{"id":"https://openalex.org/W978838221","doi":"https://doi.org/10.1007/978-1-59745-292-2_22","title":"Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression","display_name":"Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W978838221","doi":"https://doi.org/10.1007/978-1-59745-292-2_22","mag":"978838221"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59745-292-2_22","doi":"https://doi.org/10.1007/978-1-59745-292-2_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-292-2_22","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transforming Growth Factor-\u03b2 in Cancer Therapy, Volume I","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2505592081","display_name":"Transforming Growth Factor-\u03b2 in Cancer Therapy, Volume I"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049694850","display_name":"Tetsu Hayashida","orcid":"https://orcid.org/0000-0002-1657-803X","observed_orcids":["https://orcid.org/0000-0002-1657-803X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tetsu Hayashida","raw_affiliation_strings":["Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA","Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015089565","display_name":"Vandana Gupta","orcid":"https://orcid.org/0000-0002-4057-8451","observed_orcids":["https://orcid.org/0000-0002-4057-8451"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vandana Gupta","raw_affiliation_strings":["Department of Medicine, Genetics Program and Cancer Center, Boston University School of Medicine, Boston, MA, USA","Boston University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Genetics Program and Cancer Center, Boston University School of Medicine, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Boston University School of Medicine","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017059976","display_name":"Sam Thiagalingam","orcid":"https://orcid.org/0000-0001-5211-266X","observed_orcids":["https://orcid.org/0000-0001-5211-266X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sam Thiagalingam","raw_affiliation_strings":["Department of Medicine, Genetics Program and Cancer Center, Boston University School of Medicine, Boston, MA, USA","Boston University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Genetics Program and Cancer Center, Boston University School of Medicine, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Boston University School of Medicine","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069961391","display_name":"Shyamala Maheswaran","orcid":"https://orcid.org/0000-0002-9356-1709","observed_orcids":["https://orcid.org/0000-0002-9356-1709"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shyamala Maheswaran","raw_affiliation_strings":["Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA","Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4296,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.64110429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"355","last_page":"372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/activin","display_name":"activin","score":0.953000009059906},{"id":"https://openalex.org/keywords/inhibin","display_name":"inhibin","score":1.0},{"id":"https://openalex.org/keywords/bone-morphogenetic-proteins","display_name":"bone morphogenetic proteins","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta-superfamily","display_name":"TGF-beta superfamily","score":0.8370000123977661},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.9860000014305115},{"id":"https://openalex.org/keywords/prostate-development","display_name":"prostate development","score":0.703000009059906},{"id":"https://openalex.org/keywords/prostate-tumorigenesis","display_name":"prostate tumorigenesis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7429999709129333},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tgf-beta-receptor","display_name":"TGF-beta receptor","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.8136869668960571},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7467243671417236},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6944265365600586},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.5755288600921631},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5552680492401123},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5453230738639832},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4998359680175781},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.48900139331817627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4810669422149658},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48083338141441345},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4248148500919342},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3936547338962555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3340598940849304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23112648725509644},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1100994348526001},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.058948636054992676}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59745-292-2_22","doi":"https://doi.org/10.1007/978-1-59745-292-2_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-292-2_22","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transforming Growth Factor-\u03b2 in Cancer Therapy, Volume I","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":140,"referenced_works":["https://openalex.org/W157460414","https://openalex.org/W160696900","https://openalex.org/W1209284060","https://openalex.org/W1482212046","https://openalex.org/W1513850687","https://openalex.org/W1521581649","https://openalex.org/W1528597874","https://openalex.org/W1546394086","https://openalex.org/W1567711392","https://openalex.org/W1571917377","https://openalex.org/W1654102341","https://openalex.org/W1662874855","https://openalex.org/W1693984391","https://openalex.org/W1794189178","https://openalex.org/W1839178227","https://openalex.org/W1898988323","https://openalex.org/W1902474317","https://openalex.org/W1903013422","https://openalex.org/W1963772039","https://openalex.org/W1964084634","https://openalex.org/W1965338159","https://openalex.org/W1971245592","https://openalex.org/W1973801926","https://openalex.org/W1975577875","https://openalex.org/W1975846783","https://openalex.org/W1977410508","https://openalex.org/W1979624836","https://openalex.org/W1984445750","https://openalex.org/W1988435907","https://openalex.org/W1989245520","https://openalex.org/W1989468717","https://openalex.org/W1990596031","https://openalex.org/W1991389357","https://openalex.org/W1994280759","https://openalex.org/W1994507519","https://openalex.org/W1994738588","https://openalex.org/W1995362187","https://openalex.org/W1996717896","https://openalex.org/W1997993523","https://openalex.org/W1998927667","https://openalex.org/W1999800217","https://openalex.org/W2004213397","https://openalex.org/W2005673476","https://openalex.org/W2006632995","https://openalex.org/W2007454530","https://openalex.org/W2009342925","https://openalex.org/W2010855103","https://openalex.org/W2012271909","https://openalex.org/W2015272152","https://openalex.org/W2015777584","https://openalex.org/W2016726449","https://openalex.org/W2021868064","https://openalex.org/W2025565204","https://openalex.org/W2026974388","https://openalex.org/W2027505569","https://openalex.org/W2028174408","https://openalex.org/W2028911827","https://openalex.org/W2030908134","https://openalex.org/W2031271949","https://openalex.org/W2033620285","https://openalex.org/W2033858443","https://openalex.org/W2035066075","https://openalex.org/W2035411162","https://openalex.org/W2037325698","https://openalex.org/W2037524652","https://openalex.org/W2040366066","https://openalex.org/W2040805114","https://openalex.org/W2041814357","https://openalex.org/W2042770436","https://openalex.org/W2047403990","https://openalex.org/W2047526453","https://openalex.org/W2048896300","https://openalex.org/W2053352199","https://openalex.org/W2055489437","https://openalex.org/W2055943719","https://openalex.org/W2056948157","https://openalex.org/W2057141328","https://openalex.org/W2058378456","https://openalex.org/W2062375942","https://openalex.org/W2063220914","https://openalex.org/W2063844097","https://openalex.org/W2064224644","https://openalex.org/W2064844805","https://openalex.org/W2066758604","https://openalex.org/W2068063264","https://openalex.org/W2069233875","https://openalex.org/W2069484540","https://openalex.org/W2070033133","https://openalex.org/W2072708570","https://openalex.org/W2074985251","https://openalex.org/W2075856018","https://openalex.org/W2077243848","https://openalex.org/W2078260839","https://openalex.org/W2079608196","https://openalex.org/W2080409070","https://openalex.org/W2080816640","https://openalex.org/W2081765669","https://openalex.org/W2083320374","https://openalex.org/W2088392474","https://openalex.org/W2090046369","https://openalex.org/W2092249998","https://openalex.org/W2094522927","https://openalex.org/W2098572393","https://openalex.org/W2099704519","https://openalex.org/W2103031848","https://openalex.org/W2104568463","https://openalex.org/W2104622663","https://openalex.org/W2110405666","https://openalex.org/W2113316330","https://openalex.org/W2114905278","https://openalex.org/W2118518454","https://openalex.org/W2120225922","https://openalex.org/W2121551386","https://openalex.org/W2122367477","https://openalex.org/W2131009607","https://openalex.org/W2132199624","https://openalex.org/W2135473313","https://openalex.org/W2139256061","https://openalex.org/W2139616070","https://openalex.org/W2139675480","https://openalex.org/W2141562227","https://openalex.org/W2149218924","https://openalex.org/W2155452177","https://openalex.org/W2155470210","https://openalex.org/W2159500972","https://openalex.org/W2163802459","https://openalex.org/W2168478740","https://openalex.org/W2170085122","https://openalex.org/W2316880140","https://openalex.org/W2330429933","https://openalex.org/W2333704118","https://openalex.org/W2397870557","https://openalex.org/W2406319401","https://openalex.org/W2411456815","https://openalex.org/W2414822843","https://openalex.org/W2417865674","https://openalex.org/W2615946525","https://openalex.org/W4230956885","https://openalex.org/W4244095134","https://openalex.org/W4246141623"],"related_works":["https://openalex.org/W2096315312","https://openalex.org/W4313260395","https://openalex.org/W191997939","https://openalex.org/W2594907206","https://openalex.org/W2524245457","https://openalex.org/W2416677192","https://openalex.org/W2971160148","https://openalex.org/W4247482909","https://openalex.org/W86960128","https://openalex.org/W2581987794"],"abstract_inverted_index":{"The":[0,82,96],"transforming":[1],"growth":[2,23],"factor-\u03b2":[3],"(TGF-\u03b2)":[4],"superfamily":[5],"consists":[6],"of":[7,17,31,66,69,79,85,98,109,127],"over":[8],"35":[9],"structurally":[10],"related":[11],"proteins,":[12],"which":[13],"regulate":[14,75],"a":[15],"myriad":[16],"cellular":[18],"processes.":[19],"Signaling":[20],"by":[21,28],"these":[22],"regulatory":[24],"molecules":[25,71],"is":[26,101],"initiated":[27],"ligand-induced":[29],"hetero-oligomerization":[30],"distinct":[32],"type":[33,36],"II":[34],"and":[35,53,61,64,77,106,112,118,120,125],"I":[37],"serine/threonine":[38],"kinase":[39],"receptors":[40,54],"that":[41],"activate":[42],"receptor-activated":[43],"Smad":[44],"proteins":[45],"as":[46,48,123],"well":[47],"Smad-independent":[49],"pathways.":[50],"TGF-\u03b2-related":[51],"ligands":[52],"are":[55,72],"expressed":[56],"in":[57,87,93,115],"the":[58,80,104],"prostate":[59,88,116,128],"gland":[60],"aberrant":[62],"expression":[63,105],"function":[65],"this":[67,99],"class":[68],"signaling":[70,114],"likely":[73],"to":[74,102],"development":[76,117],"tumorigenesis":[78],"prostate.":[81],"functional":[83,107],"significance":[84,108],"TGF-\u03b2":[86],"cancer":[89,129],"has":[90],"been":[91],"reviewed":[92],"several":[94],"articles.":[95],"objective":[97],"review":[100],"evaluate":[103],"activins,":[110],"inhibins,":[111],"BMP":[113],"tumorigenesis,":[119],"their":[121],"role":[122],"modulators":[124],"biomarkers":[126],"progression.":[130]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}