{"id":"https://openalex.org/W978712406","doi":"https://doi.org/10.1109/ultsym.2011.0467","title":"A dose-efficient treatment strategy for histotripsy by removing cavitation memory","display_name":"A dose-efficient treatment strategy for histotripsy by removing cavitation memory","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W978712406","doi":"https://doi.org/10.1109/ultsym.2011.0467","mag":"978712406"},"language":"en","primary_location":{"id":"doi:10.1109/ultsym.2011.0467","doi":"https://doi.org/10.1109/ultsym.2011.0467","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ultsym.2011.0467","pdf_url":null,"source":{"id":"https://openalex.org/S4393917990","display_name":"IEEE International Ultrasonics Symposium","issn_l":"1948-5719","issn":["1948-5719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Ultrasonics Symposium","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083586867","display_name":"Tzu-Yin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tzu-Yin Wang","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017355711","display_name":"Zhen Xu","orcid":"https://orcid.org/0000-0003-0262-3044","observed_orcids":["https://orcid.org/0000-0003-0262-3044"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Xu","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046270398","display_name":"Timothy L. Hall","orcid":"https://orcid.org/0000-0002-4867-2856","observed_orcids":["https://orcid.org/0000-0002-4867-2856"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy L Hall","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088298096","display_name":"J. Brian Fowlkes","orcid":"https://orcid.org/0000-0002-4536-3919","observed_orcids":["https://orcid.org/0000-0002-4536-3919"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Brian Fowlkes","raw_affiliation_strings":["Department of Radiology, University of Michigan, Ann Arbor, MI, USA","Department of Radiology, University of Michigan, Ann Arbor, 48109 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Radiology, University of Michigan, Ann Arbor, 48109 USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113028792","display_name":"Charles A. Cain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A Cain","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03107528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1870","last_page":"1873"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11842","display_name":"Ultrasound and Cavitation Phenomena","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histotripsy","display_name":"histotripsy","score":0.972000002861023},{"id":"https://openalex.org/keywords/cavitation-bubbles","display_name":"cavitation bubbles","score":0.7070000171661377},{"id":"https://openalex.org/keywords/interpulse-interval","display_name":"interpulse interval","score":0.6660000085830688},{"id":"https://openalex.org/keywords/dose-efficiency","display_name":"dose efficiency","score":0.5950000286102295},{"id":"https://openalex.org/keywords/tissue-fragmentation","display_name":"tissue fragmentation","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C207057113","wikidata":"https://www.wikidata.org/wiki/Q201666","display_name":"Cavitation","level":2,"score":0.985801100730896},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6135560870170593},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.6111655235290527},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5365505218505859},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.514782190322876},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.45373716950416565},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.42688941955566406},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.388680100440979},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.3064180016517639},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2422744333744049},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1287490725517273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1149943470954895},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11463174223899841},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1114034652709961},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ultsym.2011.0467","doi":"https://doi.org/10.1109/ultsym.2011.0467","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ultsym.2011.0467","pdf_url":null,"source":{"id":"https://openalex.org/S4393917990","display_name":"IEEE International Ultrasonics Symposium","issn_l":"1948-5719","issn":["1948-5719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Ultrasonics Symposium","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6299999952316284}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W191624211","https://openalex.org/W1969793936","https://openalex.org/W1971037061","https://openalex.org/W1973314414","https://openalex.org/W1977670463","https://openalex.org/W1981243220","https://openalex.org/W1983395182","https://openalex.org/W1997999604","https://openalex.org/W2000747995","https://openalex.org/W2001455415","https://openalex.org/W2003553249","https://openalex.org/W2008366051","https://openalex.org/W2010462419","https://openalex.org/W2014724825","https://openalex.org/W2025105376","https://openalex.org/W2035501762","https://openalex.org/W2039856108","https://openalex.org/W2052317009","https://openalex.org/W2052886393","https://openalex.org/W2053953203","https://openalex.org/W2056025699","https://openalex.org/W2057878007","https://openalex.org/W2061913290","https://openalex.org/W2065680204","https://openalex.org/W2067810195","https://openalex.org/W2079104743","https://openalex.org/W2082883007","https://openalex.org/W2086107824","https://openalex.org/W2087457217","https://openalex.org/W2090878767","https://openalex.org/W2091580446","https://openalex.org/W2101550492","https://openalex.org/W2103849771","https://openalex.org/W2105063250","https://openalex.org/W2112916982","https://openalex.org/W2118278483","https://openalex.org/W2118727435","https://openalex.org/W2125701121","https://openalex.org/W2135558191","https://openalex.org/W2143507292","https://openalex.org/W2150660378","https://openalex.org/W2165510365","https://openalex.org/W2171435469","https://openalex.org/W2171810350"],"related_works":["https://openalex.org/W2100815284","https://openalex.org/W2883595537","https://openalex.org/W2192498114","https://openalex.org/W1989631843","https://openalex.org/W889552794","https://openalex.org/W2030576706","https://openalex.org/W1792389740","https://openalex.org/W2068104553","https://openalex.org/W4399828613","https://openalex.org/W2084579959"],"abstract_inverted_index":{"Cavitation":[0],"memory":[1,93,164],"effect":[2,29],"occurs":[3],"when":[4],"fragments":[5],"of":[6,80,131,161],"cavitation":[7,32,61,92,107,132,163],"bubbles":[8,62,133],"persist":[9],"in":[10,69,124,134],"the":[11,50,58,60,81,89,91,99,110,125,128,141,159,162],"host":[12],"medium":[13],"and":[14,77,109,145,170],"act":[15],"as":[16],"seeds":[17],"for":[18,152],"subsequent":[19],"events.":[20],"In":[21],"pulsed":[22],"cavitational":[23],"ultrasound":[24],"therapy,":[25],"or":[26,43],"histotripsy,":[27],"this":[28],"may":[30,165],"cause":[31],"to":[33,47,71,75],"repeatedly":[34],"occur":[35],"at":[36,66],"these":[37],"seeded":[38],"locations,":[39],"producing":[40],"inhomogeneous":[41],"lesions":[42],"requiring":[44],"excess":[45],"pulses":[46,136,151],"completely":[48,144],"homogenize":[49],"target":[51,82],"volume.":[52],"We":[53],"hypothesized":[54],"that":[55,158],"by":[56,97],"removing":[57],"memory,":[59],"could":[63],"be":[64],"induced":[65],"random":[67],"locations":[68],"response":[70],"each":[72],"pulse,":[73],"leading":[74],"complete":[76],"homogeneous":[78,171],"disruption":[79],"volume":[83],"with":[84,137,148],"fewer":[85,150],"pulses.":[86],"To":[87],"test":[88],"hypothesis,":[90],"was":[94,143],"passively":[95],"removed":[96],"increasing":[98,138],"time":[100],"intervals":[101],"between":[102,127],"successive":[103,135],"pulses,":[104],"\u0394t.":[105],"The":[106],"patterns":[108],"lesion":[111,142],"development":[112],"process":[113],"using":[114],"various":[115],"\u0394t's":[116],"were":[117],"studied.":[118],"Results":[119],"showed":[120],"an":[121],"exponential":[122],"decrease":[123],"similarity":[126],"spatial":[129],"distributions":[130],"\u0394t's;":[139],"correspondingly,":[140],"homogeneously":[146],"fractionated":[147],"significantly":[149],"longer":[153],"\u0394t's.":[154],"These":[155],"results":[156],"indicated":[157],"removal":[160],"produce":[166],"more":[167],"dose-efficient":[168],"treatments":[169],"lesions.":[172]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}