{"id":"https://openalex.org/W9836699","doi":"https://doi.org/10.4193/rhino09.201","title":"Anti-estrogen therapy for hereditary hemorrhagic telangiectasia - a long-term clinical trial","display_name":"Anti-estrogen therapy for hereditary hemorrhagic telangiectasia - a long-term clinical trial","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W9836699","doi":"https://doi.org/10.4193/rhino09.201","mag":"9836699","pmid":"https://pubmed.ncbi.nlm.nih.gov/21743879"},"language":"en","primary_location":{"id":"doi:10.4193/rhino09.201","doi":"https://doi.org/10.4193/rhino09.201","is_oa":true,"landing_page_url":"https://doi.org/10.4193/rhino09.201","pdf_url":"https://www.rhinologyjournal.com/download.php?id=989","source":{"id":"https://openalex.org/S94555171","display_name":"Rhinology Journal","issn_l":"0300-0729","issn":["0300-0729","1996-8604","2589-0085"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4324277485","host_organization_name":"European Rhinologic Society","host_organization_lineage":["https://openalex.org/P4324277485"],"host_organization_lineage_names":["European Rhinologic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.rhinologyjournal.com/download.php?id=989","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080581078","display_name":"Eitan Yaniv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"E. Yaniv","raw_affiliation_strings":["Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus, Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. docyaniv@yahoo.com","Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus, Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus, Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. docyaniv@yahoo.com","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus, Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074142111","display_name":"Michal Preis","orcid":"https://orcid.org/0000-0002-1770-6574","observed_orcids":["https://orcid.org/0000-0002-1770-6574"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M. Preis","raw_affiliation_strings":["Nose and Sinus Institute , Department of Otorhinolaryngology , Rabin Medical Center , Beilinson Campus , Petah Tiqwa and","Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel","Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus,","Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nose and Sinus Institute , Department of Otorhinolaryngology , Rabin Medical Center , Beilinson Campus , Petah Tiqwa and","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus,","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010833515","display_name":"Jacob Shevro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"J. Shevro","raw_affiliation_strings":["Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus,","Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus,","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108368535","display_name":"Ben I. Nageris","orcid":"https://orcid.org/0000-0002-6686-2565","observed_orcids":["https://orcid.org/0000-0002-6686-2565"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"B. Nageris","raw_affiliation_strings":["Nose and Sinus Institute , Department of Otorhinolaryngology , Rabin Medical Center , Beilinson Campus , Petah Tiqwa and","Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel","Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus,","Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nose and Sinus Institute , Department of Otorhinolaryngology , Rabin Medical Center , Beilinson Campus , Petah Tiqwa and","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus,","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111840047","display_name":"Tuvia Hadar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"T. Hadar","raw_affiliation_strings":["Nose and Sinus Institute , Department of Otorhinolaryngology , Rabin Medical Center , Beilinson Campus , Petah Tiqwa and","Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel","Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus,","Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nose and Sinus Institute , Department of Otorhinolaryngology , Rabin Medical Center , Beilinson Campus , Petah Tiqwa and","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Nose and Sinus Institute, Department of Otorhinolaryngology, Rabin Medical Center, Beilinson Campus,","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Petah Tiqwa and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8089,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.82534611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"49","issue":"2","first_page":"214","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-hemorrhagic-telangiectasia","display_name":"hereditary hemorrhagic telangiectasia","score":1.0},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.8270000219345093},{"id":"https://openalex.org/keywords/antiestrogen-therapy","display_name":"antiestrogen therapy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/epistaxis","display_name":"epistaxis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/recurrent-epistaxis","display_name":"recurrent epistaxis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.7269999980926514},{"id":"https://openalex.org/keywords/bleeding-score","display_name":"bleeding score","score":0.6259999871253967},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.7409999966621399},{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.5080000162124634},{"id":"https://openalex.org/keywords/long-term-treatment","display_name":"long-term treatment","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9894299507141113},{"id":"https://openalex.org/C2776330896","wikidata":"https://www.wikidata.org/wiki/Q1634800","display_name":"Telangiectasia","level":2,"score":0.9074171781539917},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.7520908117294312},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4868166148662567},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.46603602170944214},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.46336740255355835},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.45397379994392395},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43760427832603455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36426129937171936},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2157919704914093},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2054087221622467},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004844","descriptor_name":"Epistaxis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004844","descriptor_name":"Epistaxis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004965","descriptor_name":"Estrogen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013683","descriptor_name":"Telangiectasia, Hereditary Hemorrhagic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013683","descriptor_name":"Telangiectasia, Hereditary Hemorrhagic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4193/rhino09.201","doi":"https://doi.org/10.4193/rhino09.201","is_oa":true,"landing_page_url":"https://doi.org/10.4193/rhino09.201","pdf_url":"https://www.rhinologyjournal.com/download.php?id=989","source":{"id":"https://openalex.org/S94555171","display_name":"Rhinology Journal","issn_l":"0300-0729","issn":["0300-0729","1996-8604","2589-0085"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4324277485","host_organization_name":"European Rhinologic Society","host_organization_lineage":["https://openalex.org/P4324277485"],"host_organization_lineage_names":["European Rhinologic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology journal","raw_type":"journal-article"},{"id":"pmid:21743879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21743879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4193/rhino09.201","doi":"https://doi.org/10.4193/rhino09.201","is_oa":true,"landing_page_url":"https://doi.org/10.4193/rhino09.201","pdf_url":"https://www.rhinologyjournal.com/download.php?id=989","source":{"id":"https://openalex.org/S94555171","display_name":"Rhinology Journal","issn_l":"0300-0729","issn":["0300-0729","1996-8604","2589-0085"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4324277485","host_organization_name":"European Rhinologic Society","host_organization_lineage":["https://openalex.org/P4324277485"],"host_organization_lineage_names":["European Rhinologic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W9836699.pdf","grobid_xml":"https://content.openalex.org/works/W9836699.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W61562216","https://openalex.org/W151774832","https://openalex.org/W1977558025","https://openalex.org/W1990469044","https://openalex.org/W1991018159","https://openalex.org/W1996351190","https://openalex.org/W1998913198","https://openalex.org/W2010732756","https://openalex.org/W2018344603","https://openalex.org/W2035653033","https://openalex.org/W2041226837","https://openalex.org/W2080299984","https://openalex.org/W2089013135","https://openalex.org/W2128828071","https://openalex.org/W2150602992","https://openalex.org/W2416627181","https://openalex.org/W2438685172","https://openalex.org/W2770216137","https://openalex.org/W4234290957","https://openalex.org/W4251531555","https://openalex.org/W4299025287"],"related_works":["https://openalex.org/W1998913198","https://openalex.org/W2010732756","https://openalex.org/W2892092684","https://openalex.org/W2251446058","https://openalex.org/W4388944633","https://openalex.org/W2128828071","https://openalex.org/W1996351190","https://openalex.org/W2051726431","https://openalex.org/W2468527255","https://openalex.org/W4389663285"],"abstract_inverted_index":{"STATEMENT":[0],"OF":[1,52],"PROBLEM:":[2],"Hereditary":[3],"hemorrhagic":[4],"telangiectasia":[5],"(HHT)":[6],"is":[7],"associated":[8],"with":[9,58,68],"recurrent":[10],"epistaxis":[11,61,95,148],"in":[12,45],"90%":[13],"of":[14,32,40,48,55,60,77,80,89,92,106,115,132,147],"the":[15,38,46,104,116,122,133,145],"cases.":[16],"Good":[17],"response":[18],"to":[19,36,63,139,150],"hormone":[20],"treatment":[21,47,67,123,146],"has":[22],"been":[23],"documented,":[24],"although":[25],"its":[26],"use":[27],"remains":[28],"controversial.":[29],"The":[30,100],"aim":[31],"this":[33],"study":[34],"was":[35],"examine":[37],"efficacy":[39],"an":[41,141],"anti-estrogenic":[42],"agent,":[43],"tamoxifen,":[44],"HHT-associated":[49],"epistaxis.":[50],"METHOD":[51],"STUDY:":[53],"Out":[54],"46":[56],"patients":[57,73,83,117],"diagnosis":[59],"due":[62,149],"HHT":[64],"who":[65],"started":[66],"tamoxifen":[69],"20":[70],"mg/d,":[71],"38":[72],"completed":[74],"a":[75,86],"mean":[76],"23.4":[78],"months":[79],"treatment.":[81],"All":[82],"filled":[84],"out":[85],"self-assessment":[87],"questionnaire":[88],"rhinologic":[90],"Quality":[91,105],"Life":[93,107],"and":[94,103],"grading":[96],"scale.":[97],"MAIN":[98],"RESULTS:":[99],"bleeding":[101],"score":[102,108],"improved.":[109,113],"Hemoglobin":[110],"concentration":[111],"also":[112],"None":[114],"needed":[118],"blood":[119],"transfusions":[120],"during":[121],"period.":[124],"Only":[125],"one":[126],"patient":[127],"had":[128],"minor":[129],"side":[130],"effects":[131],"drug.":[134],"PRINCIPAL":[135],"CONCLUSIONS:":[136],"Tamoxifen":[137],"appears":[138],"be":[140],"effective":[142],"agent":[143],"for":[144],"HHT.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
