{"id":"https://openalex.org/W98250161","doi":null,"title":"Structure-Activity Relationships Analysis of (+)-Discodermolide and the Synthesis of Precursors for Further Analogue Studies","display_name":"Structure-Activity Relationships Analysis of (+)-Discodermolide and the Synthesis of Precursors for Further Analogue Studies","publication_year":2014,"publication_date":"2014-05-22","ids":{"openalex":"https://openalex.org/W98250161","mag":"98250161"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:21559","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/21559/1/ALS_Masters_thesis_ETD_submission.pdf","pdf_url":"http://d-scholarship.pitt.edu/21559/1/ALS_Masters_thesis_ETD_submission.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/21559/1/ALS_Masters_thesis_ETD_submission.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113470007","display_name":"Amy L. Short","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amy L. Short","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113470007"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13971","display_name":"Isoquinoline Alkaloid Synthesis","score":0.26339998841285706,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13971","display_name":"Isoquinoline Alkaloid Synthesis","score":0.26339998841285706,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13221","display_name":"Biological Activity of Diterpenoids and Biflavonoids","score":0.10490000247955322,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.07069999724626541,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/discodermolide","display_name":"discodermolide","score":0.9959999918937683},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9950000047683716},{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.4449999928474426},{"id":"https://openalex.org/keywords/microtubule-stabilization","display_name":"microtubule stabilization","score":0.8349999785423279},{"id":"https://openalex.org/keywords/beta-tubulin","display_name":"beta-tubulin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/paclitaxel-resistance","display_name":"paclitaxel resistance","score":0.9100000262260437},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8299999833106995},{"id":"https://openalex.org/keywords/fragment-synthesis","display_name":"fragment synthesis","score":0.675000011920929},{"id":"https://openalex.org/keywords/hqsar","display_name":"HQSAR","score":0.7570000290870667},{"id":"https://openalex.org/keywords/marine-sponge-natural-products","display_name":"marine sponge natural products","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antiproliferative-agents","display_name":"antiproliferative agents","score":0.7519999742507935},{"id":"https://openalex.org/keywords/drug-analogues","display_name":"drug analogues","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.7740966081619263},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7053956985473633},{"id":"https://openalex.org/C2777526313","wikidata":"https://www.wikidata.org/wiki/Q408201","display_name":"Epothilone","level":2,"score":0.5730732679367065},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.5687933564186096},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.5567412972450256},{"id":"https://openalex.org/C2778322223","wikidata":"https://www.wikidata.org/wiki/Q7689669","display_name":"Taxoid","level":4,"score":0.42076927423477173},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3945465087890625},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.37090808153152466},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3220086097717285},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22568866610527039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1456264853477478},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12137070298194885},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:21559","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/21559/1/ALS_Masters_thesis_ETD_submission.pdf","pdf_url":"http://d-scholarship.pitt.edu/21559/1/ALS_Masters_thesis_ETD_submission.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:98250161","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/21559/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:21559","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/21559/1/ALS_Masters_thesis_ETD_submission.pdf","pdf_url":"http://d-scholarship.pitt.edu/21559/1/ALS_Masters_thesis_ETD_submission.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W98250161.pdf","grobid_xml":"https://content.openalex.org/works/W98250161.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W1961078765","https://openalex.org/W1964247608","https://openalex.org/W1965467117","https://openalex.org/W1966487507","https://openalex.org/W1970477011","https://openalex.org/W1971579914","https://openalex.org/W1972164028","https://openalex.org/W1978852479","https://openalex.org/W1979060857","https://openalex.org/W1982478827","https://openalex.org/W1984374097","https://openalex.org/W1985501881","https://openalex.org/W1986014209","https://openalex.org/W1989217595","https://openalex.org/W1992386013","https://openalex.org/W1994206173","https://openalex.org/W1994474279","https://openalex.org/W1994692982","https://openalex.org/W1996074150","https://openalex.org/W1997607602","https://openalex.org/W1999142756","https://openalex.org/W2004208462","https://openalex.org/W2011822328","https://openalex.org/W2013273979","https://openalex.org/W2013998077","https://openalex.org/W2024849899","https://openalex.org/W2027316605","https://openalex.org/W2027517101","https://openalex.org/W2029226407","https://openalex.org/W2032396306","https://openalex.org/W2034688658","https://openalex.org/W2038036152","https://openalex.org/W2039145109","https://openalex.org/W2041920169","https://openalex.org/W2042636186","https://openalex.org/W2044066412","https://openalex.org/W2046092556","https://openalex.org/W2049583879","https://openalex.org/W2050182919","https://openalex.org/W2051528378","https://openalex.org/W2053699344","https://openalex.org/W2058462271","https://openalex.org/W2058997498","https://openalex.org/W2059315823","https://openalex.org/W2065314837","https://openalex.org/W2067978364","https://openalex.org/W2071427306","https://openalex.org/W2071817332","https://openalex.org/W2074934544","https://openalex.org/W2077735888","https://openalex.org/W2077945404","https://openalex.org/W2078364671","https://openalex.org/W2081153499","https://openalex.org/W2081190889","https://openalex.org/W2081938650","https://openalex.org/W2085531560","https://openalex.org/W2089427313","https://openalex.org/W2090500244","https://openalex.org/W2093349455","https://openalex.org/W2093609623","https://openalex.org/W2095691673","https://openalex.org/W2096475021","https://openalex.org/W2100712209","https://openalex.org/W2110945686","https://openalex.org/W2111677437","https://openalex.org/W2116826087","https://openalex.org/W2122129877","https://openalex.org/W2124166212","https://openalex.org/W2130718258","https://openalex.org/W2134262362","https://openalex.org/W2134917387","https://openalex.org/W2138224881","https://openalex.org/W2153942568","https://openalex.org/W2158473670","https://openalex.org/W2159183855","https://openalex.org/W2159671913","https://openalex.org/W2163970150","https://openalex.org/W2165762385","https://openalex.org/W2166955022","https://openalex.org/W2167032192","https://openalex.org/W2316937195","https://openalex.org/W2335579704","https://openalex.org/W2415683488","https://openalex.org/W2949219978","https://openalex.org/W2950645915","https://openalex.org/W2951049703","https://openalex.org/W2953202587","https://openalex.org/W3141114422","https://openalex.org/W3146626798"],"related_works":["https://openalex.org/W1984374097","https://openalex.org/W2352943718","https://openalex.org/W75719607","https://openalex.org/W2103955749","https://openalex.org/W2013533466","https://openalex.org/W43926717","https://openalex.org/W7015593182","https://openalex.org/W1974924571","https://openalex.org/W2049583879","https://openalex.org/W2081153499"],"abstract_inverted_index":{"In":[0],"1990,":[1],"the":[2,31,75,101,107,135,148,170,191],"natural":[3],"product":[4],"discodermolide":[5,26,72,128,141,171],"was":[6],"isolated":[7],"from":[8,106],"a":[9,42,85,138,151,199],"marine":[10],"sponge":[11],"and":[12,60,80,89,180,196],"later":[13],"found":[14],"to":[15,27,146,160,164,169,189,197],"have":[16,174,186],"exceptional":[17],"antiproliferative":[18],"activity":[19],"in":[20,49,84,98,115,177],"cancer":[21],"cells.":[22],"Further":[23],"studies":[24],"showed":[25],"stabilize":[28],"microtubules":[29],"via":[30,155],"taxoid":[32],"binding":[33],"site":[34],"on":[35],"beta-tubulin.":[36],"Unlike":[37],"paclitaxel,":[38],"it":[39],"is":[40,47,117,129],"not":[41],"substrate":[43],"for":[44,127,205],"P-glycoprotein":[45],"transport,":[46],"potent":[48],"paclitaxel-resistant":[50],"cell":[51],"lines":[52],"with":[53,66],"beta-tubulin":[54],"mutations,":[55],"exhibits":[56],"better":[57],"water":[58],"solubility,":[59],"can":[61],"act":[62],"synergistically":[63],"when":[64],"combined":[65],"paclitaxel":[67],"treatment.":[68],"For":[69],"this":[70,112],"reason,":[71],"has":[73],"been":[74,187],"focus":[76],"of":[77,104,123,137,140,150,193,203],"many":[78],"synthetic":[79,194],"biological":[81,206],"studies,":[82],"culminating":[83],"60":[86],"gram-scale":[87],"synthesis":[88],"Phase":[90],"I/II":[91],"clinical":[92],"trials":[93],"carried":[94],"out":[95],"by":[96],"Novartis":[97],"2004.":[99],"Despite":[100],"great":[102],"level":[103],"interest":[105],"scientific":[108],"community,":[109],"much":[110],"about":[111],"compound\u2019s":[113],"behavior":[114],"vivo":[116],"still":[118],"unknown.":[119],"An":[120],"extended":[121],"analysis":[122],"known":[124],"structure-activity":[125],"relationships":[126],"presented":[130],"herein.":[131],"Also":[132],"reported":[133],"are":[134,144,166],"syntheses":[136],"series":[139,202],"fragments,":[142],"which":[143],"designed":[145,188],"enable":[147],"formation":[149],"novel":[152],"analogue":[153,179],"library":[154],"late-stage":[156],"multicomponent":[157],"reactions.":[158],"Fragments":[159],"be":[161],"synthesized":[162],"prior":[163,178],"coupling":[165],"streamlined":[167],"alternatives":[168],"framework":[172],"that":[173],"shown":[175],"promise":[176],"HQSAR":[181],"studies.":[182],"Overall,":[183],"these":[184],"modifications":[185],"improve":[190],"efficiency":[192],"efforts":[195],"represent":[198],"wholly":[200],"unique":[201],"analogues":[204],"study.":[207]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}