{"id":"https://openalex.org/W979146166","doi":"https://doi.org/10.1253/circj.cj-11-0660","title":"Natriuretic Peptide-Guided Therapy for Heart Failure","display_name":"Natriuretic Peptide-Guided Therapy for Heart Failure","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W979146166","doi":"https://doi.org/10.1253/circj.cj-11-0660","mag":"979146166","pmid":"https://pubmed.ncbi.nlm.nih.gov/21791868"},"language":"en","primary_location":{"id":"doi:10.1253/circj.cj-11-0660","doi":"https://doi.org/10.1253/circj.cj-11-0660","is_oa":true,"landing_page_url":"https://doi.org/10.1253/circj.cj-11-0660","pdf_url":"https://www.jstage.jst.go.jp/article/circj/75/9/75_CJ-11-0660/_pdf","source":{"id":"https://openalex.org/S4210176241","display_name":"Circulation Journal","issn_l":"1346-9843","issn":["1346-9843","1347-4820"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Journal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/circj/75/9/75_CJ-11-0660/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068642565","display_name":"Robert John Mentz","orcid":"https://orcid.org/0000-0002-3222-1719","observed_orcids":["https://orcid.org/0000-0002-3222-1719"]},"institutions":[{"id":"https://openalex.org/I4405286153","display_name":"Duke Clinical Research Institute","ror":"https://ror.org/019mv4g96","country_code":"US","type":"facility","lineage":["https://openalex.org/I170897317","https://openalex.org/I4405286153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Mentz","raw_affiliation_strings":["Department of Cardiology, Duke Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Duke Clinical Research Institute","institution_ids":["https://openalex.org/I4405286153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022076272","display_name":"Gary Michael Felker","orcid":"https://orcid.org/0000-0002-5931-1239","observed_orcids":["https://orcid.org/0000-0002-5931-1239"]},"institutions":[{"id":"https://openalex.org/I4405286153","display_name":"Duke Clinical Research Institute","ror":"https://ror.org/019mv4g96","country_code":"US","type":"facility","lineage":["https://openalex.org/I170897317","https://openalex.org/I4405286153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Michael Felker","raw_affiliation_strings":["Department of Cardiology, Duke Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Duke Clinical Research Institute","institution_ids":["https://openalex.org/I4405286153"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405286153"],"apc_list":null,"apc_paid":null,"fwci":0.3697,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.34382195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"75","issue":"9","first_page":"2031","last_page":"2037"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natriuretic-peptides","display_name":"natriuretic peptides","score":0.847000002861023},{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.7839999794960022},{"id":"https://openalex.org/keywords/biomarker-guided-therapy","display_name":"biomarker-guided therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/heart-failure-treatment","display_name":"heart failure treatment","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7161420583724976},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.6267535090446472},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5411897897720337},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5158433318138123},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4595851004123688},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.44693809747695923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18392205238342285},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07899758219718933}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D045265","descriptor_name":"Natriuretic Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1253/circj.cj-11-0660","doi":"https://doi.org/10.1253/circj.cj-11-0660","is_oa":true,"landing_page_url":"https://doi.org/10.1253/circj.cj-11-0660","pdf_url":"https://www.jstage.jst.go.jp/article/circj/75/9/75_CJ-11-0660/_pdf","source":{"id":"https://openalex.org/S4210176241","display_name":"Circulation Journal","issn_l":"1346-9843","issn":["1346-9843","1347-4820"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Journal","raw_type":"journal-article"},{"id":"pmid:21791868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21791868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation journal : official journal of the Japanese Circulation Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1253/circj.cj-11-0660","doi":"https://doi.org/10.1253/circj.cj-11-0660","is_oa":true,"landing_page_url":"https://doi.org/10.1253/circj.cj-11-0660","pdf_url":"https://www.jstage.jst.go.jp/article/circj/75/9/75_CJ-11-0660/_pdf","source":{"id":"https://openalex.org/S4210176241","display_name":"Circulation Journal","issn_l":"1346-9843","issn":["1346-9843","1347-4820"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W979146166.pdf","grobid_xml":"https://content.openalex.org/works/W979146166.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1910579","https://openalex.org/W14674810","https://openalex.org/W22496758","https://openalex.org/W91108901","https://openalex.org/W279457074","https://openalex.org/W1945958562","https://openalex.org/W1963681897","https://openalex.org/W1965163236","https://openalex.org/W1975603373","https://openalex.org/W1981121371","https://openalex.org/W1984087017","https://openalex.org/W1988088876","https://openalex.org/W2004779219","https://openalex.org/W2005056683","https://openalex.org/W2009428581","https://openalex.org/W2017666800","https://openalex.org/W2026515462","https://openalex.org/W2036168801","https://openalex.org/W2037032663","https://openalex.org/W2040240026","https://openalex.org/W2063166582","https://openalex.org/W2063624516","https://openalex.org/W2066249273","https://openalex.org/W2075117520","https://openalex.org/W2077678288","https://openalex.org/W2095056452","https://openalex.org/W2096341267","https://openalex.org/W2120561016","https://openalex.org/W2125184590","https://openalex.org/W2131687335","https://openalex.org/W2140980422","https://openalex.org/W2141716584","https://openalex.org/W2142768873","https://openalex.org/W2147427559","https://openalex.org/W2151517168","https://openalex.org/W2160470357","https://openalex.org/W2181350280","https://openalex.org/W2208316706","https://openalex.org/W2586400969","https://openalex.org/W2614343168","https://openalex.org/W2748976992","https://openalex.org/W2916505054"],"related_works":["https://openalex.org/W2591307956","https://openalex.org/W4250811778","https://openalex.org/W2001727126","https://openalex.org/W2765325274","https://openalex.org/W2142768873","https://openalex.org/W2049651295","https://openalex.org/W2024983903","https://openalex.org/W2157543984","https://openalex.org/W2503292763","https://openalex.org/W7096939016"],"abstract_inverted_index":{"Chronic":[0],"heart":[1],"failure":[2],"(HF)":[3],"remains":[4],"a":[5],"major":[6],"medical":[7],"problem":[8],"in":[9,45,113],"the":[10,48,86,104],"developed":[11],"world,":[12],"with":[13,56,69],"rapidly":[14],"rising":[15],"prevalence,":[16],"substantial":[17,43],"morbidity,":[18],"and":[19,53,74,92,108],"high":[20],"costs.":[21],"The":[22,79],"concept":[23],"of":[24,42,50,63,81,88,98],"titrating":[25],"chronic":[26,114],"HF":[27,46],"therapies":[28],"using":[29],"physiologic":[30],"markers,":[31],"so":[32],"called":[33],"\"biomarker":[34],"guided":[35],"therapy":[36],"(BGT)\",":[37],"has":[38,95],"become":[39],"an":[40],"area":[41],"interest":[44],"given":[47],"underutilization":[49],"evidence-based":[51],"medications":[52],"suboptimal":[54],"outcomes":[55,73],"current":[57],"management":[58],"strategies.":[59],"Several":[60],"recent":[61],"trials":[62],"BGT":[64,90,112],"have":[65],"had":[66],"mixed":[67],"results,":[68],"some":[70],"demonstrating":[71],"improved":[72],"others":[75],"showing":[76],"no":[77],"benefit.":[78],"heterogeneity":[80],"patient":[82],"populations":[83],"compounded":[84],"by":[85],"lack":[87],"standardized":[89],"algorithms":[91],"trial":[93],"endpoints":[94],"complicated":[96],"interpretation":[97],"these":[99],"results.":[100],"This":[101],"article":[102],"reviews":[103],"rationale,":[105],"accumulated":[106],"data,":[107],"unanswered":[109],"questions":[110],"for":[111],"HF.":[115]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}