{"id":"https://openalex.org/W98282318","doi":null,"title":"Family Matters: Adjustment to genetic cancer susceptibility testing","display_name":"Family Matters: Adjustment to genetic cancer susceptibility testing","publication_year":2006,"publication_date":"2006-12-13","ids":{"openalex":"https://openalex.org/W98282318","mag":"98282318"},"language":"en","primary_location":{"id":"pmh:oai:repub.eur.nl:15751","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/15751","pdf_url":"http://repub.eur.nl/pub/15751","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repub.eur.nl/pub/15751","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085355195","display_name":"Iris van Oostrom","orcid":"https://orcid.org/0000-0001-6308-5046","observed_orcids":["https://orcid.org/0000-0001-6308-5046"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Iris van Oostrom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085355195"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13574","display_name":"Family Support in Illness","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psychosocial-adjustment","display_name":"psychosocial adjustment","score":0.906000018119812},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.7770000100135803},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hereditary-breast-cancer","display_name":"hereditary breast cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hereditary-colorectal-cancer","display_name":"hereditary colorectal cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lynch-syndrome","display_name":"Lynch syndrome","score":0.7170000076293945},{"id":"https://openalex.org/keywords/mutation-carriers","display_name":"mutation carriers","score":0.6430000066757202},{"id":"https://openalex.org/keywords/family-impact","display_name":"family impact","score":0.4189999997615814},{"id":"https://openalex.org/keywords/prophylactic-surgery","display_name":"prophylactic surgery","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.6906532049179077},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6442795395851135},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5770801901817322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.54777991771698},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5304740071296692},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.47158682346343994},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.46453315019607544},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1804097592830658},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1801220178604126},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17989131808280945}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repub.eur.nl:15751","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/15751","pdf_url":"http://repub.eur.nl/pub/15751","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:eur:oai:pure.eur.nl:publications/c5de203e-f54b-4d1c-8a01-03d9143aa339","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/c5de203e-f54b-4d1c-8a01-03d9143aa339","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:eur:oai:repub.eur.nl:15751","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/15751","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:98282318","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/15751/061213_Oostrom%20van%20Iris%20-%20bewerkt.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repub.eur.nl:15751","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/15751","pdf_url":"http://repub.eur.nl/pub/15751","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W98282318.pdf","grobid_xml":"https://content.openalex.org/works/W98282318.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W46942351","https://openalex.org/W205753970","https://openalex.org/W1244671447","https://openalex.org/W1559061289","https://openalex.org/W1566595428","https://openalex.org/W1569033281","https://openalex.org/W1758802144","https://openalex.org/W1781656480","https://openalex.org/W1843582003","https://openalex.org/W1963069290","https://openalex.org/W1965061090","https://openalex.org/W1968242016","https://openalex.org/W1969649027","https://openalex.org/W1971217879","https://openalex.org/W1973304738","https://openalex.org/W1974171154","https://openalex.org/W1977639214","https://openalex.org/W1977664176","https://openalex.org/W1978048301","https://openalex.org/W1978733194","https://openalex.org/W1981102152","https://openalex.org/W1981651282","https://openalex.org/W1982182377","https://openalex.org/W1982577230","https://openalex.org/W1985101852","https://openalex.org/W1986957721","https://openalex.org/W1989060327","https://openalex.org/W1993222885","https://openalex.org/W1993243508","https://openalex.org/W1993523594","https://openalex.org/W1994789648","https://openalex.org/W1997470314","https://openalex.org/W1998940064","https://openalex.org/W2002208326","https://openalex.org/W2002456187","https://openalex.org/W2005887102","https://openalex.org/W2006017095","https://openalex.org/W2009188300","https://openalex.org/W2014119318","https://openalex.org/W2015616772","https://openalex.org/W2015754157","https://openalex.org/W2015887564","https://openalex.org/W2016229413","https://openalex.org/W2021575941","https://openalex.org/W2025392773","https://openalex.org/W2026231457","https://openalex.org/W2033193475","https://openalex.org/W2035346978","https://openalex.org/W2037458211","https://openalex.org/W2037605263","https://openalex.org/W2038484584","https://openalex.org/W2043162151","https://openalex.org/W2043719388","https://openalex.org/W2045695327","https://openalex.org/W2046782791","https://openalex.org/W2047216512","https://openalex.org/W2047292805","https://openalex.org/W2047719805","https://openalex.org/W2047928426","https://openalex.org/W2049387936","https://openalex.org/W2049961750","https://openalex.org/W2051322535","https://openalex.org/W2051741411","https://openalex.org/W2053277023","https://openalex.org/W2054921882","https://openalex.org/W2055506968","https://openalex.org/W2055618045","https://openalex.org/W2055769378","https://openalex.org/W2056585512","https://openalex.org/W2059093778","https://openalex.org/W2059286462","https://openalex.org/W2059919283","https://openalex.org/W2060654347","https://openalex.org/W2061577838","https://openalex.org/W2066358461","https://openalex.org/W2066729834","https://openalex.org/W2067181991","https://openalex.org/W2068690814","https://openalex.org/W2068964225","https://openalex.org/W2069029818","https://openalex.org/W2069573564","https://openalex.org/W2071502106","https://openalex.org/W2071939918","https://openalex.org/W2072888349","https://openalex.org/W2076652679","https://openalex.org/W2079467159","https://openalex.org/W2080068218","https://openalex.org/W2080703882","https://openalex.org/W2080752222","https://openalex.org/W2084719413","https://openalex.org/W2085071409","https://openalex.org/W2090157903","https://openalex.org/W2090262813","https://openalex.org/W2092295812","https://openalex.org/W2092577342","https://openalex.org/W2094287846","https://openalex.org/W2096917033","https://openalex.org/W2097963803","https://openalex.org/W2098169412","https://openalex.org/W2099740808","https://openalex.org/W2102740368","https://openalex.org/W2107768095","https://openalex.org/W2109843843","https://openalex.org/W2111832911","https://openalex.org/W2112228221","https://openalex.org/W2117401825","https://openalex.org/W2123915321","https://openalex.org/W2124271244","https://openalex.org/W2131115934","https://openalex.org/W2132563293","https://openalex.org/W2132661220","https://openalex.org/W2133964819","https://openalex.org/W2135366381","https://openalex.org/W2136260979","https://openalex.org/W2138123424","https://openalex.org/W2138742383","https://openalex.org/W2139439655","https://openalex.org/W2141526658","https://openalex.org/W2143698296","https://openalex.org/W2144914570","https://openalex.org/W2145432309","https://openalex.org/W2147451828","https://openalex.org/W2148903353","https://openalex.org/W2156299764","https://openalex.org/W2162837522","https://openalex.org/W2164486656","https://openalex.org/W2166582036","https://openalex.org/W2170481578","https://openalex.org/W2233510298","https://openalex.org/W2480818690","https://openalex.org/W4235278625","https://openalex.org/W4415292885"],"related_works":["https://openalex.org/W2182852662","https://openalex.org/W2107768095","https://openalex.org/W4231477056","https://openalex.org/W2411297834","https://openalex.org/W2329584859","https://openalex.org/W1588469854","https://openalex.org/W1988040508","https://openalex.org/W2101413599","https://openalex.org/W1949598279","https://openalex.org/W2108988016"],"abstract_inverted_index":{"Cancer":[0],"is":[1,6,15,136],"generally":[2],"feared":[3],"because":[4],"it":[5,263],"associated":[7],"with":[8,205,312,342],"death":[9,23],"and":[10,28,50,56,149,296,299,361,365],"severe":[11],"physical":[12],"suffering.":[13],"It":[14,167,197,221,247],"one":[16,124,325],"of":[17,22,36,47,54,63,94,119,191,208,285,326,347,352,363],"the":[18,25,32,86,91,98,122,142,188,206,233,244,282,317,327,345,350],"most":[19,33],"common":[20],"causes":[21],"in":[24,43,66,81,90,132,182,268,316,355],"Netherlands.":[26],"Breast":[27],"colon":[29],"cancer":[30,37,46,58,69,75,109,128,177,192,295,298],"are":[31,45,254,335],"prevalent":[34],"types":[35,42],"among":[38],"women.":[39],"Frequently":[40],"occurring":[41],"men":[44],"colon,":[48],"lung":[49],"prostate.":[51],"About":[52],"5%":[53],"colorectal":[55,297],"breast":[57,294],"arises":[59],"as":[60],"a":[61,64,290,313],"result":[62],"mutation":[65,143,165,315],"an":[67,82,104,179],"inherited":[68],"susceptibility":[70,76,234,287],"gene.":[71],"Knowledge":[72],"about":[73,121],"these":[74],"genes":[77,321,329],"has":[78,125,159],"been":[79],"accumulating":[80],"impressive":[83],"manner":[84],"over":[85],"last":[87],"decades,":[88],"resulting":[89],"clinical":[92,353,359],"availability":[93,362],"genetic":[95,102,286],"testing":[96,139,158,288],"from":[97,147,310],"mid-nineties":[99],"onward.":[100],"Through":[101],"testing,":[103],"individual\u2019s":[105],"risk":[106,123,174,258,302],"to":[107,126,170,175,200,235,242,259,292,300,338,344],"develop":[108,127,176,260,293],"can":[110,116,144,225],"be":[111,145,171],"determined":[112],"more":[113,266],"precisely.":[114],"This":[115,277],"reduce":[117],"feelings":[118],"uncertainty":[120],"at":[129,172,178,256,280],"some":[130],"point":[131],"life.":[133],"Another":[134],"advantage":[135],"that":[137,223,249],"individuals":[138,309],"negative":[140],"for":[141,164,203,214,275,289,304],"discharged":[146],"unnecessary":[148],"possibly":[150],"invasive":[151],"early":[152,180],"detection":[153],"and/or":[154],"prevention":[155,364],"strategies.":[156],"Genetic":[157],"several":[160],"psychosocial":[161,283,340],"implications,":[162],"especially":[163],"carriers.":[166],"implies":[168,198,222],"knowing":[169],"high":[173],"stage":[181],"life,":[183],"while":[184],"often":[185],"having":[186],"witnessed":[187],"devastating":[189],"impact":[190],"on":[193,227,232,308],"close":[194,251],"family":[195,252],"members.":[196],"going":[199],"hospitals":[201],"regularly":[202],"screening":[204],"possibility":[207],"hearing":[209],"bad":[210],"news,":[211],"or":[212,228,273,319,324],"opting":[213],"far-reaching":[215],"preventive":[216],"options":[217],"like":[218],"prophylactic":[219],"surgery.":[220],"you":[224],"pass":[226],"may":[229,264],"have":[230,241],"passed":[231],"your":[236],"own":[237],"children,":[238],"who":[239],"will":[240],"face":[243],"same":[245],"fate.":[246],"means":[248],"other":[250],"members":[253],"also":[255],"increased":[257],"cancer.":[261],"Finally,":[262],"imply":[265],"difficulties":[267],"obtaining":[269],"life":[270,356],"insurance,":[271],"mortgage":[272],"insurances":[274],"disablement.":[276],"thesis":[278],"aims":[279],"understanding":[281],"consequences":[284],"predisposition":[291],"identify":[301],"factors":[303],"maladjustment.":[305],"We":[306],"focus":[307],"families":[311],"known":[314],"BRCA1":[318],"BRCA2":[320],"(breast":[322],"cancer)":[323],"HNPCC-related":[328],"(colorectal":[330],"cancer).":[331],"The":[332],"two":[333],"conditions":[334],"comparable":[336],"according":[337],"Rolland\u2019s":[339],"typology1":[341],"regard":[343],"likelihood":[346],"developing":[348],"cancer,":[349],"timing":[351],"onset":[354],"cycle,":[357],"overall":[358],"severity":[360],"treatment":[366],"options.":[367]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
