{"id":"https://openalex.org/W985444620","doi":null,"title":"VEGF\u3001ANG-1\u3001ANG-2\u3001TSP-1\u7684\u8868\u8fbe\u4e0e\u80c6\u7ba1\u7ec6\u80de\u6027\u809d\u764c\u8840\u7ba1\u751f\u6210\u548c\u4fb5\u6da6\u8f6c\u79fb\u7684\u5173\u7cfb","display_name":"VEGF\u3001ANG-1\u3001ANG-2\u3001TSP-1\u7684\u8868\u8fbe\u4e0e\u80c6\u7ba1\u7ec6\u80de\u6027\u809d\u764c\u8840\u7ba1\u751f\u6210\u548c\u4fb5\u6da6\u8f6c\u79fb\u7684\u5173\u7cfb","publication_year":2007,"publication_date":"2007-10-15","ids":{"openalex":"https://openalex.org/W985444620","mag":"985444620"},"language":"zh","primary_location":{"id":"mag:985444620","doi":null,"is_oa":false,"landing_page_url":"https://www.airitilibrary.com/Publication/alDetailedMesh?DocID=10004718-200710-23-10-2046-2050-a","pdf_url":null,"source":{"id":"https://openalex.org/S2765062696","display_name":"Zhongguo bingli shengli zazhi","issn_l":"1000-4718","issn":["1000-4718"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u570b\u75c5\u7406\u751f\u7406\u96dc\u8a8c","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048768293","display_name":"\u6c64\u5730","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6c64\u5730","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007465470","display_name":"\u5468\u5947","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5468\u5947","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022452333","display_name":"\u6881\u529b\u5efa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6881\u529b\u5efa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021816419","display_name":"P. Gang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Gang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008730766","display_name":"\u6c38\u91ce\u7693\u662d","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6c38\u91ce\u7693\u662d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09304143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"10","first_page":"2046","last_page":"2050"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.336899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9710000157356262},{"id":"https://openalex.org/keywords/angiopoietin-1","display_name":"angiopoietin-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":1.0},{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":1.0},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.9100000262260437},{"id":"https://openalex.org/keywords/intrahepatic-metastasis","display_name":"intrahepatic metastasis","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8420715928077698},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.726935863494873},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7024694681167603},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6584661602973938},{"id":"https://openalex.org/C99194444","wikidata":"https://www.wikidata.org/wiki/Q14906367","display_name":"Thrombospondin 1","level":3,"score":0.6393352746963501},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5326143503189087},{"id":"https://openalex.org/C2909146873","wikidata":"https://www.wikidata.org/wiki/Q14912185","display_name":"Angiopoietin 2","level":4,"score":0.4792880415916443},{"id":"https://openalex.org/C2779094623","wikidata":"https://www.wikidata.org/wiki/Q539710","display_name":"Angiopoietin","level":4,"score":0.47157543897628784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4445739686489105},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.4256698191165924},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38955992460250854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38891515135765076},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3808082044124603},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3546556830406189},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.257047563791275},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17887574434280396},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.11639904975891113},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0552176833152771}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:985444620","doi":null,"is_oa":false,"landing_page_url":"https://www.airitilibrary.com/Publication/alDetailedMesh?DocID=10004718-200710-23-10-2046-2050-a","pdf_url":null,"source":{"id":"https://openalex.org/S2765062696","display_name":"Zhongguo bingli shengli zazhi","issn_l":"1000-4718","issn":["1000-4718"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u570b\u75c5\u7406\u751f\u7406\u96dc\u8a8c","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2393036835","https://openalex.org/W2045470331","https://openalex.org/W2373443649","https://openalex.org/W2067724480","https://openalex.org/W2363119151","https://openalex.org/W1541846083","https://openalex.org/W3149516158","https://openalex.org/W2081557581","https://openalex.org/W2384785257","https://openalex.org/W2374568147"],"abstract_inverted_index":{"ATM:":[0],"To":[1],"investigate":[2],"the":[3,5,173,182],"angiogenesis,":[4,27],"expression":[6,61,69,109,124,183],"of":[7,35,43,102,119,134,176,184],"vascular":[8],"endothelial":[9],"growth":[10],"factor":[11],"(VEGF),":[12],"angiopoietin-1":[13],"(ANG-1),":[14],"angiopoietin-2":[15],"(ANG-2),":[16],"thrombospondin-1":[17],"(TSP-1)":[18],"in":[19,64,72,79,152],"cholangiocellular":[20],"carcinoma":[21],"(CCC)":[22],"and":[23,30,48,82,90,105,155,162,195],"relationship":[24],"with":[25,98,115,131,191],"tumor":[26,192],"differentiation,":[28,193],"invasion":[29,194],"metastasis.":[31,196],"METHODS:":[32],"33":[33],"specimen":[34],"surgically":[36],"resected":[37],"CCC":[38],"were":[39,93],"investigated.":[40],"Immunohistochemical":[41],"staining":[42],"CD34,":[44],"VEGF,":[45,185],"ANC-1,":[46],"ANG-2":[47,75,91,156],"TSP-1":[49,87,108,123,163,170],"was":[50,57,62,70,77,110,125],"carried":[51],"out.":[52],"RESULTS:":[53],"The":[54],"mean":[55],"MVD":[56,103,120,179],"(87.2\u00b152.6)/mm^2.":[58],"VEGF":[59,89],"positive":[60,68,76,86],"found":[63,94,111,127],"75.6%":[65],"cases;":[66],"ANG-1":[67],"observed":[71,151],"36%":[73],"eases;":[74],"detected":[78],"57.6%":[80],"cases":[81,84],"45.5%":[83],"exhibited":[85],"expression.":[88],"expressions":[92],"to":[95,112,128,145],"he":[96,150],"associated":[97,114,130,190],"significant":[99,116],"higher":[100,132],"level":[101,118,133],"(P\uff1c0.01":[104],"P\uff1c0.05,":[106],"respectively).":[107],"be":[113,129],"low":[117],"(P\uff1c0.01).":[121],"Positive":[122],"also":[126],"intrahepatic":[135,174],"metastasis":[136,175],"(46.7%":[137],"vs":[138],"5.6%,":[139],"P\uff1c0.05).":[140],"CONCLUSION:":[141],"Considerable":[142],"angiogenesis":[143],"compared":[144],"other":[146],"solid":[147],"tumors":[148],"can":[149],"CCC.":[153],"VFCF":[154],"might":[157],"play":[158,165],"a":[159],"proangiogenic":[160],"role":[161],"may":[164,171],"an":[166],"inhibitory":[167],"role.":[168],"Although":[169],"increase":[172],"CCC,":[177],"neither":[178],"levels":[180],"nor":[181],"ANG-1,":[186],"or":[187],"ANC-2":[188],"is":[189]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}