{"id":"https://openalex.org/W98893913","doi":null,"title":"Unraveling the genetics of lymphocytic thyroiditis using the dog as a model","display_name":"Unraveling the genetics of lymphocytic thyroiditis using the dog as a model","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W98893913","mag":"98893913"},"language":"en","primary_location":{"id":"pmh:oai:pub.epsilon.slu.se:8890","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/8890/1/sundberg_k_120515.pdf","pdf_url":"https://pub.epsilon.slu.se/8890/1/sundberg_k_120515.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pub.epsilon.slu.se/8890/1/sundberg_k_120515.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064982407","display_name":"Katarina Sundberg","orcid":"https://orcid.org/0000-0002-6641-7058","observed_orcids":["https://orcid.org/0000-0002-6641-7058"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Katarina Sundberg","raw_affiliation_strings":["Swedish UNiversity of Agricultural Sciences;"],"raw_orcid":"https://orcid.org/0000-0002-6641-7058","affiliations":[{"raw_affiliation_string":"Swedish UNiversity of Agricultural Sciences;","institution_ids":["https://openalex.org/I298625061"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064982407"],"corresponding_institution_ids":["https://openalex.org/I298625061"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11214","display_name":"Human-Animal Interaction Studies","score":0.3149000108242035,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11214","display_name":"Human-Animal Interaction Studies","score":0.3149000108242035,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.17180000245571136,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.10570000112056732,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hashimoto-s-thyroiditis","display_name":"Hashimoto's thyroiditis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/autoimmune-thyroid-disease","display_name":"autoimmune thyroid disease","score":0.8889999985694885},{"id":"https://openalex.org/keywords/anti-thyroglobulin-antibodies","display_name":"thyroglobulin antibodies","score":0.8220000267028809},{"id":"https://openalex.org/keywords/susceptibility-loci","display_name":"genetic susceptibility loci","score":0.8399999737739563},{"id":"https://openalex.org/keywords/chromosome-11","display_name":"chromosome 11","score":0.8199999928474426},{"id":"https://openalex.org/keywords/x-chromosome","display_name":"X chromosome","score":0.7820000052452087},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/immunoregulatory-genes","display_name":"immunoregulatory genes","score":0.5519999861717224},{"id":"https://openalex.org/keywords/disease-prevalence","display_name":"disease prevalence","score":0.5199999809265137},{"id":"https://openalex.org/keywords/birth-cohort","display_name":"birth cohort","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C2778696486","wikidata":"https://www.wikidata.org/wiki/Q11835644","display_name":"Thyroiditis","level":3,"score":0.646435558795929},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5690728425979614},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5538095235824585},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5500503778457642},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5116961002349854},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49723199009895325},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.460293173789978},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.44821375608444214},{"id":"https://openalex.org/C2778835679","wikidata":"https://www.wikidata.org/wiki/Q412228","display_name":"Thyroglobulin","level":3,"score":0.41464585065841675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38759276270866394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33575165271759033},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.32827073335647583},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2507769465446472},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18344929814338684},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.13732454180717468}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pub.epsilon.slu.se:8890","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/8890/1/sundberg_k_120515.pdf","pdf_url":"https://pub.epsilon.slu.se/8890/1/sundberg_k_120515.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:98893913","doi":null,"is_oa":false,"landing_page_url":"http://hunddna.slu.se/artikelserie/sundberg_k_120515.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pub.epsilon.slu.se:8890","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/8890/1/sundberg_k_120515.pdf","pdf_url":"https://pub.epsilon.slu.se/8890/1/sundberg_k_120515.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W98893913.pdf","grobid_xml":"https://content.openalex.org/works/W98893913.grobid-xml"},"referenced_works_count":128,"referenced_works":["https://openalex.org/W15174526","https://openalex.org/W88345891","https://openalex.org/W141529446","https://openalex.org/W151466811","https://openalex.org/W1516680128","https://openalex.org/W1557532746","https://openalex.org/W1696700690","https://openalex.org/W1805116264","https://openalex.org/W1940451643","https://openalex.org/W1965621126","https://openalex.org/W1965944445","https://openalex.org/W1966401136","https://openalex.org/W1966791341","https://openalex.org/W1966855857","https://openalex.org/W1967491345","https://openalex.org/W1968488340","https://openalex.org/W1970673125","https://openalex.org/W1970935798","https://openalex.org/W1971030675","https://openalex.org/W1975132252","https://openalex.org/W1978663857","https://openalex.org/W1978835344","https://openalex.org/W1979171839","https://openalex.org/W1979378256","https://openalex.org/W1981157461","https://openalex.org/W1982855130","https://openalex.org/W1983531930","https://openalex.org/W1985599438","https://openalex.org/W1986032822","https://openalex.org/W1987677365","https://openalex.org/W1988377203","https://openalex.org/W1989916106","https://openalex.org/W1993761888","https://openalex.org/W1994194462","https://openalex.org/W1994402720","https://openalex.org/W1998700764","https://openalex.org/W2004912505","https://openalex.org/W2007437829","https://openalex.org/W2008253075","https://openalex.org/W2010293202","https://openalex.org/W2014119246","https://openalex.org/W2016193783","https://openalex.org/W2020059313","https://openalex.org/W2020279596","https://openalex.org/W2024439539","https://openalex.org/W2027545702","https://openalex.org/W2029084094","https://openalex.org/W2029525545","https://openalex.org/W2031457671","https://openalex.org/W2032508052","https://openalex.org/W2034207313","https://openalex.org/W2034458200","https://openalex.org/W2036651170","https://openalex.org/W2037999529","https://openalex.org/W2039490296","https://openalex.org/W2039534921","https://openalex.org/W2039656950","https://openalex.org/W2041994695","https://openalex.org/W2042666870","https://openalex.org/W2045998248","https://openalex.org/W2046383867","https://openalex.org/W2047548224","https://openalex.org/W2050355034","https://openalex.org/W2055220223","https://openalex.org/W2059442774","https://openalex.org/W2060311755","https://openalex.org/W2062329960","https://openalex.org/W2063544841","https://openalex.org/W2067096831","https://openalex.org/W2067938725","https://openalex.org/W2067994065","https://openalex.org/W2068040418","https://openalex.org/W2069477606","https://openalex.org/W2070565176","https://openalex.org/W2073919303","https://openalex.org/W2077684781","https://openalex.org/W2077797960","https://openalex.org/W2081901919","https://openalex.org/W2082174273","https://openalex.org/W2082669774","https://openalex.org/W2085024301","https://openalex.org/W2085231230","https://openalex.org/W2085737748","https://openalex.org/W2086094222","https://openalex.org/W2086483732","https://openalex.org/W2089901745","https://openalex.org/W2094579035","https://openalex.org/W2100779666","https://openalex.org/W2101295479","https://openalex.org/W2103377785","https://openalex.org/W2103441770","https://openalex.org/W2103575733","https://openalex.org/W2105243482","https://openalex.org/W2108234281","https://openalex.org/W2111402500","https://openalex.org/W2112931786","https://openalex.org/W2114611642","https://openalex.org/W2120802636","https://openalex.org/W2121637377","https://openalex.org/W2122733513","https://openalex.org/W2124204679","https://openalex.org/W2126065508","https://openalex.org/W2127594892","https://openalex.org/W2132353098","https://openalex.org/W2134397552","https://openalex.org/W2135167801","https://openalex.org/W2135373024","https://openalex.org/W2137221262","https://openalex.org/W2139164352","https://openalex.org/W2139900172","https://openalex.org/W2140960450","https://openalex.org/W2144137532","https://openalex.org/W2146325173","https://openalex.org/W2148654292","https://openalex.org/W2155845523","https://openalex.org/W2156639627","https://openalex.org/W2161633633","https://openalex.org/W2162418988","https://openalex.org/W2163370016","https://openalex.org/W2163969306","https://openalex.org/W2167909201","https://openalex.org/W2169346460","https://openalex.org/W2169921444","https://openalex.org/W2200485632","https://openalex.org/W2270816048","https://openalex.org/W2333239350","https://openalex.org/W2427216613","https://openalex.org/W7099200879"],"related_works":["https://openalex.org/W1970925731","https://openalex.org/W7095452137","https://openalex.org/W2130897826","https://openalex.org/W1804890531","https://openalex.org/W767103321","https://openalex.org/W2065480446","https://openalex.org/W2124479090","https://openalex.org/W7011356551","https://openalex.org/W2615943815","https://openalex.org/W2539252167"],"abstract_inverted_index":{"The":[0,59],"domestic":[1],"dog,":[2],"with":[3,240],"its":[4,96],"unique":[5],"genetic":[6,42,164,203,270],"structure":[7],"formed":[8],"by":[9,181],"domestication":[10],"and":[11,41,66,82,95,107,122,136,141,154,234,244],"recent":[12],"breed":[13],"creation,":[14],"has":[15,62],"been":[16,63],"proven":[17],"to":[18,37,72,89,98,103,133],"be":[19],"an":[20,268],"excellent":[21,269],"model":[22,36,271],"for":[23,127,207,272],"mapping":[24],"disease":[25,75,83,209],"genes.":[26],"In":[27],"this":[28],"thesis,":[29],"we":[30,116,159,190,223],"use":[31],"the":[32,39,51,151,155,163,169,187,208,217,253],"dog":[33],"as":[34,201,210,212,267],"a":[35,68,144,176,182,202,213],"investigate":[38],"prevalence":[40,147],"background":[43,165],"of":[44,50,77,131,148,166,256],"canine":[45,60],"lymphocytic":[46],"thyroiditis":[47],"(CLT),":[48],"one":[49],"most":[52],"common":[53],"immune":[54],"related":[55],"diseases":[56],"in":[57,150,168,249,258],"dogs.":[58],"phenotype":[61],"carefully":[64],"characterized":[65],"suggests":[67],"strong":[69,227],"comparative":[70],"value":[71],"human":[73,99,260,273],"Hashimoto\u2019s":[74],"because":[76],"similar":[78],"etiology,":[79],"clinical":[80],"signs":[81],"progression.":[84],"Therefore,":[85],"our":[86,111,263],"aim":[87],"was":[88],"gain":[90],"increased":[91],"knowledge":[92],"about":[93],"CLT":[94,149,167,266],"relevance":[97],"autoimmune":[100,261],"thyroid":[101,137],"disease,":[102],"benefit":[104],"both":[105,200],"dogs":[106],"humans.":[108],"\\n":[109,275],"\\nIn":[110],"first":[112,188],"study":[113],"(paper":[114],"I)":[115],"screened":[117],"two":[118,173,225],"birth":[119],"cohorts":[120],"(3-4":[121],"6-7":[123],"years":[124],"old,":[125],"respectively)":[126],"elevated":[128],"serum":[129],"levels":[130],"autoantibodies":[132],"thyroglobulin":[134],"(TgAA)":[135],"stimulating":[138],"hormone":[139],"(TSH)":[140],"could":[142],"estimate":[143],"very":[145],"high":[146],"giant":[152],"schnauzer":[153],"hovawart":[156],"breeds.":[157],"Next,":[158],"aimed":[160],"at":[161],"unraveling":[162],"same":[170],"breeds,":[171],"using":[172],"different":[174],"approaches;":[175],"candidate":[177],"gene":[178],"approach":[179,189],"followed":[180],"genome-wide":[183],"association":[184,222],"analysis.":[185],"Using":[186,219],"obtained":[191],"evidence":[192],"that":[193],"DLA":[194],"class":[195],"II":[196],"polymorphisms":[197],"can":[198],"function":[199],"risk":[204],"factor":[205,215],"predisposing":[206],"well":[211],"protective":[214],"against":[216],"disease.":[218],"genome":[220],"wide":[221],"identified":[224],"additional":[226],"susceptibility":[228],"loci":[229],"located":[230],"on":[231],"chromosome":[232],"11":[233],"X.":[235],"Both":[236],"regions":[237],"harbour":[238],"genes":[239,247],"known":[241],"immune-regulatory":[242],"functions":[243],"implicates":[245],"three":[246],"involved":[248],"NF-\u03baB":[250],"pathway.":[251],"Given":[252],"reported":[254],"role":[255],"\\nNF-\u03baB":[257],"many":[259],"diseases,":[262],"results":[264],"suggest":[265],"thyroiditis.":[274]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}