{"id":"https://openalex.org/W987298331","doi":null,"title":"Efeitos do Antagonismo dos Receptores de Pept\u00eddeos Semelhantes \u00e0 Bombesina, o GRPR e o NMBR, durante o Desenvolvimento em Ratos","display_name":"Efeitos do Antagonismo dos Receptores de Pept\u00eddeos Semelhantes \u00e0 Bombesina, o GRPR e o NMBR, durante o Desenvolvimento em Ratos","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W987298331","mag":"987298331"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:1598668","doi":null,"is_oa":true,"landing_page_url":"http://tede2.pucrs.br/tede2/handle/tede/5416","pdf_url":"http://tede2.pucrs.br/tede2/handle/tede/5416","source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da PUC_RS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://tede2.pucrs.br/tede2/handle/tede/5416","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009769870","display_name":"Juliana Presti Torres","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Juliana Presti Torres","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009769870"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.2249000072479248,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.11509999632835388,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.8180000185966492},{"id":"https://openalex.org/keywords/gastrin-releasing-peptide-receptor","display_name":"gastrin-releasing peptide receptor","score":0.8370000123977661},{"id":"https://openalex.org/keywords/rc-3095","display_name":"RC-3095","score":0.9700000286102295},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.9380000233650208},{"id":"https://openalex.org/keywords/social-behavior","display_name":"social behavior","score":0.7360000014305115},{"id":"https://openalex.org/keywords/social-interaction","display_name":"social interaction","score":0.4189999997615814},{"id":"https://openalex.org/keywords/recognition-memory","display_name":"recognition memory","score":0.5659999847412109},{"id":"https://openalex.org/keywords/nmda-receptor-nr1","display_name":"NMDA receptor NR1","score":0.824999988079071},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9710000157356262},{"id":"https://openalex.org/keywords/animal-models-of-autism","display_name":"animal models of autism","score":0.5490000247955322},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4317131042480469}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:americanae.aecid.es:1598668","doi":null,"is_oa":true,"landing_page_url":"http://tede2.pucrs.br/tede2/handle/tede/5416","pdf_url":"http://tede2.pucrs.br/tede2/handle/tede/5416","source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da PUC_RS","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:tede2.pucrs.br:tede/5416","doi":null,"is_oa":true,"landing_page_url":"http://tede2.pucrs.br/tede2/handle/tede/5416","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:PUC_RS","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:987298331","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.pucrs.br/dspace/bitstream/10923/1280/1/000434361-Texto%2bCompleto-0.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:1598668","doi":null,"is_oa":true,"landing_page_url":"http://tede2.pucrs.br/tede2/handle/tede/5416","pdf_url":"http://tede2.pucrs.br/tede2/handle/tede/5416","source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da PUC_RS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7372751368","display_name":null,"funder_award_id":"303703/2009-1","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320324676","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia Translacional em Medicina","ror":"https://ror.org/01vt9w950"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W987298331.pdf","grobid_xml":"https://content.openalex.org/works/W987298331.grobid-xml"},"referenced_works_count":134,"referenced_works":["https://openalex.org/W183484377","https://openalex.org/W934614291","https://openalex.org/W1489219269","https://openalex.org/W1496193699","https://openalex.org/W1515228700","https://openalex.org/W1574339853","https://openalex.org/W1577082455","https://openalex.org/W1601632182","https://openalex.org/W1627088906","https://openalex.org/W1718598015","https://openalex.org/W1735099752","https://openalex.org/W1909229392","https://openalex.org/W1911837565","https://openalex.org/W1963556856","https://openalex.org/W1964445130","https://openalex.org/W1965981227","https://openalex.org/W1966338613","https://openalex.org/W1966937360","https://openalex.org/W1968708679","https://openalex.org/W1970629813","https://openalex.org/W1972138677","https://openalex.org/W1973868943","https://openalex.org/W1974094437","https://openalex.org/W1979553110","https://openalex.org/W1981770260","https://openalex.org/W1982112451","https://openalex.org/W1984059149","https://openalex.org/W1984974903","https://openalex.org/W1985116411","https://openalex.org/W1985870579","https://openalex.org/W1986189129","https://openalex.org/W1986350377","https://openalex.org/W1986805995","https://openalex.org/W1986970519","https://openalex.org/W1988676936","https://openalex.org/W1988714795","https://openalex.org/W1991422952","https://openalex.org/W1992489998","https://openalex.org/W1994218707","https://openalex.org/W1994421373","https://openalex.org/W2001442423","https://openalex.org/W2005149292","https://openalex.org/W2005948637","https://openalex.org/W2008814271","https://openalex.org/W2009189002","https://openalex.org/W2012645617","https://openalex.org/W2014362785","https://openalex.org/W2014401930","https://openalex.org/W2014408809","https://openalex.org/W2015268117","https://openalex.org/W2018851715","https://openalex.org/W2019018696","https://openalex.org/W2020607517","https://openalex.org/W2021367638","https://openalex.org/W2023063407","https://openalex.org/W2026905982","https://openalex.org/W2027157293","https://openalex.org/W2030258195","https://openalex.org/W2030392852","https://openalex.org/W2032596004","https://openalex.org/W2034324246","https://openalex.org/W2035541936","https://openalex.org/W2038284802","https://openalex.org/W2038324205","https://openalex.org/W2040367138","https://openalex.org/W2040806880","https://openalex.org/W2043235091","https://openalex.org/W2043245730","https://openalex.org/W2043925850","https://openalex.org/W2047602837","https://openalex.org/W2048034300","https://openalex.org/W2049511526","https://openalex.org/W2049997217","https://openalex.org/W2052389539","https://openalex.org/W2053162416","https://openalex.org/W2053909439","https://openalex.org/W2056266528","https://openalex.org/W2057370521","https://openalex.org/W2059354993","https://openalex.org/W2062098928","https://openalex.org/W2063405915","https://openalex.org/W2063519693","https://openalex.org/W2065246100","https://openalex.org/W2066442934","https://openalex.org/W2068484878","https://openalex.org/W2069213136","https://openalex.org/W2071684133","https://openalex.org/W2072887314","https://openalex.org/W2073195571","https://openalex.org/W2074414345","https://openalex.org/W2074876390","https://openalex.org/W2075528368","https://openalex.org/W2076566560","https://openalex.org/W2077204197","https://openalex.org/W2078600644","https://openalex.org/W2079463719","https://openalex.org/W2079959449","https://openalex.org/W2080354712","https://openalex.org/W2082791664","https://openalex.org/W2083356032","https://openalex.org/W2085583837","https://openalex.org/W2091151594","https://openalex.org/W2092311426","https://openalex.org/W2097856415","https://openalex.org/W2105245235","https://openalex.org/W2110929953","https://openalex.org/W2116635659","https://openalex.org/W2119804742","https://openalex.org/W2121610612","https://openalex.org/W2128772004","https://openalex.org/W2134572291","https://openalex.org/W2134700814","https://openalex.org/W2135890562","https://openalex.org/W2139092938","https://openalex.org/W2139996880","https://openalex.org/W2143294520","https://openalex.org/W2144446993","https://openalex.org/W2145235967","https://openalex.org/W2145547868","https://openalex.org/W2145661651","https://openalex.org/W2146588875","https://openalex.org/W2147343978","https://openalex.org/W2148546771","https://openalex.org/W2156694408","https://openalex.org/W2160276705","https://openalex.org/W2161450501","https://openalex.org/W2164674870","https://openalex.org/W2166137662","https://openalex.org/W2167549601","https://openalex.org/W2192638454","https://openalex.org/W2300825773","https://openalex.org/W2316069876","https://openalex.org/W2341281531","https://openalex.org/W2395038336"],"related_works":["https://openalex.org/W2280876931","https://openalex.org/W2063342955","https://openalex.org/W2225104520","https://openalex.org/W2148546771","https://openalex.org/W1979195759","https://openalex.org/W2005948637","https://openalex.org/W2242040233","https://openalex.org/W1972138677","https://openalex.org/W7018791036","https://openalex.org/W2149368284"],"abstract_inverted_index":{"INTRODU\u00c7\u00c3O:":[0],"Estudos":[1],"anteriores":[2],"de":[3,6,17,30,58,85,104,125,148,151,162,191,197,204,213,218,236,242,260,264,285,303,312,317,325,352,354,374,383,403,408,414,422,432,439,451,486,501,503,505],"nosso":[4,115],"grupo":[5,263],"pesquisa":[7],"demonstraram":[8],"que":[9,266,465,492],"o":[10,23,63,66,69,156,287,293,406,430,466],"bloqueio":[11,108,147,437,467],"do":[12,14,33,35,54,97,110,138,146,194,199,247,250,283,291,298,401,457,469],"receptor":[13,248],"pept\u00eddeo":[15],"liberador":[16],"gastrina":[18],"(GRPR)":[19],"em":[20,39,71,73,99,129,160,165,168,211,256,310,345,350,361,369,379,386,411,471,489],"ratos,":[21,72],"durante":[22,68,405],"per\u00edodo":[24,175,272,407,423],"neonatal,":[25],"produz":[26],"padr\u00f5es":[27],"comportamentais":[28],"caracter\u00edsticos":[29],"desordens":[31],"neuropsiqui\u00e1tricas":[32],"espectro":[34],"autismo,":[36],"incluindo":[37],"d\u00e9ficits":[38],"intera\u00e7\u00e3o":[40,166,326,346,362,415,490],"social":[41,131,167,215,327,347,416],"e":[42,65,88,102,158,164,171,181,208,216,252,258,279,307,322,348,377,381,392,410,441,474,488],"cogni\u00e7\u00e3o.":[43],"OBJETIVOS:":[44],"O":[45,364],"presente":[46],"trabalho":[47],"teve":[48],"como":[49],"objetivos":[50],"avaliar":[51],"os":[52,127,144,187,231,359],"efeitos":[53,145],"antagonismo":[55],"dos":[56],"receptores":[57,91,150,452],"pept\u00eddeos":[59,152],"semelhantes":[60,153],"\u00e0":[61],"bombesina,":[62,155],"GRPR":[64,157,253,440],"NMBR,":[67,292],"desenvolvimento":[70,409],"dois":[74,149],"estudos":[75],"relacionados.":[76],"Sendo":[77],"assim,":[78],"no":[79,174,271,314],"primeiro":[80],"estudo,":[81,142],"avaliamos":[82],"a":[83,121,154,455,478,494],"express\u00e3o":[84,373,450],"GRPR,":[86,111,286,375,470],"NR1":[87,246,376],"EGFR,":[89],"tr\u00eas":[90],"neuronais":[92,453],"potencialmente":[93],"envolvidos":[94],"na":[95,220,323,328,340,372,399,449,481,498],"etiologia":[96],"Autismo,":[98],"c\u00f3rtex":[100,259,380],"cerebral":[101],"hipocampo":[103,257],"ratos":[105,169,188,390],"submetidos":[106],"ao":[107,201,300],"neonatal":[109,176,342,438,468],"pelo":[112,436],"RC-3095.":[113],"Adicionalmente,":[114],"segundo":[116,141],"objetivo":[117],"foi":[118],"verificar":[119],"se":[120],"Clozapina\u00ae":[122,237,357],"seria":[123],"capaz":[124],"reverter":[126],"preju\u00edzos":[128,349,360,479],"comportamento":[130,161,214,311,402],"neste":[132,446],"potencial":[133],"modelo":[134,431],"animal":[135],"da":[136,226,228,244],"s\u00edndrome":[137],"autismo.":[139,458],"No":[140],"investigamos":[143],"NMBR":[159],"agrega\u00e7\u00e3o":[163,313,404],"machos":[170,278,391,473],"f\u00eameas":[172,280,393],"tratados":[173,337,394],"com":[177,338,366,395],"antagonistas":[178],"seletivos":[179],"RC-3095":[180,192,270,339,367,396],"PD":[182,294],"176252.":[183],"M\u00c9TODOS:":[184],"Estudo":[185,274,334,388],"1:":[186,335],"receberam":[189,233,267,281],"inje\u00e7\u00f5es":[190,234,282],"(antagonista":[193],"GRPR)":[195],"ou":[196,238,269,289,296],"ve\u00edculo":[198,268,297],"1\u00ba":[200,299],"10\u00ba":[202,301],"dias":[203,302,421],"vida":[205,304,318],"p\u00f3s":[206,305],"natal,":[207,306],"foram":[209,254,308],"testados":[210,309,418],"tarefas":[212],"mem\u00f3ria":[217,353],"reconhecimento":[219],"fase":[221,329,341],"adulta.":[222],"Uma":[223],"hora":[224],"antes":[225],"realiza\u00e7\u00e3o":[227],"tarefa":[229,324,351],"comportamental,":[230],"animais":[232,265,472],"sist\u00eamicas":[235],"salina.":[239],"As":[240],"express\u00f5es":[241,385],"mRNA":[243],"subunidade":[245],"NMDA,":[249],"EGFR":[251,378],"medidas":[255],"um":[261,483,495],"outro":[262],"neonatal.":[273],"2:":[275,389],"Ratos":[276,336],"Wistar":[277],"antagonista":[284,290],"RC-3095,":[288],"176252,":[295],"12\u00b0":[315],"dia":[316],"p\u00f3s-natal":[319],"(PN":[320,331],"12)":[321],"jovem":[330],"30).":[332],"RESULTADOS:":[333],"apresentaram":[343,397],"decr\u00e9scimos":[344,370],"reconhecimento.":[355],"A":[356],"reverteu":[358],"social.":[363],"tratamento":[365],"resultou":[368],"paralelos":[371],"aumento":[382],"suas":[384],"hipocampo.":[387],"decr\u00e9scimo":[398],"manuten\u00e7\u00e3o":[400],"diferentes":[412],"an\u00e1lises":[413],"quando":[417],"aos":[419],"30":[420],"p\u00f3s-natal.":[424],"CONCLUS\u00c3O:":[425],"Os":[426],"resultados":[427],"apresentados":[428],"validam":[429],"autismo":[433,506],"original,":[434],"induzido":[435],"demonstram":[442],"pela":[443,461],"primeira":[444,462],"vez":[445,463],"modelo,":[447],"altera\u00e7\u00f5es":[448],"associados":[454],"patog\u00eanese":[456],"Al\u00e9m":[459],"disso,":[460],"demonstramos":[464],"f\u00eameas,":[475],"est\u00e1":[476],"associado":[477],"observados":[480],"agrega\u00e7\u00e3o,":[482],"importante":[484,497],"par\u00e2metro":[485,496],"sociabilidade,":[487],"social,":[491],"corresponde":[493],"caracteriza\u00e7\u00e3o":[499],"comportamental":[500],"modelos":[502],"roedores":[504]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}