{"id":"https://openalex.org/W98388617","doi":null,"title":"Leukocyte trafficking: a special focus on VAP-1 and CLEVER-1","display_name":"Leukocyte trafficking: a special focus on VAP-1 and CLEVER-1","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W98388617","mag":"98388617"},"language":"en","primary_location":{"id":"pmh:oai:utupub.fi:11111/27608","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27608","pdf_url":"https://www.utupub.fi/bitstreams/258df753-1fc6-4212-9de2-5cb7cf1e40be/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/84981","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.utupub.fi/bitstreams/258df753-1fc6-4212-9de2-5cb7cf1e40be/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006009245","display_name":"Marika Karikoski","orcid":"https://orcid.org/0000-0001-6512-6331","observed_orcids":["https://orcid.org/0000-0001-6512-6331"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marika Karikoski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6512-6331","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006009245"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukocyte-migration","display_name":"leukocyte migration","score":0.953000009059906},{"id":"https://openalex.org/keywords/vascular-adhesion-protein-1","display_name":"VAP-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/clever-1","display_name":"Clever-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/leukocyte-endothelial-adhesion","display_name":"leukocyte-endothelial adhesion","score":0.8339999914169312},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.9319999814033508},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.7850000262260437},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.6322499513626099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41013044118881226},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37896981835365295},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.32628297805786133},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2253878116607666},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08296781778335571},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:utupub.fi:11111/27608","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27608","pdf_url":"https://www.utupub.fi/bitstreams/258df753-1fc6-4212-9de2-5cb7cf1e40be/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/84981","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"pmh:oai:www.doria.fi:10024/84981","doi":null,"is_oa":false,"landing_page_url":"http://www.doria.fi/handle/10024/84981","pdf_url":null,"source":{"id":"https://openalex.org/S4377196760","display_name":"Doria (University of Helsinki)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133731052","host_organization_name":"University of Helsinki","host_organization_lineage":["https://openalex.org/I133731052"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis (article-based)"},{"id":"pmh:oai:www.utupub.fi:10024/84981","doi":null,"is_oa":false,"landing_page_url":"http://www.utupub.fi/handle/10024/84981","pdf_url":null,"source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"mag:98388617","doi":null,"is_oa":false,"landing_page_url":"https://www.doria.fi/handle/10024/84981","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utupub.fi:11111/27608","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27608","pdf_url":"https://www.utupub.fi/bitstreams/258df753-1fc6-4212-9de2-5cb7cf1e40be/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/84981","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309952","display_name":"Ida Montinin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0269hs475"},{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320322861","display_name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/005rt3g54"},{"id":"https://openalex.org/F4320323313","display_name":"Turun Yliopisto","ror":"https://ror.org/05vghhr25"},{"id":"https://openalex.org/F4320323760","display_name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00ckakm23"},{"id":"https://openalex.org/F4320323824","display_name":"Sy\u00f6p\u00e4j\u00e4rjest\u00f6t","ror":"https://ror.org/05pgg4z49"},{"id":"https://openalex.org/F4320324148","display_name":"Orionin Tutkimuss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0296s4x19"},{"id":"https://openalex.org/F4320328090","display_name":"European Federation of Immunological Societies","ror":"https://ror.org/01ga90v78"},{"id":"https://openalex.org/F4320331826","display_name":"Turun Yliopistos\u00e4\u00e4ti\u00f6","ror":"https://ror.org/02kjggt26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W98388617.pdf","grobid_xml":"https://content.openalex.org/works/W98388617.grobid-xml"},"referenced_works_count":193,"referenced_works":["https://openalex.org/W141774154","https://openalex.org/W166076169","https://openalex.org/W1490522008","https://openalex.org/W1507221188","https://openalex.org/W1507835484","https://openalex.org/W1514064771","https://openalex.org/W1536323386","https://openalex.org/W1544936755","https://openalex.org/W1560590333","https://openalex.org/W1575005454","https://openalex.org/W1579115151","https://openalex.org/W1670464639","https://openalex.org/W1762715810","https://openalex.org/W1763686333","https://openalex.org/W1809465031","https://openalex.org/W1810389953","https://openalex.org/W1887527618","https://openalex.org/W1900762885","https://openalex.org/W1950395275","https://openalex.org/W1964264035","https://openalex.org/W1966564771","https://openalex.org/W1967906263","https://openalex.org/W1968570285","https://openalex.org/W1969662447","https://openalex.org/W1970802765","https://openalex.org/W1970942128","https://openalex.org/W1971537197","https://openalex.org/W1974405772","https://openalex.org/W1975495740","https://openalex.org/W1976169451","https://openalex.org/W1977922751","https://openalex.org/W1978628829","https://openalex.org/W1980008485","https://openalex.org/W1980460625","https://openalex.org/W1981330494","https://openalex.org/W1981868057","https://openalex.org/W1982846560","https://openalex.org/W1983962010","https://openalex.org/W1987111733","https://openalex.org/W1987308524","https://openalex.org/W1988377729","https://openalex.org/W1989850292","https://openalex.org/W1990352070","https://openalex.org/W1994417934","https://openalex.org/W1994521388","https://openalex.org/W1994710872","https://openalex.org/W1995166288","https://openalex.org/W1995826822","https://openalex.org/W1998934332","https://openalex.org/W1999185041","https://openalex.org/W1999475844","https://openalex.org/W1999626234","https://openalex.org/W2001257180","https://openalex.org/W2002148098","https://openalex.org/W2004261068","https://openalex.org/W2004570679","https://openalex.org/W2006104210","https://openalex.org/W2006608487","https://openalex.org/W2006871106","https://openalex.org/W2007160862","https://openalex.org/W2007670233","https://openalex.org/W2009887475","https://openalex.org/W2012120489","https://openalex.org/W2014143727","https://openalex.org/W2014687288","https://openalex.org/W2014991225","https://openalex.org/W2015831421","https://openalex.org/W2015981241","https://openalex.org/W2016011680","https://openalex.org/W2017441274","https://openalex.org/W2017626373","https://openalex.org/W2018186676","https://openalex.org/W2019179623","https://openalex.org/W2019431037","https://openalex.org/W2020178134","https://openalex.org/W2020357496","https://openalex.org/W2021877641","https://openalex.org/W2028328424","https://openalex.org/W2029697713","https://openalex.org/W2031576384","https://openalex.org/W2031832348","https://openalex.org/W2032494769","https://openalex.org/W2034269086","https://openalex.org/W2035809865","https://openalex.org/W2037685514","https://openalex.org/W2042047898","https://openalex.org/W2042626190","https://openalex.org/W2043689428","https://openalex.org/W2044273380","https://openalex.org/W2044701146","https://openalex.org/W2044707231","https://openalex.org/W2044845825","https://openalex.org/W2044897443","https://openalex.org/W2045637671","https://openalex.org/W2045988736","https://openalex.org/W2046754456","https://openalex.org/W2053133354","https://openalex.org/W2053643506","https://openalex.org/W2056110767","https://openalex.org/W2057748297","https://openalex.org/W2059114092","https://openalex.org/W2059756989","https://openalex.org/W2062265555","https://openalex.org/W2062623089","https://openalex.org/W2066152229","https://openalex.org/W2067816171","https://openalex.org/W2068218554","https://openalex.org/W2069088950","https://openalex.org/W2072325701","https://openalex.org/W2072512892","https://openalex.org/W2072573274","https://openalex.org/W2075131034","https://openalex.org/W2077284130","https://openalex.org/W2079082125","https://openalex.org/W2082046119","https://openalex.org/W2082665551","https://openalex.org/W2084976250","https://openalex.org/W2085680374","https://openalex.org/W2085869287","https://openalex.org/W2086157889","https://openalex.org/W2089370460","https://openalex.org/W2090755246","https://openalex.org/W2092090098","https://openalex.org/W2092880108","https://openalex.org/W2093921289","https://openalex.org/W2094724889","https://openalex.org/W2095891614","https://openalex.org/W2096786144","https://openalex.org/W2098361462","https://openalex.org/W2099388162","https://openalex.org/W2099675490","https://openalex.org/W2099929630","https://openalex.org/W2100004209","https://openalex.org/W2100231437","https://openalex.org/W2101712027","https://openalex.org/W2102558296","https://openalex.org/W2102792274","https://openalex.org/W2103758700","https://openalex.org/W2106467284","https://openalex.org/W2106562180","https://openalex.org/W2108240861","https://openalex.org/W2108346783","https://openalex.org/W2109593516","https://openalex.org/W2110780943","https://openalex.org/W2111856386","https://openalex.org/W2111939342","https://openalex.org/W2117692326","https://openalex.org/W2118278569","https://openalex.org/W2118691999","https://openalex.org/W2120316410","https://openalex.org/W2120423991","https://openalex.org/W2120862613","https://openalex.org/W2121267322","https://openalex.org/W2123055439","https://openalex.org/W2123105952","https://openalex.org/W2123774138","https://openalex.org/W2124387157","https://openalex.org/W2125650988","https://openalex.org/W2128117906","https://openalex.org/W2129566926","https://openalex.org/W2132134585","https://openalex.org/W2132312460","https://openalex.org/W2132392417","https://openalex.org/W2132495434","https://openalex.org/W2133519004","https://openalex.org/W2134138329","https://openalex.org/W2138511905","https://openalex.org/W2138958091","https://openalex.org/W2141924291","https://openalex.org/W2144732171","https://openalex.org/W2145136203","https://openalex.org/W2145431452","https://openalex.org/W2146738740","https://openalex.org/W2146981926","https://openalex.org/W2150633526","https://openalex.org/W2151224277","https://openalex.org/W2151514508","https://openalex.org/W2151659517","https://openalex.org/W2152306131","https://openalex.org/W2153170677","https://openalex.org/W2155203826","https://openalex.org/W2155453673","https://openalex.org/W2156626338","https://openalex.org/W2157805334","https://openalex.org/W2159238620","https://openalex.org/W2159588837","https://openalex.org/W2163361020","https://openalex.org/W2163751255","https://openalex.org/W2170270869","https://openalex.org/W2170663857","https://openalex.org/W2173547083","https://openalex.org/W2317145780","https://openalex.org/W4233324182"],"related_works":["https://openalex.org/W7097913110","https://openalex.org/W2016933577","https://openalex.org/W1980008485","https://openalex.org/W2285623934","https://openalex.org/W1989097738","https://openalex.org/W2017626373","https://openalex.org/W2017928154","https://openalex.org/W7099281207","https://openalex.org/W1995166288","https://openalex.org/W1998934332"],"abstract_inverted_index":{"It":[0],"is":[1],"crucial":[2],"that":[3,12,49,96],"lymphocytes":[4],"patrol":[5],"the":[6,19,36,41,46,99,104,116,126,132,144,153,161,166,185,189,208,233],"body":[7],"against":[8,136],"foreign":[9],"intruders":[10],"and":[11,28,74,84,88,120,129,222],"leukocytes":[13,27,102,164,194,237,251],"invade":[14],"inflamed":[15,127,167,239],"tissues":[16],"to":[17,71,103,110,125,130,201],"ameliorate":[18],"infection":[20,216],"or":[21,66,77,214],"injury.":[22],"The":[23],"adhesion":[24,81,100],"molecules":[25,48,95,138],"in":[26,35,59,98,122,165,195,204,238,252],"endothelial":[29,87,90,94],"cells":[30],"play":[31],"an":[32,63,140],"essential":[33],"role":[34,117,145],"immune":[37,192,210],"response":[38,69,211],"by":[39,248],"directing":[40],"traffic":[42,52,181],"of":[43,101,118,134,146,155,163,191,236],"leukocytes.":[44],"However,":[45,207],"same":[47],"guide":[50],"leukocyte":[51,123,180],"under":[53],"physiological":[54],"conditions":[55],"are":[56,93,224],"also":[57,244],"involved":[58],"pathological":[60],"situations,":[61],"when":[62],"overly":[64],"excessive":[65],"harmful":[67,234],"inflammatory":[68],"leads":[70],"tissue":[72],"destruction":[73],"organ":[75],"dysfunction":[76],"tumor":[78,205,246],"growth.":[79,206],"Vascular":[80],"protein-1":[82],"(VAP-1)":[83],"Common":[85],"lymphatic":[86,175],"vascular":[89],"receptor-1":[91],"(CLEVER-1)":[92],"participate":[97],"endothelia.":[105],"This":[106],"study":[107],"was":[108,150,197,217],"designed":[109],"elucidate,":[111],"using":[112],"different":[113],"inflammation":[114],"models,":[115],"VAP-1":[119,156,221],"CLEVER-1":[121,147,170,223,242],"migration":[124,173],"tissue,":[128],"evaluate":[131],"use":[133],"antibodies":[135,158],"these":[137],"as":[139,177,179],"anti-adhesive":[141],"therapy.":[142],"Also,":[143],"during":[148,182],"tumorigenesis":[149],"studied.":[151],"Blocking":[152],"function":[154],"with":[157],"significantly":[159],"decreased":[160],"accumulation":[162,235],"tissue.":[168],"Targeting":[169,241],"prevented":[171],"cell":[172],"via":[174],"vessels,":[176],"well":[178],"inflammation.":[183],"Following":[184],"anti-CLEVER-1":[186],"antibody":[187],"treatment":[188],"number":[190],"regulating":[193],"tumors":[196,253],"reduced,":[198],"which":[199],"led":[200],"a":[202],"decrease":[203],"normal":[209],"towards":[212],"immunization":[213],"bacterial":[215],"not":[218],"compromised.":[219],"Thus,":[220],"both":[225],"potential":[226],"targets":[227],"for":[228,231],"antiinflammatory":[229],"therapies":[230],"preventing":[232],"areas.":[240],"may":[243],"inhibit":[245],"growth":[247],"reducing":[249],"immunosuppressive":[250]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
