{"id":"https://openalex.org/W986776671","doi":"https://doi.org/10.18093/0869-0189-2014-0-4-49-56","title":"Investigation of blood neutrophil structural and functional characteristics in patients with chronic obstructive pulmonary disease and pulmonary hypertension using atomic force microscopy","display_name":"Investigation of blood neutrophil structural and functional characteristics in patients with chronic obstructive pulmonary disease and pulmonary hypertension using atomic force microscopy","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W986776671","doi":"https://doi.org/10.18093/0869-0189-2014-0-4-49-56","mag":"986776671"},"language":"en","primary_location":{"id":"doi:10.18093/0869-0189-2014-0-4-49-56","doi":"https://doi.org/10.18093/0869-0189-2014-0-4-49-56","is_oa":true,"landing_page_url":"https://doi.org/10.18093/0869-0189-2014-0-4-49-56","pdf_url":"https://journal.pulmonology.ru/pulm/article/download/438/438","source":{"id":"https://openalex.org/S4210221960","display_name":"PULMONOLOGIYA","issn_l":"0869-0189","issn":["0869-0189","2541-9617"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4362643898","host_organization_name":"Pulmonology","host_organization_lineage":["https://openalex.org/P4362643898"],"host_organization_lineage_names":["Pulmonology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Pulmonology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W986776671"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://journal.pulmonology.ru/pulm/article/download/438/438","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011817226","display_name":"Viliya Gajnitdinova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. V. Gajnitdinova","raw_affiliation_strings":["- State Institution Bashkir State Medical University , Healthcare Ministry ; Ufa , Russia;","\u0413\u0411\u041e\u0423 \u0412\u041f\u041e \"\u0411\u0430\u0448\u043a\u0438\u0440\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\" \u041c\u0438\u043d\u0437\u0434\u0440\u0430\u0432\u0430 \u0420\u043e\u0441\u0441\u0438\u0438"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"- State Institution Bashkir State Medical University , Healthcare Ministry ; Ufa , Russia;","institution_ids":["https://openalex.org/I4210120901"]},{"raw_affiliation_string":"\u0413\u0411\u041e\u0423 \u0412\u041f\u041e \"\u0411\u0430\u0448\u043a\u0438\u0440\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\" \u041c\u0438\u043d\u0437\u0434\u0440\u0430\u0432\u0430 \u0420\u043e\u0441\u0441\u0438\u0438","institution_ids":["https://openalex.org/I4210120901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035053124","display_name":"\u041b. \u0410. \u0428\u0430\u0440\u0430\u0444\u0443\u0442\u0434\u0438\u043d\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-0162-7879","observed_orcids":["https://orcid.org/0000-0003-0162-7879"]},"institutions":[{"id":"https://openalex.org/I138958963","display_name":"Bashkir State University","ror":"https://ror.org/04gr31p94","country_code":"RU","type":"education","lineage":["https://openalex.org/I138958963","https://openalex.org/I4387155162"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. A. Sharafutdinova","raw_affiliation_strings":["- State Institution Bashkir State University ; The Center of Nano and Microdynamics of Disperse Systems ; Ufa , Russia;","\u0426\u0435\u043d\u0442\u0440 \u043c\u0438\u043a\u0440\u043e) \u0438 \u043d\u0430\u043d\u043e\u043c\u0430\u0441\u0448\u0442\u0430\u0431\u043d\u043e\u0439 \u0434\u0438\u043d\u0430\u043c\u0438\u043a\u0438 \u0434\u0438\u0441\u043f\u0435\u0440\u0441\u043d\u044b\u0445 \u0441\u0438\u0441\u0442\u0435\u043c \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u0411\u0430\u0448\u043a\u0438\u0440\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"- State Institution Bashkir State University ; The Center of Nano and Microdynamics of Disperse Systems ; Ufa , Russia;","institution_ids":["https://openalex.org/I138958963"]},{"raw_affiliation_string":"\u0426\u0435\u043d\u0442\u0440 \u043c\u0438\u043a\u0440\u043e) \u0438 \u043d\u0430\u043d\u043e\u043c\u0430\u0441\u0448\u0442\u0430\u0431\u043d\u043e\u0439 \u0434\u0438\u043d\u0430\u043c\u0438\u043a\u0438 \u0434\u0438\u0441\u043f\u0435\u0440\u0441\u043d\u044b\u0445 \u0441\u0438\u0441\u0442\u0435\u043c \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u0411\u0430\u0448\u043a\u0438\u0440\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442","institution_ids":["https://openalex.org/I138958963"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076135300","display_name":"\u0418. \u041c. \u041a\u0430\u043c\u0430\u043b\u0442\u0434\u0438\u043d\u043e\u0432","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138958963","display_name":"Bashkir State University","ror":"https://ror.org/04gr31p94","country_code":"RU","type":"education","lineage":["https://openalex.org/I138958963","https://openalex.org/I4387155162"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. M. Kamaltdinov","raw_affiliation_strings":["- State Institution Bashkir State University ; The Center of Nano and Microdynamics of Disperse Systems ; Ufa , Russia;","\u0426\u0435\u043d\u0442\u0440 \u043c\u0438\u043a\u0440\u043e) \u0438 \u043d\u0430\u043d\u043e\u043c\u0430\u0441\u0448\u0442\u0430\u0431\u043d\u043e\u0439 \u0434\u0438\u043d\u0430\u043c\u0438\u043a\u0438 \u0434\u0438\u0441\u043f\u0435\u0440\u0441\u043d\u044b\u0445 \u0441\u0438\u0441\u0442\u0435\u043c \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u0411\u0430\u0448\u043a\u0438\u0440\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"- State Institution Bashkir State University ; The Center of Nano and Microdynamics of Disperse Systems ; Ufa , Russia;","institution_ids":["https://openalex.org/I138958963"]},{"raw_affiliation_string":"\u0426\u0435\u043d\u0442\u0440 \u043c\u0438\u043a\u0440\u043e) \u0438 \u043d\u0430\u043d\u043e\u043c\u0430\u0441\u0448\u0442\u0430\u0431\u043d\u043e\u0439 \u0434\u0438\u043d\u0430\u043c\u0438\u043a\u0438 \u0434\u0438\u0441\u043f\u0435\u0440\u0441\u043d\u044b\u0445 \u0441\u0438\u0441\u0442\u0435\u043c \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u0411\u0430\u0448\u043a\u0438\u0440\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442","institution_ids":["https://openalex.org/I138958963"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007911251","display_name":"Sergey Nikolaevich Avdeev","orcid":"https://orcid.org/0000-0002-5999-2150","observed_orcids":["https://orcid.org/0000-0002-5999-2150"]},"institutions":[{"id":"https://openalex.org/I64264942","display_name":"Federal Medical-Biological Agency","ror":"https://ror.org/052ay8m85","country_code":"RU","type":"government","lineage":["https://openalex.org/I64264942"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. N. Avdeev","raw_affiliation_strings":["- Pulmonology Research Institute , Federal Medical and Biological Agency of Russia ; Moscow , Russia","\u0424\u0413\u0423 \u041d\u0418\u0418 \u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0424\u041c\u0411\u0410 \u0420\u043e\u0441\u0441\u0438\u0438"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"- Pulmonology Research Institute , Federal Medical and Biological Agency of Russia ; Moscow , Russia","institution_ids":["https://openalex.org/I64264942"]},{"raw_affiliation_string":"\u0424\u0413\u0423 \u041d\u0418\u0418 \u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0424\u041c\u0411\u0410 \u0420\u043e\u0441\u0441\u0438\u0438","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":null,"issue":"4","first_page":"49","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.22849999368190765,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8159999847412109},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neutrophil-morphology","display_name":"neutrophil morphology","score":0.8389999866485596},{"id":"https://openalex.org/keywords/membrane-stiffness","display_name":"membrane rigidity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.753000020980835},{"id":"https://openalex.org/keywords/cytoplasmic-granules","display_name":"cytoplasmic granules","score":0.8080000281333923},{"id":"https://openalex.org/keywords/nuclei-segmentation","display_name":"nuclei segmentation","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8140833377838135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6559894680976868},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.5963488817214966},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.5791749358177185},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5326017737388611},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4977557957172394},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.4668263792991638},{"id":"https://openalex.org/C2780333948","wikidata":"https://www.wikidata.org/wiki/Q653305","display_name":"Spirometry","level":3,"score":0.46425941586494446},{"id":"https://openalex.org/C43044207","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Venous blood","level":2,"score":0.45712560415267944},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.45451757311820984},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3629786968231201},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.21529743075370789},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.09274336695671082},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18093/0869-0189-2014-0-4-49-56","doi":"https://doi.org/10.18093/0869-0189-2014-0-4-49-56","is_oa":true,"landing_page_url":"https://doi.org/10.18093/0869-0189-2014-0-4-49-56","pdf_url":"https://journal.pulmonology.ru/pulm/article/download/438/438","source":{"id":"https://openalex.org/S4210221960","display_name":"PULMONOLOGIYA","issn_l":"0869-0189","issn":["0869-0189","2541-9617"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4362643898","host_organization_name":"Pulmonology","host_organization_lineage":["https://openalex.org/P4362643898"],"host_organization_lineage_names":["Pulmonology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Pulmonology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18093/0869-0189-2014-0-4-49-56","doi":"https://doi.org/10.18093/0869-0189-2014-0-4-49-56","is_oa":true,"landing_page_url":"https://doi.org/10.18093/0869-0189-2014-0-4-49-56","pdf_url":"https://journal.pulmonology.ru/pulm/article/download/438/438","source":{"id":"https://openalex.org/S4210221960","display_name":"PULMONOLOGIYA","issn_l":"0869-0189","issn":["0869-0189","2541-9617"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4362643898","host_organization_name":"Pulmonology","host_organization_lineage":["https://openalex.org/P4362643898"],"host_organization_lineage_names":["Pulmonology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Pulmonology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W986776671.pdf","grobid_xml":"https://content.openalex.org/works/W986776671.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2012109265","https://openalex.org/W2049742516","https://openalex.org/W2059936047","https://openalex.org/W2110429416","https://openalex.org/W2153771907","https://openalex.org/W2164205372","https://openalex.org/W2167377685","https://openalex.org/W3093259571","https://openalex.org/W3215210255","https://openalex.org/W4211263216"],"related_works":["https://openalex.org/W2550528634","https://openalex.org/W4386300539","https://openalex.org/W10197084","https://openalex.org/W2602196801","https://openalex.org/W2255868437","https://openalex.org/W2564378888","https://openalex.org/W1691466436","https://openalex.org/W2255040332","https://openalex.org/W2110429416","https://openalex.org/W2753786588"],"abstract_inverted_index":{"Aim.":[0],"The":[1,127,194],"aim":[2],"of":[3,17,72,91,111,134],"this":[4,157],"study":[5,40],"was":[6,35,66,146],"to":[7,102,156],"investigate":[8],"structural":[9,198],"and":[10,25,54,96,108,115,131,163,179,190,199,212],"functional":[11,200],"characteristics":[12],"(morphology,":[13],"membrane":[14,128,191],"stiffness,":[15],"adhesion)":[16],"blood":[18,63,203],"neu":[19],"trophils":[20],"in":[21,43,68,81,149,159,202,208],"patients":[22,44,51,56,150,160,169,209],"with":[23,45,151,161,170,210],"COPD":[24,152,162,171,211],"pulmonary":[26,59,165],"hypertension":[27],"(PH)":[28],"using":[29,121,139],"atomic":[30],"force":[31,140],"microscopy.":[32],"Methods.":[33],"This":[34],"a":[36],"local":[37],"open":[38],"comparative":[39],"involving":[41],"30":[42],"severe":[46],"COPD.":[47],"Of":[48],"them,":[49],"15":[50,55],"had":[52,57,175],"PH":[53,154,173],"normal":[58,164],"artery":[60,166],"pressure.":[61,167],"Complete":[62],"cell":[64,106,116,182],"count":[65],"performed":[67],"the":[69,105],"1st":[70],"day":[71],"admission.":[73],"Pulse":[74],"oxymetry,":[75],"spirometry,":[76],"echocardiographic":[77],"examination":[78],"were":[79,85,94,100,118,137,205],"used":[80],"all":[82],"patients.":[83],"Neutrophils":[84],"separated":[86],"from":[87],"venous":[88],"blood.":[89],"Surfaces":[90],"10\u201312":[92],"cells":[93],"scanned":[95],"lateral":[97],"section":[98],"curves":[99],"constructed":[101],"meas":[103],"ure":[104],"height":[107,110],"maximal":[109],"cytoplasmic":[112],"granules.":[113],"Nuclear":[114],"areas":[117],"also":[119],"calculated":[120],"Pico":[122],"Image":[123],"Basic":[124],"5.1":[125],"software.":[126],"elastic":[129],"properties":[130],"adhesion":[132,144,188],"strength":[133,145,189],"native":[135],"neutrophils":[136,174,204],"evaluated":[138],"spectrometry.":[141],"Results.":[142],"Neutrophil":[143],"significantly":[147,180],"higher":[148,181],"+":[153,172],"compared":[155],"parameter":[158],"In":[168],"less":[176],"nuclear":[177],"segments":[178],"phasic":[183],"height,":[184],"increased":[185],"cytoplasm":[186],"granularity":[187],"stiffness.":[192],"Conclusion.":[193],"results":[195],"demonstrated":[196],"that":[197],"changes":[201],"more":[206],"significant":[207],"PH.":[213]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}