{"id":"https://openalex.org/W98503081","doi":"https://doi.org/10.1016/s0968-0896(99)00243-6","title":"Biosynthesis of 20-hydroxyecdysone in Ajuga hairy roots","display_name":"Biosynthesis of 20-hydroxyecdysone in Ajuga hairy roots","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W98503081","doi":"https://doi.org/10.1016/s0968-0896(99)00243-6","mag":"98503081","pmid":"https://pubmed.ncbi.nlm.nih.gov/10658597"},"language":"en","primary_location":{"id":"doi:10.1016/s0968-0896(99)00243-6","doi":"https://doi.org/10.1016/s0968-0896(99)00243-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0968-0896(99)00243-6","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079850513","display_name":"Kiyoshi Ohyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Ohyama","raw_affiliation_strings":["Department of Chemistry and Materials Science, Tokyo Institute of Technology, Meguro, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Materials Science, Tokyo Institute of Technology, Meguro, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082166328","display_name":"Tetsuo Kushiro","orcid":"https://orcid.org/0000-0002-7598-4791","observed_orcids":["https://orcid.org/0000-0002-7598-4791"]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Kushiro","raw_affiliation_strings":["Department of Chemistry and Materials Science, Tokyo Institute of Technology, Meguro, Tokyo 152-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Materials Science, Tokyo Institute of Technology, Meguro, Tokyo 152-8551, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044904063","display_name":"Kinya Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kinya Nakamura","raw_affiliation_strings":["Department of Chemistry and Materials Science, Tokyo Institute of Technology, Meguro, Tokyo 152-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Materials Science, Tokyo Institute of Technology, Meguro, Tokyo 152-8551, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066645568","display_name":"Yoshinori Fujimoto","orcid":"https://orcid.org/0009-0009-6142-0467","observed_orcids":["https://orcid.org/0009-0009-6142-0467"]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshinori Fujimoto","raw_affiliation_strings":["Department of Chemistry and Materials Science, Tokyo Institute of Technology, Meguro, Tokyo 152-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Materials Science, Tokyo Institute of Technology, Meguro, Tokyo 152-8551, Japan","institution_ids":["https://openalex.org/I114531698"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066645568"],"corresponding_institution_ids":["https://openalex.org/I114531698"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":0.2873,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.43915743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"7","issue":"12","first_page":"2925","last_page":"2930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.21940000355243683,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.10100000351667404,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/20-hydroxyecdysone","display_name":"20-hydroxyecdysone","score":0.9380000233650208},{"id":"https://openalex.org/keywords/biosynthesis","display_name":"biosynthesis","score":0.6470000147819519},{"id":"https://openalex.org/keywords/ajuga-reptans","display_name":"Ajuga reptans","score":0.871999979019165},{"id":"https://openalex.org/keywords/hairy-roots","display_name":"hairy roots","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lathosterol","display_name":"lathosterol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hydrogen-isotope-labeling","display_name":"hydrogen isotope labeling","score":0.628000020980835},{"id":"https://openalex.org/keywords/7-dehydrocholesterol","display_name":"7-dehydrocholesterol","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.753000020980835},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C2779324052","wikidata":"https://www.wikidata.org/wiki/Q423338","display_name":"20-Hydroxyecdysone","level":3,"score":0.9175273180007935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8436744809150696},{"id":"https://openalex.org/C2780022283","wikidata":"https://www.wikidata.org/wiki/Q3218465","display_name":"Lathosterol","level":5,"score":0.825749397277832},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5497735142707825},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.450094074010849},{"id":"https://openalex.org/C2776920199","wikidata":"https://www.wikidata.org/wiki/Q408028","display_name":"Epoxide","level":3,"score":0.435655802488327},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.4102192521095276},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27815935015678406},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.17388015985488892},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.16563621163368225},{"id":"https://openalex.org/C2781471481","wikidata":"https://www.wikidata.org/wiki/Q2756479","display_name":"Campesterol","level":4,"score":0.12420883774757385},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10185432434082031},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004441","descriptor_name":"Ecdysterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004441","descriptor_name":"Ecdysterone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019686","descriptor_name":"Lamiaceae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0968-0896(99)00243-6","doi":"https://doi.org/10.1016/s0968-0896(99)00243-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0968-0896(99)00243-6","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:10658597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10658597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00897:0003910378","doi":null,"is_oa":false,"landing_page_url":"http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100403060","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioorg. Med. Chem.","raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W33580109","https://openalex.org/W184583988","https://openalex.org/W1553938214","https://openalex.org/W1579109632","https://openalex.org/W1583546580","https://openalex.org/W1799300194","https://openalex.org/W1961534644","https://openalex.org/W1973069955","https://openalex.org/W1998656430","https://openalex.org/W2002813207","https://openalex.org/W2017538932","https://openalex.org/W2043479333","https://openalex.org/W2044643654","https://openalex.org/W2052436308","https://openalex.org/W2066581427","https://openalex.org/W2068912414","https://openalex.org/W2126362171","https://openalex.org/W2140542015","https://openalex.org/W2314503723","https://openalex.org/W2320040743","https://openalex.org/W2395380088","https://openalex.org/W2978776366"],"related_works":["https://openalex.org/W7144652797","https://openalex.org/W2029708628","https://openalex.org/W2068912414","https://openalex.org/W1969925710","https://openalex.org/W2014987229","https://openalex.org/W2126362171","https://openalex.org/W1973069955","https://openalex.org/W2043098065","https://openalex.org/W2017538932","https://openalex.org/W6988255724"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}