":[160],"applicable.":[161],"reason,":[165],"we":[166],"have":[167],"established":[168],"an":[169],"alcohol-dependent":[173],"rats":[174,185,205,221],"use":[177],"research.":[181],"In":[182,239,258],"given":[187],"free":[188],"access":[189],"different":[191],"solutions":[194],"(5%":[195],"20%":[197],"v/v)":[198],"tap":[200],"water.":[201],"Over":[202],"time,":[203],"develop":[206],"signs":[207],"dependence":[210],"as":[211,266],"seen":[212],"humans":[214],"(e.g.":[215],"deprivation":[216],"effect).":[217],"Organs":[218],"isolated":[219],"exposed":[222],"currently":[227],"investigated":[228],"our":[230,259],"laboratory":[231],"alcohol-related":[233],"gene-regulation":[234],"compared":[235],"non-alcoholic":[237,241,275],"littermates.":[238],"addition,":[240],"components":[242],"alcoholic":[244,263],"beverages":[245,264],"might":[246],"possibly":[252],"potentiate":[253],"toxicity":[255],"ethanol.":[257],"commonly":[261],"ingested":[262],"such":[265],"beer,":[267],"wine,":[268],"cognac,":[269],"vodka,":[270],"whisky":[272],"their":[274],"constituents":[276],"will":[277],"be":[278],"tested":[279],"future":[281],"studies.":[283]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
