{"id":"https://openalex.org/W98776891","doi":null,"title":"Use of urinary steroid profiling for diagnosing and monitoring adrenocortical tumours.","display_name":"Use of urinary steroid profiling for diagnosing and monitoring adrenocortical tumours.","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W98776891","mag":"98776891","pmid":"https://pubmed.ncbi.nlm.nih.gov/19966352"},"language":"en","primary_location":{"id":"pmid:19966352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19966352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hong Kong medical journal = Xianggang yi xue za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110276001","display_name":"Sau Cheung Tiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166598","display_name":"Queen Elizabeth Hospital","ror":"https://ror.org/05ee2qy47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210166598"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S C Tiu","raw_affiliation_strings":["Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong. tscz01@ha.org.hk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong. tscz01@ha.org.hk","institution_ids":["https://openalex.org/I4210166598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100894031","display_name":"Angel On-Kei Chan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angel O K Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023399104","display_name":"Norman Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norman F Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079696472","display_name":"C Y Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Y Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010462547","display_name":"PY Loung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Y Loung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C H Choi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C H Choi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056340630","display_name":"Chi Chung Shek","orcid":"https://orcid.org/0000-0001-8687-0979","observed_orcids":["https://orcid.org/0000-0001-8687-0979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C C Shek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6904,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.71487398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"6","first_page":"463","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urinary-steroid-profiling","display_name":"urinary steroid profiling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/adrenocortical-carcinoma","display_name":"adrenocortical carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/adrenal-adenoma","display_name":"adrenal adenoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/disease-surveillance","display_name":"disease surveillance","score":0.781000018119812},{"id":"https://openalex.org/keywords/steroid-metabolites","display_name":"steroid metabolites","score":0.628000020980835},{"id":"https://openalex.org/keywords/gas-chromatography-mass-spectrometry","display_name":"gas chromatography-mass spectrometry","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2781399356","wikidata":"https://www.wikidata.org/wiki/Q918285","display_name":"Adrenocortical carcinoma","level":2,"score":0.9006084203720093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7372761964797974},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.6612725257873535},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6318252682685852},{"id":"https://openalex.org/C2778674399","wikidata":"https://www.wikidata.org/wiki/Q4684749","display_name":"Adrenocortical adenoma","level":3,"score":0.5909287929534912},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5394182801246643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4907125234603882},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4302799105644226},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.3062838613986969},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.10292530059814453}],"mesh":[{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018246","descriptor_name":"Adrenocortical Adenoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018246","descriptor_name":"Adrenocortical Adenoma","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D018268","descriptor_name":"Adrenocortical Carcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018268","descriptor_name":"Adrenocortical Carcinoma","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19966352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19966352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hong Kong medical journal = Xianggang yi xue za zhi","raw_type":"Journal Article"},{"id":"mag:98776891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19966352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2051037343","https://openalex.org/W2092128647","https://openalex.org/W2091317012","https://openalex.org/W1829257219","https://openalex.org/W6959796113","https://openalex.org/W7099652561","https://openalex.org/W2002793270","https://openalex.org/W2467620512","https://openalex.org/W2903858140","https://openalex.org/W3063787156"],"abstract_inverted_index":{"It":[0],"has":[1],"been":[2],"suggested":[3],"that":[4],"urinary":[5,38,73,128],"steroid":[6,39,74,94,106,129],"profiling":[7,130],"may":[8],"be":[9,137],"used":[10],"to":[11,117],"provide":[12],"information":[13],"aiding":[14],"the":[15,23,37,109,140],"diagnosis":[16,141],"and":[17,49,52,65,104,142],"monitoring":[18,143],"of":[19,27,41,72,87,98,114,144],"adrenocortical":[20,45,63,81,145],"carcinoma.":[21,146],"Nonetheless,":[22],"abnormal":[24,70],"patterns":[25,71],"suggestive":[26],"adrenal":[28],"malignancy":[29],"are":[30],"not":[31],"well":[32],"defined.":[33],"We":[34],"retrospectively":[35],"studied":[36],"profiles":[40],"five":[42],"patients":[43,60,79],"with":[44,56,61,80],"carcinoma":[46,82],"at":[47,50,83],"presentation":[48,84],"follow-up,":[51],"compared":[53],"these":[54],"results":[55],"those":[57],"from":[58],"76":[59],"benign":[62],"adenoma":[64],"172":[66],"healthy":[67],"controls.":[68],"Three":[69],"excretion":[75,97],"were":[76],"identified":[77],"in":[78,92,108,126,139],"and/or":[85],"follow-up":[86],"residual":[88],"disease:":[89],"(1)":[90],"hypersecretion":[91],"multiple":[93],"axes;":[95],"(2)":[96],"unusual":[99],"metabolites,":[100],"notably":[101],"5-pregnene-3alpha,16alpha,20alpha-triol,":[102],"5-pregnene-3beta,16alpha,20alpha-triol,":[103],"neonatal":[105],"metabolites":[107],"post-neonatal":[110],"period;":[111],"(3)":[112],"increase":[113],"tetrahydro-11-deoxycortisol":[115],"relative":[116],"total":[118],"cortisol":[119],"metabolites.":[120],"These":[121],"preliminary":[122],"findings":[123],"offer":[124],"ways":[125],"which":[127],"performed":[131],"using":[132],"gas":[133],"chromatography-mass":[134],"spectrometry":[135],"can":[136],"helpful":[138]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}