{"id":"https://openalex.org/W987810374","doi":null,"title":"Utilizzo dei fibroblasti in coltura nella diagnostica biochimica delle malattie da accumulo lisosomale","display_name":"Utilizzo dei fibroblasti in coltura nella diagnostica biochimica delle malattie da accumulo lisosomale","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W987810374","mag":"987810374"},"language":"it","primary_location":{"id":"pmh:oai:boa.unimib.it:10281/14490","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10281/14490","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026249978","display_name":"V Chigorno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chigorno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035014869","display_name":"Sandro Sonnino","orcid":"https://orcid.org/0000-0001-8180-5908","observed_orcids":["https://orcid.org/0000-0001-8180-5908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandro Sonnino","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8180-5908","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010537056","display_name":"Giancarlo Goi","orcid":"https://orcid.org/0000-0003-0578-1312","observed_orcids":["https://orcid.org/0000-0003-0578-1312"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Goi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0578-1312","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066783333","display_name":"Marina Pitto","orcid":"https://orcid.org/0000-0001-7300-3016","observed_orcids":["https://orcid.org/0000-0001-7300-3016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marina Pitto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7300-3016","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":null,"first_page":"112","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12604","display_name":"Glycogen Storage Diseases and Myoclonus","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cultured-fibroblasts","display_name":"cultured fibroblasts","score":0.972000002861023},{"id":"https://openalex.org/keywords/lysosomal-storage-disorders","display_name":"lysosomal storage disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/biochemical-diagnosis","display_name":"biochemical diagnosis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/fluorescent-substrate","display_name":"fluorescent substrate","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.5017297267913818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36420583724975586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35816431045532227},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3426669239997864},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.09272041916847229}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:boa.unimib.it:10281/14490","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10281/14490","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:987810374","doi":null,"is_oa":false,"landing_page_url":"https://boa.unimib.it/handle/10281/14490","pdf_url":null,"source":{"id":"https://openalex.org/S5406936165","display_name":"Biochimica Clinica","issn_l":"0392-7091","issn":["0392-7091","0393-0564"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800528","host_organization_name":"Edizioni Minerva Medica","host_organization_lineage":["https://openalex.org/P4320800528"],"host_organization_lineage_names":["Edizioni Minerva Medica"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"BIOCHIMICA CLINICA","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W149130878","https://openalex.org/W583431406","https://openalex.org/W585721197","https://openalex.org/W1483242733","https://openalex.org/W1536736330","https://openalex.org/W1549799773","https://openalex.org/W1607224521","https://openalex.org/W1988022242","https://openalex.org/W1988190120","https://openalex.org/W2000387027","https://openalex.org/W2032073915","https://openalex.org/W2041108499","https://openalex.org/W2047210662","https://openalex.org/W2060147167","https://openalex.org/W2086693653","https://openalex.org/W2152085422","https://openalex.org/W2171479896"],"related_works":["https://openalex.org/W2416866737","https://openalex.org/W2396081850","https://openalex.org/W20912500","https://openalex.org/W2993733955","https://openalex.org/W2055282511","https://openalex.org/W4291415259","https://openalex.org/W7017804223","https://openalex.org/W2418356159","https://openalex.org/W2427774774","https://openalex.org/W7113042636"],"abstract_inverted_index":{"Use":[0],"of":[1,8,22,29,53,63,70],"cultured":[2,23,43],"fibroblasts":[3,24],"for":[4,25,66,79],"the":[5,15,20,26,51,61,67,76],"biochemical":[6,27,68],"diagnosis":[7,28,69],"lysosomal":[9,71],"metabolic":[10,30,46,55],"diseases.":[11,31],"This":[12],"review":[13],"delineates":[14],"main":[16],"advantages":[17],"deriving":[18],"from":[19],"use":[21,62],"Fibroblasts":[32],"can":[33],"be":[34],"frozen":[35],"in":[36],"liquid":[37],"nitrogen":[38],"and":[39,42,75],"successively":[40],"re-plated":[41],"without":[44],"undergoing":[45],"modifications,":[47],"thus":[48],"making":[49],"possible":[50],"execution":[52],"comparative":[54],"studies":[56],"on":[57],"viable":[58],"cells.":[59],"Furthermore,":[60],"these":[64],"cells":[65],"diseases":[72],"is":[73],"described":[74],"specific":[77],"techniques":[78],"their":[80],"recognition,":[81],"principally":[82],"using":[83],"radioactive":[84],"and/or":[85],"fluorescent":[86],"substrates,":[87],"are":[88],"summarized.":[89]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}