{"id":"https://openalex.org/W9793269","doi":null,"title":"The sequential approach to relapse prevention in unipolar depression.","display_name":"The sequential approach to relapse prevention in unipolar depression.","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W9793269","mag":"9793269","pmid":"https://pubmed.ncbi.nlm.nih.gov/16946806","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1489834"},"language":"en","primary_location":{"id":"pmid:16946806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16946806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World psychiatry : official journal of the World Psychiatric Association (WPA)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041026518","display_name":"Giovanni Andrea Fava","orcid":"https://orcid.org/0000-0002-1690-5344","observed_orcids":["https://orcid.org/0000-0002-1690-5344"]},"institutions":[{"id":"https://openalex.org/I4537092","display_name":"Addis Ababa University","ror":"https://ror.org/038b8e254","country_code":"ET","type":"education","lineage":["https://openalex.org/I4537092"]}],"countries":["ET"],"is_corresponding":false,"raw_author_name":"Giovanni A Fava","raw_affiliation_strings":["Department of Psychiatry, Faculty of Medicine, Addis Ababa University, PO Box 9086, Addis Ababa, Ethiopia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Faculty of Medicine, Addis Ababa University, PO Box 9086, Addis Ababa, Ethiopia","institution_ids":["https://openalex.org/I4537092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027531316","display_name":"Chiara Ruini","orcid":"https://orcid.org/0000-0002-7805-3183","observed_orcids":["https://orcid.org/0000-0002-7805-3183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiara Ruini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8771,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.72899623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"1","issue":"1","first_page":"10","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10214","display_name":"Psychotherapy Techniques and Applications","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.7960000038146973},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9739999771118164},{"id":"https://openalex.org/keywords/sequential-therapy","display_name":"sequential therapy","score":0.6639999747276306},{"id":"https://openalex.org/keywords/residual-symptoms","display_name":"residual symptoms","score":0.5210000276565552},{"id":"https://openalex.org/keywords/cognitive-therapy","display_name":"cognitive therapy","score":0.49300000071525574},{"id":"https://openalex.org/keywords/antidepressant-treatment","display_name":"antidepressant treatment","score":0.460999995470047},{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.5260000228881836},{"id":"https://openalex.org/keywords/cognitive-behavioral-techniques","display_name":"cognitive-behavioral techniques","score":0.4259999990463257},{"id":"https://openalex.org/keywords/long-term-prognosis","display_name":"long-term prognosis","score":0.4880000054836273},{"id":"https://openalex.org/keywords/imipramine","display_name":"imipramine","score":0.5559999942779541},{"id":"https://openalex.org/keywords/exposure-therapy","display_name":"exposure therapy","score":0.5479999780654907},{"id":"https://openalex.org/keywords/social-anxiety-disorder","display_name":"social anxiety disorder","score":0.6029999852180481},{"id":"https://openalex.org/keywords/panic-disorder","display_name":"panic disorder","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.7993450164794922},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6455082297325134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5582825541496277},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5155177116394043},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5034112334251404},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.4855043888092041},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4567064940929413},{"id":"https://openalex.org/C2777342061","wikidata":"https://www.wikidata.org/wiki/Q7836891","display_name":"Treatment-resistant depression","level":4,"score":0.45669442415237427},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4178895950317383},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.37852391600608826},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3733379542827606},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3709685802459717},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.3596586287021637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18753355741500854},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.12341904640197754},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:16946806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16946806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World psychiatry : official journal of the World Psychiatric Association (WPA)","raw_type":"Journal Article"},{"id":"mag:9793269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16946806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W54798487","https://openalex.org/W1749069295","https://openalex.org/W1964791906","https://openalex.org/W1965588015","https://openalex.org/W1969210003","https://openalex.org/W1989627644","https://openalex.org/W1995241110","https://openalex.org/W1995582902","https://openalex.org/W2021661943","https://openalex.org/W2026642769","https://openalex.org/W2031966147","https://openalex.org/W2040362267","https://openalex.org/W2043569410","https://openalex.org/W2045802554","https://openalex.org/W2052785022","https://openalex.org/W2058213326","https://openalex.org/W2061813324","https://openalex.org/W2094031475","https://openalex.org/W2100495048","https://openalex.org/W2106906813","https://openalex.org/W2108563980","https://openalex.org/W2116773974","https://openalex.org/W2126566535","https://openalex.org/W2152972772","https://openalex.org/W2153029414","https://openalex.org/W2418436655","https://openalex.org/W2460220342"],"related_works":["https://openalex.org/W7052444211","https://openalex.org/W1589821828","https://openalex.org/W2060832457","https://openalex.org/W2085923532","https://openalex.org/W1561344637","https://openalex.org/W2103319508","https://openalex.org/W3046057820","https://openalex.org/W1876480437","https://openalex.org/W3110083724","https://openalex.org/W2795657852"],"abstract_inverted_index":{"The":[0,442],"chronic":[1],"and":[2,27,101,135,159,202,281,371,434,455,541],"recurrent":[3,457,488],"nature":[4],"of":[5,24,34,76,80,95,99,106,133,144,156,169,172,188,199,206,224,245,272,278,299,340,358,368,378,383,400,409,418,426,432,445,466,481,522],"major":[6,226,401,451],"depressive":[7,227,452],"disorders":[8,108,146,228],"is":[9,47,137,177],"getting":[10],"increasing":[11],"attention":[12,112],"(1,2).":[13],"Longterm":[14],"pharmacological":[15],"strategies":[16,92,217],"have":[17,218,250],"been":[18,194,219,251,389],"suggested":[19],"as":[20,209,257,502],"an":[21],"effective":[22,240],"means":[23],"preventing":[25],"relapse":[26,410,468,523],"recurrence":[28],"in":[29,72,103,113,174,181,190,210,221,253,279,289,305,329,353,428,437,449,456,464,520,538,548],"depression":[30,212,246,402,433,458,489,540],"(3).":[31],"However,":[32,119,214],"duration":[33],"drug":[35,46,69,88,384],"treatment":[36,89,105,200,387,496],"does":[37,62],"not":[38,63,325,363],"seem":[39],"to":[40,166,197,230,238,284,295,312,343,349,351,365,373,405,415,461,474,478],"affect":[41],"long-term":[42,393],"prognosis":[43],"once":[44],"the":[45,68,104,114,130,145,167,170,222,231,270,282,286,297,300,316,322,366,416,424,429,479,531,535],"discontinued.":[48],"Whether":[49],"you":[50,66],"treat":[51],"a":[52,73,78,140,178,313,419,485,516],"depressed":[53],"patient":[54],"for":[55,268],"3":[56,59],"months":[57],"or":[58,385,497,508],"years,":[60],"it":[61,120],"matter":[64],"when":[65,491],"stop":[67],"(4).":[70],"Further,":[71,129,396],"sizeable":[74],"percentage":[75],"patients":[77,346,492],"loss":[79],"therapeutic":[81],"effects":[82],"occurs,":[83],"despite":[84],"compliance":[85],"with":[86,338,391,505],"antidepressant":[87],"(5).":[90],"Alternative":[91],"are":[93],"thus":[94],"crucial":[96],"value.\r\n\r\nThe":[97],"combination":[98,280],"psychotherapy":[100,136,160],"pharmacotherapy":[102,134,158,427],"affective":[107],"has":[109,121,193,388,413],"attracted":[110],"considerable":[111],"past":[115],"two":[116,287,317],"decades":[117],"(6).":[118],"obtained":[122,252,337],"limited":[123,196],"support":[124],"from":[125,321],"controlled":[126,290],"trials":[127],"(7,8).":[128],"simultaneous":[131],"administration":[132,164,187],"based":[138,422],"on":[139,423,487],"cross-sectional,":[141],"flat":[142],"view":[143],"which":[147,533],"ignores":[148],"their":[149,162],"longitudinal":[150],"development":[151,417],"(9).":[152],"An":[153],"alternative":[154],"way":[155],"integrating":[157],"involves":[161],"sequential":[163,175,191,301,359,420,536],"according":[165],"stages":[168,367],"disorder.\r\n\r\nAdministration":[171],"treatments":[173,189],"order":[176,192],"common":[179],"practice":[180],"clinical":[182,185,498,549],"medicine.":[183],"In":[184,484],"psychiatry,":[186],"mainly":[195],"instances":[198],"resistance":[201],"involved":[203],"different":[204,274],"types":[205],"drugs,":[207],"such":[208,256],"drug-refractory":[211],"(10).":[213],"cognitive":[215,243,309,341,435,494],"behavioral":[216,495],"successful":[220],"management":[223,499],"drug-resistant":[225],"(11),":[229],"same":[232],"extent":[233],"that":[234],"imipramine":[235],"was":[236,362],"found":[237],"be":[239,462,475,546],"after":[241,381,493],"unsuccessful":[242],"therapy":[244,342,436],"(12).":[247],"Similar":[248,333],"results":[249,335,444],"other":[254],"disorders,":[255],"panic":[258,344],"(13).\r\n\r\nWithin":[259],"psychotherapeutic":[260,386],"approaches,":[261,360],"Emmelkamp":[262],"et":[263],"al":[264],"(14)":[265],"deserve":[266],"credit":[267],"suggesting":[269],"feasibility":[271],"applying":[273],"therapies":[275],"consecutively":[276],"instead":[277],"need":[283],"compare":[285],"approaches":[288,318],"studies.":[291],"A":[292],"first":[293],"attempt":[294],"demonstrate":[296],"effectiveness":[298],"approach":[302,537,544],"(involving":[303],"exposure":[304,352],"vivo":[306,354],"followed":[307],"by":[308],"therapy)":[310],"compared":[311],"strategy":[314,421],"where":[315],"were":[319,336,500],"integrated":[320],"start,":[323],"did":[324],"yield":[326],"significant":[327],"differences":[328,513],"social":[330],"phobia":[331],"(15).":[332],"disappointing":[334],"application":[339],"disorder":[345,453],"who":[347],"failed":[348],"respond":[350],"(16).":[355],"This":[356,412],"type":[357],"however,":[361],"targeted":[364],"illness":[369],"(9),":[370],"particularly":[372],"residual":[374,379,398,439,482,506],"symptoms":[375,380,399,408,507],"(1).\r\n\r\nThe":[376],"presence":[377],"completion":[382],"correlated":[390],"poor":[392],"outcome":[394],"(17).":[395],"some":[397],"may":[403],"progress":[404],"become":[406],"prodromal":[407],"(18).":[411],"led":[414],"use":[425],"acute":[430],"phase":[431,440],"its":[438],"(19).":[441],"preliminary":[443],"this":[446,526,543],"strategy,":[447],"both":[448],"primary":[450],"(20,21)":[454],"(22),":[459,490],"appear":[460],"promising":[463],"terms":[465,521],"differential":[467],"rate.":[469],"Its":[470],"preventive":[471],"effect":[472],"appears":[473],"directly":[476],"related":[477],"abatement":[480],"symptoms.":[483],"study":[486],"classified":[501],"still":[503],"presenting":[504],"being":[509],"fully":[510],"asymptomatic,":[511],"striking":[512],"emerged,":[514],"during":[515],"2":[517],"year":[518],"follow-up,":[519],"rate":[524],"(23).\r\n\r\nIn":[525],"paper,":[527],"we":[528],"briefly":[529],"describe":[530],"studies":[532],"developed":[534],"unipolar":[539],"how":[542],"can":[545],"implemented":[547],"practice.":[550]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}