{"id":"https://openalex.org/W97923480","doi":"https://doi.org/10.1007/978-1-4020-8831-5_4","title":"Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System","display_name":"Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W97923480","doi":"https://doi.org/10.1007/978-1-4020-8831-5_4","mag":"97923480","pmid":"https://pubmed.ncbi.nlm.nih.gov/18751909"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4020-8831-5_4","doi":"https://doi.org/10.1007/978-1-4020-8831-5_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4020-8831-5_4","pdf_url":null,"source":{"id":"https://openalex.org/S2755327719","display_name":"Sub-cellular biochemistry/Subcellular biochemistry","issn_l":"0306-0225","issn":["0306-0225","2542-8810"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Subcellular Biochemistry","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W3020951402","display_name":"Lipids in Health and Disease"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073541643","display_name":"Filomena Fezza","orcid":"https://orcid.org/0000-0003-2263-2909","observed_orcids":["https://orcid.org/0000-0003-2263-2909"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filomena Fezza","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I116067653","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chiara De Simone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiara De Simone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046131086","display_name":"Daniele Amadio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniele Amadio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084489352","display_name":"Mauro Maccarrone","orcid":"https://orcid.org/0000-0002-3990-2963","observed_orcids":["https://orcid.org/0000-0002-3990-2963"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mauro Maccarrone","raw_affiliation_strings":["Department of Experimental Medicine & Biochemical Sciences, University of Rome\u201cTor Vergata\u201d, Rome, Ital, Italy","European Center for Brain Research (CERC)/IRCCS S. Lucia Foundation, Ital","University of Rome\u201cTor Vergata\u201d, Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine & Biochemical Sciences, University of Rome\u201cTor Vergata\u201d, Rome, Ital, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"European Center for Brain Research (CERC)/IRCCS S. Lucia Foundation, Ital","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"University of Rome\u201cTor Vergata\u201d, Rome","institution_ids":["https://openalex.org/I116067653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":34.2466,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.99799599,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"49","issue":null,"first_page":"101","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fatty-acid-amide-hydrolase","display_name":"fatty acid amide hydrolase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.9390000104904175},{"id":"https://openalex.org/keywords/anandamide","display_name":"anandamide","score":0.9950000047683716},{"id":"https://openalex.org/keywords/2-arachidonoylglycerol","display_name":"2-arachidonoylglycerol","score":0.9919999837875366},{"id":"https://openalex.org/keywords/faah-inhibitors","display_name":"FAAH inhibitors","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cannabinoid-receptors","display_name":"cannabinoid receptors","score":0.9259999990463257},{"id":"https://openalex.org/keywords/delta9-tetrahydrocannabinol","display_name":"delta-9-tetrahydrocannabinol","score":0.8510000109672546},{"id":"https://openalex.org/keywords/membrane-transporters","display_name":"membrane transporters","score":0.5789999961853027},{"id":"https://openalex.org/keywords/intracellular-degradation","display_name":"intracellular degradation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6769999861717224},{"id":"https://openalex.org/keywords/central-nervous-system-diseases","display_name":"central nervous system disorders","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C2781144285","wikidata":"https://www.wikidata.org/wiki/Q21113274","display_name":"Fatty acid amide hydrolase","level":5,"score":0.9903537631034851},{"id":"https://openalex.org/C2779783865","wikidata":"https://www.wikidata.org/wiki/Q410228","display_name":"Anandamide","level":5,"score":0.9381996393203735},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.9117828011512756},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.7192478775978088},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.5991420745849609},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5451147556304932},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5015566349029541},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4752611517906189},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43239152431488037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35326892137527466},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.05269786715507507}],"mesh":[{"descriptor_ui":"D000099252","descriptor_name":"Fatty Acid Amide Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043882","descriptor_name":"Receptors, Cannabinoid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063385","descriptor_name":"Cannabinoid Receptor Modulators","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D063385","descriptor_name":"Cannabinoid Receptor Modulators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/978-1-4020-8831-5_4","doi":"https://doi.org/10.1007/978-1-4020-8831-5_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4020-8831-5_4","pdf_url":null,"source":{"id":"https://openalex.org/S2755327719","display_name":"Sub-cellular biochemistry/Subcellular biochemistry","issn_l":"0306-0225","issn":["0306-0225","2542-8810"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Subcellular Biochemistry","raw_type":"book-chapter"},{"id":"pmid:18751909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18751909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sub-cellular biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/39177","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/39177","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/bookPart"},{"id":"pmh:oai:ricerca.univaq.it:11697/155910","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11697/155910","pdf_url":null,"source":{"id":"https://openalex.org/S7407055225","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi dell Aquila","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bookPart"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":155,"referenced_works":["https://openalex.org/W1490088833","https://openalex.org/W1513097147","https://openalex.org/W1568165441","https://openalex.org/W1591647183","https://openalex.org/W1602606610","https://openalex.org/W1619879290","https://openalex.org/W1713068177","https://openalex.org/W1781506262","https://openalex.org/W1819429514","https://openalex.org/W1832918544","https://openalex.org/W1929488495","https://openalex.org/W1966146877","https://openalex.org/W1967526820","https://openalex.org/W1967815685","https://openalex.org/W1968366571","https://openalex.org/W1968447753","https://openalex.org/W1969338731","https://openalex.org/W1969657888","https://openalex.org/W1970077719","https://openalex.org/W1970191667","https://openalex.org/W1970440451","https://openalex.org/W1974020846","https://openalex.org/W1977183929","https://openalex.org/W1977869194","https://openalex.org/W1978379381","https://openalex.org/W1978677134","https://openalex.org/W1979137283","https://openalex.org/W1980420294","https://openalex.org/W1986487334","https://openalex.org/W1988519309","https://openalex.org/W1989073099","https://openalex.org/W1989974239","https://openalex.org/W1994809856","https://openalex.org/W1995793646","https://openalex.org/W1997128892","https://openalex.org/W1999822120","https://openalex.org/W1999822411","https://openalex.org/W2003594380","https://openalex.org/W2005308104","https://openalex.org/W2005310692","https://openalex.org/W2006730284","https://openalex.org/W2007924093","https://openalex.org/W2007931918","https://openalex.org/W2015426635","https://openalex.org/W2016078643","https://openalex.org/W2016821576","https://openalex.org/W2017201270","https://openalex.org/W2018797949","https://openalex.org/W2018922931","https://openalex.org/W2019373484","https://openalex.org/W2020077226","https://openalex.org/W2020414448","https://openalex.org/W2020678194","https://openalex.org/W2023733270","https://openalex.org/W2024653583","https://openalex.org/W2026704145","https://openalex.org/W2027885602","https://openalex.org/W2027991357","https://openalex.org/W2029877782","https://openalex.org/W2030129723","https://openalex.org/W2030623240","https://openalex.org/W2032087136","https://openalex.org/W2033822988","https://openalex.org/W2035298337","https://openalex.org/W2036000997","https://openalex.org/W2036082258","https://openalex.org/W2036815337","https://openalex.org/W2037224101","https://openalex.org/W2041074139","https://openalex.org/W2042921052","https://openalex.org/W2045068394","https://openalex.org/W2050550918","https://openalex.org/W2051621327","https://openalex.org/W2052329951","https://openalex.org/W2053028764","https://openalex.org/W2053910424","https://openalex.org/W2054936982","https://openalex.org/W2056188558","https://openalex.org/W2056827996","https://openalex.org/W2057126072","https://openalex.org/W2060288239","https://openalex.org/W2061306380","https://openalex.org/W2062867847","https://openalex.org/W2065679828","https://openalex.org/W2066350084","https://openalex.org/W2067705047","https://openalex.org/W2068949598","https://openalex.org/W2069460649","https://openalex.org/W2069518482","https://openalex.org/W2071631452","https://openalex.org/W2072391296","https://openalex.org/W2078861500","https://openalex.org/W2080649553","https://openalex.org/W2083371696","https://openalex.org/W2083897137","https://openalex.org/W2084652074","https://openalex.org/W2085418154","https://openalex.org/W2085741941","https://openalex.org/W2086534710","https://openalex.org/W2087723063","https://openalex.org/W2088083175","https://openalex.org/W2089573633","https://openalex.org/W2090173711","https://openalex.org/W2092993992","https://openalex.org/W2093601305","https://openalex.org/W2093814212","https://openalex.org/W2095193282","https://openalex.org/W2096529235","https://openalex.org/W2097717578","https://openalex.org/W2100713606","https://openalex.org/W2100977821","https://openalex.org/W2106462471","https://openalex.org/W2106607972","https://openalex.org/W2107296905","https://openalex.org/W2108656555","https://openalex.org/W2112924959","https://openalex.org/W2113920734","https://openalex.org/W2114103705","https://openalex.org/W2114113964","https://openalex.org/W2115350007","https://openalex.org/W2116707337","https://openalex.org/W2119551996","https://openalex.org/W2120027741","https://openalex.org/W2124248227","https://openalex.org/W2125036810","https://openalex.org/W2126304984","https://openalex.org/W2128604157","https://openalex.org/W2129714107","https://openalex.org/W2129968939","https://openalex.org/W2130780097","https://openalex.org/W2131697810","https://openalex.org/W2134266820","https://openalex.org/W2136399145","https://openalex.org/W2137704643","https://openalex.org/W2138357748","https://openalex.org/W2141551684","https://openalex.org/W2147326175","https://openalex.org/W2149381430","https://openalex.org/W2152976365","https://openalex.org/W2154142977","https://openalex.org/W2156809732","https://openalex.org/W2157400187","https://openalex.org/W2157501942","https://openalex.org/W2166074238","https://openalex.org/W2166379515","https://openalex.org/W2166806732","https://openalex.org/W2166997091","https://openalex.org/W2167845627","https://openalex.org/W2168094733","https://openalex.org/W2168187266","https://openalex.org/W2182085115","https://openalex.org/W2207073089","https://openalex.org/W2302613558","https://openalex.org/W4241363254","https://openalex.org/W4406985722"],"related_works":["https://openalex.org/W7056517260","https://openalex.org/W1974020846","https://openalex.org/W2108241949","https://openalex.org/W1965526018","https://openalex.org/W2062173041","https://openalex.org/W2102984876","https://openalex.org/W2144774634","https://openalex.org/W2026874594","https://openalex.org/W1970077719","https://openalex.org/W2981393398"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}