{"id":"https://openalex.org/W98290453","doi":null,"title":"Production of Acid-Labile-Alpha Interferon by AIDS Patients","display_name":"Production of Acid-Labile-Alpha Interferon by AIDS Patients","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W98290453","mag":"98290453"},"language":"en","primary_location":{"id":"mag:98290453","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a237252.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021843632","display_name":"Susana A. Serrate","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susana A. Serrate","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057154873","display_name":"Carl W. Dieffenbach","orcid":"https://orcid.org/0000-0002-4929-7509","observed_orcids":["https://orcid.org/0000-0002-4929-7509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl W. Dieffenbach","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4929-7509","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109118570","display_name":"Robert M. Friedman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M. Friedman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00465008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.3644999861717224,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.906000018119812},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.8209999799728394},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.9739999771118164},{"id":"https://openalex.org/keywords/interferon-therapy","display_name":"interferon therapy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/kaposi-sarcoma","display_name":"Kaposi's sarcoma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lentivirus","display_name":"lentivirus","score":0.8730000257492065},{"id":"https://openalex.org/keywords/murine-leukemia-virus","display_name":"murine leukemia virus","score":0.6179999709129333},{"id":"https://openalex.org/keywords/mouse-mammary-tumor-virus","display_name":"mouse mammary tumor virus","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6339457631111145},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5894352793693542},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5472830533981323},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5180604457855225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4956926107406616},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.49327558279037476},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.49021369218826294},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4771515727043152},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3628532290458679},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18902525305747986}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:98290453","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a237252.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2028362497","https://openalex.org/W2031286781","https://openalex.org/W148963236","https://openalex.org/W2138241632","https://openalex.org/W2119370734","https://openalex.org/W206219072","https://openalex.org/W2598882409","https://openalex.org/W2288517100","https://openalex.org/W7097549167","https://openalex.org/W1993002796"],"abstract_inverted_index":{"Abstract":[0],":":[1],"Recently,":[2],"there":[3],"has":[4],"been":[5,113],"interest":[6],"in":[7,19,26,35,45,49,121],"the":[8,13,20,39,53,122],"production":[9],"of":[10,15,24,41,55,60,75,99,110,124,139],"IFNs":[11,25,91],"during":[12],"course":[14],"HIV":[16,76],"infections,":[17],"and":[18,68,104,130],"possible":[21],"therapeutic":[22],"use":[23],"AIDS-associated":[27],"Kaposi":[28],"sarcoma":[29],"(Krown":[30],"et":[31,84,88],"al,":[32,85,89],"1990)":[33],"or":[34],"AIDS.":[36],"These":[37],"were":[38],"subjects":[40],"two":[42],"meetings":[43],"held":[44],"New":[46],"York":[47],"City":[48],"1990,":[50],"partially":[51],"on":[52,97],"basis":[54],"a":[56,69,93],"report":[57,71],"that":[58,72],"treatment":[59,74],"clinical":[61],"AIDS":[62],"with":[63],"IFN":[64,135],"alpha":[65],"is":[66],"effective,":[67],"preliminary":[70],"long-term":[73],"carriers":[77],"prolonged":[78],"their":[79],"asymptomatic":[80],"incubation":[81],"period":[82],"(Lane":[83],"1990;":[86],"Rivero":[87],"1990).":[90],"have":[92,112],"significant":[94],"inhibitory":[95],"effects":[96],"replication":[98],"retroviruses,":[100],"including":[101],"lentiviruses":[102],"(Friedman":[103],"Pitha,":[105],"1984).":[106],"Two":[107],"major":[108],"mechanisms":[109],"action":[111],"identified,":[114],"both":[115],"relating":[116],"to":[117],"virus":[118,140],"assembly:":[119],"(1)":[120],"case":[123],"most":[125],"murine":[126],"leukemia":[127],"viruses":[128],"(MLVs)":[129],"mouse":[131],"mammary":[132],"tumor":[133],"virus,":[134],"caused":[136],"an":[137],"inhibition":[138],"budding.":[141]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}