{"id":"https://openalex.org/W9817620","doi":"https://doi.org/10.1007/978-1-4615-1965-2_2","title":"Substrate Binding Pocket Structure of Human Aldehyde Dehydrogenases","display_name":"Substrate Binding Pocket Structure of Human Aldehyde Dehydrogenases","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W9817620","doi":"https://doi.org/10.1007/978-1-4615-1965-2_2","mag":"9817620","pmid":"https://pubmed.ncbi.nlm.nih.gov/7484415"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4615-1965-2_2","doi":"https://doi.org/10.1007/978-1-4615-1965-2_2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-1965-2_2","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1973255655","display_name":"Enzymology and Molecular Biology of Carbonyl Metabolism 5"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031671611","display_name":"Shih\u2010Jiun Yin","orcid":"https://orcid.org/0000-0002-6263-8400","observed_orcids":["https://orcid.org/0000-0002-6263-8400"]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Jiun Yin","raw_affiliation_strings":["Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052013584","display_name":"Ming-Fang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Fang Wang","raw_affiliation_strings":["Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111556330","display_name":"Chih\u2010Li Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Li Han","raw_affiliation_strings":["Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009725330","display_name":"Sung-Ling Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Sung-Ling Wang","raw_affiliation_strings":["Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China","institution_ids":["https://openalex.org/I68171755"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I68171755"],"apc_list":null,"apc_paid":null,"fwci":1.2581,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.65806452,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"372","issue":null,"first_page":"9","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase","display_name":"aldehyde dehydrogenase","score":0.859000027179718},{"id":"https://openalex.org/keywords/substrate-binding-pocket","display_name":"substrate binding pocket","score":0.9160000085830688},{"id":"https://openalex.org/keywords/acetaldehyde","display_name":"acetaldehyde","score":0.6510000228881836},{"id":"https://openalex.org/keywords/aldehyde-oxidation","display_name":"aldehyde oxidation","score":0.4970000088214874},{"id":"https://openalex.org/keywords/enzyme-structure","display_name":"enzyme structure","score":0.3880000114440918},{"id":"https://openalex.org/keywords/sequence-homology","display_name":"sequence homology","score":0.5220000147819519},{"id":"https://openalex.org/keywords/aldh1","display_name":"ALDH1","score":0.5960000157356262},{"id":"https://openalex.org/keywords/aldh2","display_name":"ALDH2","score":0.8859999775886536},{"id":"https://openalex.org/keywords/human-liver-enzymes","display_name":"human liver enzymes","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.94765704870224},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6994142532348633},{"id":"https://openalex.org/C2777595113","wikidata":"https://www.wikidata.org/wiki/Q61457","display_name":"Acetaldehyde","level":3,"score":0.6553864479064941},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.6196661591529846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6024298667907715},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4861125946044922},{"id":"https://openalex.org/C2779825165","wikidata":"https://www.wikidata.org/wiki/Q101497","display_name":"Aldehyde","level":3,"score":0.4530108869075775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4446139931678772},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.4105520248413086},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.36965057253837585},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.22679635882377625},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19313475489616394},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-4615-1965-2_2","doi":"https://doi.org/10.1007/978-1-4615-1965-2_2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-1965-2_2","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:7484415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7484415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W113313279","https://openalex.org/W144336813","https://openalex.org/W162258464","https://openalex.org/W171382270","https://openalex.org/W349644444","https://openalex.org/W628273134","https://openalex.org/W1244636074","https://openalex.org/W1484196488","https://openalex.org/W1503086187","https://openalex.org/W1545782352","https://openalex.org/W1565629087","https://openalex.org/W1568509972","https://openalex.org/W1571689153","https://openalex.org/W1573199302","https://openalex.org/W1575005673","https://openalex.org/W1586529577","https://openalex.org/W1587373255","https://openalex.org/W1589027452","https://openalex.org/W1604995875","https://openalex.org/W1607600381","https://openalex.org/W1775749144","https://openalex.org/W1854024296","https://openalex.org/W1889077695","https://openalex.org/W1965674627","https://openalex.org/W1965763707","https://openalex.org/W1972816445","https://openalex.org/W1973255655","https://openalex.org/W1991065242","https://openalex.org/W1994773589","https://openalex.org/W2001342878","https://openalex.org/W2017542670","https://openalex.org/W2019716219","https://openalex.org/W2029671623","https://openalex.org/W2034647911","https://openalex.org/W2043285923","https://openalex.org/W2048537862","https://openalex.org/W2049584032","https://openalex.org/W2056936605","https://openalex.org/W2058372849","https://openalex.org/W2058648535","https://openalex.org/W2066131491","https://openalex.org/W2081351575","https://openalex.org/W2094392670","https://openalex.org/W2101798930","https://openalex.org/W2128635872","https://openalex.org/W2156895606","https://openalex.org/W2298207820","https://openalex.org/W2412040283","https://openalex.org/W2414928869","https://openalex.org/W2443945720","https://openalex.org/W2969273703","https://openalex.org/W4255568223","https://openalex.org/W4300638156","https://openalex.org/W6610051346","https://openalex.org/W6639751288"],"related_works":["https://openalex.org/W175577563","https://openalex.org/W2070001837","https://openalex.org/W2149793095","https://openalex.org/W2404468360","https://openalex.org/W2049584032","https://openalex.org/W4409806631","https://openalex.org/W3030140754","https://openalex.org/W2047626540","https://openalex.org/W2923998001","https://openalex.org/W105085748"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
