{"id":"https://openalex.org/W98108242","doi":null,"title":"Central nervous system as a possible site of HCV replication.","display_name":"Central nervous system as a possible site of HCV replication.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W98108242","mag":"98108242","pmid":"https://pubmed.ncbi.nlm.nih.gov/18572506"},"language":"en","primary_location":{"id":"pmid:18572506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18572506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Przeglad epidemiologiczny","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071606380","display_name":"Agnieszka Bednarska","orcid":"https://orcid.org/0000-0001-7303-7451","observed_orcids":["https://orcid.org/0000-0001-7303-7451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnieszka Bednarska","raw_affiliation_strings":["Wojew\u00f3dzki Szpital Zaka\u017any w Warszawie. basand@mp.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wojew\u00f3dzki Szpital Zaka\u017any w Warszawie. basand@mp.pl","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078642431","display_name":"Andrzej Horban","orcid":"https://orcid.org/0000-0003-3274-4162","observed_orcids":["https://orcid.org/0000-0003-3274-4162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrzej Horban","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018290358","display_name":"Marek Radkowski","orcid":"https://orcid.org/0000-0003-1808-679X","observed_orcids":["https://orcid.org/0000-0003-1808-679X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marek Radkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2019,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.60254301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"61","issue":"4","first_page":"739","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuroinvasion","display_name":"neuroinvasion","score":0.8489999771118164},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hcv-replication","display_name":"HCV replication","score":0.7540000081062317},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.996999979019165},{"id":"https://openalex.org/keywords/cns-macrophages","display_name":"CNS macrophages","score":0.7960000038146973},{"id":"https://openalex.org/keywords/neurological-symptoms","display_name":"neurological symptoms","score":0.652999997138977},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/viral-pathogenesis","display_name":"viral pathogenesis","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7792258858680725},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6625708937644958},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6537001132965088},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6423967480659485},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5672824382781982},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5089206695556641},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.4966171383857727},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.4853000044822693},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.46852463483810425},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.46607375144958496},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.46029385924339294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45018470287323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4001162648200989},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33307790756225586},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020805","descriptor_name":"Central Nervous System Viral Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:18572506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18572506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Przeglad epidemiologiczny","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.497.2173","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.497.2173","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.pzh.gov.pl/oldpage/przeglad_epimed/61-4/614_14.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W165055539","https://openalex.org/W1547384224","https://openalex.org/W1656291587","https://openalex.org/W1766512274","https://openalex.org/W1904708579","https://openalex.org/W1949134722","https://openalex.org/W1974441274","https://openalex.org/W1975448167","https://openalex.org/W1979368286","https://openalex.org/W1979675922","https://openalex.org/W1988254695","https://openalex.org/W1992189812","https://openalex.org/W1997312284","https://openalex.org/W1998120197","https://openalex.org/W2006309458","https://openalex.org/W2009230499","https://openalex.org/W2020228123","https://openalex.org/W2022291864","https://openalex.org/W2028289853","https://openalex.org/W2043019442","https://openalex.org/W2047298360","https://openalex.org/W2055091163","https://openalex.org/W2060551307","https://openalex.org/W2064278664","https://openalex.org/W2065710821","https://openalex.org/W2069782517","https://openalex.org/W2070274890","https://openalex.org/W2075199481","https://openalex.org/W2092482063","https://openalex.org/W2101464141","https://openalex.org/W2108869753","https://openalex.org/W2114354962","https://openalex.org/W2121909582","https://openalex.org/W2140236713","https://openalex.org/W2146942744","https://openalex.org/W2164048076","https://openalex.org/W3025122695"],"related_works":["https://openalex.org/W2075281999","https://openalex.org/W2027573355","https://openalex.org/W4232100360","https://openalex.org/W2409433582","https://openalex.org/W22424246","https://openalex.org/W4392125722","https://openalex.org/W1040541717","https://openalex.org/W2061720475","https://openalex.org/W2081499342","https://openalex.org/W1518177083"],"abstract_inverted_index":{"There":[0],"is":[1],"mounting":[2],"evidence":[3],"of":[4,52,61],"HCV":[5,40,68],"neuroinvasion":[6],"on":[7],"the":[8,25,29,37,49],"clinical":[9],"and":[10,46],"molecular":[11],"level.":[12],"It":[13,31],"seems":[14],"that":[15,36],"microglia":[16],"cells,":[17],"representing":[18],"a":[19,57],"resident":[20],"CNS":[21,42],"macrophages":[22,38],"population,":[23],"are":[24,65],"main":[26],"target":[27],"for":[28],"virus.":[30],"can":[32,55],"be":[33],"also":[34],"speculated":[35],"carry":[39],"to":[41],"compartment.":[43],"Nonspecific":[44],"inflammation":[45],"changes":[47],"in":[48,59,67],"metabolic":[50],"pathway":[51],"infected":[53,69],"cells":[54],"play":[56],"role":[58],"pathogenesis":[60],"neurological":[62],"symptoms":[63],"which":[64],"observed":[66],"patients.":[70]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}