{"id":"https://openalex.org/W98397698","doi":null,"title":"Capecitabine and oxaliplatin (XELOX) as first-line treatment for patients with metastatic colorectal cancer.","display_name":"Capecitabine and oxaliplatin (XELOX) as first-line treatment for patients with metastatic colorectal cancer.","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W98397698","mag":"98397698","pmid":"https://pubmed.ncbi.nlm.nih.gov/20148449"},"language":"en","primary_location":{"id":"pmid:20148449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20148449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of B.U.ON. : official journal of the Balkan Union of Oncology","raw_type":"Clinical Trial, Phase II"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079287636","display_name":"Didem Kara\u00e7etin","orcid":"https://orcid.org/0000-0001-5359-5958","observed_orcids":["https://orcid.org/0000-0001-5359-5958"]},"institutions":[{"id":"https://openalex.org/I4210157622","display_name":"\u015ei\u015fli Etfal E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/05fmwts39","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210157622"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"D Karacetin","raw_affiliation_strings":["Radiation Oncology Clinic, Sisli Etfal Research and Training Hospital, Istanbul, Turkey. didemkaracetin@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Clinic, Sisli Etfal Research and Training Hospital, Istanbul, Turkey. didemkaracetin@gmail.com","institution_ids":["https://openalex.org/I4210157622"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102915694","display_name":"B\u00fclent Yal\u00e7\u0131n","orcid":"https://orcid.org/0000-0002-4431-8948","observed_orcids":["https://orcid.org/0000-0002-4431-8948"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Yalcin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023418283","display_name":"Beg\u00fcm \u00d6kten","orcid":"https://orcid.org/0000-0001-7820-2380","observed_orcids":["https://orcid.org/0000-0001-7820-2380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Okten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S Ozturk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Ozturk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008883925","display_name":"O Maral","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Maral","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068727097","display_name":"O Incekara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Incekara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.01259824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"4","first_page":"605","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capecitabine","display_name":"capecitabine","score":0.9169999957084656},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":1.0},{"id":"https://openalex.org/keywords/xelox","display_name":"XELOX","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/first-line-chemotherapy","display_name":"first-line chemotherapy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7570000290870667},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":1.0},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6060000061988831},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.9482041597366333},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.8758161664009094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.863457202911377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7163622379302979},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6389116048812866},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.566505491733551},{"id":"https://openalex.org/C2776581026","wikidata":"https://www.wikidata.org/wiki/Q864868","display_name":"Bone marrow suppression","level":3,"score":0.4738871455192566},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4288366734981537},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.42592161893844604},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3805341124534607},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33481264114379883}],"mesh":[{"descriptor_ui":"D000069287","descriptor_name":"Capecitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012449","descriptor_name":"Safety","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20148449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20148449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of B.U.ON. : official journal of the Balkan Union of Oncology","raw_type":"Clinical Trial, Phase II"},{"id":"mag:98397698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20148449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2113919377","https://openalex.org/W1978141307","https://openalex.org/W2999149094","https://openalex.org/W2029516905","https://openalex.org/W2080786332","https://openalex.org/W2210225408","https://openalex.org/W2093252674","https://openalex.org/W2388758644","https://openalex.org/W2411643846","https://openalex.org/W2286406868"],"abstract_inverted_index":{"PURPOSE:":[0],"For":[1],"almost":[2],"40":[3],"years,":[4],"5-fluorouracil":[5],"(5-FU)":[6],"had":[7],"been":[8,41],"the":[9,34,72,172],"only":[10],"drug":[11],"with":[12,21,80,106,154,222,234],"demonstrated":[13],"activity":[14],"against":[15],"(CRC),":[16],"commonly":[17],"used":[18,32],"in":[19,33,47,50,59,78,232],"combination":[20,54,218],"leucovorin":[22],"(LV).":[23],"Oxaliplatin":[24],"and":[25,49,52,74,93,121,126,137,179,199,212,229],"capecitabine":[26,139,221],"are":[27],"two":[28],"relatively":[29],"novel":[30],"drugs":[31,39],"treatment":[35,103],"of":[36,66,76,114,219],"CRC.":[37],"These":[38],"have":[40],"found":[42],"to":[43,70,104,226],"act":[44],"synergistically,":[45],"both":[46],"vivo":[48],"vitro":[51],"their":[53],"(XELOX)":[55],"is":[56],"highly":[57],"active":[58],"metastatic":[60],"colorectal":[61],"cancer":[62],"(mCRC).":[63],"The":[64,83,217],"aim":[65],"this":[67],"study":[68,84],"was":[69,98,205],"determine":[71],"safety":[73],"efficacy":[75],"XELOX":[77,97],"patients":[79,105,151,190,233],"mCRC.":[81,107,235],"METHODS:":[82],"endpoints":[85],"were":[86,152,171],"response":[87,187,193],"rates,":[88],"toxicity,":[89],"progression":[90],"free":[91],"(PFS)":[92],"overall":[94],"survival":[95,214],"(OS).":[96],"administered":[99],"as":[100],"first":[101],"line":[102],"Patient":[108],"selection":[109],"criteria":[110],"included":[111],"histological":[112],"confirmation":[113],"mCRC,":[115],"ECOG":[116,165],"performance":[117],"status":[118],"(PS)":[119],"<or=2,":[120],"adequate":[122],"bone":[123,180],"marrow,":[124],"renal":[125],"hepatic":[127],"function.":[128],"Patients":[129],"received":[130],"oxaliplatin":[131,224],"130":[132],"mg/m(2)":[133,141],"i.v.,":[134],"day":[135],"1,":[136],"oral":[138,220],"1000":[140],"twice":[142],"daily,":[143],"days":[144],"1-14,":[145],"every":[146],"3":[147],"weeks.":[148],"RESULTS:":[149],"34":[150],"treated":[153],"XELOX;":[155],"males/":[156],"females":[157],"23/11,":[158],"median":[159,208],"age":[160],"53.5":[161],"years":[162],"(range":[163],"42-65),":[164],"PS":[166],"0/1":[167],"52%/48%.":[168],"Metastatic":[169],"sites":[170],"liver":[173],"(23/34;":[174],"67%),":[175],"lung":[176],"(7/34;":[177],"20%),":[178],"(4/34;":[181],"11%).":[182],"No":[183],"patient":[184],"achieved":[185],"complete":[186],"(CR),":[188],"14":[189],"showed":[191],"partial":[192],"(PR),":[194],"8":[195],"stable":[196],"disease":[197],"(SD)":[198],"11":[200],"progressed":[201],"(PD).":[202],"Median":[203],"PFS":[204],"5.5":[206],"months,":[207],"OS":[209],"12.9":[210],"months":[211],"1-year":[213],"52%.":[215],"CONCLUSION:":[216],"i.v.":[223],"appears":[225],"be":[227],"effective":[228],"well":[230],"tolerated":[231]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}