{"id":"https://openalex.org/W982743738","doi":null,"title":"TAFIa is a Novel Inhibitor of Tumour Angiogenesis in Breast Cancer","display_name":"TAFIa is a Novel Inhibitor of Tumour Angiogenesis in Breast Cancer","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W982743738","mag":"982743738"},"language":"en","primary_location":{"id":"pmh:oai:scholar.uwindsor.ca:etd-6325","doi":null,"is_oa":true,"landing_page_url":"https://scholar.uwindsor.ca/etd/5326","pdf_url":null,"source":{"id":"https://openalex.org/S4306400430","display_name":"Scholarship at UWindsor (University of Windsor)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74413500","host_organization_name":"University of Windsor","host_organization_lineage":["https://openalex.org/I74413500"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholar.uwindsor.ca/etd/5326","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068009145","display_name":"Jennifer Lynn Balun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer Lynn Balun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068009145"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.47510001063346863,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.47510001063346863,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.26339998841285706,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.24959999322891235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombomodulin","display_name":"thrombomodulin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tafia","display_name":"TAFIa","score":0.8830000162124634},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.953000009059906},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.6439999938011169},{"id":"https://openalex.org/keywords/protein-c","display_name":"protein C","score":0.7960000038146973},{"id":"https://openalex.org/keywords/plasminogen-activation","display_name":"plasminogen activation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/extracellular-matrix-proteolysis","display_name":"extracellular matrix proteolysis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/tube-formation","display_name":"tube formation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7210000157356262},{"id":"https://openalex.org/keywords/antimetastatic-effect","display_name":"antimetastatic effect","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5774539113044739},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.564713716506958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5599356889724731},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5554929375648499},{"id":"https://openalex.org/C2776056115","wikidata":"https://www.wikidata.org/wiki/Q574834","display_name":"Angiogenesis inhibitor","level":3,"score":0.43719711899757385},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3996683955192566},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3562285900115967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33733251690864563}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:scholar.uwindsor.ca:etd-6325","doi":null,"is_oa":true,"landing_page_url":"https://scholar.uwindsor.ca/etd/5326","pdf_url":null,"source":{"id":"https://openalex.org/S4306400430","display_name":"Scholarship at UWindsor (University of Windsor)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74413500","host_organization_name":"University of Windsor","host_organization_lineage":["https://openalex.org/I74413500"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:uwindsor.scholaris.ca:20.500.14776/5323","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14776/5323","pdf_url":null,"source":{"id":"https://openalex.org/S4306400430","display_name":"Scholarship at UWindsor (University of Windsor)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74413500","host_organization_name":"University of Windsor","host_organization_lineage":["https://openalex.org/I74413500"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:982743738","doi":null,"is_oa":false,"landing_page_url":"https://scholar.uwindsor.ca/cgi/viewcontent.cgi?article=6325&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholar.uwindsor.ca:etd-6325","doi":null,"is_oa":true,"landing_page_url":"https://scholar.uwindsor.ca/etd/5326","pdf_url":null,"source":{"id":"https://openalex.org/S4306400430","display_name":"Scholarship at UWindsor (University of Windsor)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74413500","host_organization_name":"University of Windsor","host_organization_lineage":["https://openalex.org/I74413500"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":161,"referenced_works":["https://openalex.org/W32167704","https://openalex.org/W121755589","https://openalex.org/W1264942373","https://openalex.org/W1486830389","https://openalex.org/W1512983489","https://openalex.org/W1514226843","https://openalex.org/W1516603921","https://openalex.org/W1521574535","https://openalex.org/W1555312557","https://openalex.org/W1555806697","https://openalex.org/W1565086756","https://openalex.org/W1567591901","https://openalex.org/W1573363574","https://openalex.org/W1679229092","https://openalex.org/W1684253917","https://openalex.org/W1740440689","https://openalex.org/W1840889595","https://openalex.org/W1926488772","https://openalex.org/W1954576125","https://openalex.org/W1964350146","https://openalex.org/W1966509573","https://openalex.org/W1967045339","https://openalex.org/W1967365012","https://openalex.org/W1967470122","https://openalex.org/W1968084778","https://openalex.org/W1971144980","https://openalex.org/W1972739162","https://openalex.org/W1973645860","https://openalex.org/W1975027475","https://openalex.org/W1975273342","https://openalex.org/W1977327764","https://openalex.org/W1977497608","https://openalex.org/W1977799997","https://openalex.org/W1978139448","https://openalex.org/W1980312970","https://openalex.org/W1980470187","https://openalex.org/W1981201118","https://openalex.org/W1983703392","https://openalex.org/W1985804036","https://openalex.org/W1991154912","https://openalex.org/W1991306519","https://openalex.org/W1991842901","https://openalex.org/W1994930469","https://openalex.org/W1996810856","https://openalex.org/W1996910230","https://openalex.org/W1998026311","https://openalex.org/W1998218979","https://openalex.org/W1999966784","https://openalex.org/W2000000541","https://openalex.org/W2003500892","https://openalex.org/W2005334224","https://openalex.org/W2006720521","https://openalex.org/W2008020967","https://openalex.org/W2008654831","https://openalex.org/W2012080977","https://openalex.org/W2013336992","https://openalex.org/W2016411107","https://openalex.org/W2019399234","https://openalex.org/W2020625616","https://openalex.org/W2022180932","https://openalex.org/W2026329451","https://openalex.org/W2026996188","https://openalex.org/W2029325734","https://openalex.org/W2029325748","https://openalex.org/W2029453461","https://openalex.org/W2030615367","https://openalex.org/W2032653142","https://openalex.org/W2034269086","https://openalex.org/W2034600376","https://openalex.org/W2035974720","https://openalex.org/W2038723412","https://openalex.org/W2039881470","https://openalex.org/W2040972148","https://openalex.org/W2041916290","https://openalex.org/W2042093092","https://openalex.org/W2044321029","https://openalex.org/W2044772588","https://openalex.org/W2049827480","https://openalex.org/W2052841974","https://openalex.org/W2056146626","https://openalex.org/W2056894234","https://openalex.org/W2057286297","https://openalex.org/W2057497222","https://openalex.org/W2057952723","https://openalex.org/W2058239698","https://openalex.org/W2059413861","https://openalex.org/W2060481368","https://openalex.org/W2062253564","https://openalex.org/W2062594120","https://openalex.org/W2063575076","https://openalex.org/W2063754581","https://openalex.org/W2063982283","https://openalex.org/W2066822578","https://openalex.org/W2070093899","https://openalex.org/W2071359561","https://openalex.org/W2073251971","https://openalex.org/W2075123115","https://openalex.org/W2077129920","https://openalex.org/W2078104401","https://openalex.org/W2082561187","https://openalex.org/W2082910811","https://openalex.org/W2084243362","https://openalex.org/W2085505088","https://openalex.org/W2087740619","https://openalex.org/W2087840851","https://openalex.org/W2088579185","https://openalex.org/W2090062844","https://openalex.org/W2090706464","https://openalex.org/W2090842150","https://openalex.org/W2091084650","https://openalex.org/W2091760375","https://openalex.org/W2092565468","https://openalex.org/W2092798021","https://openalex.org/W2095036479","https://openalex.org/W2095847870","https://openalex.org/W2100918981","https://openalex.org/W2102577298","https://openalex.org/W2105823536","https://openalex.org/W2106093405","https://openalex.org/W2107277218","https://openalex.org/W2107848687","https://openalex.org/W2112509531","https://openalex.org/W2112996675","https://openalex.org/W2113321082","https://openalex.org/W2116943300","https://openalex.org/W2117692326","https://openalex.org/W2117910659","https://openalex.org/W2119811619","https://openalex.org/W2120136262","https://openalex.org/W2121141343","https://openalex.org/W2122407131","https://openalex.org/W2125043984","https://openalex.org/W2126254515","https://openalex.org/W2126810504","https://openalex.org/W2129537774","https://openalex.org/W2135332384","https://openalex.org/W2135351121","https://openalex.org/W2135552434","https://openalex.org/W2143681162","https://openalex.org/W2144257419","https://openalex.org/W2144744111","https://openalex.org/W2146519773","https://openalex.org/W2146916102","https://openalex.org/W2147867270","https://openalex.org/W2150776809","https://openalex.org/W2154377273","https://openalex.org/W2158387300","https://openalex.org/W2158965678","https://openalex.org/W2161666019","https://openalex.org/W2163572012","https://openalex.org/W2165388517","https://openalex.org/W2166970179","https://openalex.org/W2167709602","https://openalex.org/W2169145856","https://openalex.org/W2171663131","https://openalex.org/W2171998177","https://openalex.org/W2320070423","https://openalex.org/W2400141735","https://openalex.org/W2414137000","https://openalex.org/W2420540114","https://openalex.org/W2804842145"],"related_works":["https://openalex.org/W2580045055","https://openalex.org/W7205219945","https://openalex.org/W7052862643","https://openalex.org/W2565494685","https://openalex.org/W1937278795","https://openalex.org/W7205037888","https://openalex.org/W2930910285","https://openalex.org/W2403503400","https://openalex.org/W2562033521","https://openalex.org/W1975273342"],"abstract_inverted_index":{"Thrombomodulin":[0],"(TM)":[1],"is":[2,43,54,64],"known":[3,45],"mostly":[4],"for":[5,56,66],"its":[6,77],"role":[7,23,78],"in":[8,24,79,112,146],"the":[9,31,67,80,88],"regulation":[10],"of":[11,34,48,70,82,90,97,101,104,109,127],"hemostasis,":[12],"but":[13],"it":[14,42],"has":[15],"also":[16,122],"been":[17],"shown":[18],"to":[19,76],"play":[20],"an":[21,124],"antimetastatic":[22,58,68],"cancer.":[25],"A":[26],"previous":[27],"study":[28],"showed":[29],"that":[30,62,141],"anitmetastatic":[32],"effects":[33,69],"TM":[35],"were":[36],"dependent":[37],"on":[38,92,132],"thrombin":[39],"binding.":[40],"However,":[41],"not":[44],"which":[46],"substrate":[47],"thrombin-TM,":[49],"protein":[50],"C":[51],"or":[52],"TAFI,":[53],"responsible":[55,65],"these":[57],"effects.":[59],"We":[60,86,106,121],"hypothesized":[61],"TAFI":[63,128],"TM,":[71],"specifically":[72],"tumour":[73,93,144],"angiogenesis,":[74],"due":[75],"inhibition":[81,96,108],"pericellular":[83],"plasminogen":[84],"activation.":[85],"determined":[87],"effect":[89,126],"TAFIa":[91,98,110,142],"angiogenesis":[94,145],"through":[95],"and":[99,118,135],"manipulation":[100],"cofactor":[102],"ability":[103],"TM.":[105],"found":[107,123],"resulted":[111],"increased":[113],"proliferation,":[114],"invasion,":[115],"tube":[116,133],"formation,":[117],"ECM":[119,136],"proteolysis.":[120,137],"inhibitory":[125],"activation":[129],"by":[130],"thrombin-TM":[131],"formation":[134],"Our":[138],"results":[139],"suggest":[140],"inhibits":[143],"breast":[147],"cancer":[148],"cells.":[149]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}
